scholarly journals Factors Associated with Latent Tuberculosis Infection among the Hospital Employees in a Tertiary Hospital of Northeastern Thailand

2020 ◽  
Vol 17 (18) ◽  
pp. 6876
Author(s):  
Patimaporn Chanpho ◽  
Naesinee Chaiear ◽  
Supot Kamsa-ard
Keyword(s):  
High Risk ◽  
Latent Tuberculosis Infection ◽  
Conditional Logistic Regression ◽  
Critical Role ◽  
Latent Tuberculosis ◽  
Tertiary Hospital ◽  
Tuberculosis Infection ◽  
P Value ◽  
Factors Associated ◽  
Northeastern Thailand

Latent tuberculosis infection (LTBI) can develop into tuberculosis (TB). The WHO requires the discovery and management of LTBI among high-risk groups. Health care workers (HCWs) constitute a high-risk group. Factors associated with LTBI among HCWs in Thailand need further study. The current study aimed to explore the factors related to LTBI among Thai HCWs. A hospital-based, matched case-control study was conducted. All cases and controls were HCWs at a tertiary hospital in northeastern Thailand. Between 2017 and 2019, a total of 85 cases of interferon-γ release assays (IGRAs)-proven LTBI, and 170 control subjects were selected from a hospital (two controls per case). The two recruited controls were individually matched with LTBI cases by sex and age (±5 years). Secondary data were obtained from the occupational health and safety office. Case HCWs had a higher proportion of significant factors than control HCWs (i.e., working closely with pulmonary TB—94.1% vs. 88.8%, and working in the area of aerosol-generating procedures (AGPs) 81.2% vs. 69.4%). The bivariate conditional logistic regression showed that the occurrence of LTBI in HCWs was statistically significant (p-value < 0.05), particularly with respect to: workplaces of AGPs (crude OR = 1.90, 95% CI: 1.01–3.58, p = 0.041); among HCWs performing AGPs (crude OR = 2.04, 95% CI: 1.20, 3.48, p = 0.007); and, absent Bacille Calmette-Guérin (BCG) scar (crude OR = 2.59, 95% CI: 1.50–4.47, p = 0.001). Based on the multivariable conditional logistics analysis, HCWs who performed AGPs while contacting TB cases had a statistically significant association with LTBI (adjusted OR = 1.82, 95% CI: 1.04–3.20, p = 0.035). HCWs who reported the absence of a BCG scar had a statistically significant association with LTBI (adjusted OR = 2.49, 95% CI: 1.65–5.36, p = 0.001), whereas other factors including close contact with TB (adjusted OR = 2.44, 95% CI: 0.74, 8.09, p = 0.123) were not significantly associated with LTBI. In conclusion, HCWs who performed AGPs and were absent a BCG scar had a significant association with LTBI, while other factors played a less critical role.

Incidence and Risk Factors Associated with Latent Tuberculosis Infection and Pulmonary Tuberculosis among People Deprived of Liberty in Colombian Prisons

2021 ◽  
Author(s):  
Mariana Herrera ◽  
Yoav Keynan ◽  
Lucelly López ◽  
Diana Marín ◽  
Luisa Arroyave ◽  
...  
Keyword(s):  
High Risk ◽  
Incidence Rate ◽  
Respiratory Symptoms ◽  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Incidence Rates ◽  
Tuberculosis Infection ◽  
Current Cigarette Smoking ◽  
Factors Associated ◽  
Increased Risk

People deprived of liberty (PDL) are at high risk of acquiring Mycobacterium tuberculosis infection (latent tuberculosis infection [LTBI]) and progressing to active tuberculosis (TB). We sought to determine the incidence rates and factors associated with LTBI and active TB in Colombian prisons. Using information of four cohort studies, we included 240 PDL with two-step tuberculin skin test (TST) negative and followed them to evaluate TST conversion, as well as, 2,134 PDL that were investigated to rule out active TB (1,305 among people with lower respiratory symptoms of any duration, and 829 among people without respiratory symptoms and screened for LTBI). Latent tuberculosis infection incidence rate was 2,402.88 cases per 100,000 person-months (95% CI 1,364.62–4,231.10) in PDL with short incarceration at baseline, and 419.66 cases per 100,000 person-months (95% CI 225.80–779.95) in individuals with long incarceration at baseline (who were enrolled for the follow after at least 1 year of incarceration). The TB incidence rate among PDL with lower respiratory symptoms was 146.53 cases/100,000 person-months, and among PDL without respiratory symptoms screened for LTBI the incidence rate was 19.49 cases/100,000 person-months. History of Bacillus Calmette-Guerin vaccination decreased the risk of acquiring LTBI among PDL who were recently incarcerated. Female sex, smoked drugs, and current cigarette smoking were associated with an increased risk of developing active TB. This study shows that PDL have high risk for LTBI and active TB. It is important to perform LTBI testing at admission to prison, as well as regular follow-up to control TB in prisons.

scholarly journals Prevalence and factors associated with latent tuberculosis infection in an indigenous population in the Brazilian Amazon

2016 ◽  
Vol 49 (4) ◽  
pp. 456-464 ◽  
Author(s):  
Jocieli Malacarne ◽  
Diana Patricia Giraldo Rios ◽  
Cosme Marcelo Furtado Passos da Silva ◽  
José Ueleres Braga ◽  
Luiz Antonio Bastos Camacho ◽  
...  
Keyword(s):  
Indigenous Population ◽  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Brazilian Amazon ◽  
Tuberculosis Infection ◽  
Factors Associated

scholarly journals 938Identification of High Risk Healthcare Workers with Latent Tuberculosis Infection (LTBI) in an Inner City Healthcare System

2014 ◽  
Vol 1 (suppl_1) ◽  
pp. S273-S273
Author(s):  
Sorabh Dhar ◽  
Anupama Neelakanta ◽  
Jisha John ◽  
Russell Grimshaw ◽  
Jim Russell ◽  
...  
Keyword(s):  
High Risk ◽  
Inner City ◽  
Healthcare System ◽  
Healthcare Workers ◽  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Tuberculosis Infection

scholarly journals Gender Disparities in Latent Tuberculosis Infection in High-Risk Individuals: A Cross-Sectional Study

PLoS ONE ◽  
2014 ◽  
Vol 9 (11) ◽  
pp. e110104 ◽  
Author(s):  
Wen-Ying Ting ◽  
Shiang-Fen Huang ◽  
Ming-Che Lee ◽  
Yung-Yang Lin ◽  
Yu-Chin Lee ◽  
...  
Keyword(s):  
High Risk ◽  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Cross Sectional Study ◽  
Gender Disparities ◽  
Tuberculosis Infection ◽  
Sectional Study ◽  
Cross Sectional

Factors Associated with the Treatment of Latent Tuberculosis Infection Among Health-Care Workers at a Midwestern Teaching Hospital

CHEST Journal ◽  
2002 ◽  
Vol 122 (5) ◽  
pp. 1609-1614 ◽  
Author(s):  
Sunita J. Shukla ◽  
David K. Warren ◽  
Keith F. Woeltje ◽  
Carol A. Gruber ◽  
Victoria J. Fraser
Keyword(s):  
Health Care ◽  
Teaching Hospital ◽  
Health Care Workers ◽  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Tuberculosis Infection ◽  
Factors Associated ◽  
Care Workers
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