The Epigenetic Overlap between Obesity and Mood Disorders: A Systematic Review

(1) Background: Obesity and mood disorders are considered as the most prevalent morbidities in many countries. We suppose that epigenetic mechanisms may induce higher rates of obesity in subjects who suffer from mood disorders. In this systematic review, we focused on the potential roles of DNA methylation on mood disorders and obesity development. (2) Methods: This systematic review was conducted in accordance with the PRISMA statement and registered in Prospero. A systematic search was conducted in MEDLINE, Scopus, Web of Science, Cochrane Central database, EMBASE, and CINHAL. We also conducted a Grey literature search, such as Google Scholar. (3) Results: After deduplication, we identified 198 potentially related citations. Finally, ten unique studies met our inclusion criteria. We have found three overlap genes that show significant DNA methylation changes, both in obesity and depression. Pathway analysis interaction for TAPBP, BDNF, and SORBS2 confirmed the relation of these genes in both obesity and mood disorders. (4) Conclusions: While mechanisms linking both obesity and mood disorders to epigenetic response are still unknown, we have already known chronic inflammation induces a novel epigenetic program. As the results of gene enrichment, pathways analysis showed that TAPBP, BDNF, and SORBS2 linked together by inflammatory pathways. Hypermethylation in these genes might play a crucial rule in the co-occurrence of obesity and mood disorders.

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The Role of Epigenetics in Periodontal and Systemic Diseases and Smoking: A Systematic Review

Applied Sciences ◽

10.3390/app11115269 ◽

2021 ◽

Vol 11 (11) ◽

pp. 5269

Author(s):

Ismael Khouly ◽

Rosalie Salus Braun ◽

Michelle Ordway ◽

Iya Ghassib ◽

Lena Larsson ◽

...

Keyword(s):

Systematic Review ◽

Dna Methylation ◽

Web Of Science ◽

Periodontal Diseases ◽

Smoking Habit ◽

Patient Characteristics ◽

Systemic Diseases ◽

Inclusion Criteria ◽

Search Terms

The aims of this systematic review were to identify and synthesize the evidence for an association in DNA methylation/histone modifications between periodontal diseases and systemic diseases/smoking. Electronic database searches using relevant search terms in PubMed, Embase, MEDLINE, CINAHL, Web of Science, Scopus, and SciELO, and manual searches, were independently conducted to identify articles meeting the inclusion criteria. Nine studies of 1482 participants were included. Periodontitis was compared to metabolic disorders, rheumatoid arthritis (RA), cancer, and smokers, as well as healthy controls. Substantial variation regarding the reporting of sample sizes and patient characteristics, statistical analyses, and methodology was found. IL6 and TNF were modified similarly in RA and periodontitis. While TIMP-3 and GSTP-1 were significantly lower in periodontitis patients and controls than in cancer, SOCS-1, RMI2, CDH1, and COX2 were modified similarly in both cancer and periodontitis. While TLR4 in and CXCL8 were affected in periodontitis independent of smoking habit, smoking might change the transcription and methylation states of ECM organization-related genes, which exacerbated the periodontal condition. There was some evidence, albeit inconsistent, for an association between DNA methylation and periodontal diseases and systemic diseases or smokers compared to healthy patients or non-smokers.

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Impact of Vibration on the Levels of Biomarkers: A Systematic Review

The Journal of Indian Orthodontic Society ◽

10.1177/03015742211019520 ◽

2021 ◽

pp. 030157422110195

Author(s):

Ashish Agrawal ◽

TM Chou

Keyword(s):

Systematic Review ◽

Web Of Science ◽

Tooth Movement ◽

Orthodontic Tooth Movement ◽

Cochrane Collaboration ◽

Risk Of Bias ◽

Cochrane Library ◽

Inclusion Criteria ◽

Electronic Search ◽

Proquest Dissertation

Introduction: The objective of this systematic review is to assess the effect of vibrational force on biomarkers for orthodontic tooth movement. Methods: An electronic search was conducted for relevant studies (up to December 31, 2020) on the following databases: Pubmed, Google scholar, Web of Science, Cochrane Library, Wiley Library, and ProQuest Dissertation Abstracts and Thesis database. Hand searching of selected orthodontic journals was also undertaken. The selected studies were assessed for the risk of bias in Cochrane collaboration risk of bias tool. The “traffic plot” and “weighted plot” risk of bias distribution are designed in the RoB 2 tool. The 2 authors extracted the data and analyzed it. Results: Six studies fulfilled the inclusion criteria. The risks of biases were high for 4, low and some concern for other 2 studies. The biomarkers, medium, device, frequency and duration of device, as well as other data were extracted. The outcomes of the studies were found to be heterogenous. Conclusion: One study showed highly statistically significant levels of IL-1 beta with <.001. Rate of tooth movement was correlated with levels of released biomarkers under the influence of vibrational force in 3 studies, but it was found to be significant only in 1 study. It was further observed that vibration does not have any significant reduction in pain and discomfort.

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Caffeine and Cognitive Functions in Sports: A Systematic Review and Meta-Analysis

Nutrients ◽

10.3390/nu13030868 ◽

2021 ◽

Vol 13 (3) ◽

pp. 868

Author(s):

Jorge Lorenzo Calvo ◽

Xueyin Fei ◽

Raúl Domínguez ◽

Helios Pareja-Galeano

Keyword(s):

Systematic Review ◽

Reaction Time ◽

Cognitive Performance ◽

Cognitive Functions ◽

Web Of Science ◽

Meta Analysis ◽

Caffeine Intake ◽

Inclusion Criteria ◽

Research Protocols ◽

The Relationship

Cognitive functions are essential in any form of exercise. Recently, interest has mounted in addressing the relationship between caffeine intake and cognitive performance during sports practice. This review examines this relationship through a structured search of the databases Medline/PubMed and Web of Science for relevant articles published in English from August 1999 to March 2020. The study followed PRISMA guidelines. Inclusion criteria were defined according to the PICOS model. The identified records reported on randomized cross-over studies in which caffeine intake (as drinks, capsules, energy bars, or gum) was compared to an identical placebo situation. There were no filters on participants’ training level, gender, or age. For the systematic review, 13 studies examining the impacts of caffeine on objective measures of cognitive performance or self-reported cognitive performance were selected. Five of these studies were also subjected to meta-analysis. After pooling data in the meta-analysis, the significant impacts of caffeine only emerged on attention, accuracy, and speed. The results of the 13 studies, nevertheless, suggest that the intake of a low/moderate dose of caffeine before and/or during exercise can improve self-reported energy, mood, and cognitive functions, such as attention; it may also improve simple reaction time, choice reaction time, memory, or fatigue, however, this may depend on the research protocols.

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Viral hepatitis associated hepatocellular carcinoma on the African continent, the past, present, and future: a systematic review

BMC Cancer ◽

10.1186/s12885-021-08426-y ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Ottovon Bismark Dakurah ◽

Cynthia Raissa Tchuem Tamandjou ◽

Moleen Zunza ◽

Wolfgang Preiser ◽

Tongai Gibson Maponga

Keyword(s):

Hepatocellular Carcinoma ◽

Systematic Review ◽

Hepatitis B ◽

Viral Hepatitis ◽

Web Of Science ◽

African Continent ◽

Inclusion Criteria ◽

Hepatitis D ◽

The Past ◽

B Virus

Abstract Background Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths in Africa. In Africa, the major causes of HCC include chronic infection with hepatitis B virus (HBV) and/or hepatitis C virus (HCV). Knowledge of the changes in the incidence of viral hepatitis-associated HCC over time and the factors responsible for such changes is key in informing policies for the prevention of viral hepatitis-associated HCC in Africa. Aim The study aimed to systematically summarize the changes in the prevalence of viral hepatitis among HCC patients and the overall effect of the prevalence of viral hepatitis on the incidence of HCC over the past four decades in Africa (1980–2019). Methods A literature search was conducted in MEDLINE (PubMed), Google Scholar, Science Direct, Scopus, Web of Science, and African wide web for articles published on viral hepatitis-associated HCC in Africa from 1980 to 2019. The abstracts of the articles were screened for eligibility and those meeting the inclusion criteria were retrieved and reviewed. Results A total of 272 studies were included in the analysis. Viral hepatitis-related HCC incidence changed by 1.17% (95% confidence interval (CI): 0.63–1.71, p < 0.001), 0.82% (95% CI: 0.45–1.18, p < 0.001), and 3.34% (95% CI: 2.44–4.25, p < 0.001) for every 1% change in the prevalence of HBV, HCV, and hepatitis D virus (HDV) respectively, per decade. The incidence of HBV-related HCC decreased by − 0.50% (95% CI: − 0.74 – − 0.25, p < 0.001) over the last 40 years, while HCV-related HCC increased. Conclusion Overall, the incidence of viral hepatitis-associated HCC has not declined, mainly due to no decline in the prevalence of HCV, HDV, and the high number of chronic hepatitis B carriers on the African continent. There is an urgent need for the allocation of resources for the implementation of treatment and preventive programs for HBV, HCV, HDV, and HCC in Africa. This systematic review is registered with PROSPERO®, number CRD42020169723.

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Heart rate variability as a strain indicator for psychological stress for emergency physicians during work and alert intervention: a systematic review

Journal of Occupational Medicine and Toxicology ◽

10.1186/s12995-021-00313-3 ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Beatrice Thielmann ◽

Robert Pohl ◽

Irina Böckelmann

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Systematic Reviews ◽

Web Of Science ◽

Meta Analysis ◽

Emergency Physicians ◽

Inclusion Criteria ◽

Objective Monitoring ◽

Prisma Statement ◽

Health Studies

Abstract Background The workloads of emergency physicians are severe. The prevalence of burnout among emergency physicians is higher than with other physicians or compared to the general population. The analysis of heart rate variability (HRV) is a valid method for objective monitoring of workload. The aim of this paper is to systematically evaluate the literature on heart rate variability as an objective indicator for mental stress of emergency physicians. Methods A systematic literature review examining heart rate variability of emergency physicians in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement for reporting systematic reviews was performed. PubMed, Ovid, Cochrane Libary, Scopus, and Web of Science electronic databases were used. The methodological quality was evaluated by using a modified STARD for HRV. Results Two studies matched the inclusion criteria by using HRV between alert intervention and two other studies were considered that used HRV in other question areas. It showed an adaptation of HRV under stress. The studies were not comparable. Conclusions There is a need for occupational health studies that examine strains and stress of emergency physicians. The well-established parasympathetic mediated HRV parameters seem to be suitable parameters to objectify the stress.

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Glycemic Index of Gluten-Free Bread and Their Main Ingredients: A Systematic Review and Meta-Analysis

Foods ◽

10.3390/foods10030506 ◽

2021 ◽

Vol 10 (3) ◽

pp. 506

Author(s):

Bernardo Romão ◽

Ana Luísa Falcomer ◽

Gabriela Palos ◽

Sandra Cavalcante ◽

Raquel Braz Assunção Botelho ◽

...

Keyword(s):

Systematic Review ◽

Glycemic Index ◽

Resistant Starch ◽

Web Of Science ◽

Meta Analysis ◽

Gluten Free ◽

Inclusion Criteria ◽

Glycemic Profile

This study aimed to perform a systematic review and meta-analysis of the glycemic index (GI) of gluten-free bread (GFB) and its main ingredients. The systematic review followed PRISMA guidelines, using seven electronic databases (PubMed, EMBASE, Scopus, Science Direct, Web of Science, gray literature research with Google Scholar, and patents with Google Patent tool), from inception to November 2020. Eighteen studies met the inclusion criteria evaluating 132 GFB samples. Five articles tested GI in vivo, eleven in vitro; and two studies tested both methods. The analysis showed that 60.7% (95% CI: 40.2–78.1%) of the samples presented high glycemic indexes, evidencing a high glycemic profile for GFB. Only 18.2% (95% CI: 11.7–27.2%) of the bread samples presented in the studies were classified as a low GI. Meta-analysis presented moderate/low heterogenicity between studies (I2 = 61% and <1% for both high and low GIs) and reinforced the proportion of high GIs. Lower GIs were found in formulations based on Colocasia esculenta flour or enriched with fiber, yogurt and curd cheese, sourdough, psyllium, hydrocolloids, enzymes, fructans, and resistant starch, highlighting the efficacy of these ingredients to lower GFBs’ GI. GFB tends to present high GI, impacting the development of chronic diseases when consumed.

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Physical exercise, IGF-1 and cognition A systematic review of experimental studies in the elderly

Dementia & Neuropsychologia ◽

10.1590/1980-57642018dn12-020003 ◽

2018 ◽

Vol 12 (2) ◽

pp. 114-122 ◽

Cited By ~ 17

Author(s):

Angelica Miki Stein ◽

Thays Martins Vital Silva ◽

Flávia Gomes de Melo Coelho ◽

Franciel José Arantes ◽

José Luiz Riani Costa ◽

...

Keyword(s):

Systematic Review ◽

Physical Exercise ◽

Longitudinal Studies ◽

Web Of Science ◽

Experimental Studies ◽

The Elderly ◽

Inclusion Criteria ◽

Exercise Induced ◽

Assessment Results

ABSTRACT One of hypothetical mechanisms related to cognition is exercise-induced IGF-1. Objective: The aim of this study was to analyze the effects of exercise on IGF-1 levels and cognition in the elderly. Methods: The article searches were conducted on Pubmed, Web of Science, PsycINFO and Scielo databases and reviewed according to PRISMA guidelines. The inclusion criteria were: [1] original articles published up to 2017; [2] samples including elderly; [3] protocols including physical exercise; [4] longitudinal studies having exercise as main outcome; [5] assessment of IGF-1; [6] cognition assessment. Results: Seven studies were included in this review. Three of the studies showed an exercise-induced increase in IGF-1; three found stable IGF-1 levels and one found a reduction in IGF-1; with and without improvement in cognition. Conclusion: Disparities in the type of physical exercise, protocols and samples under different conditions hinder the establishment of a consensus on IGF-1, cognition and physical exercise.

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The Association Between Dental Anxiety And Psychiatric Disorders And Symptoms: A Systematic Review

Clinical Practice and Epidemiology in Mental Health ◽

10.2174/1745017901814010207 ◽

2018 ◽

Vol 14 (1) ◽

pp. 207-222 ◽

Cited By ~ 3

Author(s):

Harri Halonen ◽

Jenna Nissinen ◽

Heli Lehtiniemi ◽

Tuula Salo ◽

Pirkko Riipinen ◽

...

Keyword(s):

Systematic Review ◽

Psychiatric Disorders ◽

Web Of Science ◽

Dental Anxiety ◽

Data Sources ◽

Inclusion Criteria ◽

Clinical Interviews ◽

Specific Phobias ◽

Axis I ◽

High Level

Background:A growing amount of evidence suggests that dental anxiety is associated with other psychiatric disorders and symptoms. A systematic review was conducted to critically evaluate the studies of comorbidity of dental anxiety with other specific phobias and other Axis I psychiatric disorders.Objective:The aim of the review was to explore how dental anxiety is associated with other psychiatric disorders and to estimate the level of comorbid symptoms in dental anxiety patients.Methods:The review was conducted and reported in accordance with the MOOSE statement. Data sources included PubMed, PsycInfo, Web of Science and Scopus.Results:The search produced 631 hits, of which 16 unique records fulfilled the inclusion criteria. The number of eligible papers was low. Study populations were heterogeneous including 6,486 participants, and a total of 25 tests and in few cases clinical interviews were used in the evaluation processes. The results enhanced the idea about the comorbidity between dental anxiety and other psychiatric disorders. The effect was found strong in several studies.Conclusion:Patients with a high level of dental anxiety are more prone to have a high level of comorbid phobias, depression, mood disorders and other psychiatric disorders and symptoms.

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From Mind to Picture: A Systematic Review on Children’s and Adolescents’ Understanding of the Link between Artists and Pictures

10.31234/osf.io/4ed52 ◽

2019 ◽

Author(s):

Romina Vivaldi ◽

Richard P. Jolley ◽

Sarah E Rose

Keyword(s):

Systematic Review ◽

Theory Of Mind ◽

Web Of Science ◽

Empirical Studies ◽

Child Psychology ◽

Inclusion Criteria ◽

Developmental Milestones ◽

Italian Language ◽

The World ◽

The Subject

Pictorial symbols have multiple layers of meaning: not only do they represent objects, events and ideas about the world, they also represent the intentions of artists as well as other artist attributes (age, skill, originality and knowledge, mood, style and sentience). Although children’s developmental milestones of pictorial understanding have been the subject of a long-standing debate, their understanding of the relation between artists and pictures has often been neglected. The aim of this article was to conduct a systematic review on children’s and adolescents’ understanding of the relation between artists and pictures. PsycINFO and Web of Science databases were searched for English, Spanish, German, and Italian language empirical studies that examined this link in 2- to 18-year- olds. Forty-two citations (64 studies) from 14 different countries met the inclusion criteria. Results revealed the majority of the studies focused on the understanding of the artist’s intention. Although research on children’s and adolescents’ understanding of other attributes is scarce, and there were inconsistencies across the methodologies used, it seems that they first acknowledge intention and only later become more aware of how artist’s attributes are communicated through intention. The results of the review encourage subsequent research to provide a clearer conceptualised model of child and adolescent understanding of the artist-picture relationship. Such a model should be placed within a wider framework of the network of relationship between the artist, picture, world and beholder. Finally, consideration of how the development of understanding the artist-picture relationship is bi-directionally influenced with other developmental milestones in the child psychology is encouraged, particularly picture-production and theory of mind, and variations in atypical populations.

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Regreso a la presencialidad en el sector educación posterior al confinamiento, ¿es seguro volver? Una revisión sistemática rápida de la literatura Returning to Presence in the Post-Confinement Education Sector, Is It Safe to Return? A Rapid Systematic Review of the Literature

10.31219/osf.io/zn4xm ◽

2021 ◽

Author(s):

Marieta Gómez Montero ◽

Gabriela Gómez Gómez1 ◽

Luisa López-Sarasty ◽

Valentina Moncada Cortes ◽

Francisco Palencia-Sánchez

Keyword(s):

Systematic Review ◽

Negative Impact ◽

Grey Literature ◽

Virtual Education ◽

Educational Institutions ◽

Evidence Based ◽

Review Of The Literature ◽

Inclusion Criteria ◽

Revisión Sistemática ◽

Social Abilities

Objective: The purpose of this review is to collect and synthesize the information available about the strategies and recommendations established around the world, to guarantee the reopening of educational institutions, in a safe manner, in the context of the COVID-19 pandemic. In addition, it seeks to propose evidence-based recommendations, which allow the safe reopening of educational institutions in Colombia. Methods: A systematic review of the literature was carried out in databases such as Embase, Scopus, and Web of Science, as well as research in grey literature, social media, Google, and Google Scholar. In order to do this, a search equation was proposed, and subsequently, 19 articles were chosen, which met the determined inclusion criteria. Results: According to the analyzed literature, the recommendations come to light in order to guarantee a safe return. Conclusions: The COVID-19 pandemic, has caused an impact in all spheres of society, being the education, one of the most affected, because it has had a negative impact on the development of cognitive and social abilities, in particular, in the new generations, as a result of social distancing and the change of modality to remote and/or virtual education. For this reason, it is considered a priority the reopening educational institutions, in a safe manner, considering the evidence-based recommendations.

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