scholarly journals Sex- and Gender-Based Analysis in Cannabis Treatment Outcomes: A Systematic Review

Author(s):  
Andreea C. Brabete ◽  
Lorraine Greaves ◽  
Natalie Hemsing ◽  
Julie Stinson

There is evidence that sex- and gender-related factors are involved in cannabis patterns of use, health effects and biological mechanisms. Women and men report different cannabis use disorder (CUD) symptoms, with women reporting worse withdrawal symptoms than men. The objective of this systematic review was to examine the effectiveness of cannabis pharmacological interventions for women and men and the uptake of sex- and gender-based analysis in the included studies. Two reviewers performed the full-paper screening, and data was extracted by one researcher. The search yielded 6098 unique records—of which, 68 were full-paper screened. Four articles met the eligibility criteria for inclusion. From the randomized clinical studies of pharmacological interventions, few studies report sex-disaggregated outcomes for women and men. Despite emergent evidence showing the influence of sex and gender factors in cannabis research, sex-disaggregated outcomes in pharmacological interventions is lacking. Sex- and gender-based analysis is incipient in the included articles. Future research should explore more comprehensive inclusion of sex- and gender-related aspects in pharmacological treatments for CUD.

2016 ◽  
Vol 10 (3) ◽  
pp. 246-251 ◽  
Author(s):  
Akilesh Anand Prakash

Incisura fibularis (IF) is an important landmark in assessing syndesmotic stability radiologically postinjury. The purpose of this review was to explore the anatomy and morphometrics of this widely used anatomical landmark and to further the understanding of the same. A systematic review was conducted online using PubMed and Google Scholar, per PRISMA guidelines. Predefined eligibility criteria were applied, and the data thus compiled were analyzed. Wide variability in morphometrics and, thus, anatomy of IF were observed in the present review, which was influenced by gender. There was no side-to-side variability seen in this study. The study stresses the need to consider the anatomical and gender-based variability while assessing syndesmotic stability and further supports the recommendation of side-to-side comparison. Levels of Evidence: Anatomical, Level V


Author(s):  
Matthew J. Loscalzo ◽  
Karen L. Clark ◽  
Courtney Bitz ◽  
Justin M. Yopp ◽  
Donald L. Rosenstein

This chapter outlines two innovative sex- and gender-based biopsychosocial interventions: Couples Coping with Cancer Together and Single Fathers Due to Cancer. The foundation of each intervention is based on strengths inherent to the participants’ gender. Couples Coping with Cancer Together focuses on patients and partners during both active treatment and survivorship. Single Fathers Due to Cancer engages widowed fathers and their children. These two programs illustrate the relevance of sex (a one-time biological event determined at conception: male, female, intersex) and gender (how individuals defines themselves and their lives) differences in coping with the challenges of cancer. Future research is essential to empirically explore interventional studies that focus on gender-related strengths.


2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Lisa Wandschneider ◽  
Stephanie Batram-Zantvoort ◽  
Oliver Razum ◽  
Céline Miani

Abstract Background Gender as a social construct contributes to determine who migrates and which migration-related risks and opportunities emerge in all phases of the migration trajectory. Simultaneously, migration influences the individual as well as societal definition and perception of gender roles. An explicit gender perspective in migration-related epidemiological research can contribute to adequately analyse and interpret the health of migrants. This systematic review gives a comprehensive overview on how gender has been conceptualised, operationalised and measured in social epidemiologic studies aiming to assess the influence of gender on health among migrants. Methods We searched PubMed, Embase, CINAHL, the Cochrane Library, EconLit and PsycINFO and conducted backward reference searching. Reviewers independently selected studies, extracted data and conducted the quality assessment. Eligible studies actively aimed to understand, identify or explain the influence of gender on migrants’ health, whereby the role of gender can encompass a variety of mechanisms, processes or states of differentiation, discrimination and/or inequality. Results Almost all of the 43 studies were cross-sectional and focussed on health outcomes in the post-migration phase. The most common theme of research was the health of male migrants in the US, and in particular of men who have sex with men (MSM). All studies treated gender as a binary variable (men vs. women), without discussing additional types of gender identities. A minority of studies differentiated clearly between sex and gender. Gender was mostly operationalised through attitudes toward gender roles and gender-based discrimination, experienced at the individual level. Community and societal level gender measures capturing structural gender determinants were underrepresented. Conclusions The intersections of migration and gender suggested synergistic effects on health that only become visible when considering those two social determinants together. Future research needs to embrace a multilevel and non-binary understanding of gender and reflect on the influence of gender in the different phases of the migration journey. Systematic review registration PROSPERO CRD42019124698.


2021 ◽  
Author(s):  
Stella R Sheeba ◽  
Rocco Cavaleri ◽  
Simon J Summers ◽  
Cherylea J Browne

Abstract Background: Concussion is a form of mild traumatic brain injury (mTBI) that disrupts brain function. Although symptoms are mostly transient, recovery can be delayed and result in post-concussive syndrome (PCS). Vestibular and oculomotor deficits are among the most debilitating impairments associated with PCS. Non-pharmacological interventions provide treatment with limited side effects in comparison to pharmacological interventions. The aim of this review is to synthesise and evaluate the effectiveness of non-pharmacological interventions that have been used to target vestibular and oculomotor deficits in PCS.Methods: Advanced searches will be conducted in electronic databases to identify articles eligible for inclusion. Studies employing non-pharmacological treatments for vestibular and/or oculomotor dysfunction in PCS will be included if they meet the eligibility criteria. Outcomes will be those pertaining to measures of oculomotor and vestibular function, in addition to adverse events. Meta-analysis will be undertaken using a random effects model followed by an assessment of clinical significance for each outcome as published in literature. Discussion: While non-pharmacological interventions are used commonly to treat vestibular and oculomotor deficits in PCS, the effectiveness of these treatments is yet to be completely elucidated. The present review will explore the effectiveness of non-pharmacological treatments for vestibular and oculomotor deficits in PCS to inform practice and future research.Systematic review registration: PROSPERO CRD42021254720


2020 ◽  
Author(s):  
Kurt D Shulver ◽  
Nicholas A Badcock

We report the results of a systematic review and meta-analysis investigating the relationship between perceptual anchoring and dyslexia. Our goal was to assess the direction and degree of effect between perceptual anchoring and reading ability in typical and atypical (dyslexic) readers. We performed a literature search of experiments explicitly assessing perceptual anchoring and reading ability using PsycInfo (Ovid, 1860 to 2020), MEDLINE (Ovid, 1860 to 2019), EMBASE (Ovid, 1883 to 2019), and PubMed for all available years up to June (2020). Our eligibility criteria consisted of English-language articles and, at minimum, one experimental group identified as dyslexic - either by reading assessment at the time, or by previous diagnosis. We assessed for risk of bias using an adapted version of the Newcastle-Ottawa scale. Six studies were included in this review, but only five (n = 280 participants) were included in the meta-analysis (we were unable to access the necessary data for one study).The overall effect was negative, large and statistically significant; g = -0.87, 95% CI [-1.47, 0.27]: a negative effect size indicating less perceptual anchoring in dyslexic versus non-dyslexic groups. Visual assessment of funnel plot and Egger’s test suggest minimal bias but with significant heterogeneity; Q (4) = 9.70, PI (prediction interval) [-2.32, -0.58]. The primary limitation of the current review is the small number of included studies. We discuss methodological limitations, such as limited power, and how future research may redress these concerns. The variability of effect sizes appears consistent with the inherent variability within subtypes of dyslexia. This level of dispersion seems indicative of the how we define cut-off thresholds between typical reading and dyslexia populations, but also the methodological tools we use to investigate individual performance.


2020 ◽  
Vol 4 ◽  
pp. 247028972098001
Author(s):  
Rebecca Leeds ◽  
Ari Shechter ◽  
Carmela Alcantara ◽  
Brooke Aggarwal ◽  
John Usseglio ◽  
...  

Sex differences in cardiovascular disease (CVD) mortality have been attributed to differences in pathophysiology between men and women and to disparities in CVD management that disproportionately affect women compared to men. Similarly, there has been investigation of differences in the prevalence and presentation of insomnia attributable to sex. Few studies have examined how sex and insomnia interact to influence CVD outcomes, however. In this review, we summarize the literature on sex-specific differences in the prevalence and presentation of insomnia as well as existing research regarding the relationship between insomnia and CVD outcomes as it pertains to sex. Research to date indicate that women are more likely to have insomnia than men, and there appear to be differential associations in the relation between insomnia and CVD by sex. We posit potential mechanisms of the relationship between sex, insomnia and CVD, discuss gaps in the existing literature, and provide commentary on future research needed in this area. Unraveling the complex relations between sex, insomnia, and CVD may help to explain sex-specific differences in CVD, and identify sex-specific strategies for promotion of cardiovascular health. Throughout this review, terms “men” and “women” are used as they are in the source literature, which does not differentiate between sex and gender. The implications of this are also discussed.


2021 ◽  
pp. 001458582199184
Author(s):  
Danila Cannamela

In her debut book Dolore minimo, Giovanna Cristina Vivinetto engages in a reflection on motherhood to recount an autobiographical story of gender self-determination and male to female transition. This article explores Vivinetto’s poetry as the retelling of transformative moments in two mother–daughter relationships, which generate a reshaping of life and language. In the book, these two storylines intersect, blur, and even overlap, creating a poetic discourse in which the maternal acts simultaneously as powerful catalyzer and producer of meanings. In discussing how, in Dolore minimo, the relationship of two atypical mothers becomes the creative site of a new possible symbolic order, my analysis engages an atypical approach: it reads Vivinetto’s queer representation of motherhood via the theorization developed by the women of Diotima—including, in particular, Luisa Muraro, Chiara Zamboni, Diana Sartori, and Ida Dominijanni. These feminist thinkers have been generally criticized for reinforcing binary understandings of sex and gender, based on an essentialist view of the category of woman. Yet, what if the feminism forwarded by Diotima, by positioning the feminine as a creative producer and first-person narrator of change, could still offer a productive avenue for dialogue? The article begins with a discussion of Diotima’s key theorizations, which lays the groundwork for interpreting the maternal poetics of Dolore minimo. The subsequent sections examine in more depth how Vivinetto’s poetry has reinvented the figure of the mother as a teacher and learner of new words, and how, through this reinvention, she has crafted a maternal language that knits together new relations of contiguity and change. Ultimately, by redeploying the figure of the mother beyond cisgender norms, Vivinetto’s poetry is revealing the inexhaustible vitality of this character.


2021 ◽  
pp. 026921632110321
Author(s):  
Florence Reedy ◽  
Mark Pearson ◽  
Sarah Greenley ◽  
Joseph Clark ◽  
David C Currow ◽  
...  

Background: In combination with non-pharmacological interventions, opioids may safely reduce chronic breathlessness in patients with severe illness. However, implementation in clinical practice varies. Aim: To synthesise the published literature regarding health professionals’, patients’ and families’ views on the use of opioids for chronic breathlessness, identifying issues which influence implementation in clinical practice. Design: Systematic review and synthesis using the five-stage framework synthesis method. Data sources: Three electronic databases (MEDLINE, Embase via OVID, ASSIA via Proquest) were searched (March 2020) using a predefined search strategy. Studies were also citation chained from key papers. Papers were screened against a priori eligibility criteria. Data were extracted from included studies using the framework synthesis method. Qualitative and quantitative data were synthesised using the pillar process. Included studies were critically appraised using the Mixed-Methods Appraisal Tool. Results: After de-duplication, 843 papers were identified. Following screening, 22 studies were included. Five themes were developed: (i) clinician/patient characteristics, (ii) education/knowledge/experience, (iii) relationship between clinician/family, (iv) clinician/patient fear of opioids and (v) regulatory issues. Conclusions: There are significant barriers and enablers to the use of opioids for the symptomatic reduction of chronic breathlessness based on the knowledge, views and attitudes of clinicians, patients and families. Clinicians’ interactions with patients and their families strongly influences adherence with opioid treatment regimens for chronic breathlessness. Clinicians’, patients’ and families’ knowledge about the delicate balance between benefits and risks is generally poor. Education for all, but particularly clinicians, is likely to be a necessary (but insufficient) factor for improving implementation in practice.


2021 ◽  
Vol 14 ◽  
Author(s):  
Joel Owen ◽  
Louise Crouch-Read ◽  
Matthew Smith ◽  
Paul Fisher

Abstract For more than a decade, Improving Access to Psychological Therapies (IAPT) has been training a new workforce of psychological therapists. Despite evidence of stress and burnout both in trainee mental health professionals, and qualified IAPT clinicians, little is known about these topics in IAPT trainees. Consequently, this systematic review sought to establish the current state of the literature regarding stress and burnout in IAPT trainees. Electronic databases were searched to identify all published and available unpublished work relating to the topic. On the basis of pre-established eligibility criteria, eight studies (including six unpublished doctoral theses) were identified and assessed for quality. This review identifies that research into the experience of IAPT trainees is under-developed. Existing evidence tentatively suggests that IAPT trainees may experience levels of stress and burnout that are higher than their qualified peers and among the higher end of healthcare professionals more generally. The experience of fulfilling dual roles as mental health professionals and university students concurrently appears to be a significant source of stress for IAPT trainees. More research regarding the levels and sources of stress and burnout in IAPT trainees is urgently needed to confirm and extend these findings. Recommendations for future research in the area are given. Key learning aims (1) To establish the current state of the literature regarding stress and burnout in IAPT trainees. (2) To raise practitioner, service and education-provider awareness regarding the levels and perceived sources of stress and burnout in IAPT trainees. (3) To make recommendations regarding future research on the topic.


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