scholarly journals Principles and Methods for Evidence-Based Quantification of the Effect of Seat Belt Non-Use in Crash-Related Litigation

2021 ◽  
Vol 18 (18) ◽  
pp. 9455
Author(s):  
Michael D. Freeman
Keyword(s):  
Relative Risk ◽  
Injury Risk ◽  
Seat Belt ◽  
Attributable Risk ◽  
Anatomical Location ◽  
Absolute Increase ◽  
Relevant Evidence ◽  
Hypothetical Scenario ◽  
Contributory Negligence ◽  
The Difference

Traffic crashes are a common cause of injury and death, and often result from the negligent actions of an inattentive, speeding, or impaired driver. In such cases, a civil legal action may be brought by an injured claimant for compensation for injuries resulting from a crash. Crash-related litigation is defended on various theories, one of which is to raise the issue of contributory negligence when the claimant was not using an available seat belt at the time of the crash, based on the assertion that the claimed injuries would have been avoided or minimized to some degree if the claimant had been restrained. At present, there are no published standards or systematic approach for assessing and quantifying the contribution of seat belt non-use to the cause of a claimant’s specific injury. A reliable medicolegal analysis that addresses whether contributory negligence can be proven in a specific case requires a multidisciplinary approach: First, the nature and severity of the crash must be reconstructed as it affected the vehicle kinetics (engineering) and in turn affected the kinematics of the occupant (biomechanics), next, the injuries must be described and scaled for severity (medicine/pathology), and finally, the risk of the known injuries given the actual circumstances of the crash and occupant (i.e., unbelted) are compared to the risk of the same injuries, and the same crash circumstances, but in the hypothetical scenario in which the claimant is belted. In the present discussion, methods for analyzing the presence and quantifying the degree of contributory negligence for seat belt non-use, suitable for presentation in a medicolegal setting, are described and illustrated with an example from the author’s personal case inventory. A detailed reconstruction of the crash is described, along with the associated occupant kinematics, and the resulting observed injuries. The injuries are then categorized by their anatomical location, type, and severity using Abbreviated Injury Scale designations. Quantification of the injury risk for the actual (unbelted) vs. hypothetical (belted) scenario is based on case-specific analysis of data accessed from a US national crash injury database The difference in risk for the two exposure scenarios can be quantified in terms of either relative risk (a risk ratio) or attributable risk (a risk proportion), with the goal to determine whether the analysis meets the threshold of a relative risk of >2.0, or an attributable risk of 50%, in order to meet the “more probable than not” standard typically required by courts. As a final step in a reliable analysis that exceeds the legal threshold for relevant evidence, the absolute increase in risk is used to quantify the degree to which the claimant’s seat belt non-use contributed to the likelihood of their injuries.

scholarly journals The Burden of the Nondiversifiable Risk of Entrepreneurship

2010 ◽  
Vol 100 (3) ◽  
pp. 1163-1194 ◽  
Author(s):  
Robert E Hall ◽  
Susan E Woodward
Keyword(s):  
Relative Risk ◽  
Risk Aversion ◽  
Venture Capital ◽  
Dynamic Program ◽  
Certainty Equivalent ◽  
Important Class ◽  
Relative Risk Aversion ◽  
The Past ◽  
Equity Value ◽  
The Difference

Entrepreneurship is risky. We study the risk facing a well-documented and important class of entrepreneurs, those backed by venture capital. Using a dynamic program, we calculate the certainty-equivalent of the difference between the cash rewards that entrepreneurs actually received over the past 20 years and the cash that entrepreneurs would have received from a risk-free salaried job. The payoff to a venture-backed entrepreneur comprises a below-market salary and a share of the equity value of the company when it goes public or is acquired. We find that the typical venture-backed entrepreneur received an average of $5.8 million in exit cash. Almost three-quarters of entrepreneurs receive nothing at exit and a few receive over a billion dollars. Because of the extreme dispersion of payoffs, an entrepreneur with a coefficient of relative risk aversion of two places a certainty equivalent value only slightly greater than zero on the distribution of outcomes she faces at the time of her company's launch. (JEL G24, G32, L26, M13)

Risky Business: Making Sense of Estimates of Risk

1998 ◽  
Vol 43 (4) ◽  
pp. 411-415 ◽  
Author(s):  
David L Streiner
Keyword(s):  
Relative Risk ◽  
Odds Ratio ◽  
Risk Difference ◽  
Attributable Risk ◽  
Absolute Difference ◽  
Number Needed To Treat ◽  
Making Sense ◽  
Specific Outcome ◽  
Relative Differences ◽  
Risky Business

This article describes various indices of risk, which is the probability that a person will develop a specific outcome. The risk difference is the absolute difference in risks between 2 groups and can be used either to compare the outcome of 2 groups, one of which was exposed to some genetic or environmental factor, or to see how much of an effect a treatment may have. The reciprocal of the risk difference, the number needed to treat, expresses how many patients must receive the intervention in order for 1 person to derive some benefit. Attributable risk reflects the proportion of cases due to some putative cause and indicates the number of cases that can be averted if the cause were removed. Finally, the relative risk and odds ratio reflect the relative differences between groups in achieving some outcome, either good (a cure) or bad (development of a disorder).

Abstract 13306: Combined Assessment of Acute Kidney Injury and Increased Plasma Concentration of D-dimer Is Useful for Evaluating 1-year Mortality in Patients Hospitalized to Coronary Care Units

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Shigeru Matsui ◽  
Junichi Ishii ◽  
Ryuunosuke Okuyama ◽  
Hiroshi Takahashi ◽  
Hideki Kawai ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Relative Risk ◽  
Kidney Injury ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Absolute Increase ◽  
Ventricular Ejection Fraction ◽  
Coronary Syndrome ◽  
Coronary Care ◽  
D Dimer

Background: Acute kidney injury (AKI) detected after admission to coronary care unit (CCU) is associated with very poor outcomes. We prospectively investigated the prognostic value of a combination of AKI and high plasma D-dimer levels for 1-year mortality in patients hospitalized to CCUs. Methods: D-dimer, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and high-sensitive C-reactive protein (hsCRP) levels were measured in 1228 patients on admission to CCUs, of whom 56% had decompensated heart failure and 38% had acute coronary syndrome. AKI was defined as an increase of >25% in creatinine from baseline or an absolute increase of ≥0.5 mg/dL within 48 h after admission. Left ventricular ejection fraction (LVEF) and E/e’ ratio were estimated using echocardiography with tissue Doppler imaging. Results: AKI was detected in 163 (13%) patients. During 1-year follow-up period, there were 149 (12%) deaths. The patients who died were older (median: 77 vs. 73 years; p < 0.0001) and exhibited higher D-dimer (2.7 vs. 1.3 μg/mL; p < 0.0001), NT-proBNP (5495 vs. 1525 pg/mL; p < 0.0001), and hsCRP levels (0.92 vs, 0.26 mg/L; p < 0.0001) and E/e’ ratio (15.0 vs. 13.2; p = 0.006). They also had a higher incidence of AKI (26% vs. 12%; p < 0.0001) and lower LVEF (39% vs. 49%; p < 0.0001) and estimated glomerular filtration rate (45 vs. 62 mL/min/1.73 m 2 ; p < 0.0001) than patients who survived. Multivariate Cox regression analysis, including 12 clinical, biochemical, and echocardiographic variables, identified AKI (relative risk: 1.79; p = 0.008) and increased D-dimer level (relative risk: 1.83 per 10-fold increment; p = 0.002) as independent predictors of 1-yeart mortality. The combined assessment of AKI and D-dimer quartiles was significantly associated with 1-year mortality rates (Figure). Conclusions: The combined assessment of AKI and high D-dimer levels may be useful for evaluating the risk of 1-year mortality in patients admitted to CCUs.

11. Damages

2019 ◽  
pp. 288-323
Author(s):  
Richard Taylor ◽  
Damian Taylor
Keyword(s):  
Legal Knowledge ◽  
Key Points ◽  
Contributory Negligence ◽  
Liquidated Damages ◽  
The Difference ◽  
The Relationship ◽  
Reliance Interest

Without assuming prior legal knowledge, books in the Directions series introduce and guide readers through key points of law and legal debate. Questions, diagrams and exercises help readers to engage fully with each subject and check their understanding as they progress. This chapter examines the principles by which contractual damages are assessed. The discussions cover the aim of contractual damages, the difference between damages in contract and in tort; the relationship between the expectation interest and the reliance interest; cost of cure and difference in value; remoteness of damage; foreseeability and assumption of risk; non-pecuniary losses; mitigation; contributory negligence; and penalties, liquidated damages and forfeiture.

11. Damages

2017 ◽  
Author(s):  
Richard Taylor ◽  
Damian Taylor
Keyword(s):  
Legal Knowledge ◽  
Key Points ◽  
Contributory Negligence ◽  
Liquidated Damages ◽  
The Difference ◽  
The Relationship ◽  
Reliance Interest

Without assuming prior legal knowledge, books in the Directions series introduce and guide readers through key points of law and legal debate. Questions, diagrams and exercises help readers to engage fully with each subject and check their understanding as they progress. This chapter examines the principles by which contractual damages are assessed. The discussions cover the aim of contractual damages, the difference between damages in contract and in tort; the relationship between the expectation interest and the reliance interest; cost of cure and difference in value; remoteness of damage; foreseeability and assumption of risk; non-pecuniary losses; mitigation; contributory negligence; and penalties, liquidated damages and forfeiture.

Loss of hypoxic pulmonary vasoconstriction in chronic pneumonia is not mediated by nitric oxide

1993 ◽  
Vol 265 (5) ◽  
pp. H1523-H1528 ◽  
Author(s):  
D. G. McCormack ◽  
N. A. Paterson
Keyword(s):  
Nitric Oxide ◽  
Pressor Response ◽  
Hypoxic Pulmonary Vasoconstriction ◽  
Sprague Dawley ◽  
Absolute Increase ◽  
Pulmonary Vasoconstriction ◽  
Sprague Dawley Rats ◽  
Before And After ◽  
Inflammatory Processes ◽  
The Difference

In pulmonary inflammatory processes such as pneumonia there is diminished hypoxic pulmonary vasoconstriction (HPV). We investigated whether the attenuated HPV in pneumonia is a due to excess nitric oxide (NO) release. Sprague-Dawley rats were anesthetized, and a slurry (0.06 ml) of infected agar beads (containing 6 x 10(5) Pseudomonas aeruginosa organisms) or control (sterile) beads was then injected into a distal bronchus through a tracheotomy. After the establishment of a chronic P. aeruginosa pneumonia (7-10 days later) animals were instrumented for hemodynamic monitoring, and the response to exposure to hypoxic gas (fraction of inspired O2 = 0.08) was recorded before and after the administration of NG-monomethyl-L-arginine (L-NMMA; 50 mg/kg), an inhibitor of NO synthesis. The hypoxic pressor response, as assessed by the absolute increase in pulmonary arterial pressure (PAP) and total pulmonary resistance (TPR), was reduced in infected animals compared with control animals. The change in PAP and TPR was 8.5 +/- 0.7 and 0.053 +/- 0.007, respectively, in control animals compared with 5.9 +/- 0.5 and 0.041 +/- 0.011 in infected animals. After L-NMMA the increase in PAP and TPR during hypoxia was greater in both control and infected animals. However, treatment with L-NMMA did not affect the difference between control and infected animals. We conclude that excess release of NO does not account for the attenuated hypoxic pressor response in pneumonia.

Relationships Among PlayerLoad, High-Intensity Intermittent Running Ability, and Injury Risk in Professional Rugby League Players

2020 ◽  
Vol 15 (3) ◽  
pp. 423-429 ◽  
Author(s):  
Billy T. Hulin ◽  
Tim J. Gabbett ◽  
Nathan J. Pickworth ◽  
Rich D. Johnston ◽  
David G. Jenkins
Keyword(s):  
Relative Risk ◽  
Confidence Interval ◽  
Physical Performance ◽  
Injury Risk ◽  
Moving Average ◽  
Rugby League ◽  
Running Performance ◽  
Maximal Effort ◽  
Weighted Moving Average ◽  
Exponentially Weighted

Purpose: To examine relationships among physical performance, workload, and injury risk in professional rugby league players. Methods: Maximal-effort (n = 112) and submaximal (n = 1084) running performances of 45 players were recorded from 1 club over 2 consecutive seasons. Poorer and better submaximal running performance was determined by higher and lower exercise heart rates, respectively. Exponentially weighted moving averages and daily rolling averages were used to assess microtechnology-derived acute and chronic field-based workloads. The associations among within-individual submaximal running performance, workload, and noncontact lower-limb injury were then investigated. Results: The injury risk associated with poorer submaximal performance was “likely” greater than stable (relative risk = 1.8; 90% confidence interval, 0.9–3.7) and better submaximal performance (relative risk = 2.0; 90% confidence interval, 0.9–4.4). Compared with greater submaximal performance, poorer performance was associated with lower chronic workloads (effect size [d] = 0.82 [0.13], large) and higher acute:chronic workload ratios (d = 0.49 [0.14], small). Chronic workload demonstrated a “nearly perfect” positive relationship with maximal-effort running performance (exponentially weighted moving average, R2 = .91 [.15]; rolling average, R2 = .91 [.14]). At acute:chronic workload ratios >1.9, no differences in injury risk were found between rolling average and exponentially weighted moving average methods (relative risk = 1.1; 90% confidence interval, 0.3–3.8; unclear). Conclusions: Reductions in submaximal running performance are related with low chronic workloads, high acute:chronic workload ratios, and increased injury risk. These findings demonstrate that a submaximal running assessment can be used to provide information on physical performance and injury risk in professional rugby league players.

The results obtained from studies of causation

2017 ◽  
Author(s):  
Mark Elwood
Keyword(s):  
Relative Risk ◽  
Intervention Studies ◽  
Case Control ◽  
Risk Difference ◽  
Attributable Risk ◽  
Number Needed To Treat ◽  
Case Control Studies ◽  
Sampling Schemes ◽  
Multiplicative Models ◽  
The Relationship

This chapter shows the format and derivation of results from studies. Cohort and intervention studies yield relative risk and risk difference, also known as attributable risk, and number needed to treat (NNT). Count and person-time methods are shown. Additive and multiplicative models for two or more exposures are shown. Case-control studies give primarily odds ratio; the relationship between this and relative risk is explained. Different sampling schemes for case-control studies include methods were a case can also be a control. Surveys yield results similar to cohort studies.

scholarly journals Partnerships of Bidders with Constant Relative Risk Aversions

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Pingping Zhao ◽  
Kaili Xiang ◽  
Peimin Chen
Keyword(s):  
Relative Risk ◽  
Risk Aversion ◽  
Relative Risk Aversion ◽  
Unique Equilibrium ◽  
Risk Neutral ◽  
Bid Price ◽  
Risk Aversion Coefficient ◽  
Constant Relative Risk Aversion ◽  
The Difference

In this paper, we study a dynamic auction for allocating a single indivisible project while different participants have different bid values for the project. When the price rises continuously, the bidders can retreat the auction and obtain the compensation by the difference between the price at retreating time and the previous bid price. The final successful bidder achieves the project and pays compensations to others. We show that the auction of bidders with constant relative risk aversion (CRRA) has a unique equilibrium. While the relative risk aversion coefficient approaches to zero, the equilibrium with CRRA bidders would approach to the equilibrium with risk-neutral bidders.

Sign in / Sign up

Export Citation Format

Share Document