Risk Factors Associated with 30-Day Mortality in Older Patients with Influenza

Background: Influenza is a common viral condition, but factors related to short-term mortality have not been fully studied in older adults. Our objective was to determine whether there is an association between geriatric factors and 30-day mortality. Methods: This was a retrospective cohort design. All patients aged 75 years and over, with a diagnosis of influenza confirmed by a positive RT-PCR, were included. The primary endpoint was death within the 30 days after diagnosis. Results: 114 patients were included; 14 (12.3%) patients died within 30 days. In multivariate analysis these patients were older (OR: 1.37 95% CI (1.05, 1.79), p = 0.021), and had a lower ADL score (OR: 0.36 95% CI (0, 17; 0.75), p = 0.006), and a higher SOFA score (OR: 2.30 95% CI (1.07, 4.94), p = 0.03). Oseltamivir treatment, initiated within the first 48 h, was independently associated with survival (OR: 0.04 95% CI (0.002, 0.78), p = 0.034). Conclusions: Identification of mortality risk factors makes it possible to consider specific secondary prevention measures such as the rapid introduction of antiviral treatment. Combined with primary prevention, these measures could help to limit the mortality associated with influenza in older patients.

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Mo-P4:284 Factors associated with short-term mortality in older patients with acute ischemic stroke

Atherosclerosis Supplements ◽

10.1016/s1567-5688(06)80417-4 ◽

2006 ◽

Vol 7 (3) ◽

pp. 108

Author(s):

G. Guerra ◽

G. Zuliani ◽

A. Cherubini ◽

C. Ruggiero ◽

F. Di Todaro ◽

...

Keyword(s):

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Older Patients ◽

Short Term ◽

Factors Associated ◽

Short Term Mortality

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Short-term mortality and risk factors associated with reoperation after emergency amputation of the lower limbs

Journal of Orthopaedic Science ◽

10.1016/j.jos.2019.05.018 ◽

2020 ◽

Vol 25 (3) ◽

pp. 435-440 ◽

Cited By ~ 1

Author(s):

Shuichi Miyamoto ◽

Makoto Otsuka ◽

Fumio Hasue ◽

Takayuki Fujiyoshi ◽

Koushirou Kamiya ◽

...

Keyword(s):

Risk Factors ◽

Lower Limbs ◽

Short Term ◽

Factors Associated ◽

Short Term Mortality

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Risk assessment models for potential use in the emergency department have lower predictive ability in older patients compared to the middle-aged for short-term mortality – a retrospective cohort study

BMC Geriatrics ◽

10.1186/s12877-019-1154-7 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 2

Author(s):

Martin Schultz ◽

Line Jee Hartmann Rasmussen ◽

Nicolas Carlson ◽

Rasmus Bo Hasselbalch ◽

Birgitte Nybo Jensen ◽

...

Keyword(s):

Risk Assessment ◽

Emergency Department ◽

Cohort Study ◽

Older Patients ◽

Retrospective Cohort ◽

Predictive Ability ◽

Short Term ◽

Risk Assessment Models ◽

Short Term Mortality ◽

Potential Use

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Risk factors associated with short‐term mortality and recurrence of status epilepticus in dogs

Journal of Veterinary Internal Medicine ◽

10.1111/jvim.16353 ◽

2022 ◽

Author(s):

Rory Fentem ◽

Alberta Stefani ◽

Rodrigo Gutierrez Quintana ◽

Emili Alcoverro ◽

Gareth Michael Couper Jones ◽

...

Keyword(s):

Risk Factors ◽

Status Epilepticus ◽

Short Term ◽

Factors Associated ◽

Short Term Mortality

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COVID-19 in Pediatric Inpatients: A Multi-Center Observational Study of Factors Associated with Negative Short-Term Outcomes

Children ◽

10.3390/children8110951 ◽

2021 ◽

Vol 8 (11) ◽

pp. 951

Author(s):

Sara Rubenstein ◽

Emily Grew ◽

Katharine Clouser ◽

Alexander Kwok ◽

Aravindhan Veerapandiyan ◽

...

Keyword(s):

Older Patients ◽

Severe Disease ◽

Laboratory Data ◽

The United States ◽

Medical Conditions ◽

Rt Pcr ◽

Short Term ◽

Factors Associated ◽

Number Of Individuals ◽

To Receive

Most cases of COVID-19 in children and adolescents are mild or asymptomatic, but a small number of individuals may develop severe disease, requiring PICU admission and/or mechanical ventilation. We assessed the factors associated with negative short-term outcomes of COVID-19 in 82 pediatric patients at three hospitals within the United States during the spring and summer of 2020 using medical records, laboratory data, and imaging studies of all patients admitted with a positive RT-PCR test for SARS-CoV-2. We found that older patients were more likely to have an extended hospital stay, and those with high BMIs (over 25) were more likely to be admitted to the PICU during the early pandemic. In addition, older patients, those with high BMIs, and those with underlying medical conditions, were more likely to receive respiratory support. Given the association of age, BMI, and underlying medical conditions with more severe COVID-19, clinicians should keep these factors in mind when treating patients.

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Risk Factors and Causes of Short-Term Mortality after Emergency Department Discharge in Older Patients: Using Nationwide Health Insurance Claims Data

Annals of Geriatric Medicine and Research ◽

10.4235/agmr.19.0029 ◽

2019 ◽

Vol 23 (3) ◽

pp. 133-140 ◽

Cited By ~ 2

Author(s):

Seunggu Na ◽

Yongil Cho ◽

Tae Ho Lim ◽

Hyunggoo Kang ◽

Jaehoon Oh ◽

...

Keyword(s):

Risk Factors ◽

Emergency Department ◽

Older Patients ◽

Claims Data ◽

Short Term ◽

Short Term Mortality ◽

Insurance Claims Data ◽

Health Insurance Claims Data ◽

Health Insurance Claims ◽

Emergency Department Discharge

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Risk factors associated with short term mortality changes over time, after arrival to the emergency department

Scandinavian Journal of Trauma Resuscitation and Emergency Medicine ◽

10.1186/s13049-018-0493-2 ◽

2018 ◽

Vol 26 (1) ◽

Cited By ~ 1

Author(s):

Camilla Nørgaard Bech ◽

Mikkel Brabrand ◽

Søren Mikkelsen ◽

Annmarie Lassen

Keyword(s):

Risk Factors ◽

Emergency Department ◽

Short Term ◽

Factors Associated ◽

Short Term Mortality ◽

Changes Over Time ◽

Over Time

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Risk Factors of Daptomycin-Induced Eosinophilic Pneumonia in a Population with Osteoarticular Infection

Antibiotics ◽

10.3390/antibiotics10040446 ◽

2021 ◽

Vol 10 (4) ◽

pp. 446

Author(s):

Laura Soldevila-Boixader ◽

Bernat Villanueva ◽

Marta Ulldemolins ◽

Eva Benavent ◽

Ariadna Padulles ◽

...

Keyword(s):

Risk Factors ◽

Adverse Effect ◽

Cohort Study ◽

Retrospective Cohort Study ◽

Older Patients ◽

Retrospective Cohort ◽

Joint Infection ◽

Eosinophilic Pneumonia ◽

Severe Adverse Effect ◽

Osteoarticular Infection

Background: Daptomycin-induced eosinophilic pneumonia (DEP) is a rare but severe adverse effect and the risk factors are unknown. The aim of this study was to determine risk factors for DEP. Methods: A retrospective cohort study was performed at the Bone and Joint Infection Unit of the Hospital Universitari Bellvitge (January 2014–December 2018). To identify risk factors for DEP, cases were divided into two groups: those who developed DEP and those without DEP. Results: Among the whole cohort (n = 229) we identified 11 DEP cases (4.8%) and this percentage almost doubled in the subgroup of patients ≥70 years (8.1%). The risk factors for DEP were age ≥70 years (HR 10.19, 95%CI 1.28–80.93), therapy >14 days (7.71, 1.98–30.09) and total cumulative dose of daptomycin ≥10 g (5.30, 1.14–24.66). Conclusions: Clinicians should monitor cumulative daptomycin dosage to minimize DEP risk, and be cautious particularly in older patients when the total dose of daptomycin exceeds 10 g.

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Characteristics, outcomes and risk factors for mortality of 522 167 patients hospitalised with COVID-19 in Brazil: a retrospective cohort study

BMJ Open ◽

10.1136/bmjopen-2021-049089 ◽

2021 ◽

Vol 11 (5) ◽

pp. e049089

Author(s):

Marcia C Castro ◽

Susie Gurzenda ◽

Eduardo Marques Macário ◽

Giovanny Vinícius A França

Keyword(s):

Risk Factors ◽

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Cox Proportional Hazards ◽

Secondary Outcome ◽

Hospital Death ◽

Factors Associated ◽

Icu Admission ◽

Hospitalised Patients

ObjectiveTo provide a comprehensive description of demographic, clinical and radiographic characteristics; treatment and case outcomes; and risk factors associated with in-hospital death of patients hospitalised with COVID-19 in Brazil.DesignRetrospective cohort study of hospitalised patients diagnosed with COVID-19.SettingData from all hospitals across Brazil.Participants522 167 hospitalised patients in Brazil by 14 December 2020 with severe acute respiratory illness, and a confirmed diagnosis for COVID-19.Primary and secondary outcome measuresPrevalence of symptoms and comorbidities was compared by clinical outcomes and intensive care unit (ICU) admission status. Survival was assessed using Kaplan Meier survival estimates. Risk factors associated with in-hospital death were evaluated with multivariable Cox proportional hazards regression.ResultsOf the 522 167 patients included in this study, 56.7% were discharged, 0.002% died of other causes, 30.7% died of causes associated with COVID-19 and 10.2% remained hospitalised. The median age of patients was 61 years (IQR, 47–73), and of non-survivors 71 years (IQR, 60–80); 292 570 patients (56.0%) were men. At least one comorbidity was present in 64.5% of patients and in 76.8% of non-survivors. From illness onset, the median times to hospital and ICU admission were 6 days (IQR, 3–9) and 7 days (IQR, 3–10), respectively; 15 days (IQR, 9–24) to death and 15 days (IQR, 11–20) to hospital discharge. Risk factors for in-hospital death included old age, Black/Brown ethnoracial self-classification, ICU admission, being male, living in the North and Northeast regions and various comorbidities. Age had the highest HRs of 5.51 (95% CI: 4.91 to 6.18) for patients≥80, compared with those ≤20.ConclusionsCharacteristics of patients and risk factors for in-hospital mortality highlight inequities of COVID-19 outcomes in Brazil. As the pandemic continues to unfold, targeted policies that address those inequities are needed to mitigate the unequal burden of COVID-19.

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