scholarly journals The effects of Astragalus Membranaceus Active Extracts on Autophagy-related Diseases

2019 ◽  
Vol 20 (8) ◽  
pp. 1904 ◽  
Author(s):  
Shan ◽  
Zheng ◽  
Li
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Therapeutic Potential ◽  
Biological Activities ◽  
Cellular Tissue ◽  
Astragalus Membranaceus ◽  
Positive Effects ◽  
Associated Diseases ◽  
Evolutionarily Conserved ◽  
Anti Inflammation

Autophagy is an evolutionarily conserved ‘self-eating’ process that maintains cellular, tissue, and organismal homeostasis. New studies on autophagy, mediated by subsets of autophagy proteins, are emerging in many physiological and pathological processes. Astragalus membranaceus (AM), also named Huangqi, is one of the fundamental herbs in traditional Chinese medicine and its extracts have been proved to possess many biological activities related to autophagy, including anti-oxidation, anti-inflammation, anticancer, anti-photoaging, and improvement of cardiomyocyte function. Evidence suggests that AM extracts can have therapeutic potential in autophagy dysregulation-associated diseases because of their biological positive effects. Here we will review the literature concerning the effects of AM extracts on autophagy dysregulation-associated diseases.

scholarly journals Leonurine, a Potential Agent of Traditional Chinese Medicine: Recent Updates and Future Perspectives

2016 ◽  
Vol 11 (11) ◽  
pp. 1934578X1601101 ◽  
Author(s):  
Di Yang ◽  
Wanwan Jia ◽  
Yi Zhun Zhu
Keyword(s):  
Natural Products ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Therapeutic Potential ◽  
Biological Activities ◽  
Future Perspectives ◽  
Effective Agent ◽  
Recent Advances

Herba Leonuri, also named Chinese Motherwort, has been extensively investigated as an effective agent on the uterus system. Our group has been studying the natural products of Herba Leonuri for several years, and during this period, many biological activities of the drug were recognized. Leonurine (4-guanidino- N-butyl-syringate) is an alkaloid present in Herba Leonuri. Recently, growing evidence has highlighted the therapeutic potential of leonurine in multiple diseases, especially cardiovascular. In this review, we discuss the biological activities of leonurine, as well as recent advances involving this alkaloid.

Recent Development of Oridonin Derivatives with Diverse Pharmacological Activities

2018 ◽  
Vol 19 (2) ◽  
pp. 114-124 ◽  
Author(s):  
Weiyan Cheng ◽  
Chuanhui Huang ◽  
Weifeng Ma ◽  
Xin Tian ◽  
Xiaojian Zhang
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Biological Activities ◽  
Biological Properties ◽  
Clinical Applications ◽  
Structure Modification ◽  
Pharmacological Activities ◽  
The Poor ◽  
Structure Activity ◽  
Anti Inflammation

Oridonin is one of the major components isolated from Isodon rubescens, a traditional Chinese medicine, and it has been confirmed to exhibit many kinds of biological activities including anticancer, anti-inflammation, antibacterial and so on. However, the poor pharmaceutical property limits the clinical applications of oridonin. So many strategies have been explored in the purpose of improving the potencies of oridonin, and structure modification is one thus way. This review outlines the landscape of the recent development of oridonin derivatives with diverse pharmacological activities, mainly focusing on the biological properties, structure-activity relationships, and mechanism of actions.

Cardiovascular Modulating Effects of Magnolol and Honokiol, Two Polyphenolic Compounds from Traditional Chinese Medicine-Magnolia Officinalis

2020 ◽  
Vol 21 (6) ◽  
pp. 559-572 ◽  
Author(s):  
Yuan Yuan ◽  
Xiaocui Zhou ◽  
Yuanyuan Wang ◽  
Yan Wang ◽  
Xiangyan Teng ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Cardiac Hypertrophy ◽  
Therapeutic Potential ◽  
Current Data ◽  
Polyphenolic Compounds ◽  
Comprehensive Review ◽  
Magnolia Officinalis

Honokiol and its isomer magnolol are poly-phenolic compounds isolated from the Magnolia officinalis that exert cardiovascular modulating effects via a variety of mechanisms. They are used as blood-quickening and stasis-dispelling agents in Traditional Chinese Medicine and confirmed to have therapeutic potential in atherosclerosis, thrombosis, hypertension, and cardiac hypertrophy. This comprehensive review summarizes the current data regarding the cardioprotective mechanisms of those compounds and identifies areas for further research.

Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCγ1- and Ca2+-dependent apoptosis

Blood ◽  
2008 ◽  
Vol 111 (4) ◽  
pp. 2354-2363 ◽  
Author(s):  
Sven Baumann ◽  
Stefanie C. Fas ◽  
Marco Giaisi ◽  
Wolfgang W. Müller ◽  
Anette Merling ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Therapeutic Potential ◽  
Human T Cell ◽  
Voltage Dependent ◽  
Ca2 Channels ◽  
Malignant T Cells

Herbs have successfully been used in traditional Chinese medicine for centuries. However, their curative mechanisms remain largely unknown. In this study, we show that Wogonin, derived from the traditional Chinese medicine Huang-Qin (Scutellaria baicalensis Georgi), induces apoptosis in malignant T cells in vitro and suppresses growth of human T-cell leukemia xenografts in vivo. Importantly, Wogonin shows almost no toxicity on T lymphocytes from healthy donors. Wogonin induces prolonged activation of PLCγ1 via H2O2 signaling in malignant T cells, which leads to sustained elevation of cytosolic Ca2+ in malignant but not normal T cells. Subsequently, a Ca2+ overload leads to disruption of the mitochondrial membrane. The selective effect of Wogonin is due to its differential regulation of the redox status of malignant versus normal T cells. In addition, we show that the L-type voltage-dependent Ca2+ channels are involved in the intracellular Ca2+ mobilization in T cells. Furthermore, we show that malignant T cells possess elevated amounts of voltage-dependent Ca2+ channels compared with normal T cells, which further enhance the cytotoxicity of Wogonin for malignant T cells. Taken together, our data show a therapeutic potential of Wogonin for the treatment of hematologic malignancies.

scholarly journals Application of Herbal Medicines with Heat-Clearing Property to Anti-Microinflammation in the Treatment of Diabetic Kidney Disease

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Jing Guo ◽  
Yabin Gao ◽  
Yaoxian Wang ◽  
Wei Jing Liu ◽  
Jingwei Zhou ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Kidney Disease ◽  
Traditional Chinese Medicine ◽  
Diabetic Kidney Disease ◽  
Herbal Medicines ◽  
Pathogenic Factor ◽  
Diabetic Kidney ◽  
Global Pandemic ◽  
Anti Inflammation ◽  
Made In

Diabetic kidney disease (DKD) is a global pandemic, and microinflammation has been reported as an important pathogenic factor of DKD. Traditional Chinese Medicine (TCM) has been used in the treatment of DKD for thousands of years, and modern Chinese medicine studies have found that herbal medicines with heat-clearing property have a curative anti-inflammation effect in DKD. This article reviews the new clinical and experimental progress made in herbal medicines with heat-clearing property, in the treatment of DKD, as well as their safety aspects.

Therapeutic Potential of Wenshen Xiaozheng Tang, a Traditional Chinese Medicine Prescription, for Treating Endometriosis

2013 ◽  
Vol 20 (10) ◽  
pp. 1215-1223 ◽  
Author(s):  
Zhenzhen Zhang ◽  
Chunping Hu ◽  
Weiwei Tang ◽  
Tao Gui ◽  
Ruyun Qian ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Therapeutic Potential ◽  
Medicine Prescription ◽  
Chinese Medicine Prescription

scholarly journals Therapeutic Potential of Traditional Chinese Medicine on Inflammatory Diseases

2013 ◽  
Vol 3 (3) ◽  
pp. 142-151 ◽  
Author(s):  
Wen-Hsin Tsai ◽  
Chih-Ching Yang ◽  
Ping-Chia Li ◽  
Wang-Chuan Chen ◽  
Chiang-Ting Chien
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Therapeutic Potential ◽  
Inflammatory Diseases

scholarly journals Research Progress on the Antitumor Effect of Polysaccharides from Fungus Used in Traditional Chinese Medicine

2021 ◽  
Vol 5 (5) ◽  
pp. 7-10
Author(s):  
Ru Xiang ◽  
Bing Xu
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Antitumor Effect ◽  
Biological Activities ◽  
Research Progress ◽  
Cancer Breast ◽  
Wide Range ◽  
Low Toxicity ◽  
Fungal Polysaccharides ◽  
Cancer Côlon

Cancer is a serious threat to human health. Fungal polysaccharide is a polar biological macromolecule with low toxicity. It has a wide range of biological activities, including immune regulation, antitumor activity, and antiviral activity. In recent years, the research results have shown that polysaccharides from fungus in traditional Chinese medicine have excellent antitumor effect in liver cancer, gastric cancer, breast cancer, colon cancer, esophageal cancer, and lung cancer. Therefore, the research and development of fungal polysaccharides are of great significance for the development of antitumor drugs in the future.

scholarly journals Research progress of icariin, an extract of traditional Chinese medicine, in the treatment of asthma

2022 ◽  
Vol 50 (1) ◽  
pp. 9-16
Author(s):  
Jia-ying Yuan ◽  
Zhi-ying Tong ◽  
Yu-chao Dong ◽  
Jia-yi Zhao ◽  
Yan Shang
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Biological Activities ◽  
Airway Disease ◽  
Research Direction ◽  
Research Progress ◽  
Therapeutic Drug ◽  
First Choice ◽  
Wide Range ◽  
New Research

Bronchial asthma is a common chronic airway disease, and long-term management of asthma is the focus and difficulty of clinical treatment. Glucocorticoids are often used as the first choice for the treatment of asthma. However, the occurrence of hormone dependence, hormone resistance, local and systemic adverse reactions caused by hormone application also brings problems for the treatment of asthma. Finding safe and effective new therapeutic drugs is an important research direction at present. Icariin is the effective ingredient of traditional Chinese medicine Epimedium. It has various biological activities such as anti-inflammatory, anti-oxidative stress, and immune regulation. It has high safety and has a wide range of clinical applications. Icariin has the characteristics of multi-target intervention in the treatment of asthma. This article reviews recent studies in order to provide new research directions for further therapeutic drug development.

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