scholarly journals Exposure to Dental Filling Materials and the Risk of Dementia: A Population-Based Nested Case Control Study in Taiwan

2019 ◽  
Vol 16 (18) ◽  
pp. 3283 ◽  
Author(s):  
Natalia Mikhailichenko ◽  
Kimitoshi Yagami ◽  
Jeng-Yuan Chiou ◽  
Jing-Yang Huang ◽  
Yu-Hsun Wang ◽  
...  
Keyword(s):  
Large Scale ◽  
Population Based ◽  
Epidemiologic Studies ◽  
Toxic Substances ◽  
Filling Material ◽  
Dental Practice ◽  
Dental Filling ◽  
Filling Materials ◽  
People With Dementia ◽  
Somatic Diseases

When studying the range of toxic substances triggering dementia, special attention should be paid to the materials used in dental practice, particularly to dental fillings containing amalgam. This necessitated conducting large-scale epidemiologic studies. The aim of our research was to determine the risk factors for developing dementia when filling materials containing amalgam are used in dental practice. In order to achieve the set goals, the following tasks were undertaken: (1) The social and demographic characteristics of the examined patients were studied; (2) the spectrum of concomitant somatic diseases was determined in patients of different gender and age; and (3) the relationship between dementia incidence and the volume of dental filling material containing amalgam was identified in patients with different somatic diseases. In general, the research conducted did not reveal any direct relationship between the development of dementia and the volume of filling material containing amalgam. However, among the people with dementia, there were persons for whom its progression was accelerated in cases where a large volume of dental filling material containing amalgam was present.

Research Status and Development Trend of High Sand Filling Materials

2017 ◽  
Vol 727 ◽  
pp. 1079-1083 ◽  
Author(s):  
Yong Liu ◽  
Jie Chen
Keyword(s):  
Large Scale ◽  
Low Cost ◽  
Rock Fracture ◽  
Mining Area ◽  
Development Trend ◽  
Filling Material ◽  
Control Effect ◽  
Filling Materials ◽  
Local Water ◽  
The Stability

The coal is main energy in our country, it takes many economy and environment problems in the process of exploitation process.With the development of large-scale mining area, mining of rock fracture field and the change of the terrain, vegetation and ecological environmental impact of surface water, ground seriously. This paper introduces about goaf paste filling mining which is the important part of coal green mining technology, it is an effective method to solve subsidence and the problem of coal mining surface ecological environment. Occurrence of aeolian sand and flexible strip filling control effect on the stability of water-resisting layer create conditions for the development of the local water filling mining.The paste filling material prepared with cemented Filling materials has the advantages of low cost and environment protection, which can take the various benefits such as economy, society and environment to diggings.

scholarly journals Influence of dental filling material type on the concentration of interleukin 9 in the samples of gingival crevicular fluid

2016 ◽  
Vol 73 (8) ◽  
pp. 728-734 ◽  
Author(s):  
Vladimir Stefanovic ◽  
Ervin Taso ◽  
Aleksandra Petkovic-Curcin ◽  
Mirjana Djukic ◽  
Milka Gardasevic ◽  
...  
Keyword(s):  
Dental Pulp ◽  
Wound Repair ◽  
Gingival Crevicular Fluid ◽  
Prospective Clinical Study ◽  
Filling Material ◽  
Gingival Index ◽  
Dental Fillings ◽  
Dental Filling ◽  
Filling Materials ◽  
Pulp Inflammation

Background/Aim. Several cytokines and lymphokines (IL1?, ENA78, IL6, TNF?, IL8 and S100A8) are expressed during dental pulp inflammation. Analysis of gingival crevicu-lar fluid (GCF) offers a non-invasive means of studying gen-eral host response in oral cavity. Although GCF levels of various mediators could reflect the state of inflammation both in dental pulp and gingiva adjacent to a tooth, GCF samples of those without significant gingivitis could be inter-preted as reflection of pulpal process. The aim of this study was to investigate IL9 GCF values in patients with dental car-ies and to assess possible influence of various dental fillings materials on local IL9 production. Methods. The study group included 90 patients, aged 18?70, with inclusion and exclusion criteria in the prospective clinical study. Of the 6 types of material used for the restoration of prepared cavities, 3 were intended for temporary and 3 for definitive restora-tion. According to dental fillings weight, all the participants were divided into 3 groups: those with fillings lighter than 0.50 g, those with 0.50?1.00 g, and those with fillings heavier than 1.00 g. Samples were taken from gingival sulcus using the filter paper technique. Clinical parameters were deter-mined by bleeding index, plaque index (Silness-Lou, 0?3), gingival index (0?3), and gingival sulcus depth. Cytokine con-centrations were assessed using commercially available cy-tomix. Results. According to the weight of dental fillings, there was a clear decreament trend of IL9 values meaning that dental defects greater than 1.00 g of dental filling were associated with lower GCF IL9 concentration. The IL9 val-ues correlated with the degree of gingival index and depth of gingival sulcus, being higher with more advanced gingivitis and more pronounced anatomical changes in the tooth edge. Different filling materials exerted various local IL9 responses. Zink polycarbonate cement and amalgam fillings induced a significant and long-lasting local IL9 decrement, while the use of Tetric EvoCeram and GMA-BISK significantly increased IL9 levels. Conclusion. The obtained results indicate that IL9 GCF could be regarded as a measure of odontoblasts? re-sponse to the extensity of dental caries. The type of material used for dental fillings could profoundly alter biological func-tion of gingival and pulpal cells. Also, the results obtained in this study suggest that some materials could even enhance wound repair by modulating macrophage activation.

scholarly journals Risk Factors of Dermatophytosis in Young Adults: A Nationwide Population-Based Study

2022 ◽  
Author(s):  
Joon Ho Son ◽  
Jee Yun Doh ◽  
Kyungdo Han ◽  
Yeong Ho Kim ◽  
Ju Hee Han ◽  
...  
Keyword(s):  
Risk Factors ◽  
Waist Circumference ◽  
Large Scale ◽  
Fungal Infections ◽  
Heavy Drinking ◽  
Population Based ◽  
Epidemiologic Studies ◽  
Lifestyle Modifications ◽  
Korean National Health Insurance ◽  
Using Data

Abstract Dermatophytosis includes all fungal infections caused by dermatophytes in humans. Some risk factors for the development of subtypes of dermatophytosis have been studied; however, large-scale epidemiologic studies on risk factors for total dermatophytosis are scarce. We investigated the risk factors of dermatophytosis using a nationwide study. Total 4,532,655 subjects with dermatophytosis aged between 20 to 40 years were examined using data from the Korean National Health Insurance Service from 2009 to 2018. Women showed a lower risk of development of dermatophytosis compared to men (hazard ratio [HR], 0.848; 95% confidence interval [CI], 0.843–0.853). Subjects with elevated waist circumference (HR, 1.057; 95% CI, 1.048–1.065), heavy drinking (HR, 1.053; 95% CI, 1044–1.061), engaging in mild-to-heavy exercise (HR, 1.071; 95% CI, 1.064–1.077) had a higher risk of dermatophytosis. In addition, subjects with body mass index (BMI) of more than 30 kg/m2 exhibited a higher risk of dermatophytosis (HR, 1.36; 95% CI, 1.342–1.378) compared to those with BMIs in the range of 18.5 to 23 kg/m2. In this study, the risk of developing dermatophytosis significantly increased in individuals with elevated waist circumference or high BMI. Lifestyle modifications, including weight management, are suggested to be important in preventing dermatophytosis.

scholarly journals Parallel Assessment Challenges in Nutritional and Sleep Epidemiology

2020 ◽  
Author(s):  
G L Dunietz ◽  
E C Jansen ◽  
S D Hershner ◽  
L M O’Brien ◽  
K E Peterson ◽  
...  
Keyword(s):  
Public Health ◽  
Health Outcomes ◽  
Sleep Duration ◽  
Clinical Studies ◽  
Large Scale ◽  
Population Based ◽  
Epidemiologic Studies ◽  
Nutritional Epidemiology ◽  
Insufficient Sleep ◽  
Methodological Challenges

Abstract Sleep has been consistently linked to health outcomes in clinical studies, but only in recent years has sleep become a focus in epidemiologic studies and public health. In particular, the sizable prevalence of insufficient sleep in the population warrants well-designed epidemiologic studies to examine its impact on public health. As a developing field, sleep epidemiology encounters methodological challenges similar to those faced by nutritional epidemiology research. In this article, we describe a few central challenges related to assessment of sleep duration in population-based studies in comparison to measurement challenges in nutritional epidemiology. In addition, we highlight three strategies applied in nutritional epidemiology to address measurement challenges and suggest ways these strategies may be implemented in large-scale sleep investigations.

scholarly journals Mechanical Stress Exploration Inside of Dental Filling Materials by Means of Electronic Speckle Pattern Interferometry / Shearography

2017 ◽  
Vol 54 (4) ◽  
pp. 616-619
Author(s):  
Alina Ormenisan ◽  
Daniel Tamas Szava ◽  
Ioan Szava ◽  
Ciprian Dalai
Keyword(s):  
Speckle Pattern ◽  
Glass Ionomer Cement ◽  
Academic Research ◽  
Mechanical Stresses ◽  
Electronic Speckle Pattern Interferometry ◽  
Filling Material ◽  
Dental Tissues ◽  
Vertical Loading ◽  
Dental Filling ◽  
Filling Materials

Possible causes of microleakage and microfractures of dental fillings are often in the center of many academic research and investigations. Some authors found that one important cause of microleakage is the contraction/ shrinkage of the filling materials during polymerization. The purpose of this study is to demonstrate that microcracks and consequent microleakage is influenced by mechanical stresses occurring inside of dental filling materials and at the interface of the dental cavities and dental filling materials. We also tried to evaluate the deformation of some dental filling material types during mechanical loading. Cylindrical specimens were made of different types of dental filling materials, namely microhybrid composites and glass ionomer cement. Some extracted teeth were prepared with class II cavities, and filled. The lateral swelling of the tested specimens and the deformation of the filled teeth during vertical axial loading was measured with an optical method, ESPI/ Shearography.Of the tested specimen, the least deformable dental filling materials were the composite materials. During occlusal vertical loading of the filled teeth, there were found that mechanical stresses were different inside of the filling material than inside of the walls of the dental tissues, mechanical stressed being concentrated at the restoration interface. The ESPI/Shearography meth ode proved to be very useful for investigation in this field. Due to mechanical stresses accumulating at the interface of the dental filling material and the walls of the dental cavity, it is possible that later microcracks to appear due to masticatory forces.

Reaction-based Enumeration, Active Learning, and Free Energy Calculations to Rapidly Explore Synthetically Tractable Chemical Space and Optimize Potency of Cyclin Dependent Kinase 2 Inhibitors

2019 ◽  
Author(s):  
Kyle Konze ◽  
Pieter Bos ◽  
Markus Dahlgren ◽  
Karl Leswing ◽  
Ivan Tubert-Brohman ◽  
...  
Keyword(s):  
Free Energy ◽  
Drug Discovery ◽  
Active Learning ◽  
Large Scale ◽  
Chemical Space ◽  
Population Based ◽  
Free Energy Calculations ◽  
Computational Technique ◽  
Cyclin Dependent Kinase ◽  
Energy Calculations

We report a new computational technique, PathFinder, that uses retrosynthetic analysis followed by combinatorial synthesis to generate novel compounds in synthetically accessible chemical space. Coupling PathFinder with active learning and cloud-based free energy calculations allows for large-scale potency predictions of compounds on a timescale that impacts drug discovery. The process is further accelerated by using a combination of population-based statistics and active learning techniques. Using this approach, we rapidly optimized R-groups and core hops for inhibitors of cyclin-dependent kinase 2. We explored greater than 300 thousand ideas and identified 35 ligands with diverse commercially available R-groups and a predicted IC<sub>50</sub> < 100 nM, and four unique cores with a predicted IC<sub>50</sub> < 100 nM. The rapid turnaround time, and scale of chemical exploration, suggests that this is a useful approach to accelerate the discovery of novel chemical matter in drug discovery campaigns.

Reaction-based Enumeration, Active Learning, and Free Energy Calculations to Rapidly Explore Synthetically Tractable Chemical Space and Optimize Potency of Cyclin Dependent Kinase 2 Inhibitors

2019 ◽  
Author(s):  
Kyle Konze ◽  
Pieter Bos ◽  
Markus Dahlgren ◽  
Karl Leswing ◽  
Ivan Tubert-Brohman ◽  
...  
Keyword(s):  
Free Energy ◽  
Drug Discovery ◽  
Active Learning ◽  
Large Scale ◽  
Chemical Space ◽  
Population Based ◽  
Free Energy Calculations ◽  
Computational Technique ◽  
Cyclin Dependent Kinase ◽  
Energy Calculations

We report a new computational technique, PathFinder, that uses retrosynthetic analysis followed by combinatorial synthesis to generate novel compounds in synthetically accessible chemical space. Coupling PathFinder with active learning and cloud-based free energy calculations allows for large-scale potency predictions of compounds on a timescale that impacts drug discovery. The process is further accelerated by using a combination of population-based statistics and active learning techniques. Using this approach, we rapidly optimized R-groups and core hops for inhibitors of cyclin-dependent kinase 2. We explored greater than 300 thousand ideas and identified 35 ligands with diverse commercially available R-groups and a predicted IC<sub>50</sub> < 100 nM, and four unique cores with a predicted IC<sub>50</sub> < 100 nM. The rapid turnaround time, and scale of chemical exploration, suggests that this is a useful approach to accelerate the discovery of novel chemical matter in drug discovery campaigns.

scholarly journals Validation of the Japanese Version of the Center for Epidemiologic Studies Depression Scale—Revised: A Preliminary Analysis

2021 ◽  
Vol 11 (8) ◽  
pp. 107
Author(s):  
Hirohito Tsuboi ◽  
Yui Takakura ◽  
Hiromasa Tsujiguchi ◽  
Sakae Miyagi ◽  
Keita Suzuki ◽  
...  
Keyword(s):  
Factor Analysis ◽  
Depressive Symptoms ◽  
Native Speakers ◽  
Depression Scale ◽  
Japanese Version ◽  
Population Based ◽  
Epidemiologic Studies ◽  
Community Dwelling ◽  
Two Factors ◽  
Study Population

To make the Japanese version of the CESD-R—a revised version of the Center for Epidemiologic Studies depression scale (CES-D)—in the assessment of depressive symptoms in a general population. The English version of CESD-R was translated into Japanese, and back-translated into English by three native speakers of Japanese and English; then, we selected the version most completely consistent with the original items. The CESD-R was applied to 398 community-dwelling people (191 men: 48.0%, and 207 women: 52.0%) who were over 40 years old. The Japanese version of the CES-D was also carried out in the same population. Factor analysis was performed. Additionally, the correlations between the CESD-R and CES-D results were identified. The CESD-R scores showed a significantly positive correlation with CES-D scores (r = 0.74, p < 0.0005). Analysis of the CESD-R yielded a Cronbach’s alpha result of 0.90. Factor analysis revealed one principal factor in the CESD-R, whereas the original CES-D had two factors because of reversed items. The Japanese version of the CESD-R appears to have the reliability to be applicable for assessing depressive symptoms in population-based samples. However, because the Japanese expressions for some items might be unusual, our study population was also limited; further studies on other populations and on incorporating improved Japanese terminology will be needed.

scholarly journals Use of Antiplatelet Agents Decreases the Positive Predictive Value of Fecal Immunochemical Tests for Colorectal Cancer but Does Not Affect Their Sensitivity

2021 ◽  
Vol 11 (6) ◽  
pp. 497
Author(s):  
Yoonsuk Jung ◽  
Eui Im ◽  
Jinhee Lee ◽  
Hyeah Lee ◽  
Changmo Moon
Keyword(s):  
Colorectal Cancer ◽  
Large Scale ◽  
Screening Program ◽  
Antiplatelet Agents ◽  
Population Based ◽  
Small Sample ◽  
Antithrombotic Agents ◽  
Predictive Values ◽  
Prescription Rates ◽  
Small Sample Sizes

Previous studies have evaluated the effects of antithrombotic agents on the performance of fecal immunochemical tests (FITs) for the detection of colorectal cancer (CRC), but the results were inconsistent and based on small sample sizes. We studied this topic using a large-scale population-based database. Using the Korean National Cancer Screening Program Database, we compared the performance of FITs for CRC detection between users and non-users of antiplatelet agents and warfarin. Non-users were matched according to age and sex. Among 5,426,469 eligible participants, 768,733 used antiplatelet agents (mono/dual/triple therapy, n = 701,683/63,211/3839), and 19,569 used warfarin, while 4,638,167 were non-users. Among antiplatelet agents, aspirin, clopidogrel, and cilostazol ranked first, second, and third, respectively, in terms of prescription rates. Users of antiplatelet agents (3.62% vs. 4.45%; relative risk (RR): 0.83; 95% confidence interval (CI): 0.78–0.88), aspirin (3.66% vs. 4.13%; RR: 0.90; 95% CI: 0.83–0.97), and clopidogrel (3.48% vs. 4.88%; RR: 0.72; 95% CI: 0.61–0.86) had lower positive predictive values (PPVs) for CRC detection than non-users. However, there were no significant differences in PPV between cilostazol vs. non-users and warfarin users vs. non-users. For PPV, the RR (users vs. non-users) for antiplatelet monotherapy was 0.86, while the RRs for dual and triple antiplatelet therapies (excluding cilostazol) were 0.67 and 0.22, respectively. For all antithrombotic agents, the sensitivity for CRC detection was not different between users and non-users. Use of antiplatelet agents, except cilostazol, may increase the false positives without improving the sensitivity of FITs for CRC detection.

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