Meta-Analysis on Associations of RGS1 and IL12A Polymorphisms with Celiac Disease Risk

ABSTRACT BACKGROUND: There is increasing evidence to show that TNF-α -308G>A polymorphism may be a risk factor for celiac disease, but the results are inconsistent. OBJECTIVE: Thus, we aimed to perform a meta-analysis involving published studies up to January 2019 to elucidate the association. METHODS: To assess the effect of TNF-α -308G>A polymorphism on celiac disease susceptibility, we searched PubMed, ISI Web of Knowledge, Chinese National Knowledge Infrastructure (CNKI) databases to identify eligible studies, without restriction. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the susceptibility to celiac disease. RESULTS: A total of 11 studies with 1147 cases and 1774 controls were selected for this meta-analysis. The pooled results indicated that TNF-α -308G>A polymorphism was associated with increased risk of celiac disease (A vs G: OR=2.077, 95% CI=1.468-2.939, P=≤0.001; AA vs GG: OR=8.512, 95% CI=3.740-19.373, P=≤0.001; AA+AG vs GG: OR=1.869, 95% CI=1.161-3.008, P=0.010; and AA+AG vs GG: OR=4.773, 95% CI=3.181-7.162, P≤0.001). Subgroup analysis by ethnicity also revealed significant association in Caucasians. In addition, there was a significant association between TNF-α -308G>A polymorphism and celiac disease risk in Italy, Spain and PCR-FRLP group studies. CONCLUSION: Our meta-analysis suggests that the TNF-α -308G>A polymorphism plays an important role in celiac disease susceptibility. However, our results are still needed to strengthen by further studies in different ethnicities and larger sample sizes.

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ASSOCIATIONS OF IL-6 -174G>C AND IL-10 -1082A>G POLYMORPHISMS WITH SUSCEPTIBILITY TO CELIAC DISEASE: EVIDENCE FROM A META-ANALYSIS AND LITERATURE REVIEW

Arquivos de Gastroenterologia ◽

10.1590/s0004-2803.201900000-60 ◽

2019 ◽

Vol 56 (3) ◽

pp. 323-328 ◽

Cited By ~ 1

Author(s):

Majid AFLATOONIAN ◽

Gholamreza SIVANDZADEH ◽

Majid MOROVATI-SHARIFABAD ◽

Seyed Reza MIRJALILI ◽

Mohammad Javad AKBARIAN-BAFGHI ◽

...

Keyword(s):

Celiac Disease ◽

Literature Review ◽

Publication Bias ◽

Web Of Science ◽

Disease Risk ◽

Meta Analysis ◽

Case Control ◽

Case Control Studies ◽

Potential Association ◽

Increased Risk

ABSTRACT BACKGROUND: There has been little evidence to suggest that the IL-6 -174G>C and IL-10 -1082A>G polymorphisms are significantly associated with susceptibility to celiac disease. Thus, we performed the present meta-analysis to explore the potential association between these polymorphisms and celiac disease risk. METHODS: Eligible studies were searched in PubMed, Medline, Embase, Web of Science and CNKI database up to April 20, 2019. Odds ratios with 95% confidence interval were calculated to assess the potential associations. Moreover, we performed the heterogeneity, sensitivity, and publication bias tests to clarify and validate the pooled results. RESULTS: Overall, nine case-control studies involving five studies with 737 cases and 1,338 control on IL-6 -174G>C polymorphism and four studies with 923 cases and 864 controls on IL-10 -1082A>G polymorphism were selected. The pooled ORs showed that the IL-6 -174G>C and IL-10 -1082A>G polymorphisms were not significantly associated with increased risk of celiac disease under all five genetic models. There was no publication bias. CONCLUSION: To the best of our knowledge, this is the first meta-analysis summarizing all of the available studies on the association of IL-6 -174G>C and IL-10 -1082A>G polymorphisms with celiac disease. Our results suggest that the IL-6 -174G>C and IL-10 -1082A>G polymorphisms may not be associated with increased risk of celiac disease. Moreover, large and well-designed studies are needed to fully describe the association of IL-6 -174G>C and IL-10 -1082A>G polymorphisms with celiac disease.

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The burden of cardiovascular disease risk factors in the Middle East: A systematic review and meta-analysis focusing on primary prevention

Current Vascular Pharmacology ◽

10.2174/1573406416666200611104143 ◽

2020 ◽

Vol 18 ◽

Author(s):

Akshaya Srikanth Bhagavathula ◽

Abdullah Shehab ◽

Anhar Ullah ◽

Jamal Rahmani

Keyword(s):

Risk Factors ◽

Systematic Review ◽

Cardiovascular Disease ◽

Family History ◽

Primary Prevention ◽

Middle East ◽

Disease Risk ◽

Meta Analysis ◽

Middle Eastern ◽

History Of

Background: The increasing incidence of cardiovascular disease (CVD) threatens the Middle Eastern population. Several epidemiological studies have assessed CVD and its risk factors in terms of the primary prevention of CVD in the Middle East. Therefore, summarizing the information from these studies is essential. Aim: We conducted a systematic review to assess the prevalence of CVD and its major risk factors among Middle Eastern adults based on the literature published between January 1, 2012 and December 31, 2018 and carried out a meta-analysis. Methods: We searched electronic databases such as PubMed/Medline, ScienceDirect, Embase and Google Scholar to identify literature published from January 1, 2012 to December 31, 2018. All the original articles that investigated the prevalence of CVD and reported at least one of the following factors were included: hypertension, diabetes, dyslipidaemia, smoking and family history of CVD. To summarize CVD prevalence, we performed a random-effects meta-analysis. Results: A total of 41 potentially relevant articles were included, and 32 were included in the meta-analysis (n=191,979). The overall prevalence of CVD was 10.1% (95% confidence interval (CI): 7.1-14.3%, p<0.001) in the Middle East. A high prevalence of CVD risk factors, such as dyslipidaemia (43.3%; 95% CI: 21.5-68%), hypertension (26.2%; 95% CI: 19.6-34%) and diabetes (16%; 95% CI: 9.9-24.8%), was observed. The prevalence rates of other risk factors, such as smoking (12.4%; 95% CI: 7.7-19.4%) and family history of CVD (18.7%; 95% CI: 15.4-22.5%), were also high. Conclusion: The prevalence of CVD is high (10.1%) in the Middle East. The burden of dyslipidaemia (43.3%) in this region is twice as high as that of hypertension (26.2%) and diabetes mellitus (16%). Multifaceted interventions are urgently needed for the primary prevention of CVD in this region.

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Association between genetic variants in ZNF365 and inflammatory bowel disease risk in Caucasians: a meta-analysis and trial sequential analysis

Expert Review of Clinical Immunology ◽

10.1080/1744666x.2021.1939012 ◽

2021 ◽

Author(s):

Peng-bo Wu ◽

Yu Zhang ◽

Gang Nie ◽

Xu Huang ◽

Yuan-jie Yu ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Genetic Variants ◽

Sequential Analysis ◽

Disease Risk ◽

Meta Analysis ◽

Trial Sequential Analysis ◽

Inflammatory Bowel

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Dental disease risk in children with autism: a meta-analysis

Evidence-Based Dentistry ◽

10.1038/s41432-021-0165-3 ◽

2021 ◽

Vol 22 (1) ◽

pp. 34-35

Author(s):

N. Thomas ◽

S. Blake

Keyword(s):

Disease Risk ◽

Meta Analysis ◽

Children With Autism ◽

Dental Disease

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Safety of Adding Oats to a Gluten-Free Diet for Patients With Celiac Disease: Systematic Review and Meta-analysis of Clinical and Observational Studies

Gastroenterology ◽

10.1053/j.gastro.2017.04.009 ◽

2017 ◽

Vol 153 (2) ◽

pp. 395-409.e3 ◽

Cited By ~ 37

Author(s):

María Inés Pinto-Sánchez ◽

Natalia Causada-Calo ◽

Premysl Bercik ◽

Alexander C. Ford ◽

Joseph A. Murray ◽

...

Keyword(s):

Systematic Review ◽

Celiac Disease ◽

Observational Studies ◽

Meta Analysis ◽

Gluten Free Diet ◽

Gluten Free

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Abstract P375: Vascular Age Versus Calendar Age as Surrogate for Atherosclerotic Burden and Cardiovascular Disease Risk

Circulation ◽

10.1161/circ.127.suppl_12.ap375 ◽

2013 ◽

Vol 127 (suppl_12) ◽

Author(s):

Sanne A Peters ◽

Karlijn A Groenewegen ◽

Hester M den Ruijter ◽

Michiel L Bots

Keyword(s):

Cardiovascular Disease ◽

Cardiovascular Risk ◽

Disease Risk ◽

Meta Analysis ◽

Cardiovascular Disease Risk ◽

Intima Media Thickness ◽

Chronological Age ◽

Specific Reference ◽

Communication Tool ◽

Vascular Age

Background Vascular age is the chronological age of an individual adjusted by their level of atherosclerosis. Vascular age can be used as understandable communication tool towards patients. It has been proposed that carotid intima-media thickness (CIMT) could be used to estimate the vascular age in individuals. The issue on how to best estimate vascular age remains an unanswered question and was evaluated in this study. Methods Data were used from the USE-IMT study collaboration, a global individual patient data meta-analysis including 14 population-based cohorts contributing data for 45 828 individuals. We used two methods to define vascular age. First, vascular age was the age at which a participant’s CIMT value would be at the 50th percentile of the age-and sex specific reference values of the healthy USE-IMT subpopulation (VA50). Second, vascular age was the age at which the estimated cardiovascular risk equals the risk of the observed CIMT value (VArisk). Results Mean (+/- standard deviation [SD]) chronological age, VA50, and VArisk were 58 (9), 63 (19), and 59 (7) years, respectively. VArisk was 0.24 yrs higher in women and 1.5 yrs higher in men than chronological age whereas VA50 was 4.4 yrs higher in women and 5.8 yrs higher in men than chronological age. After adjustment for traditional cardiovascular risk factors, a SD increase in VA50 and VArisk was associated with a 15% (95% confidence interval [CI]: 1.12; 1.19) and 22% (95% CI: 1.17; 1.28) higher risk of cardiovascular disease. For comparison, a SD increase in mean common CIMT increased the risk of cardiovascular disease with 15% (95% CI: 1.12; 1.19). Conclusion We presented two distinct measures a vascular age: VA50, and VArisk. VA50 is a straightforward translation of CIMT and is a measure of the age at which the average person would be expected to have a certain CIMT. In contrast, VArisk incorporates information about expected cardiovascular risk and is the chronological age of a person that conveys the same risk as the CIMT. VA50 and VArisk might provide a convenient transformation of CIMT to a scale that is more easily understood by patients and clinicians.

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