scholarly journals Comparative Transcriptomic Analysis of Biological Process and Key Pathway in Three Cotton (Gossypium spp.) Species Under Drought Stress

2019 ◽  
Vol 20 (9) ◽  
pp. 2076 ◽  
Author(s):  
Md Mosfeq-Ul Hasan ◽  
Fanglu Ma ◽  
Faisal Islam ◽  
Muhammad Sajid ◽  
Zakaria H. Prodhan ◽  
...  
Keyword(s):  
Drought Stress ◽  
Heat Shock ◽  
Drought Tolerance ◽  
Heat Shock Protein ◽  
Molecular Mechanisms ◽  
Biological Process ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Small Heat Shock Protein ◽  
Cotton Species

Drought is one of the most important abiotic stresses that seriously affects cotton growth, development, and production worldwide. However, the molecular mechanism, key pathway, and responsible genes for drought tolerance incotton have not been stated clearly. In this research, high-throughput next generation sequencing technique was utilized to investigate gene expression profiles of three cotton species (Gossypium hirsutum, Gossypium arboreum, and Gossypium barbadense L.) under drought stress. A total of 6968 differentially expressed genes (DEGs) were identified, where 2053, 742, and 4173 genes were tested as statistically significant; 648, 320, and 1998 genes were up-regulated, and 1405, 422, and 2175 were down-regulated in TM-1, Zhongmian-16, and Pima4-S, respectively. Total DEGs were annotated and classified into functional groups under gene ontology analysis. The biological process was present only in tolerant species(TM-1), indicating drought tolerance condition. The Kyoto encyclopedia of genes and genomes showed the involvement of plant hormone signal transduction and metabolic pathways enrichment under drought stress. Several transcription factors associated with ethylene-responsive genes (ICE1, MYB44, FAMA, etc.) were identified as playing key roles in acclimatizing to drought stress. Drought also caused significant changes in the expression of certain functional genes linked to abscisic acid (ABA) responses (NCED, PYL, PP2C, and SRK2E), reactive oxygen species (ROS) related in small heat shock protein and 18.1 kDa I heat shock protein, YLS3, and ODORANT1 genes. These results will provide deeper insights into the molecular mechanisms of drought stress adaptation in cotton.

scholarly journals Heat Shock Protein 22 in Physiological and Pathological Hearts: Small Molecule, Large Potentials

Cells ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 114
Author(s):  
Xiaonan Sun ◽  
Sharadhi Siri ◽  
Amirah Hurst ◽  
Hongyu Qiu
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Molecular Mechanisms ◽  
Heart Diseases ◽  
Pressure Overload ◽  
Small Heat Shock Protein ◽  
Cardiac Metabolism ◽  
Vital Role ◽  
Post Translational Modification ◽  
Heat Shock Protein 22

Small heat shock protein 22 (HSP22) belongs to the superfamily of heat shock proteins and is predominantly expressed in the heart, brain, skeletal muscle, and different types of cancers. It has been found that HSP22 is involved in variant cellular functions in cardiomyocytes and plays a vital role in cardiac protection against cardiomyocyte injury under diverse stress. This review summarizes the multiple functions of HSP22 in the heart and the underlying molecular mechanisms through modulating gene transcription, post-translational modification, subcellular translocation of its interacting proteins, and protein degradation, facilitating mitochondrial function, cardiac metabolism, autophagy, and ROS production and antiapoptotic effect. We also discuss the association of HSP22 in cardiac pathologies, including human dilated cardiomyopathy, pressure overload-induced heart failure, ischemic heart diseases, and aging-related cardiac metabolism disorder. The collected information would provide insights into the understanding of the HSP22 in heart diseases and lead to discovering the therapeutic targets.

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