scholarly journals The SADDEN DEATH Study: Results from a Pilot Study in Non-ICU COVID-19 Spanish Patients

2021 ◽  
Vol 10 (4) ◽  
pp. 825
Author(s):  
Carlos Nicolás Pérez-García ◽  
Daniel Enríquez-Vázquez ◽  
Manuel Méndez-Bailón ◽  
Carmen Olmos ◽  
Juan Carlos Gómez-Polo ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Troponin I ◽  
Laboratory Data ◽  
Clinical Manifestations ◽  
Case Series ◽  
Functional Independence ◽  
Unexpected Death ◽  
Study Results ◽  
Male Sex

Introduction: The worldwide pandemic, coronavirus disease 2019 (COVID-19) is a novel infection with serious clinical manifestations, including death. Our aim is to describe the first non-ICU Spanish deceased series with COVID-19, comparing specifically between unexpected and expected deaths. Methods: In this single-centre study, all deceased inpatients with laboratory-confirmed COVID-19 who had died from March 4 to April 16, 2020 were consecutively included. Demographic, clinical, treatment, and laboratory data, were analyzed and compared between groups. Factors associated with unexpected death were identified by multivariable logistic regression methods. Results: In total, 324 deceased patients were included. Median age was 82 years (IQR 76–87); 55.9% males. The most common cardiovascular risk factors were hypertension (78.4%), hyperlipidemia (57.7%), and diabetes (34.3%). Other common comorbidities were chronic kidney disease (40.1%), chronic pulmonary disease (30.3%), active cancer (13%), and immunosuppression (13%). The Confusion, BUN, Respiratory Rate, Systolic BP and age ≥65 (CURB-65) score at admission was >2 in 40.7% of patients. During hospitalization, 77.8% of patients received antivirals, 43.3% systemic corticosteroids, and 22.2% full anticoagulation. The rate of bacterial co-infection was 5.5%, and 105 (32.4%) patients had an increased level of troponin I. The median time from initiation of therapy to death was 5 days (IQR 3.0–8.0). In 45 patients (13.9%), the death was exclusively attributed to COVID-19, and in 254 patients (78.4%), both COVID-19 and the clinical status before admission contributed to death. Progressive respiratory failure was the most frequent cause of death (92.0%). Twenty-five patients (7.7%) had an unexpected death. Factors independently associated with unexpected death were male sex, chronic kidney disease, insulin-treated diabetes, and functional independence. Conclusions: This case series provides in-depth characterization of hospitalized non-ICU COVID-19 patients who died in Madrid. Male sex, insulin-treated diabetes, chronic kidney disease, and independency for activities of daily living are predictors of unexpected death.

scholarly journals Evaluation of symptoms, radiological findings, laboratory data and outcome in COVID-19 patients with chronic kidney disease at Tehran, Iran

2021 ◽  
Author(s):  
Yasaman Sadat Keshmiri ◽  
Sina Khosravi Mirzaie ◽  
Shahnaz Sali ◽  
Davood Yadegarynia ◽  
Sara Abolghasemi ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Large Population ◽  
Laboratory Data ◽  
Clinical Manifestations ◽  
Ground Glass Opacity ◽  
Underlying Disease ◽  
Cross Sectional Study ◽  
Common Finding ◽  
Cross Sectional

Abstract Background: Chronic kidney disease (CKD) patients are a large population and of significant importance. Except for having an underlying disease, they have some other risk factors, for example, old age, impaired immune function, and other comorbidities that make them more susceptible to the new SARS-COV2 infection.Methods: As data on CKD patients with SARS-CoV-2 Infection is limited, we decided to carry out a cross-sectional study at Labbafinezhad Hospital on 78 CKD patients with approved COVID-19 infection either on dialysis or not. We have also incorporated CKD patients with kidney transplant history. Results: The mean age of the patients was 64.04 years, including 53 women and 25 men. Among all symptoms, dyspnea (19.2%) was the most prevalent one. Laboratory data analysis shows an increase in LDH, Creatinine, and ESR and CRP levels. The most common finding on chest CT-Scan was bilateral ground-glass opacity detected in 31 (86.1%) patients, followed by pleural effusion (12.8%) and atelectasis (19%). Among included patients, 53 (74.6%) had hypoxia (o2 saturation 94% and lower), 47 (81%) had tachypnea (respiratory rate over 16) and 9 (23.1%) had some reduction in the level of consciousness (GCS lower than 15). Conclusion: Due to the important effect of underlying medical conditions on the outcome of COVID-19 patients, evaluation of clinical manifestations, radiologic findings, laboratory data, and outcome of COVID-19 patients with chronic kidney disease is important to establish a perspective for physicians to manage CKD patients.

scholarly journals Evaluation of symptoms, radiological findings, laboratory data and outcome in COVID-19 patients with chronic kidney disease at Tehran, Iran

2020 ◽  
Author(s):  
Yasaman Sadat Keshmiri ◽  
Sina Khosravi Mirzaie ◽  
Shahnaz Sali ◽  
Davood Yadegarynia ◽  
Sara Abolghasemi ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Large Population ◽  
Laboratory Data ◽  
Clinical Manifestations ◽  
Ground Glass Opacity ◽  
Underlying Disease ◽  
Cross Sectional Study ◽  
Common Finding ◽  
Cross Sectional

Abstract Background: Chronic kidney disease (CKD) patients are a large population and of significant importance. Except for having an underlying disease, they have some other risk factors, for example, old age, impaired immune function, and other comorbidities that make them more susceptible to the new SARS-COV2 infection.Methods: As data on CKD patients with SARS-CoV-2 Infection is limited, we decided to carry out a cross-sectional study at Labbafinezhad Hospital on 78 CKD patients with approved COVID-19 infection either on dialysis or not. We have also incorporated CKD patients with kidney transplant history. Results: The mean age of the patients was 64.04 years, including 53 women and 25 men. Among all symptoms, dyspnea (19.2%) was the most prevalent one. Laboratory data analysis shows an increase in LDH, Creatinine, and ESR and CRP levels. The most common finding on chest CT-Scan was bilateral ground-glass opacity detected in 31 (86.1%) patients, followed by pleural effusion (12.8%) and atelectasis (19%). Among included patients, 53 (74.6%) had hypoxia (o2 saturation 94% and lower), 47 (81%) had tachypnea (respiratory rate over 16) and 9 (23.1%) had some reduction in the level of consciousness (GCS lower than 15). Conclusion: Due to the important effect of underlying medical conditions on the outcome of COVID-19 patients, evaluation of clinical manifestations, radiologic findings, laboratory data, and outcome of COVID-19 patients with chronic kidney disease is important to establish a perspective for physicians to manage CKD patients.

scholarly journals Drug Induced Encephalopathy in Patients with Chronic Kidney Disease: A Case Series

2018 ◽  
Vol 8 (2) ◽  
pp. 172-176
Author(s):  
Wasim Md Mohosin Ul Haque ◽  
Tabassum Samad ◽  
Muhammad Abdur Rahim ◽  
Shudhanshu Kumar Saha ◽  
Sarwar Iqbal
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Renal Impairment ◽  
Side Effect ◽  
Case Series ◽  
Special Group ◽  
Drug Induced ◽  
Reduced Dose

Drug induced encephalopathy is an established side effect of many drugs when used in a higher dose. Though we do not encounter this side effect frequently in our day to day practice, yet with renal impairment this is not uncommon. Even with a reduced dose many of these can precipitate encephalopathy in this special group of patients. We are presenting here a series of seven such cases of drug induced encephalopathy in patients with renal impairment.Birdem Med J 2018; 8(2): 172-176

scholarly journals EFFECT OF SUBCUTANEOUS RECOMBINANT HUMAN ERYTHROPOIETIN ON BLOOD PRESSURE IN PRE-DIALYSIS CHRONIC KIDNEY DISEASE (CKD) PATIENTS

2021 ◽  
Vol 71 (1) ◽  
pp. 261-65
Author(s):  
Muhammad Sajid Hussain ◽  
Qasim Raza ◽  
Muhammad Omer Aamir ◽  
Nadia Murtaza ◽  
Sadia Naureen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Chronic Kidney Disease ◽  
Body Weight ◽  
Kidney Disease ◽  
Recombinant Human Erythropoietin ◽  
Case Series ◽  
Military Hospital ◽  
P Value ◽  
Human Erythropoietin ◽  
Age Range

Objective: To determine the effect of subcutaneous recombinant human erythropoietin on blood pressure in predialysis chronic kidney disease (CKD) patients. Study Design: Case-series descriptive study. Place and Duration of Study: Combined Military Hospital Peshawar, from Mar 2016 to Sep 2016. Methodology: A total of 100 cases were enrolled. Inclusion criteria was patients of 18 to 60 years of both gender & estimated glomerular filtration rate (eGFR) below 30 mL/min/1.73 m2 having Hb <10g/dL and pre-dialysis while Exclusion Criteria was pregnancy or lactation, BP more than 140/90 mmHg, patients on Haemodialysis and worsening renal function. Baseline BP, body weight and eGFR of anaemic chronic kidney disease patients were recorded prior to EPO Alpha therapy. Erythropoiesis-stimulating agents (ESAs) i.e. EPO Alpha (50-100 Units/kg thrice or once weekly) was administered subcutaneously. Subsequent blood pressure, body weight and eGFR monitoring was done after 2 and 4 weeks post EPO Alpha injection. Results: Mean age range was 46.71 years with range of 20-60 years, 73 (73%) were male while 27 (27%) werefemales. Mean ± SD for other quantitative variables like eGFR was 23.12 ± 5.28, Hb levels (g/dL) was 8.62 ± 0.85,Weight (kg) was 56.66 ± 6.62 and duration of CKD was 9.87 ± 4.02. Frequency of Hypertension (post EPO) was 2(2%) and p-value was 0.453. Conclusion: We concluded that the frequency of hypertension in pre-dialysis patients with chronic kidney disease (CKD) receiving recombinant human erythropoietin (rhEPo) subcutaneously (SC) in low doses, is very low, so rhEPo can be used subcutaneously......................

scholarly journals HUBUNGAN ANTARA MEROKOK DENGAN GAMBARAN FUNGSI GINJAL PADA KARYAWAN PT.X

2021 ◽  
Vol 7 (3) ◽  
pp. 147-152
Author(s):  
Nur Syamsi ◽  
Andi Alfia Muthmainnah Tanra ◽  
Mariani Rasjid HS
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Function ◽  
Kidney Disease ◽  
Analytical Study ◽  
Smoking Habit ◽  
Cross Sectional ◽  
Consecutive Sampling ◽  
Study Results ◽  
Cross Sectional Design ◽  
Global Health Problem

The chronic kidney disease is a global health problem with increasing prevalence and incidence and a poor prognosis. Therefore, those brought about by risk factors are primarily those which can be modified and controlled for their occurrence.  One of the risk factor is smoking habit. The objective of this study was to determine the associations between smoking and renal function profiles in PT.X employees. The study was conducted by using descriptive analytical study with a cross sectional design based on smoking habits and blood test samples of employees. The sample were 40 employees in PT.X which determined by consecutive sampling. The results showed that there were no associations between smoking with age (p = 0.222) and azotemia (p = 1.00) but there were associations between smoking and blood creatinine levels (p = 0.001), urea (p = 0.023), eGFR (p. = 0.001), and the stages of chronic kidney disease (p = 0.047).  Based on the study results, in can be concluded that there were associations between smoking and renal function profiles among employees of PT. X

scholarly journals Características Clínicas, epidemiológicas y evolución de Pacientes con Enfermedad Renal Crónica estadío 5, del año 2005 al 2015 en el Hospital de Especialidades Pediátricas Omar Torrijos H. Panamá.

2018 ◽  
Vol 1 (38) ◽  
Author(s):  
Ariana Guerra ◽  
Basilio Dobras
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Clinical Situation ◽  
Chronic Dialysis ◽  
Dialysis Treatment ◽  
Evolution Characteristics ◽  
Specialty Hospital ◽  
Common Etiology ◽  
Male Sex ◽  
Epidemiologic Characteristics

<p>[Clinical and epidemiologic characteristics and evolution of patients with stage 5 Renal cronic disease, from year 2005 to 2015 at the Omar Torrijos H. Pediatric Hospital, Panama]</p><p>Resumen<br />Introducción: La incidencia y prevalencia de ERC-5 en niños ha ido en aumento. Es poco lo que se conoce respecto a la epidemiología de la ERC en niños y su manejo constituye un reto importante para los sistemas de salud. En Panamá no contamos con estudios que analicen la situación epidemiológica y clínica de niños con ERC. El objetivo del presente estudio es describir las características clínicas, epidemiológicas y evolución de pacientes pediátricos con enfermedad renal crónica estadio 5 atendidos en el servicio de Nefrología del hospital de Especialidades Pediátricas. Metodología: Se realizó un estudio observacional, descriptivo, retrospectivo, de los pacientes con enfermedad renal crónica estadio 5 atendidos en el Servicio de Nefrología del Hospital de Especialidades Pediátricas desde enero de 2005 a diciembre de 2015. Resultados: El promedio de edad al momento de la detección de la ERC-5 fue de 8.4 años. El sexo masculino predominó con una relación 1.4: 1. Predominó el grupo etario escolar de 6 a 10 años, y los adolescentes entre 11 a 15 años, con 14 casos cada uno. La incidencia anual fue de 3.0 casos, o 3.4 por millón de la población relacionada con la edad. La etiología más común fue la glomerulopatía 15 (44.1 %) Todos los pacientes tenían anemia y todos recibieron tratamiento dialítico crónico luego del establecimiento del diagnóstico mayormente diálisis peritoneal. Conclusión: Para Panamá, el promedio de edad al momento de la detección de la ERC-5 fue de 8.4 años, predominando el sexo masculino. La causa etiológica más común fue la glomerulopatía. Todos presentaban anemia al momento del diagnóstico y todos recibieron tratamiento dialítico crónico luego del establecimiento del diagnóstico, mayormente peritoneal.<br />Abstract<br />Introduction: The incidence and prevalence of CKD-5 in children has been increasing. Little is known about the epidemiology of CKD in children and its management constitutes a major challenge for health systems. In Panama, we do not have studies that analyze the epidemiological and clinical situation of children with CKD. The aim of the present study is to describe the clinical, epidemiological and evolution characteristics of pediatric patients with stage 5 chronic kidney disease treated in the Nephrology service of the Pediatric Specialty Hospital. Methodology: An observational, descriptive, retrospective study of patients with stage 5 chronic kidney disease treated at the Nephrology Service of the Pediatric Specialty Hospital from January 2005 to December 2015 was performed. Results: The average age at the time of The detection of CKD-5 was 8.4 years. The male sex predominated with a 1.4: 1 ratio. The school age group was predominantly between 6 and 10 years old, and adolescents between 11 and 15 years old, with 14 cases each. The annual incidence was 3.0 cases, or 3.4 per million of the population related to age. The most common etiology was glomerulopathy 15 (44.1%). All the patients had anemia and all received chronic dialysis treatment after the establishment of the diagnosis, mainly peritoneal dialysis. Conclusion: For Panama, the average age at the time of detection of CKD-5 was 8.4 years, predominantly male. The most common etiologic cause was glomerulopathy. All had anemia at the time of diagnosis and all received chronic dialysis treatment after the establishment of the diagnosis, mostly peritoneal.</p>

THE CHANGES OF RENAL FUNCTION STATUS BASED ON PROTEINURIA AND GLOMERULUS FILTRATION RATE IN PATIENTS WITH HISTORY OF PREECLAMPSIA WITH SEVERE FEATURES

2021 ◽  
pp. 279-282
Author(s):  
Chairul Adilla Ardy ◽  
Muara Panusunan Lubis ◽  
Cut Adeya Adella ◽  
Hotma Partogi Pasaribu ◽  
Muhammad Rusda ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Function ◽  
Kidney Disease ◽  
Serum Creatinine ◽  
Late Onset ◽  
Case Series ◽  
Sampling Technique ◽  
Time Interval ◽  
History Of ◽  
The Mean

Background: Preeclampsia with severe features is an endothelial disease that causes renal system disorders during pregnancy. Preeclampsia is an important cause of acute kidney injury and risk for chronic kidney disease. Methods: This study was a case series conducted at the Department of Obstetrics and Gynecology, H. Adam Malik General Hospital Medan, Indonesia starting from December 2019 until January 2020. Total sampling technique was employed obtaining 31 subjects with a history of preeclampsia with severe features for at least 3 months to 2 years postpartum, without a history of chronic disease, diabetes mellitus, and congenital kidney disorders. Proteinuria, serum creatinine, and GFR calculations were performed. Results: There were 31 patients who met the inclusion and exclusion criteria. At a time interval of 4 - ≤13 months postpartum, 2 levels of proteinuria +1 (0-2), serum creatinine 0.81 ± 0.21 mg/dl, and levels of GFR 109.57 ± 25.13 (ml/min/1.73 m ). Whereas at the time interval of >13 - 24 months postpartum, levels of proteinuria +1 (0-3), serum creatinine 0.85 ± 0.23 mg/dl, and GFR 2 levels of 104. 41 ± 28.45 (ml/min/1.73 m ). The mean of serum creatinine before delivery was 0.69 ± 0.15 mg/dl and after delivery was 0.83 ± 0.22 mg/dl. The mean of GFR postpartum at group of history of early onset preeclampsia was 103.07 ± 25.23 2 2 (ml/min/1.73 m ) and group of history of late onset preeclampsia was 113.40 ± 28.24 (ml/min/1.73 m ). Conclusion: There was a tendency for a decrease in renal function among women with a history of preeclampsia with severe features with ndings of persistent proteinuria from more than 3 to 24 months postpartum, an increase in mean of serum creatinine levels from before and after delivery and a decrease in GFR, but it was not signicant. This was related to the slow course of chronic kidney disease, so it had to be followed up periodically.

Chronic Kidney Failure and Dialysis

2018 ◽  
Author(s):  
Raghu V Durvasula ◽  
Jonathan Himmelfarb
Keyword(s):  
United States ◽  
Chronic Kidney Disease ◽  
Peritoneal Dialysis ◽  
Kidney Disease ◽  
Renal Disease ◽  
Chronic Renal Disease ◽  
Clinical Manifestations ◽  
Kidney Injury ◽  
The United States ◽  
Clinical Syndrome

Chronic kidney disease (CKD) is a clinical syndrome arising from progressive kidney injury, formerly known as chronic renal failure, chronic renal disease, and chronic renal insufficiency. It is classified into five stages based primarily on glomerular filtration rate (GFR). This article discusses the epidemiology of CKD and end-stage renal disease (ESRD), as well as etiology and genetics, pathophysiology, and pathogenesis. The section on diagnosis looks at clinical manifestations and physical findings, laboratory (and other) tests, imaging studies, and biopsy. A short section on differential diagnosis is followed by a discussion of treatment, including hemodialysis and peritoneal dialysis. Long-term complications of patients on dialysis include cardiovascular disease, renal osteodystrophy, dialysis-related amyloidosis, and acquired cystic disease (renal cell carcinoma). The final section addresses prognosis and socioeconomic burden. Figures include the classification system for CKD, prevalence of CKD in the United States, rising prevalence, risk of, and leading causes of ESRD in the United States, plus the changing prevalence of ESRD over time, clinical manifestations of uremia, and an overview of hemodialysis circuit. Tables look at the burden of CKD relative to other chronic disorders, the specific hereditary causes of kidney disease, and situations when serum creatinine does not accurately predict GFR. Other tables list equations for estimating GFR, the causes of CKD without shrunken kidneys, and clinical features distinguishing chronic kidney disease from acute kidney injury. ESRD and indications for initiation of dialysis are presented, as well as typical composition of dialysate and reasons for failure of peritoneal dialysis. This chapter contains 71 references.

Chronic Kidney Failure and Dialysis

2017 ◽  
Author(s):  
Raghu V Durvasula ◽  
Jonathan Himmelfarb
Keyword(s):  
United States ◽  
Chronic Kidney Disease ◽  
Peritoneal Dialysis ◽  
Kidney Disease ◽  
Renal Disease ◽  
Chronic Renal Disease ◽  
Clinical Manifestations ◽  
Kidney Injury ◽  
The United States ◽  
Clinical Syndrome

Chronic kidney disease (CKD) is a clinical syndrome arising from progressive kidney injury, formerly known as chronic renal failure, chronic renal disease, and chronic renal insufficiency. It is classified into five stages based primarily on glomerular filtration rate (GFR). This article discusses the epidemiology of CKD and end-stage renal disease (ESRD), as well as etiology and genetics, pathophysiology, and pathogenesis. The section on diagnosis looks at clinical manifestations and physical findings, laboratory (and other) tests, imaging studies, and biopsy. A short section on differential diagnosis is followed by a discussion of treatment, including hemodialysis and peritoneal dialysis. Long-term complications of patients on dialysis include cardiovascular disease, renal osteodystrophy, dialysis-related amyloidosis, and acquired cystic disease (renal cell carcinoma). The final section addresses prognosis and socioeconomic burden. Figures include the classification system for CKD, prevalence of CKD in the United States, rising prevalence, risk of, and leading causes of ESRD in the United States, plus the changing prevalence of ESRD over time, clinical manifestations of uremia, and an overview of hemodialysis circuit. Tables look at the burden of CKD relative to other chronic disorders, the specific hereditary causes of kidney disease, and situations when serum creatinine does not accurately predict GFR. Other tables list equations for estimating GFR, the causes of CKD without shrunken kidneys, and clinical features distinguishing chronic kidney disease from acute kidney injury. ESRD and indications for initiation of dialysis are presented, as well as typical composition of dialysate and reasons for failure of peritoneal dialysis. This chapter contains 71 references.

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