scholarly journals Periodontal Conditions and Whole Salivary IL-17A and -23 Levels among Young Adult Cannabis sativa (Marijuana)-Smokers, Heavy Cigarette-Smokers and Non-Smokers

2020 ◽  
Vol 17 (20) ◽  
pp. 7435
Author(s):  
Fawad Javed ◽  
Abeer S. Al-Zawawi ◽  
Khaled S. Allemailem ◽  
Ahmad Almatroudi ◽  
Abid Mehmood ◽  
...  
Keyword(s):  
Young Adult ◽  
Cannabis Sativa ◽  
Demographic Data ◽  
Stage Iv ◽  
The United States ◽  
Marginal Bone Loss ◽  
Clinical Attachment Loss ◽  
Cigarette Smokers ◽  
Probing Depth ◽  
Whole Saliva

In the United States, prevalence of marijuana-use has doubled in the past 2 decades. The aim was to compare the periodontal conditions and whole-salivary IL-17A and IL-23 levels among young adult marijuana-smokers, heavy cigarette-smokers and non-smokers. Self-reported marijuana-smokers, heavy-cigarette-smokers, non-smokers with periodontitis and periodontally-healthy non-smokers were included. Demographic data was recorded and full-mouth plaque index (PI), bleeding on probing (BoP), probing depth (PD) and clinical attachment loss (AL), marginal bone loss (MBL) and missing teeth were recorded. Levels of IL-17A and IL-23 levels were measured in the whole saliva. p < 0.01 was considered statistically significant. Fifteen-marijuana-smokers, 15 heavy-cigarette-smokers, 16 non-smokers-with-periodontitis and 15 periodontally-healthy-non-smokers) were included. The clinicoradiographic parameters were worse among marijuana-smokers (p < 0.01), cigarette-smokers (p < 0.01) and non-smokers-with-periodontitis (p < 0.01) than periodontally-healthy-non-smokers. Marijuana- and cigarette-smokers had Stage-IV/Grade C and non-smokers with periodontitis had Stage-III/Grade-C. Salivary IL-17A and IL-23 levels were higher in marijuana-smokers than cigarette-smokers (p < 0.01) and non-smokers-with-periodontitis (p < 0.01). Whole salivary IL-17A and IL-23 levels were higher among cigarette-smokers than non-smokers with periodontitis (p < 0.01) and periodontally-healthy-individuals (p < 0.01). Marijuana- and heavy cigarette-smokers have comparable clinicoradiographic periodontal statuses. This rejects hypothesis-1. However, whole salivary immunoinflammatory response may be moderately worse in marijuana-smokers compared with heavy cigarette-smokers and non-smoker with periodontitis thereby supporting hypothesis-2.

scholarly journals Serum Inflammatory and Prooxidant Marker Levels in Different Periodontal Disease Stages

Healthcare ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 1070
Author(s):  
Ricardo Andreu ◽  
Sergio Santos-del-Riego ◽  
Francisco Payri
Keyword(s):  
Periodontal Disease ◽  
Inflammatory Diseases ◽  
Stage Iv ◽  
High Sensitivity ◽  
Cross Sectional Study ◽  
Oxidative Stress Biomarkers ◽  
Clinical Attachment Loss ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Probing Depth

Background: Periodontitis has been associated to systemic diseases and this association could be due to an increase in circulating inflammatory and oxidative stress biomarkers in the periodontal disease. This study aimed to evaluate the relationship between inflammatory and pro-oxidant markers according to different stages of periodontitis. Methods: This cross-sectional study included 70 subjects who were divided into three groups according to periodontitis stage: stage II (n = 22), stage III (n = 30), and stage IV (n = 18). We evaluated periodontal parameters and levels of high-sensitivity C-reactive protein (hsCRP), fibrinogen, and malondialdehyde (MDA) in serum, and 8-hydroxy-2′-deoxyguanosine (8-OHdG) in urine. Results: Serum hsCRP and fibrinogen levels were associated with periodontitis severity, which were higher in stage IV than in stages III and II of periodontitis (p = 0.003 and p = 0.025, respectively). We observed a slight yet insignificant increase in MDA levels related to periodontitis severity. Probing depth and clinical attachment loss were associated with serum fibrinogen and hsCRP levels. However, there were no significant associations between periodontal variables and MDA and 8-OHdG levels. Conclusion: Our data support an association between periodontitis and systemic inflammation, which increases with periodontal disease severity. This indicates the importance of the early diagnosis and treatment of periodontal disease to avoid the development or worsening of systemic inflammatory diseases.

scholarly journals New classification of periodontal diseases (NCPD): an application in a sub-Saharan country

BDJ Open ◽  
2021 ◽  
Vol 7 (1) ◽  
Author(s):  
William Ndjidda Bakari ◽  
Diabel Thiam ◽  
Ndeye Lira Mbow ◽  
Anna Samb ◽  
Mouhamadou Lamine Guirassy ◽  
...  
Keyword(s):  
Periodontal Diseases ◽  
Stage Iv ◽  
Multidisciplinary Care ◽  
Median Number ◽  
Clinical Attachment Loss ◽  
Significance Threshold ◽  
Probing Depth ◽  
The Mean ◽  
Sub Saharan

Abstract Purpose To determine the clinical and radiological profile of periodontitis according to the 2018 NCPD, in a Dakar (Senegal) based periodontal clinic. Methods This is a descriptive study based on patient’s records in the periodontology clinic. The study was conducted between November 2018 and February 2020 (15 months). All periodontitis cases were included in the study. Incomplete records (due to lack of radiographic workup or unusable periodontal charting) were excluded. Periodontitis diagnosis was established based on criteria used in the 2018 NCPD. Statistical analysis was carried out using SPSS version 20.0, with the significance threshold set at 0.05. Results A total number of 517 patient records were collected during the study period but only 127 periodontitis records were complete. The mean age of participants was 46.8 ± 13.8 years and 63.8% of participants were males. The mean plaque index and bleeding on probing (BOP) were 74% ± 21.3 and 58.1% ± 25.1, respectively. The mean maximum clinical attachment loss was 8.7 mm ±2.7, with a probing depth greater than 6 mm present in 50.4% of the sample. The median number of missing teeth was 3 (interquartile range 5–1). Pathological mobility was present in 60.6% of the patients and 78.0% had occlusion problems. Bone crest defect at the most affected site was moderate in 52.8% of cases. The ratio of bone loss to age greater than one concerned 66.1% of the sample. Generalised (81.9%), Stage IV (70.1%) and grade C (69.3%) were the most encountered diagnosis. The disease severity was associated with age (r = 0.241; P < 0.001), BOP (r = 0.230; P = 0.013) and the number of teeth with pathological mobility (r = 0.318; P < 0.001). Conclusion Patients with periodontitis in this study had advanced forms of the disease and required multidisciplinary care. Clinical hindsight is necessary to improve this classification.

scholarly journals Prognostic factors affecting the short-term efficacy of non-surgical treatment of chronic periodontitis: a multilevel modeling analysis

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Hui-Jie Liu ◽  
Bo Wang ◽  
Ao-Chen Wang ◽  
Dan-Hong Zhang ◽  
Cui Mao ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Multilevel Modeling ◽  
Stage Iv ◽  
Short Term ◽  
Clinical Attachment Loss ◽  
Factors Affecting ◽  
Term Efficacy ◽  
Modeling Analysis ◽  
Probing Depth ◽  
Non Surgical Treatment

Abstract Background This study is aimed to analyze the prognostic factors affecting the short-term efficacy of non-surgical treatment of patients in periodontitis from stage II to stage IV by the multilevel modeling analysis. Materials and methods A total of 58 patients with chronic periodontitis were included in this study. Patients were clinically explored before and 3 months after the treatment and the difference in probing depth was determined [Reduction of probing depth (Δ PD) = baseline PD – finial probing depth (FPD)] which is considered as the therapeutic evaluation. Three different levels were analyzed: patients, teeth and sites to construct a multi-layer linear model. Results Probing depth (PD) improved significantly compared with that before treatment (p < 0.05), in which FPD was (3.90 ± 1.39) mm, and the ΔPD was (1.79 ± 0.97) mm. Compared with the mesial sites and distal sites of the multi-rooted teeth, the number of PD ≥ 5 mm or PD < 5 mm after the treatment was significantly different (P < 0.05), and the proportion of PD < 5 mm was higher in mesial sites. The null model showed that Δ PD varied greatly between groups at various levels (P < 0.001), with prediction variable of site level, tooth level, and patient level accounted for 66%, 18%, and 16% of the overall difference, respectively. The complete model showed that the Δ PD of smokers was significantly lower than that of non-smokers (P < 0.001). The Δ PD of the mesial and distal sites was larger than that of the buccolingual central site (P < 0.001). The Δ PD of single-rooted teeth was larger than that of multi-rooted teeth (P < 0.001). The baseline PD, tooth mobility (TM), bleeding index (BI), clinical attachment loss (CAL) were significantly negatively correlated with Δ PD (P < 0.001). Conclusions Patients with periodontitis from stage II to stage IV, who were non-smoking, have good compliance, good awareness of oral health, and low percentage sites with PD ≥ 5 mm at baseline, single-rooted teeth with hypomobility, less clinical attachment loss and lower bleeding index and sites of mesial or distal can obtain an ideal short-term efficacy of non-surgical treatment.

Systemic therapy for advanced anorectal squamous cell carcinomas: A single institutional experience.

2016 ◽  
Vol 34 (4_suppl) ◽  
pp. 728-728 ◽  
Author(s):  
Patrick McKay Boland ◽  
Katy Wang ◽  
Aniqa Kohen
Keyword(s):  
Squamous Cell ◽  
Demographic Data ◽  
Single Agent ◽  
Stage Iv ◽  
The United States ◽  
Squamous Cell Carcinomas ◽  
Patient Choice ◽  
Primary Tumors ◽  
Systemic Treatments ◽  
Definitive Therapy

728 Background: Anorectal squamous cell carcinomas (SCCs) are rare in the United States with < 10,000 cases annually. Uncommonly, patients present with stage IV disease or recurrence after definitive therapy. Limited options exist for these patients. We queried Roswell Park Cancer Institute (RPCI) patient records to determine systemic treatments utilized and outcomes for these patients. Methods: Patients with anal or rectal SCC between 1/1/99 and 7/1/2014 were identified via the cancer registry. 65 patients were flagged for review. From manual review, 31 patients received treatment at RPCI and were deemed evaluable. Demographic data, histology, staging, treatment history, time receiving any specific therapy and response assessment were abstracted from the records. Results: Of the 31 patients, 45% were male, 55% female. Primary tumors were anorectal (84%) or rectal (16%) in origin. 5(16%) presented with rectal SCC. Sites of metastatic disease were most commonly identified as lymph nodes (48%), liver (35) or lung (16%). At the time of analysis 5 (16%) were alive, with 3 (10%) disease free. Median overall survival (OS) was 44.1 months (95% CI, 28.9 - 62.6). The most commonly utilized chemotherapy regimens were 5-fu/cisplatin (n = 22 patients) and taxol (n = 10). Mean time on therapy was 4 months for 5-fu/platinum doublets (n = 24), 4 months for taxanes/platinum combinations (n = 6), 3.4 months for anti-EGFR containing regimens (n = 7) and 2.43 months for taxane monotherapy (n = 10). The most common reasons for discontinuation of therapy were progressive disease (47%) or patient choice (15%). Conclusions: New therapies are desperately needed for advanced anorectal SCCs. At present, 5-FU/cisplatin is the best endorsed and most frequently utilized regimen. Consistent with other reports, platinum doublets and anti-EGFR targeted therapies appear to confer significant benefits, within the realm of 5-fu/cisplatin, with single agent taxanes appearing to have lesser activity. Small absolute patient numbers and lack of reliable response measurements preclude firm conclusions. Future clinical trials to evaluate systemic therapies in advanced anorectal SCCs, including anti-EGFR regimens, are warranted.

scholarly journals Little Cigars and Cigarillos Use Among Young Adult Cigarette Smokers in the United States: Understanding Risk of Concomitant Use Subtypes

2016 ◽  
Vol 18 (12) ◽  
pp. 2234-2242 ◽  
Author(s):  
Kymberle Landrum Sterling ◽  
Craig S. Fryer ◽  
Ian Pagano ◽  
Pebbles Fagan
Keyword(s):  
United States ◽  
Young Adult ◽  
The United States ◽  
Cigarette Smokers

Creating a ‘Masala’ Self: Bicultural Identity in Desi Young Adult Novels

2010 ◽  
Vol 3 (2) ◽  
pp. 119-133 ◽  
Author(s):  
Michelle Superle
Keyword(s):  
Young Adult ◽  
Young People ◽  
Identity Development ◽  
Small Body ◽  
The United States ◽  
Young Adult Fiction ◽  
Bicultural Identity ◽  
The United Kingdom ◽  
Institutional Forces ◽  
Cultural Identity Development

In the past two decades, the previously silent voices of diasporic Indian writers for young people have emerged, and a small body of texts has begun to develop in the United States and the United Kingdom. One of the major preoccupations of these texts is cultural identity development, especially in the novels published for a young adult audience, which often feature protagonists in the throes of an identity crisis. For example, the novels The Roller Birds of Rampur (1991) by Indi Rana, Born Confused (2002) by Tanuja Desai Hidier, and The Not-So-Star-Spangled Life of Sunita Sen (2005) by Mitali Perkins all focus on an adolescent girl coping with her bicultural identity with angst and confusion, and delineate the ways her self-concept and relationships are affected. The texts are empowering in their suggestion that young people have the agency to explore and create their own balanced bicultural identities, but like other young adult fiction, they ultimately situate adolescents within insurmountable institutional forces that are much more powerful than any individual.

Evaluation of Renal Function of Apparently Healthy Male Cannabis Smokers of College of Health Sciences, Nnewi Campus, Anambra State, Nigeria

2018 ◽  
Vol 4 (01) ◽  
Author(s):  
Analike Rosemary Adamma ◽  
Emekwue Loveth ◽  
Ogbodo Emmanuel Chukwuemeka ◽  
Ezeugwunne Ifeoma Priscilla ◽  
Onoh Joy Obioma ◽  
...  
Keyword(s):  
Uric Acid ◽  
Cannabis Sativa ◽  
Demographic Data ◽  
Cannabis Use ◽  
Total Carbon ◽  
Total Calcium ◽  
Healthy Male ◽  
Anambra State ◽  
Control Subjects ◽  
Apparently Healthy

The use of Cannabis sativa is on the increase worldwide especially among adolescents and youths. This study investigated the effect of cannabis smoking on renal functions in young and apparently healthy male students of Nnamdi Azikiwe University, Nnewi campus, Anambra state, Nigeria. A total of 60 male (40 cannabis smokers and 20 controls) subjects participated in this study. A well-structured questionnaire was used to obtain the demographic data and anthropometric of subjects. Thereafter, 5mls of fasting blood sample was collected from the subjects into plain container for the estimation of biochemical parameters (creatinine, urea, uric acid, electrolytes). Renal parameters were estimated using standard methods. Data obtained were statistically analyzed using paired student t-test and pearson r correlation. Result showed that the mean serum levels of urea, creatinine, K+, Na+, Cl-, ionized calcium, total calcium, total carbon dioxide, anion gap, and pH were not significantly different in both smokers and control subjects(p>0.05). However, there was significantly higher mean serum level of uric acid (2.42 ± 38.54 vs 1.92 ± 41.61; p<0.05) and total calcium (16.0 ± 0.30 vs 10.24 ± 0.18; p<0.05) in smokers compared with control subjects. Again, BMI was significantly higher in smokers compared with non-smokers (23.96 ± 3.15; p<0.05 Vs 21.95 ± 2.17; p<0.05). Therefore, cannabis use had no deleterious effect on the kidneys, but the significantly higher uric acid levels in the smokers may provide some anti-oxidant protection. However, further studies are necessary to further unravel the full potentials of cannabis use.

Operation of a hyperbaric oxygen therapy center in Korea: Report of our experience from a setting in its nascent stages

2019 ◽  
pp. 135-143
Author(s):  
Yoon Seop Kim ◽  
Yoonsuk Lee ◽  
Sun Ju Kim ◽  
Sung Oh Hwang ◽  
Yong Sung Cha ◽  
...  
Keyword(s):  
Critically Ill ◽  
Hyperbaric Oxygen ◽  
Critically Ill Patients ◽  
Demographic Data ◽  
Developed Countries ◽  
The United States ◽  
Medical Society ◽  
Hyperbaric Medicine ◽  
Therapy Center ◽  
Hbo2 Therapy

Purpose: Hyperbaric medicine is nascent in Korea when compared to other developed countries, such as the United States and Japan. Our facility has been managed by physicians with certifications from the Undersea and Hyperbaric Medical Society (UHMS) and National Oceanic and Atmospheric Administration in diving and clinical diseases since October 2016. This study was conducted to share similar issues that are encountered during the establishment of a program in a new area through our experiences in the operation of a hyperbaric oxygen (HBO2) therapy center. Methods: In this retrospective observational study we collected data on HBO2 patients treated at our center between October 2016 and June 2018 after HBO2 was conducted by HBO2-certified physicians. We then compared demographic data of patients with data from January 2011 to September 2015 – before HBO2 operations were conducted by HBO2-certified physicians. Result: A total of 692 patients received 5,130 treatments. Twelve indicated diseases were treated using HBO2 therapy. Fifty-six critically ill patients with intubation received HBO2. Although two patients experienced seizure due to oxygen toxicity during the study period, certified physicians and inside attendant took immediate corrective action. Conclusion: After the establishment of the HBO2 center operated by physicians with certification, more patients, including critically ill patients, received HBO2 safely for various diseases. In order to improve the practice of hyperbaric medicine in Korea, the Korean Academy of Undersea and Hyperbaric Medicine (KAUHM), an advanced and well-organized academic society, should communicate often with HBO2 centers, with the aim to set Korean education programs at UHMS course levels and increase reimbursement for HBO2 therapy.

scholarly journals Examining the Economic and Environmental Impacts of COVID-19 Using Earth Observation Data

2020 ◽  
Vol 13 (1) ◽  
pp. 5
Author(s):  
William Straka ◽  
Shobha Kondragunta ◽  
Zigang Wei ◽  
Hai Zhang ◽  
Steven D. Miller ◽  
...  
Keyword(s):  
Air Quality ◽  
Los Angeles ◽  
Environmental Impacts ◽  
Demographic Data ◽  
The United States ◽  
Earth Observation ◽  
Observation Data ◽  
Washington Dc ◽  
Mobility Data ◽  
Earth Observation Data

The COVID-19 pandemic has infected almost 73 million people and is responsible for over 1.63 million fatalities worldwide since early December 2019, when it was first reported in Wuhan, China. In the early stages of the pandemic, social distancing measures, such as lockdown restrictions, were applied in a non-uniform way across the world to reduce the spread of the virus. While such restrictions contributed to flattening the curve in places like Italy, Germany, and South Korea, it plunged the economy in the United States to a level of recession not seen since WWII, while also improving air quality due to the reduced mobility. Using daily Earth observation data (Day/Night Band (DNB) from the National Oceanic and Atmospheric Administration Suomi-NPP and NO2 measurements from the TROPOspheric Monitoring Instrument TROPOMI) along with monthly averaged cell phone derived mobility data, we examined the economic and environmental impacts of lockdowns in Los Angeles, California; Chicago, Illinois; Washington DC from February to April 2020—encompassing the most profound shutdown measures taken in the U.S. The preliminary analysis revealed that the reduction in mobility involved two major observable impacts: (i) improved air quality (a reduction in NO2 and PM2.5 concentration), but (ii) reduced economic activity (a decrease in energy consumption as measured by the radiance from the DNB data) that impacted on gross domestic product, poverty levels, and the unemployment rate. With the continuing rise of COVID-19 cases and declining economic conditions, such knowledge can be combined with unemployment and demographic data to develop policies and strategies for the safe reopening of the economy while preserving our environment and protecting vulnerable populations susceptible to COVID-19 infection.

scholarly journals Employment of Young Adult Cancer Caregivers, Other Disease Caregivers, and Non-Caregiving Adults

2021 ◽  
Vol 18 (14) ◽  
pp. 7452
Author(s):  
Echo L. Warner ◽  
Andrew R. Wilson ◽  
Jessica G. Rainbow ◽  
Lee Ellington ◽  
Anne C. Kirchhoff
Keyword(s):  
Young Adult ◽  
The United States ◽  
Behavioral Risk ◽  
Behavioral Risk Factor Surveillance ◽  
Adjusted Incidence Rate ◽  
Cancer Caregivers ◽  
Employment Goals ◽  
Caregiving Roles ◽  
Rate Ratios ◽  
Young Adult Cancer

Young adults are increasingly taking on caregiving roles in the United States, and cancer caregivers often experience a greater burden than other caregivers. An unexpected caregiving role may disrupt caregiver employment, leading to lost earning potential and workforce re-entry challenges. We examined caregiving employment among young adult caregivers (i.e., family or friends) using the 2015 Behavioral Risk Factor Surveillance System (BRFSS), which included caregiving, employment, and sociodemographic variables. Respondents’ ages varied between 18 and 39, and they were categorized as non-caregivers (n = 16,009), other caregivers (n = 3512), and cancer caregivers (n = 325). Current employment was compared using Poisson regressions to estimate adjusted incidence rate ratios (aIRR) and 95% confidence intervals (95% CI), including gender-stratified models. We estimated employment by cancer caregiving intensity (low, moderate, high). Cancer caregivers at all other income levels were more likely to be employed than those earning below USD 20,000 (aIRR ranged: 1.88–2.10, all p< 0.015). Female cancer caregivers who were 25–29 (aIRR = 0.71, 95% CI = 0.51–1.00) and single (aIRR = 0.70, 95% CI = 0.52–0.95) were less likely to be employed than their counterparts. College-educated males were 19% less likely to be employed than high school-educated caregivers (95% CI = 0.68–0.98). Evaluating caregiver employment goals and personal financial situations may help identify those at risk for employment detriments, especially among females, those with lower educational attainment, and those earning below USD 20,000 annually.

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