scholarly journals Women with Fibromyalgia Prefer Resistance Exercise with Heavy Loads—A Randomized Crossover Pilot Study

2021 ◽  
Vol 18 (12) ◽  
pp. 6276
Author(s):  
Ulf Mathias Andersson ◽  
Anna Cristina Åberg ◽  
Lena von Koch ◽  
Annie Palstam
Keyword(s):  
Physical Exercise ◽  
Resistance Exercise ◽  
Exercise Session ◽  
Heavy Load ◽  
Chronic Pain Condition ◽  
Moderate Load ◽  
Lactate Levels ◽  
Heavy Loads ◽  
Exercise Induced ◽  
Elevated Lactate

Fibromyalgia (FM) is a chronic pain condition associated with impaired muscle strength and exercise-induced pain. Physical exercise has been highlighted, by international clinical guidelines and stakeholders, as an essential component of rehabilitation in FM. Exposure to pain during exercise is generally correlated with elevated lactate levels and, additionally, is one known reason for persons with FM to avoid physical exercise and activity. A crossover design was used to test and evaluate an approach consisting of resistance exercise with heavy loads and a low number of repetitions among ten women with FM. The participants were consecutively recruited to test and perform exercise with two different resistance levels (A = light/moderate load, and B = heavy load) in a randomized crossover trial using an AB/BA setting. Results showed that the heavy load exercise session was experienced as more positive than the light/moderate load exercise session and that lower lactate levels followed exercise with heavier weight loads. This is promising and indicates that the approach of heavy weight loads and accustomed repetitions is accepted in FM and has the potential to attenuate hesitation to exercise due to exercise-induced pain. However, these effects need to be further investigated in more extensive studies.

scholarly journals Lactate and BDNF: Key Mediators of Exercise Induced Neuroplasticity?

2020 ◽  
Vol 9 (4) ◽  
pp. 1136 ◽  
Author(s):  
Patrick Müller ◽  
Yves Duderstadt ◽  
Volkmar Lessmann ◽  
Notger G. Müller
Keyword(s):  
Physical Exercise ◽  
High Intensity ◽  
Long Term Potentiation ◽  
Potential Mediator ◽  
Term Potentiation ◽  
Lactate Levels ◽  
Exercise Induced ◽  
Lactate Infusion ◽  
Relationship Of

Accumulating evidence from animal and human studies supports the notion that physical exercise can enhance neuroplasticity and thus reduce the risk of several neurodegenerative diseases (e.g., dementia). However, the underlying neurobiological mechanisms of exercise induced neuroplasticity are still largely unknown. One potential mediator of exercise effects is the neurotrophin BDNF, which enhances neuroplasticity via different pathways (e.g., synaptogenesis, neurogenesis, long-term potentiation). Current research has shown that (i) increased peripheral lactate levels (following high intensity exercise) are associated with increased peripheral BDNF levels, (ii) lactate infusion at rest can increase peripheral and central BDNF levels and (iii) lactate plays a very complex role in the brain’s metabolism. In this review, we summarize the role and relationship of lactate and BDNF in exercise induced neuroplasticity.

mTOR signaling response to resistance exercise is altered by chronic resistance training and detraining in skeletal muscle

2013 ◽  
Vol 114 (7) ◽  
pp. 934-940 ◽  
Author(s):  
Riki Ogasawara ◽  
Koji Kobayashi ◽  
Arata Tsutaki ◽  
Kihyuk Lee ◽  
Takashi Abe ◽  
...  
Keyword(s):  
Resistance Training ◽  
Resistance Exercise ◽  
Intracellular Signaling ◽  
Gastrocnemius Muscle ◽  
Male Rats ◽  
Exercise Session ◽  
Signaling Proteins ◽  
Signaling Mechanisms ◽  
Exercise Induced ◽  
Training And Detraining

Resistance training-induced muscle anabolism and subsequent hypertrophy occur most rapidly during the early phase of training and become progressively slower over time. Currently, little is known about the intracellular signaling mechanisms underlying changes in the sensitivity of muscles to training stimuli. We investigated the changes in the exercise-induced phosphorylation of hypertrophic signaling proteins during chronic resistance training and subsequent detraining. Male rats were divided into four groups: 1 bout (1B), 12 bouts (12B), 18 bouts (18B), and detraining (DT). In the DT group, rats were subjected to 12 exercise sessions, detrained for 12 days, and then were subjected to 1 exercise session before being killed. Isometric training consisted of maximum isometric contraction, which was produced by percutaneous electrical stimulation of the gastrocnemius muscle every other day. Muscles were removed 24 h after the final exercise session. Levels of total and phosphorylated p70S6K, 4E-BP1, rpS6, and p90RSK levels were measured, and phosphorylation of p70S6K, rpS6, and p90RSK was elevated in the 1B group compared with control muscle (CON) after acute resistance exercise, whereas repeated bouts of exercise suppressed those phosphorylation in both 12B and 18B groups. Interestingly, these phosphorylation levels were restored after 12 days of detraining in the DT group. On the contrary, phosphorylation of 4E-BP1 was not altered with chronic training and detraining, indicating that, with chronic resistance training, anabolic signaling becomes less sensitive to resistance exercise stimuli but is restored after a short detraining period.

Analysis of glycemic safety of a moderate-intensity resistance exercise session in patients with diabetes type 1

2020 ◽  
Vol 19 (1) ◽  
pp. 16
Author(s):  
Leandro Paim Da Cruz Carvalho ◽  
Samira Socorro Nunes De Souza ◽  
Djenane Cristovam Souza ◽  
Flávio De Souza Araujo ◽  
Ferdinando Oliveira Carvalho ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Blood Glucose ◽  
Physical Exercise ◽  
Resistance Exercise ◽  
Repeated Measures ◽  
Pancreatic Beta Cells ◽  
Moderate Intensity ◽  
Exercise Session ◽  
Resistance Exercise Session

 Introduction: Type 1 diabetes is an autoimmune disease that results in the destruction of pancreatic beta cells, implying the use of insulin therapy to maintain adequate blood glucose levels. When stimulated by physical exercise, glycemic homeostasis becomes impaired, providing complications in the daily lives of this population, constituting a barrier to physical exercise practice. Objective: To evaluate the glycemic safety of a resistance exercise session of moderate intensity in people with type 1 diabetes. Methods: 12 people with type 1 diabetes (7 men), performed a resistance exercise session of moderate intensity at 60% of 1 RM consisting of 7 exercises. Capillary blood glucose was assessed at the pre-session (GP), immediately after (G IA) and 20 minutes after (G 20). ANOVA for repeated measures was performed (p <0.05). Results: In the absolute values of glycemia, no significant differences were found (P = 0.061). However, when checking the delta blood glucose variation, a difference was found between G IA and G20 vs GP (P <0.05). Clinically important reductions above 20mg / dl (PI: ~ 37mg / dl; 20P: ~ 45mg / dl) without providing hypoglycemia. Conclusion: A moderate-intensity resistance exercise session proved to be safe from a glycemic point of view in people with type 1 diabetes.Keywords: diabetes mellitus type 1, resistance training, exercise. 

scholarly journals The Effects of Acute Cardiovascular Exercise on Memory and Its Associations With Exercise-Induced Increases in Neurotrophic Factors

2021 ◽  
Vol 13 ◽  
Author(s):  
Laura A. Kuhne ◽  
Anna-Maria Ksiezarczyk ◽  
Klaus-Michael Braumann ◽  
Rüdiger Reer ◽  
Thomas Jacobs ◽  
...  
Keyword(s):  
Physical Exercise ◽  
Neurotrophic Factors ◽  
Neurotrophic Factor ◽  
Human Memory ◽  
Exercise Session ◽  
Cardiovascular Exercise ◽  
Age Related ◽  
Significant Difference ◽  
Exercise Induced ◽  
Induced Changes

Due to increasing life expectancy, low-cost interventions to counteract age-related memory impairment have gained popularity. Physical activity has been shown to positively affect memory and hippocampal plasticity in rodents and humans. These effects have been proposed to be mediated by the release of neurotrophic factors. However, studies examining the effects of a single cardiovascular exercise session on human memory have yielded conflicting results. Moreover, it remains unclear whether exercise-induced memory enhancements are related to changes in peripheral neurotrophic factor concentrations. The present study tested whether one bout of cardiovascular exercise during an early phase of memory consolidation, compared to one bout of stretching and toning, positively affected memory. Furthermore, it was analyzed whether exercise-induced changes in the brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) were related to memory enhancement after a single bout of physical exercise. Fifty healthy participants (20–40 years) were randomly assigned to either a cycling group (BIKE) or a stretching and toning group (STRETCH). Participants performed an implicit vocabulary learning task which was immediately followed by physical exercise. Memory for the learned vocabulary was tested 1–2 weeks later. To measure exercise-induced changes in serum neurotrophic factor levels, blood samples were collected at rest (baseline) and immediately after the exercise session. Results did not show a significant difference in memory between the BIKE group and the STRETCH group. However, in the BIKE group, a larger increase in BDNF and VEGF levels was observed than in the STRETCH group. Moreover, the increase in BDNF and memory performance tended to be positively related in the BIKE group. We speculate that the correlation between exercise-increased BDNF levels and memory in the cycling group may indicate an involvement of BDNF in mediating memory processes after acute cardiovascular exercise.

The Effect of Resistance Exercise Priming in the Morning on Afternoon Sprint Cross-Country Skiing Performance

2021 ◽  
pp. 1-8
Author(s):  
Bjarne Rud ◽  
Eivind Øygard ◽  
Even B. Dahl ◽  
Gøran Paulsen ◽  
Thomas Losnegard
Keyword(s):  
Resistance Exercise ◽  
Low Frequency ◽  
Exercise Session ◽  
Oxygen Cost ◽  
Single Session ◽  
Countermovement Jump ◽  
Heavy Load ◽  
Low Frequency Fatigue ◽  
Cross Country ◽  
Resistance Exercise Session

Purpose: We tested whether a single session of heavy-load resistance priming conducted in the morning improved double-poling (DP) performance in the afternoon. Methods: Eight national-level male cross-country skiers (mean [SD]: 23 [3] y, 184 [6] cm, 73 [7] kg, maximum oxygen consumption = 69 [6] mL·kg−1·min−1) carried out 2 days of afternoon performance tests. In the morning, 5 hours before tests, subjects were counterbalanced to either a session of 3 × 3 repetitions (approximately 85%–90% 1-repetition maximum) of squat and sitting pullover exercises or no exercise. The performance was evaluated in DP as time to exhaustion (TTE) (approximately 3 min) on a treadmill and 30-m indoor sprints before and after TTE (30-m DP pre/post). Furthermore, submaximal DP oxygen cost, countermovement jump, and isometric knee-extension force during electrical stimulation were conducted. Participants reported perceived readiness on test days. Results: Resistance exercise session versus no exercise did not differ for TTE (approximately 3 min above) (mean ± 95% confidence interval = 3.6% ± 6.0%; P = .29; effect size [ES], Cohen d = 0.27), 30-m DP pre (−0.56% ± 0.80%; P = .21; ES = 0.20), 30-m DP post (−0.18% ± 1.13%; P = .76; ES = 0.03), countermovement jump (−2.0% ± 2.8%; P = .21; ES = 0.12), DP oxygen cost (−0.13% ± 2.04%; P = .91; ES = 0.02), or perceived readiness (P ≥ .11). Electrical stimulation force was not different in contraction or relaxation time but revealed low-frequency fatigue in the afternoon for the resistance exercise session only (−12% [7%]; P = .01; ES = 1.3). Conclusion: A single session of heavy-load, low-volume resistance exercise in the morning did not increase afternoon DP performance of short duration in high-level skiers. However, leg low-frequency fatigue after resistance priming, together with the presence of small positive effects in 2 out of 3 DP tests, may indicate that the preconditioning was too strenuous.

Can IGF-1 Serum Levels Really be Changed by Acute Physical Exercise? A Systematic Review and Meta-Analysis

2020 ◽  
Vol 17 (5) ◽  
pp. 575-584
Author(s):  
Diego de Alcantara Borba ◽  
Eduardo da Silva Alves ◽  
João Paulo Pereira Rosa ◽  
Lucas Alves Facundo ◽  
Carlos Magno Amaral Costa ◽  
...  
Keyword(s):  
Systematic Review ◽  
Physical Exercise ◽  
Resistance Exercise ◽  
Meta Analysis ◽  
Random Effect ◽  
Serum Levels ◽  
Exercise Session ◽  
Exercise Load ◽  
Exercise Type ◽  
Acute Physical Exercise

Background: Physical exercise plays an important role in metabolic health, especially in the insulin-like growth factor-1 (IGF-1) system. The objective of this study was to perform a systematic review and meta-analysis to evaluate the effects of a single endurance and resistance exercise session on IGF-1 serum. Methods: The systematic review was performed in SPORTDiscus, MEDLINE, PubMed, and Google Scholar databases. All analyses are based on random-effect models. The study identified 249 records of which 21 were included. Results: There was an effect of endurance exercise on total IGF-1 (P = .01), but not for free IGF-1 (P = .36). Resistance exercise similarly only affected total IGF-1 (P = .003) and not free IGF-1 (P = .37). The effect size indicated that total IGF-1 is more affected (ES = 0.81) by endurance than by resistance exercise (ES = 0.46). The present study showed that IGF-1 serum concentrations are altered by exercise type, but in conditions which are not well-defined. Conclusions: The systematic review and meta-analysis suggest that there is no determinant in serum IGF-1 changes for the exercise load characteristic. Therefore, physical exercise may be an alternative treatment to control changes in IGF-1 metabolism and blood concentration.

scholarly journals MAXIMUM EFFORT TRAINING PERFORMED IN HYPOXIA ALTERS THE MOOD PROFILE

2018 ◽  
Vol 24 (6) ◽  
pp. 440-445
Author(s):  
Sara Quaglia de Campos Giampá ◽  
Jorge Fernando Tavares de Souza ◽  
Marco Túlio de Mello ◽  
Sergio Tufik ◽  
Ronaldo Vagner Thomatieli dos Santos ◽  
...  
Keyword(s):  
Physical Exercise ◽  
Sea Level ◽  
Blood Lactate ◽  
Physiological Responses ◽  
Exercise Session ◽  
Physiological Variables ◽  
Hemoglobin Saturation ◽  
Lactate Levels ◽  
Mood Scale ◽  
Blood Lactate Levels

ABSTRACT Introduction: Physical exercise at high altitude has become constant. However, the risks associated with this type of exercise represent a major concern, considering the influence of important stressors such as hypoxia and physical exercise on psychobiological and physiological responses. Objective: Analyze the mood state and behavior of physiological variables of volunteers subjected to a progressive loading protocol until they reached maximum volitional exhaustion, both at sea level and at a simulated altitude of 4500 meters. Method: For both conditions studied, the volunteers responded to two instruments that assess mood responses: The Brunel Mood Scale and the Visual Analogue Mood Scale. They also underwent blood sampling to measure blood lactate levels and to evaluate oxygen-hemoglobin saturation. These procedures were performed before, immediately after, and 30 and 60 minutes after the end of the protocol. Results: Hypoxia triggered negative effects on mood responses, especially when compared to sea level conditions. An increase in fatigue level (p=0.02) and mental confusion (p=0.04) was observed immediately after the exercise session, and reduction of vigor (p=0.03) was noted at 30 minutes, accompanied by a reduction in oxygen-hemoglobin saturation immediately after the session and at 30 minutes. There was also an increase in blood lactate levels immediately after the session (p=0.006). Conclusion: The particularities of the hypoxic environment associated with maximum exercise are able to cause a deterioration of mood and physiological responses, which can negatively modulate physical performance. This is a cross-sectional clinical study.

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