scholarly journals The Role of Physiotherapy in the New Treatment Landscape for Haemophilia

2021 ◽  
Vol 10 (13) ◽  
pp. 2822
Author(s):  
Sébastien Lobet ◽  
Merel Timmer ◽  
Christoph Königs ◽  
David Stephensen ◽  
Paul McLaughlin ◽  
...  
Keyword(s):  
Primary Care ◽  
Crucial Role ◽  
Essential Role ◽  
Joint Damage ◽  
Mild Phenotype ◽  
Advanced Therapies ◽  
Specialist Treatment ◽  
New Treatment ◽  
New Treatments

The physiotherapist plays an essential role for people with haemophilia, an inherited bleeding disease responsible for musculoskeletal complications. Yet, with the advent of new and advanced therapies, the medical landscape is changing, and physiotherapy must adapt alongside. This paper considers whether there will still be a need for physiotherapy in the era of advanced therapies, and discusses ways in which services should evolve to complement emerging treatment paradigms for haemostasis in people with haemophilia. Ultimately, physiotherapy will remain an important element of care, even for people with little joint damage and low risks in the era of the new mild phenotype. However, competencies will need to evolve, and physiotherapists in both primary care and specialist treatment centres should work with haematology colleagues to develop more sensitive tools for detecting early joint changes. Physiotherapists will also play a crucial role in counselling and physically coaching, monitoring the musculoskeletal status of people with haemophilia who have transitioned to new treatments.

Maximising Soft Power: the Role of Digital Diplomacy in Building Trust with Nation-Branding

2021 ◽  
Vol 1 (2) ◽  
pp. 1-19
Author(s):  
Jess Gosling
Keyword(s):  
Crucial Role ◽  
Soft Power ◽  
Driving Force ◽  
Public Diplomacy ◽  
Essential Role ◽  
Nation Branding ◽  
Building Trust ◽  
The Creation ◽  
Digital Diplomacy

Perceptions of attractiveness and trustworthiness impact the prosperity and influence of countries. A country's soft power is not guaranteed. Countries have their brands, an image shaped by the behaviour of governments, by what they do and say, whom they associate with, and how they conduct themselves on the global stage. Increasingly, digital diplomacy plays a crucial role in the creation and application of soft power. This paper argues that digital diplomacy is increasingly vital in the articulation of soft power. Digital diplomacy is a new way of conducting public diplomacy, offering new and unparalleled ways of building trust with previously disengaged audiences. Soft power is now the driving force behind reputation and influence on the global stage, where increasingly digital diplomacy plays an essential role.

The role of CT, PET-CT, and MRI in ovarian cancer

2021 ◽  
Vol 94 (1125) ◽  
pp. 20210117
Author(s):  
Maurits Peter Engbersen ◽  
Willemien Van Driel ◽  
Doenja Lambregts ◽  
Max Lahaye
Keyword(s):  
Ovarian Cancer ◽  
Essential Role ◽  
Advanced Ovarian Cancer ◽  
Emission Tomography ◽  
Current Position ◽  
Positron Emission ◽  
Pet Ct ◽  
New Treatment ◽  
Ct And Mri

New treatment developments in ovarian cancer have led to a renewed interest in staging advanced ovarian cancer. The treatment of females with ovarian cancer patients has a strong multidisciplinary character with an essential role for the radiologist. This review aims to provide an overview of the current position of CT, positron emission tomography-CT, and MRI in ovarian cancer and how imaging can be used to guide multidisciplinary team discussions.

Improving the prevention and management of respiratory diseases in China: the crucial role of primary care

2015 ◽  
Vol 3 (11) ◽  
pp. e35
Author(s):  
Chunhua Chi ◽  
Aziz Sheikh ◽  
Mi Yao ◽  
Kar Keung Cheng ◽  
Chen Wang
Keyword(s):  
Primary Care ◽  
Crucial Role ◽  
Respiratory Diseases

scholarly journals Essential Role of the p110β Subunit of Phosphoinositide 3-OH Kinase in Male Fertility

2010 ◽  
Vol 21 (5) ◽  
pp. 704-711 ◽  
Author(s):  
Elisa Ciraolo ◽  
Fulvio Morello ◽  
Robin M. Hobbs ◽  
Frieder Wolf ◽  
Romina Marone ◽  
...  
Keyword(s):  
Male Fertility ◽  
Essential Role ◽  
Spermatogenic Cells ◽  
Male Mice ◽  
Catalytic Subunits ◽  
Adult Testis ◽  
New Treatments ◽  
The Way

Phosphoinositide 3-kinases (PI3K) are key molecular players in male fertility. However, the specific roles of different p110 PI3K catalytic subunits within the spermatogenic lineage have not been characterized so far. Herein, we report that male mice expressing a catalytically inactive p110β develop testicular hypotrophy and impaired spermatogenesis, leading to a phenotype of oligo-azoospermia and defective fertility. The examination of testes from p110β-defective tubules demonstrates a widespread loss in spermatogenic cells, due to defective proliferation and survival of pre- and postmeiotic cells. In particular, p110β is crucially needed in c-Kit–mediated spermatogonial expansion, as c-Kit–positive cells are lost in the adult testis and activation of Akt by SCF is blocked by a p110β inhibitor. These data establish that activation of the p110β PI3K isoform by c-Kit is required during spermatogenesis, thus opening the way to new treatments for c-Kit positive testicular cancers.

scholarly journals The Role of 2-Oxoglutarate Dependent Dioxygenases in Gliomas and Glioblastomas: A Review of Epigenetic Reprogramming and Hypoxic Response

2021 ◽  
Vol 11 ◽  
Author(s):  
Rebekah L. I. Crake ◽  
Eleanor R. Burgess ◽  
Janice A. Royds ◽  
Elisabeth Phillips ◽  
Margreet C. M. Vissers ◽  
...  
Keyword(s):  
Patient Survival ◽  
Hypoxia Inducible Factor ◽  
Treatment Strategies ◽  
Low Grade ◽  
Histone Demethylases ◽  
Dioxygenase Enzymes ◽  
New Treatment ◽  
New Treatments ◽  
The Brain

Gliomas are a heterogeneous group of cancers that predominantly arise from glial cells in the brain, but may also arise from neural stem cells, encompassing low-grade glioma and high-grade glioblastoma. Whereas better diagnosis and new treatments have improved patient survival for many cancers, glioblastomas remain challenging with a highly unfavorable prognosis. This review discusses a super-family of enzymes, the 2-oxoglutarate dependent dioxygenase enzymes (2-OGDD) that control numerous processes including epigenetic modifications and oxygen sensing, and considers their many roles in the pathology of gliomas. We specifically describe in more detail the DNA and histone demethylases, and the hypoxia-inducible factor hydroxylases in the context of glioma, and discuss the substrate and cofactor requirements of the 2-OGDD enzymes. Better understanding of how these enzymes contribute to gliomas could lead to the development of new treatment strategies.

Producing a Distant Centre: The role of wilderness in the post-Mao Tibetan Buddhist revival

2019 ◽  
Vol 53 (3) ◽  
pp. 822-845
Author(s):  
YASMIN CHO
Keyword(s):  
Crucial Role ◽  
Essential Role ◽  
Social Space ◽  
Sichuan Province ◽  
Tibetan Buddhist ◽  
Autonomous Region ◽  
Tibet Autonomous Region ◽  
The Tibet Autonomous Region

AbstractThis article addresses how wilderness—through its qualities of remoteness and wildness—plays an essential role in the production of a vital religious centre in Tibet. By drawing on in-depth ethnographic observations in Yachen Gar, a mega-sized Buddhist encampment in the nomadic grasslands of China's northwestern Sichuan province, I examine the spatial and material features of the encampment, how various agents utilize these features to produce specific relations with it, and how, in this process, Yachen has become a centre of the Buddhist revival in Kham Tibet. I will present three ethnographic accounts—which focus on a Tibetan nun from the Tibet Autonomous Region (TAR), Chinese pilgrims, and reactions to the spread of electricity in Yachen—to address the ways in which Yachen is emplaced within the spatial and material tensions implemented and imagined by different participants. These accounts ultimately show how materiality plays a crucial role in forging the various contesting relations, actions, and meanings that constitute a social space.

scholarly journals The Essential Role of Primary Care Professionals in Achieving Health for All

2019 ◽  
Vol 17 (4) ◽  
pp. 293-295 ◽  
Author(s):  
Maria van den Muijsenbergh ◽  
Chris van Weel
Keyword(s):  
Primary Care ◽  
Essential Role ◽  
Primary Care Professionals

scholarly journals Hepatic cyst: what diagnosis?

2020 ◽  
Vol 7 (12) ◽  
pp. 4184
Author(s):  
Anwar Rahali ◽  
Faisal El Mouhafid ◽  
Yasser El Brahmi ◽  
Abdelmounaim Ait Ali
Keyword(s):  
Essential Role ◽  
Histological Analysis ◽  
Treatment Options ◽  
Liver Cyst ◽  
Hepatic Cyst ◽  
Diagnostic Tools ◽  
Endemic Country ◽  
Natural Evolution ◽  
New Treatment

In this article, presented as the case of a 43-year-old patient with liver cyst posing the problem of positive diagnosis. The uncharacterizable radiology and the questionable serology have demonstrated the essential role of surgery and histological analysis in the management of this type of lesion. This case raises questions that patients and clinicians are often faced with in a hydatid disease endemic country. Through this article, we aim to discussed the latest news on diagnostic tools, the natural evolution of the disease, differential diagnoses as well as new treatment options for cystic hepatic lesion.

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