scholarly journals Environmental and Endogenous Acids Can Trigger Allergic-Type Airway Reactions

2020 ◽  
Vol 17 (13) ◽  
pp. 4688
Author(s):  
Giuliano Molinari ◽  
Laura Molinari ◽  
Elsa Nervo
Keyword(s):  
Air Pollutants ◽  
Basic Mechanism ◽  
Point Of View ◽  
Intracellular Acidification ◽  
Common Cause ◽  
Respiratory Disorders ◽  
Root Cause ◽  
Biochemical Mechanisms ◽  
The Common ◽  
Airways Inflammation

Inflammatory allergic and nonallergic respiratory disorders are spreading worldwide and often coexist. The root cause is not clear. This review demonstrates that, from a biochemical point of view, it is ascribable to protons (H+) released into cells by exogenous and endogenous acids. The hypothesis of acids as the common cause stems from two considerations: (a) it has long been known that exogenous acids present in air pollutants can induce the irritation of epithelial surfaces, particularly the airways, inflammation, and bronchospasm; (b) according to recent articles, endogenous acids, generated in cells by phospholipases, play a key role in the biochemical mechanisms of initiation and progression of allergic-type reactions. Therefore, the intracellular acidification and consequent Ca2+ increase, induced by protons generated by either acid pollutants or endogenous phospholipases, may constitute the basic mechanism of the multimorbidity of these disorders, and environmental acidity may contribute to their spread.

scholarly journals Acids Can Promote the Onset and Multimorbidity of Allergic and Nonallergic Airway Diseases

2019 ◽  
Author(s):  
Giuliano Molinari ◽  
Laura Molinari ◽  
Elsa Nervo
Keyword(s):  
Air Pollutants ◽  
Causal Mechanism ◽  
Intracellular Acidification ◽  
Common Cause ◽  
Root Cause ◽  
Airway Diseases ◽  
Biochemical Mechanisms ◽  
The Common ◽  
Airways Inflammation ◽  
In Cells

Inflammatory allergic and nonallergic respiratory pathologies often co-exist. The root cause is not clear. This paper demonstrates that it is ascribable to protons (H+) released into cells by exogenous and endogenous acids. The hypothesis of acids as the common cause stems from two considerations: a) it has long been known that exogenous acids present in air pollutants can induce the irritation of epithelial surfaces, particularly the airways, inflammation and bronchospasm; b) according to recent articles, endogenous acids, generated in cells by phospholipases, play a key role in the biochemical mechanisms of initiation and progression of allergic responses. Therefore, the intracellular acidification and consequent Ca2+ increase, induced by protons generated by either acid pollutants or endogenous phospholipases, may be the causal mechanism of the multimorbidity of these diseases, and environmental acidity may contribute to their spread.

The Principle of the Common Cause

2009 ◽  
Author(s):  
Gabor Hofer-Szabo ◽  
Miklos Redei ◽  
Laszlo E. Szabo
Keyword(s):  
Common Cause ◽  
The Common

Funerary Ritual

2019 ◽  
pp. 292-309
Author(s):  
Mireia López-Bertran
Keyword(s):  
Point Of View ◽  
Good Death ◽  
Social Implications ◽  
Archaeological Remains ◽  
Deceased Person ◽  
Funerary Rituals ◽  
The Social ◽  
The Common ◽  
Funerary Rites ◽  
Written Sources

This chapter explores the funerary rites in the Phoenician-Punic world from a comprehensive point of view, and it focuses on the common points arising from a large amount of data. The concern for burying their deceased and the belief in the soul’s afterlife show that the Phoenicians considered death as a transformation rather than as the end of a person’s life. Through our access to archaeological remains and written sources, we can reconstruct the existence of a meaningful burial program that was destined to provide a “good death” and afterlife. Funerary rituals, thus, are the actions or gestures to achieve this goal. The aim of this chapter is to explain the rites that family members undertook once someone died, in order to transform correctly the deceased person into an otherworldly being, the ancestor. The social implications of the data arising from burials are also briefly considered.

Busting Myths in Compound Handling Practices for Assay Developers

2021 ◽  
pp. 247263032110233
Author(s):  
Rosalia Gonzales ◽  
Travis Mathewson ◽  
Jefferson Chin ◽  
Holly McKeith ◽  
Lane Milde ◽  
...  
Keyword(s):  
The Other ◽  
Common Goal ◽  
Collaborative Relationship ◽  
Sample Handling ◽  
Root Cause ◽  
The Common ◽  
Recommended Practices ◽  
Handling Practices ◽  
The One

Since the advent of modern-day screening collections in the early 2000s, various aspects of our knowledge of good handling practices have continued to evolve. Some early practices, however, continue to prevail due to the absence of defining data that would bust the myths of tradition. The lack of defining data leads to a gap between plate-based screeners, on the one hand, and compound sample handling groups, on the other, with the latter being the default party to blame when an assay goes awry. In this paper, we highlight recommended practices that ensure sample integrity and present myth busting data that can help determine the root cause of an assay gone bad. We show how a strong and collaborative relationship between screening and sample handling groups is the better state that leads to the accomplishment of the common goal of finding breakthrough medicines.

scholarly journals Clinical Profile of Acute Poisoning in Children at a Teaching Hospital in Lalitpur

2014 ◽  
Vol 34 (2) ◽  
pp. 100-103 ◽  
Author(s):  
Ajaya Kumar Dhakal ◽  
D Shrestha ◽  
A Shakya ◽  
SC Shah ◽  
H Shakya
Keyword(s):  
Teaching Hospital ◽  
Hospital Admissions ◽  
Acute Poisoning ◽  
Childhood Mortality ◽  
Age Group ◽  
Common Cause ◽  
Mortality And Morbidity ◽  
History Of ◽  
The Common ◽  
Poisoning In Children

Introduction: Acute poisonings are one of the common cause of emergency visits and hospital admissions and is potentially preventable cause of childhood mortality and morbidity. The objectives of this study were to identify the common type of poisoning in children, to determine types of poisoning according to age and to find out the common age group in which the incidence of poisoning was high.Materials and Methods: It was a descriptive observational study done in a teaching hospital in Lalitpur, Nepal in patients aged 1 month to 18 years who visited the emergency department and were admitted to hospital with history of alleged poisoning from 2009 July to 2014 January.Results: Fifty patients were included. Drugs, kerosene and organophosphorus were most common cause of poisoning. Drugs and kerosene below 10 years of age and organophosphorus and drugs above 10 years of age were common types of poisoning. Maximum numbers (50%) of children with poisoning cases were below five year of age. Mean duration of hospital stay was 2.1days and mean age of poisoning was 7.8 years with a male(54%) predominance. Majority of poisoning occurred at home (84%) and 68% of patients were symptomatic at presentation to hospital with 84% of patients presenting to hospital within six hours.Conclusion: This study showed that drugs, kerosene and organophosphorus were most common forms of poisoning. Young children were most vulnerable for acute poisoning.DOI: http://dx.doi.org/10.3126/jnps.v34i2.10139J Nepal Paediatr Soc 2014;34(2):100-103 

scholarly journals Hyperbolastic Models from a Stochastic Differential Equation Point of View

Mathematics ◽  
2021 ◽  
Vol 9 (16) ◽  
pp. 1835
Author(s):  
Antonio Barrera ◽  
Patricia Román-Román ◽  
Francisco Torres-Ruiz
Keyword(s):  
Differential Equation ◽  
Simulated Data ◽  
Real Data ◽  
Point Of View ◽  
Likelihood Method ◽  
Numerical Resolution ◽  
The Family ◽  
The Common ◽  
Linear Differential ◽  
Mean Function

A joint and unified vision of stochastic diffusion models associated with the family of hyperbolastic curves is presented. The motivation behind this approach stems from the fact that all hyperbolastic curves verify a linear differential equation of the Malthusian type. By virtue of this, and by adding a multiplicative noise to said ordinary differential equation, a diffusion process may be associated with each curve whose mean function is said curve. The inference in the resulting processes is presented jointly, as well as the strategies developed to obtain the initial solutions necessary for the numerical resolution of the system of equations resulting from the application of the maximum likelihood method. The common perspective presented is especially useful for the implementation of the necessary procedures for fitting the models to real data. Some examples based on simulated data support the suitability of the development described in the present paper.

scholarly journals A Mathematical Study of Barcelona Metro Network

Electronics ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 557
Author(s):  
Irene Mariñas-Collado ◽  
Elisa Frutos Bernal ◽  
Maria Teresa Santos Martin ◽  
Angel Martín del Rey ◽  
Roberto Casado Vara ◽  
...  
Keyword(s):  
Clustering Analysis ◽  
Transportation Network ◽  
Point Of View ◽  
Statistical Point ◽  
Transport Services ◽  
Urban Public Transport ◽  
The Common ◽  
Subway Stations ◽  
Metro Network

The knowledge of the topological structure and the automatic fare collection systems in urban public transport produce many data that need to be adequately analyzed, processed and presented. These data provide a powerful tool to improve the quality of transport services and plan ahead. This paper aims at studying, from a mathematical and statistical point of view, the Barcelona metro network; specifically: (1) the structural and robustness characteristics of the transportation network are computed and analyzed considering the complex network analysis; and (2) the common characteristics of the different subway stations of Barcelona, based on the passenger hourly entries, are identified through hierarchical clustering analysis. These results will be of great help in planning and restructuring transport to cope with the new social conditions, after the pandemic.

An overview of proximal suspensory ligament desmitis

UK-Vet Equine ◽  
2019 ◽  
Vol 3 (5) ◽  
pp. 175-181
Author(s):  
Jonathan Anderson
Keyword(s):  
Treatment Options ◽  
Poor Performance ◽  
Diagnostic Techniques ◽  
Common Cause ◽  
Suspensory Ligament ◽  
The Common ◽  
Hindlimb Lameness

Proximal suspensory disease is a common cause of both forelimb and hindlimb lameness and poor performance in the horse. The following article describes the common presentations, diagnostic techniques and treatment options for the condition in both the forelimbs and the hindlimbs.

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