Cold Atmospheric Plasma: A Powerful Tool for Modern Medicine

Cold atmospheric plasma use in clinical studies is mainly limited to the treatment of chronic wounds, but its application in a wide range of medical fields is now the goal of many analyses. It is therefore likely that its application spectrum will be expanded in the future. Cold atmospheric plasma has been shown to reduce microbial load without any known significant negative effects on healthy tissues, and this should enhance its possible application to any microbial infection site. It has also been shown to have anti-tumour effects. In addition, it acts proliferatively on stem cells and other cultivated cells, and the highly increased nitric oxide levels have a very important effect on this proliferation. Cold atmospheric plasma use may also have a beneficial effect on immunotherapy in cancer patients. Finally, it is possible that the use of plasma devices will not remain limited to surface structures, because current endeavours to develop sufficiently miniature microplasma devices could very likely lead to its application in subcutaneous and internal structures. This study summarises the available literature on cold plasma action mechanisms and analyses of its current in vivo and in vitro use, primarily in the fields of regenerative and dental medicine and oncology.

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Overview of Cold Atmospheric Plasma in Wounds Treatment

Medical & Clinical Research ◽

10.33140/mcr.05.10.04 ◽

2020 ◽

Vol 5 (10) ◽

Keyword(s):

Wound Healing ◽

Skin Wound ◽

Atmospheric Plasma ◽

Active Components ◽

Negative Effects ◽

Skin Wound Healing ◽

Cold Atmospheric Plasma ◽

In Vivo Experiments

Cold atmospheric plasma (CAP), a room temperate ionised gas, known as the fourth state of matter is an ionised gas and can be produced from argon, helium, nitrogen, oxygen or air at atmospheric pressure and low temperatures. CAP has become a new promising way for many biomedical applications, such as disinfection, cancer treatment, root canal treatment, wound healing, and other medical applications. Among these applications, investigations of plasma for skin wound healing have gained huge success both in vitro and in vivo experiments without any known significant negative effects on healthy tissues. The development of CAP devices has led to novel therapeutic strategies in wound healing, tissue regeneration and skin infection management. CAP consists of a mixture of multitude of active components such as charged particles, electric field, UV radiation, and reactive gas species which can act synergistically. CAP has lately been recognized as an alternative approach in medicine for sterilization of wounds by its antiseptic effects and promotion of wound healing by stimulation of cell proliferation and migration of wound related skin cells. With respect to CAP applications in medicine, this review focuses particularly on the potential of CAP and the known molecular basis for this action. We summarize the available literature on the plasma devices developed for wound healing, the current in vivo and in vitro use of CAP, and the mechanism behind it as well as the biosafety issues.

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The Application of the Cold Atmospheric Plasma-Activated Solutions in Cancer Treatment

Anti-Cancer Agents in Medicinal Chemistry ◽

10.2174/1871520617666170731115233 ◽

2018 ◽

Vol 18 (6) ◽

pp. 769-775 ◽

Cited By ~ 13

Author(s):

Dayun Yan ◽

Jonathan H. Sherman ◽

Michael Keidar

Keyword(s):

Cancer Treatment ◽

Atmospheric Plasma ◽

Current Status ◽

Cold Atmospheric Plasma ◽

Anti Cancer ◽

Long Time ◽

Key Topics ◽

The Common

Background: Over the past five years, the cold atmospheric plasma-activated solutions (PAS) have shown their promissing application in cancer treatment. Similar as the common direct cold plasma treatment, PAS shows a selective anti-cancer capacity in vitro and in vivo. However, different from the direct cold atmospheric plasma (CAP) treatment, PAS can be stored for a long time and can be used without dependence on a CAP device. The research on PAS is gradually becoming a hot topic in plasma medicine. Objectives: In this review, we gave a concise but comprehensive summary on key topics about PAS including the development, current status, as well as the main conclusions about the anti-cancer mechanism achieved in past years. The approaches to make strong and stable PAS are also summarized.

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Inositol phosphates: health implications, methods of analysis, and occurrence in plant foods

Journal of Food Bioactives ◽

10.31665/jfb.2018.1126 ◽

2018 ◽

Vol 1 ◽

Cited By ~ 1

Author(s):

Quynh H. Duong ◽

Karen G. Lapsley ◽

Ronald B. Pegg

Keyword(s):

Inositol Phosphates ◽

Negative Effects ◽

Plant Foods ◽

Plant Seeds ◽

Cell Functions ◽

Wide Range ◽

Multiple Cell ◽

The Relationship

Inositol phosphates (InsPs), especially myo-inositol hexakisphosphate (InsP6), are important binders of phosphorus and minerals in plant seeds. However, they have long been considered as anti-nutritional components of plant foods due to their possible negative effects on the absorption of minerals and proteins in mammals. On the other hand, recent findings have found InsPs to be ubiquitous in eukaryote cells and actively participating in multiple cell functions. In vivo and in vitro studies have also documented the preventive potential of these compounds against the development of a wide range of diseases. In light of these findings, interest in the relationship between these compounds and human health has been renewed. It is suggested that the interactions of InsPs with other nutrients in the gut are complex, that the absorption of dietary InsPs might be implied but is not certain, and that the disease fighting capabilities of InsPs hold both promises and limitations. At the same time, the analysis of these compounds in foods and biological samples still faces many challenges, calling for more advanced modification and developments in the future.

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The efficacy and safety of cold atmospheric plasma as a novel therapy for diabetic wound in vitro and in vivo

International Wound Journal ◽

10.1111/iwj.13341 ◽

2020 ◽

Vol 17 (3) ◽

pp. 851-863 ◽

Cited By ~ 1

Author(s):

Rui He ◽

Qin Li ◽

Wenqi Shen ◽

Tao Wang ◽

Huijuan Lu ◽

...

Keyword(s):

Atmospheric Plasma ◽

Diabetic Wound ◽

Efficacy And Safety ◽

Novel Therapy ◽

Cold Atmospheric Plasma

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Comparative Study between Direct and Indirect Treatment with Cold Atmospheric Plasma on In Vitro and In Vivo Models of Wound Healing

Plasma Medicine ◽

10.1615/plasmamed.2019028659 ◽

2018 ◽

Vol 8 (4) ◽

pp. 379-401 ◽

Cited By ~ 1

Author(s):

Constance Duchesne ◽

Nadira Frescaline ◽

Jean-Jacques Lataillade ◽

Antoine Rousseau

Keyword(s):

Wound Healing ◽

Comparative Study ◽

Atmospheric Plasma ◽

In Vivo Models ◽

Cold Atmospheric Plasma ◽

Indirect Treatment

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The Emerging Role of Cold Atmospheric Plasma in Implantology: A Review of the Literature

Nanomaterials ◽

10.3390/nano10081505 ◽

2020 ◽

Vol 10 (8) ◽

pp. 1505 ◽

Cited By ~ 1

Author(s):

Wang Lai Hui ◽

Vittoria Perrotti ◽

Flavia Iaculli ◽

Adriano Piattelli ◽

Alessandro Quaranta

Keyword(s):

New Technologies ◽

Atmospheric Plasma ◽

Oral Diseases ◽

Air Plasma ◽

Review Of The Literature ◽

Air Abrasion ◽

Cold Atmospheric Plasma ◽

Osteoblast Activity

In recent years, cold atmospheric plasma (CAP) technologies have received increasing attention in the field of biomedical applications. The aim of this article is to review the currently available literature to provide an overview of the scientific principles of CAP application, its features, functions, and its applications in systemic and oral diseases, with a specific focus on its potential in implantology. In this narrative review, PubMed, Medline, and Scopus databases were searched using key words like “cold atmospheric plasma”, “argon plasma”, “helium plasma”, “air plasma”, “dental implants”, “implantology”, “peri-implantitis”, “decontamination”. In vitro studies demonstrated CAP’s potential to enhance surface colonization and osteoblast activity and to accelerate mineralization, as well as to determine a clean surface with cell growth comparable to the sterile control on both titanium and zirconia surfaces. The effect of CAP on biofilm removal was revealed in comparative studies to the currently available decontamination modalities (laser, air abrasion, and chlorhexidine). The combination of mechanical treatments and CAP resulted in synergistic antimicrobial effects and surface improvement, indicating that it may play a central role in surface “rejuvenation” and offer a novel approach for the treatment of peri-implantitis. It is noteworthy that the CAP conditioning of implant surfaces leads to an improvement in osseointegration in in vivo animal studies. To the best of our knowledge, this is the first review of the literature providing a summary of the current state of the art of this emerging field in implantology and it could represent a point of reference for basic researchers and clinicians interested in approaching and testing new technologies.

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