scholarly journals Natural Autoantibodies in Chronic Pulmonary Diseases

2020 ◽  
Vol 21 (3) ◽  
pp. 1138 ◽  
Author(s):  
Kiyoharu Fukushima ◽  
Kazuyuki Tsujino ◽  
Shinji Futami ◽  
Hiroshi Kida
Keyword(s):  
Peripheral Tolerance ◽  
Pulmonary Diseases ◽  
Unknown Etiology ◽  
Natural Autoantibodies ◽  
Intracellular Proteins ◽  
Chronic Pulmonary Diseases ◽  
Long Time ◽  
Non Coding Rnas ◽  
Alveolar Proteinosis ◽  
Disease Specific

In autoantibody-mediated autoimmune diseases, pathogenic autoantibodies generated by a failure of central or peripheral tolerance, have different effects mediated by a variety of mechanisms. Interestingly, even non-autoimmune chronic diseases have a set of disease-specific natural autoantibodies that are maintained for a long time. Because most of these natural autoantibodies target intracellular proteins or long non-coding RNAs, they are speculated to be non-pathological and have some important as yet unrecognized physiological functions such as debris clearance. Recently, we revealed a set of disease-specific natural autoantibodies of chronic pulmonary diseases with unknown etiology by protein arrays that enable detection of specific autoantibodies against >8000 targets. Surprisingly, some of the targeted antigens of disease-specific autoantibodies were subsequently reported by other laboratories as strongly associated with the disease, suggesting that these antigens reflect the pathology of each disease. Furthermore, some of these autoantibodies that target extracellular antigens might modify the original course of each disease. Here, we review the disease-specific natural autoantibodies of chronic pulmonary diseases, including chronic fibrosing idiopathic interstitial pneumonias, sarcoidosis, and autoimmune pulmonary alveolar proteinosis, and discuss their utility and effects.

Chronic pulmonary diseases are independent risk factors for complications after radical nephrectomy

2011 ◽  
Vol 43 (4) ◽  
pp. 1025-1031 ◽  
Author(s):  
Hüsnü Tokgöz ◽  
Bülent Akduman ◽  
İlker Ünal ◽  
Bülent Erol ◽  
Ersöz Akyürek ◽  
...  
Keyword(s):  
Risk Factors ◽  
Radical Nephrectomy ◽  
Pulmonary Diseases ◽  
Chronic Pulmonary Diseases ◽  
Independent Risk Factors

scholarly journals Tissue-informed engineering strategies for modeling human pulmonary diseases

2019 ◽  
Vol 316 (2) ◽  
pp. L303-L320 ◽  
Author(s):  
Kolene E. Bailey ◽  
Michael L. Floren ◽  
Tyler J. D’Ovidio ◽  
Steven R. Lammers ◽  
Kurt R. Stenmark ◽  
...  
Keyword(s):  
Disease Modeling ◽  
Rapid Development ◽  
Rapid Expansion ◽  
Pulmonary Diseases ◽  
Chronic Obstructive ◽  
Management Options ◽  
Dynamic Changes ◽  
Human Pathology ◽  
Chronic Pulmonary Diseases

Chronic pulmonary diseases, including idiopathic pulmonary fibrosis (IPF), pulmonary hypertension (PH), and chronic obstructive pulmonary disease (COPD), account for staggering morbidity and mortality worldwide but have limited clinical management options available. Although great progress has been made to elucidate the cellular and molecular pathways underlying these diseases, there remains a significant disparity between basic research endeavors and clinical outcomes. This discrepancy is due in part to the failure of many current disease models to recapitulate the dynamic changes that occur during pathogenesis in vivo. As a result, pulmonary medicine has recently experienced a rapid expansion in the application of engineering principles to characterize changes in human tissues in vivo and model the resulting pathogenic alterations in vitro. We envision that engineering strategies using precision biomaterials and advanced biomanufacturing will revolutionize current approaches to disease modeling and accelerate the development and validation of personalized therapies. This review highlights how advances in lung tissue characterization reveal dynamic changes in the structure, mechanics, and composition of the extracellular matrix in chronic pulmonary diseases and how this information paves the way for tissue-informed engineering of more organotypic models of human pathology. Current translational challenges are discussed as well as opportunities to overcome these barriers with precision biomaterial design and advanced biomanufacturing techniques that embody the principles of personalized medicine to facilitate the rapid development of novel therapeutics for this devastating group of chronic diseases.

scholarly journals Quantitative and Chemical Fingerprint Analysis for the Quality Evaluation of Platycodi Radix Collected from Various Regions in China by HPLC Coupled with Chemometrics

Molecules ◽  
2018 ◽  
Vol 23 (7) ◽  
pp. 1823 ◽  
Author(s):  
Haiyang Lu ◽  
Mengzhen Ju ◽  
Shanshan Chu ◽  
Tao Xu ◽  
Yuzhe Huang ◽  
...  
Keyword(s):  
Quality Evaluation ◽  
Southern China ◽  
Pulmonary Diseases ◽  
Evaporative Light Scattering Detection ◽  
Fingerprint Analysis ◽  
Light Scattering Detection ◽  
Platycodi Radix ◽  
Evaporative Light Scattering ◽  
Long Time

Platycodi Radix (PR) is the root of Platycodon grandiflorum (Jacq.) A. DC., which has been used for a long time in China to treat pulmonary diseases. The present study aimed to evaluate the quality of PR samples collected from 23 regions of 11 provinces in China. Eight saponins were quantified using HPLC coupled with evaporative light scattering detection (HPLC-ELSD). The samples with the highest total contents of saponins were from southern China, such as Yunnan, Guangxi, Jiangxi, and Guangzhou. The fingerprint analysis of PR samples was conducted by HPLC-UV method. Nineteen common peaks were selected and the similarity values varied from 0.607 to 0.921. These findings indicated that the saponins contents of PR from different regions varied significantly, with PR samples from southern China having the highest contents of saponins. These comprehensive methods were successful in evaluating the quality of PR samples from northern and southern China, which will serve as a guide for the development of PR as a clinical medication.

Differential diagnosis of chronic cardiac and pulmonary insufficiency using echocardiographic examination

1997 ◽  
Vol 78 (4) ◽  
pp. 255-258
Author(s):  
V. P. Kozlov ◽  
T. Ya. Miloslavskaya
Keyword(s):  
Differential Diagnosis ◽  
Pulmonary Diseases ◽  
Pulmonary Insufficiency ◽  
Control Group ◽  
Chronic Pulmonary Diseases ◽  
Echocardiographic Examination ◽  
Group A

The echocardiographic examination of 78 patients with chronic pulmonary diseases and 85 patients with various stages of cardiac and pulmonary insufficiency is performed. As many as 28 patients without cardiac and pulmonary diseases are examined as a control group. A group of patients (20) with combination of chronic cardiac and pulmonary diseases is stood out. The results of the investigations revealed the reliable changes of the echocardiographic indices that can be used for the differential diagnosis of chronic cardiac and pulmonary insufficiency.

Psychometric validation of the Korean PROMIS-29 Profile v2.1 among patients with chronic pulmonary diseases in Korea

2021 ◽  
Author(s):  
heesu nam ◽  
Danbee Kang ◽  
Bo Guen Kim ◽  
Sun Hye Shin ◽  
Hye Yun Park ◽  
...  
Keyword(s):  
Psychometric Validation ◽  
Pulmonary Diseases ◽  
Chronic Pulmonary Diseases

Remote Electronic Monitoring in Chronic Pulmonary Diseases

2013 ◽  
pp. 173-190
Author(s):  
S. Bella ◽  
F. Murgia
Keyword(s):  
Remote Monitoring ◽  
Validation Studies ◽  
Respiratory Diseases ◽  
Electronic Monitoring ◽  
Pulmonary Diseases ◽  
Economic Viability ◽  
Chronic Respiratory Diseases ◽  
Chronic Pulmonary Diseases ◽  
Operating Method

In this chapter the main aspects of telemonitoring are described and discussed in the field of chronic respiratory diseases. The authors describe the various challenges they faced, in the order in which they did. First, they face the problem of effectiveness of the method, then, the problems related to the economic viability, and finally, the problems related to the operating method. The authors conclude that remote monitoring is a promising method in terms of effectiveness of follow-up that must be performed under well controlled conditions. They still require further validation studies to improve the effectiveness and reduce the effects of new issues that arise.

Independent Association of Interleukin 6 With Low Dynamic Lung Function and Airflow Limitation in Well-Treated People With Human Immunodeficiency Virus

2020 ◽  
Author(s):  
Rebekka F Thudium ◽  
Andreas D Knudsen ◽  
Jakob Hjorth Von Stemann ◽  
Malene Hove-Skovsgaard ◽  
Hedda Hoel ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Lung Function ◽  
Hiv Infection ◽  
Interleukin 6 ◽  
Smoking Status ◽  
Airflow Limitation ◽  
Pulmonary Diseases ◽  
Increased Risk ◽  
Immunodeficiency Virus ◽  
Chronic Pulmonary Diseases

Abstract Background Human immunodeficiency virus (HIV) infection is associated with an increased risk of chronic pulmonary diseases. We compared cytokine concentrations (interleukin 6 [IL-6], interleukin 1β, 2, 4, 10, and 17A, tumor necrosis factor α, interferon γ, soluble CD14 [sCD14] and soluble CD163 [sCD163]) in people with HIV (PWH) and uninfected controls and investigated whether elevated cytokine concentrations were independently associated with lung function indices in PWH. Methods We performed spirometry and measured cytokine concentrations by Luminex immunoassays or enzyme-linked immunoassay in 951 PWH and 79 uninfected controls from the Copenhagen Comorbidity in HIV Infection study. Regression analyses were used to explore associations between elevated cytokine concentrations and lung function indices. Results PWH were predominantly male (84.6%) and 94.2% had undetectable viral replication. In PWH, elevated IL-6 was associated with lower forced expiratory volume in 1 second (−212 mL [95% confidence interval, −308 to −116 mL]), lower forced vital capacity (−208 mL [−322 to −93 mL]), and airflow limitation (aOR, 2.62 [1.58–4.36]) (all P < .001) in models adjusted for age, sex, ethnicity, smoking status, body mass index, and CD4 T-cell nadir. The association between IL-6 and dynamic lung function was modified by smoking (P for interaction = .005). Conclusion IL-6 levels were elevated and independently associated with low dynamic lung function and airflow limitation in well-treated PWH, suggesting that systemic inflammation may contribute to the pathogenesis of chronic pulmonary diseases.

scholarly journals Genomic Virulence Features of Two Novel Species Nocardia barduliensis sp. nov. and Nocardia gipuzkoensis sp. nov., Isolated from Patients with Chronic Pulmonary Diseases

2020 ◽  
Vol 8 (10) ◽  
pp. 1517
Author(s):  
Imen Nouioui ◽  
Carlos Cortés-Albayay ◽  
Meina Neumann-Schaal ◽  
Diego Vicente ◽  
Gustavo Cilla ◽  
...  
Keyword(s):  
Novel Species ◽  
Sequence Similarity ◽  
Genetic Maps ◽  
Pulmonary Diseases ◽  
Comparative Genomic ◽  
Syntenic Block ◽  
Rrna Gene ◽  
Old Patients ◽  
Mycolic Acids ◽  
Chronic Pulmonary Diseases

Strains 335427T and 234509T, isolated from two 76-year-old patients with chronic pulmonary diseases, were the subject of polyphasic taxonomic studies and comparative genomic analyses for virulence factors. The 16 rRNA gene sequence similarity between strains 335427T and 234509T and their closest phylogenetic neighbors Nocardia asiatica NBRC 100129T and Nocardia abscessus NBRC 100374T were 99.5% and 100%, respectively. Digital DNA–DNA hybridization values between the aforementioned studied strains were well below the 70% threshold for assigning prokaryotic strains to a novel species. Strains 335427T and 234509T have genome sizes of 8.49 Mpb and 8.07 Mpb, respectively, with G + C content of 68.5%. Isolate 335427T has C16:0, C18:1 ω9c, C18:0 and C18:0 10 methyl as major fatty acids (>15%) and mycolic acids formed of 52–54 carbon atoms. However, only C18:1 ω9c was detected for isolate 234509T, which had mycolic acids with 44–56 carbon. Based on phenotypic and genetic data, strains 335427T (DSM 109819T = CECT 9924T) and 234509T (DSM 111366T = CECT 30129T) merit recognition as novel species, which are named Nocardia barduliensis sp. nov. and Nocardia gipuzkoensis sp. nov., respectively. All the strains studied had homologous VF-associated genes to those described in M. tuberculosis, including experimentally verified virulence genes in humans related to tuberculosis. The narGHIJ (nitrate reduction pathway) and gvpAFGOJLMK (gas vesicles) genetic maps of strains 335427T, 234509T, NBRC 100129T and NBRC 100374T showed the same syntenic block and raise the question of whether their functions are interlinked during the infection of the human host. However, further research is required to decipher the role of the gas vesicle in the pathogenicity mechanism of Nocardia spp.

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