Association between Metabolic Syndrome and the Number of Remaining Teeth in Postmenopausal Women: A Cross-Sectional Analysis Using the Korean National Health and Nutritional Examination Survey

There are very few studies on metabolic syndrome (MetS) and oral health in postmenopausal women. The purpose of this cross-sectional study was to determine the association between MetS and its components and the number of remaining teeth in postmenopausal women in Korea. The study selected 3320 menopausal women (40–79 years old) from those who participated in the seventh Korea National Health and Nutrition Survey (2016–2018). Multiple regression and multiple logistic regression analyses were performed to determine the association between MetS and its components and the number of remaining teeth. According to the multiple regression analysis, the regression coefficient (B) values were −1.62 (p < 0.05), −1.31 (p < 0.05), −1.60 (p < 0.05), and −2.28 (p < 0.05) in the hypertension group, hyperglycemia group, low high-density lipoprotein (HDL) cholesterol group, and MetS prevalence group, respectively. This indicates that the number of remaining teeth was lower in the MetS prevalence group as compared to the non-prevalence groups. As observed in the multiple logistic regression analysis, the odds ratio of the number of remaining teeth (less than 20) was higher in the MetS prevalence group (1.82 (p < 0.05)) as compared to the non-prevalence groups (1.25 (p < 0.05) in the abdominal obesity group, 1.50 (p < 0.05) in the hypertension group, 1.36 (p <0.05) in the hyperglycemia group, and 1.72 (p < 0.05) in the low HDL cholesterol group). Therefore, our results indicate that abdominal obesity, hypertension, diabetes, dyslipidemia, and prevalence of MetS are associated with tooth loss in postmenopausal women.

Download Full-text

Association between Hyperuricemia and Metabolic Syndrome: An Epidemiological Study of a Labor Force Population in Taiwan

BioMed Research International ◽

10.1155/2015/369179 ◽

2015 ◽

Vol 2015 ◽

pp. 1-7 ◽

Cited By ~ 12

Author(s):

Cheng-Yu Wei ◽

Chia-Cheng Sun ◽

James Cheng-Chung Wei ◽

Hsu-Chih Tai ◽

Chien-An Sun ◽

...

Keyword(s):

Metabolic Syndrome ◽

Logistic Regression ◽

Regression Analysis ◽

Logistic Regression Analysis ◽

Multiple Logistic Regression Analysis ◽

Density Lipoprotein ◽

Cross Sectional Study ◽

Multiple Logistic Regression ◽

Cross Sectional ◽

The Relationship

The increasing prevalence of metabolic syndrome (MetS) has become an important issue worldwide. Metabolic comorbidities of hypertension, obesity, and hyperlipidemia are shown as important risk factors for incident gout. The purpose of this study was to investigate the relationship between hyperuricemia and MetS. This is a cross-sectional study. The effective sample included 21,544 individuals who received worker health examinations at a local teaching hospital in Changhua County from 2008~2012. We used multiple logistic regression analysis to investigate the influences of hyperuricemia on MetS. The results showed that individuals with MetS had significantly higher blood pressure, fasting plasma glucose, triglycerides, waist circumference, and high-density lipoprotein cholesterol than those without MetS(P<0.001). Multiple logistic regression analysis revealed hyperuricemia to be an important factor of MetS. The risk of developing MetS is higher with high levels of serum uric acid (SUA) and the odds ratio (OR) of having MetS is 4.98 times higher for Tertile 3 than for Tertile 1 (95% CI = 4.16–5.97) and 4 times higher for Quartile 4 than for Quartile 1 (95% CI = 3.59–4.46). In conclusion, males are more likely to develop MetS than females, and the risk of having MetS increases with age and SUA concentration.

Download Full-text

Cross-Sectional Association between Hypercholesterolemia and Knee Pain in the Elderly with Radiographic Knee Osteoarthritis: Data from the Korean National Health and Nutritional Examination Survey

Journal of Clinical Medicine ◽

10.3390/jcm10050933 ◽

2021 ◽

Vol 10 (5) ◽

pp. 933

Author(s):

Byung Woo Cho ◽

Du Seong Kim ◽

Hyuck Min Kwon ◽

Ick Hwan Yang ◽

Woo-Suk Lee ◽

...

Keyword(s):

Logistic Regression ◽

Regression Analysis ◽

Knee Pain ◽

Logistic Regression Analysis ◽

National Health ◽

Large Scale ◽

Metabolic Diseases ◽

The Elderly ◽

Cross Sectional ◽

Ordinal Logistic Regression Analysis

Few studies have reported the relationship between knee pain and hypercholesterolemia in the elderly population with osteoarthritis (OA), independent of other variables. The aim of this study was to reveal the association between knee pain and metabolic diseases including hypercholesterolemia using a large-scale cohort. A cross-sectional study was conducted using data from the Korea National Health and the Nutrition Examination Survey (KNHANES-V, VI-1; 2010–2013). Among the subjects aged ≥60 years, 7438 subjects (weighted number estimate = 35,524,307) who replied knee pain item and performed the simple radiographs of knee were enrolled. Using multivariable ordinal logistic regression analysis, variables affecting knee pain were identified, and the odds ratio (OR) was calculated. Of the 35,524,307 subjects, 10,630,836 (29.9%) subjects experienced knee pain. Overall, 20,290,421 subjects (56.3%) had radiographic OA, and 8,119,372 (40.0%) of them complained of knee pain. Multivariable ordinal logistic regression analysis showed that among the metabolic diseases, only hypercholesterolemia was positively correlated with knee pain in the OA group (OR 1.24; 95% Confidence Interval 1.02–1.52, p = 0.033). There were no metabolic diseases correlated with knee pain in the non-OA group. This large-scale study revealed that in the elderly, hypercholesterolemia was positively associated with knee pain independent of body mass index and other metabolic diseases in the OA group, but not in the non-OA group. These results will help in understanding the nature of arthritic pain, and may support the need for exploring the longitudinal associations.

Download Full-text

Association between the non-HDL-cholesterol to HDL-cholesterol ratio and non-alcoholic fatty liver disease in Chinese children and adolescents: a large single-center cross-sectional study

10.21203/rs.3.rs-63438/v3 ◽

2020 ◽

Author(s):

Shouxing Yang ◽

Jinwei Zhong ◽

Mengsi Ye ◽

Lei Miao ◽

Guangrong Lu ◽

...

Keyword(s):

Logistic Regression ◽

Regression Analysis ◽

Children And Adolescents ◽

Binary Logistic Regression ◽

Hdl Cholesterol ◽

Chinese Children ◽

Binary Logistic Regression Analysis ◽

Cross Sectional ◽

Alcoholic Fatty Liver ◽

Chinese Children And Adolescents

Abstract Background: The non-HDL-cholesterol to HDL-cholesterol (NHDLC/HDLC) ratio is closely related to a variety of dyslipidemia-related diseases. This study aimed to inspect the relationship between the NHDLC/HDLC ratio and non-alcoholic fatty liver (NAFLD) in children and adolescents.Methods: In this cross-sectional survey, a total of 7,759 eligible Chinese children and adolescents (5,692 boys and 2,067 girls) received routine medical examinations. The anthropometric and laboratory data of the subjects were collected. NAFLD was diagnosed by liver ultrasonography. Binary logistic regression analysis was performed on the NHDLC/HDLC ratio, NHDLC, HDLC and NAFLD. Receiver operating characteristic (ROC) curve analysis was exploited to compare the diagnostic significance of the above parameters for NAFLD.Results: The total prevalence of NAFLD was 4.36%, and the prevalence in boys was higher than that in girls (5.61% vs. 1.9%, P < 0.001). The prevalence of NAFLD was positively correlated with the NHDLC/HDLC ratio (P < 0.001). The binary logistic regression analysis demonstrated that the OR was 8.61 (95% CI, 5.90-12.57, P < 0.001) in tertile 3 (highest NHDLC/HDLC ratio) compared with tertile 1 (lowest NHDLC/HDLC ratio). After adjustment for age, sex, body mass index (BMI), alanine aminotransferase (ALT), uric acid (UA), total bilirubin (TB), fasting plasma glucose (FPG) and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), the OR for tertile 3 (OR=1.83, 95% CI, 1.04-3.22, P = 0.035) was still significantly higher than that of tertile 1. The area under the curve (AUC) of the NHDLC/HDLC ratio of boys was 0.787, which was significantly greater than that of NHDLC and HDLC (0.719 and 0.726, P < 0.001). For girls, the AUC of the NHDLC/HDLC ratio was 0.763, which was also significantly greater than that of NHDLC (0.661, P < 0.001). Furthermore, the cutoff point of the NHDLC/HDLC ratio was 2.475 in boys and 2.695 in girls. In addition, the AUC of the NHDLC/HDLC ratio was 0.761 in subjects with normal ALT levels (ALT ≤ 40 U/L), which was significantly higher than that of NHDLC (0.680, P < 0.001) and HDLC (0.724, P = 0.007). For subjects with elevated ALT levels (ALT > 40 U/L), the AUC of the NHDLC/HDLC ratio (0.746) was also significantly greater than that of NHDLC (0.646, P < 0.001)Conclusions: The NHDLC/HDLC ratio was positively correlated with NAFLD in Chinese children and adolescents. It may serve as an effective indicator to help identify NAFLD in children and adolescents.

Download Full-text

Midnight salivary cortisol secretion and the use of antidepressants were associated with abdominal obesity in women with type 1 diabetes: a cross sectional study

Diabetology & Metabolic Syndrome ◽

10.1186/s13098-019-0481-3 ◽

2019 ◽

Vol 11 (1) ◽

Cited By ~ 1

Author(s):

Eva Olga Melin ◽

Magnus Hillman ◽

Maria Thunander ◽

Mona Landin-Olsson

Keyword(s):

Type 1 Diabetes ◽

Logistic Regression ◽

Abdominal Obesity ◽

Salivary Cortisol ◽

Cross Sectional Study ◽

Cortisol Secretion ◽

Multiple Logistic Regression ◽

Sectional Study ◽

Cross Sectional

Abstract Background Abdominal obesity is a risk factor for cardiovascular disease. The aim was to explore the influence of midnight salivary cortisol (MSC), antidepressants and sex on abdominal obesity in type 1 diabetes (T1D). We controlled for physical inactivity, smoking, depression and alexithymia. Methods Cross sectional study of 190 T1D patients (86 women/104 men, 18–59 years, diabetes duration 1–55 years), consecutively recruited from one specialist diabetes outpatient clinic. Anthropometrics, blood pressure, saliva and blood samples were collected, supplemented with data from electronic medical records. Depression and alexithymia were assessed by self-report instruments. MSC (nmol/l) was categorised into 3 levels: high MSC: (≥ 6.7) (n = 64); intermediate MSC: ≥ 3.7− < 6.7) (n = 64); low MSC (< 3.7) (n = 62). Abdominal obesity was defined as waist circumference (meters) ≥ 0.88 for women and as ≥ 1.02 for men. Multiple logistic regression analyses (Backward: Wald) were performed. The Hosmer and Lemeshow test for goodness-of-fit and Nagelkerke R2 were used to evaluate each multiple logistic regression analysis model. Results The prevalence of abdominal obesity was three times higher in the women than in the men (24% versus 8%) (p = 0.002). Antidepressants were used by 10% of the women and by 4% of the men (p = 0.09). The prevalence of high MSC was 1.7 times higher in the women (43% versus 26%); the prevalence of both intermediate MSC (28% versus 38%) and low MSC (29% versus 36%) were lower in the women (p = 0.048). Significant associations with abdominal obesity were for all 190 patients: female sex (adjusted odds ratio (AOR) 3.4 (confidence interval (CI) 1.4–8.2)) and the use of antidepressants (AOR 4.3 (CI 1.2–14.8)); for the 86 women: high MSC (AOR 18.4 (CI 1.9–181)) and use of antidepressants (AOR 12.2 (CI 2.0–73.6)); and for the 104 men: alexithymia (AOR 5.2 (CI 1.1–24.9)). Conclusions Clear sex differences were demonstrated with a distinct higher prevalence of abdominal obesity, as well as a distinct higher prevalence of high midnight salivary cortisol in the women with type 1 diabetes. High midnight salivary cortisol secretion and the use of antidepressants were independent risk factors for abdominal obesity in the women.

Download Full-text

The Study of Clustering Effects of Behavior Risk Factors in Patients with Metabolic Syndrome in Southern China: A Cross-Sectional Study

Journal of Diabetes Research ◽

10.1155/2020/6478393 ◽

2020 ◽

Vol 2020 ◽

pp. 1-10

Author(s):

Huiwu Han ◽

Fan Zheng ◽

Weiwei Dai ◽

Hua Peng ◽

Shi Zhou ◽

...

Keyword(s):

Risk Factors ◽

Metabolic Syndrome ◽

Logistic Regression ◽

Regression Analysis ◽

Logistic Regression Analysis ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Salty Taste ◽

Clustering Effect

Objectives. Metabolic syndrome (MetS) is now becoming a serious public health threat. Some behaviors risk factors were considered to be associated with MetS and interacted to adversely affect MetS. However, the clustering effects of behavior risk factors of MetS among Chinese population remain unclear. The aim of this study is to observe the behavior risk factors and their clustering effects of MetS in China. Methods. A cross-sectional study design was used. Subjects were recruited in the departments of Cardiology Clinic, Endocrine Clinic, and Health Management from March to December 2019. A demographic sheet was designed to collect the demographic and clinical characteristics of the subjects. International Physical Activity Questionnaire-Short was applied to evaluate the level of PA in this study. Other behavior risk factors were observed by the questionnaire. The stepwise logistic regression analysis was performed to identify the determinants of MetS. The multiple logistic regression analysis was used to analyze the clustering effects of behavior risk factors in MetS. Results. There are a total of 532 eligible subjects (56.6% females; mean age was 48.4±15.3 years), and approximately 33.3% were diagnosed as MetS. The subjects with a smoking habit (heavy and long-time history) had a 1.833-fold higher risk for MetS than their counterparts (none and light smoking), and the subjects that preferred salty taste had a 1.626-fold higher risk for MetS than the comparison cohort. Smoking and alcohol drinking had the highest clustering effect on MetS among the behavior risk factors. Conclusions. The main finding of this study was that smoking and salty taste preference were the independent determinants of MetS. Smoking and alcohol consumption had the highest clustering effect on southern Chinese MetS.

Download Full-text

Prevalence of Abdominal Obesity and Metabolic Syndrome in Children and Adolescents: A Community Based Cross-Sectional Study

Iranian Journal of Public Health ◽

10.18502/ijph.v49i2.3106 ◽

2020 ◽

Author(s):

Nastaran AHMADI ◽

Seyed Mahmood SADR ◽

Mohammad Reza MOHAMMADI ◽

Masoud MIRZAEI ◽

Amir Hooshang MEHRPARVAR ◽

...

Keyword(s):

Metabolic Syndrome ◽

Children And Adolescents ◽

Abdominal Obesity ◽

Adult Population ◽

International Diabetes Federation ◽

Hdl Cholesterol ◽

National Study ◽

Cross Sectional ◽

Common Component ◽

Low Hdl

Background: Although the prevalence of abdominal obesity and metabolic syndrome has been widely studied in the adult population, little is known about it in children and adolescents especially in developing countries. This study aimed to determine the prevalence of abdominal obesity and metabolic syndrome among children and adolescents in Yazd Greater Area, Iran; over the period of 2016-2017. Methods: This study was part of a larger national study with a cross-sectional design. Using multistage cluster random sampling method, 1035 children, and adolescents of both sexes aged 6-18 yr were randomly selected from rural and urban districts in Yazd Greater Area, Iran. Components of metabolic syndrome, and anthropometry measured in the standard situation. Results: The prevalence of abdominal obesity in children 6-10 yr old was 13.2% in boys versus 24.7% in girls. The overall prevalence of metabolic syndrome according to International Diabetes Federation (IDF) criteria in adolescents aged 10-18 yr old was 7.6% (9.4% in boys). The most prevalent metabolic syndrome components were low HDL-cholesterol (56.2%) and abdominal obesity (27.8%). Conclusion: Comparatively, the prevalence of metabolic syndrome in Yazd is high. Low HDL-cholesterol levels and abdominal obesity were the most common component, and family history of heart disease, BMI, and male gender were the main determinants of metabolic syndrome in adolescents.

Download Full-text

Complications as important predictors of disability in ischemic stroke

Zinc supplementation improves heme biosynthesis in rats exposed to lead ◽

10.18051/univmed.2017.v36.197-204 ◽

2017 ◽

Vol 36 (3) ◽

pp. 197

Author(s):

Rizaldy Taslim Pinzon ◽

Rosa De Lima Renita Sanyasi

Keyword(s):

Logistic Regression ◽

Regression Analysis ◽

Ischemic Stroke ◽

Logistic Regression Analysis ◽

Predictive Factors ◽

Recurrent Stroke ◽

Multiple Logistic Regression Analysis ◽

Multiple Logistic Regression ◽

Cross Sectional ◽

Stroke Registry

Background Stroke is the main cause of disability and death in many countries. The high incidence of disability in stroke survivors requires special attention to determine various predictive factors of disability. This study aimed to identify the various predictive factors of disability in ischemic stroke. Methods This study was a cross sectional study on 4510 ischemic stroke patients. Each patient’s data had been recorded in the electronic stroke registry of Bethesda Hospital. Ischemic stroke diagnosis was confirmed by brain CT scan, which was interpreted by a neurologist and a radiologist. Disability was assessed using the modified Rankin scale. Predictors of disability were assessed. Multiple logistic regression analysis was used to analyse the data. Results The subjects were predominantly males, >60 years of age, and suffered stroke for the first time. The incidence of disability was 31.5% (1420/4510). Multiple logistic regression analysis showed that the presence of complications (OR: 6.43; 95% CI: 4.74-8.73; p<0.001), decreased level of consciousness (OR: 4.82; 95% CI: 3.95-5.90; p <0.001), onset ³3 hours (OR: 1.93; 95% CI: 1.52-2.45; p<0.001), recurrent stroke (OR: 1.63; 95% CI: 1.39-1.90; p<0.001), and age >60 years (OR: 1.55; 95% CI: 1.35-1.79; p<0.001) were independent predictive factors of disability. Conclusion We demonstrated that a substantial proportion of patients with ischemic stroke become disabled. And the presence of complications was the most predictive factor of disability in ischemic stroke.

Download Full-text

Gender Difference in the Association Between Serum Uric Acid Level and Metabolic Syndrome and Components: A Cross-Sectional Analysis Among Chinese Young Adults

10.21203/rs.3.rs-155347/v1 ◽

2021 ◽

Author(s):

Zhengmei Fang ◽

Yan Chen ◽

Lijun Zhu ◽

Lianping He ◽

Yuelong Jin ◽

...

Keyword(s):

Metabolic Syndrome ◽

Young Adults ◽

Logistic Regression ◽

Uric Acid ◽

Serum Uric Acid ◽

Multiple Logistic Regression Analysis ◽

Confounding Factors ◽

Multiple Logistic Regression ◽

Cross Sectional ◽

Chinese Young Adults

Abstract Background This study aimed to investigate the associations between serum uric acid (SUA) levels and metabolic syndrome (MetS) and MetS components in Chinese young adults. Methods A cross-sectional survey was conducted among 3044 young adults (1266 men and 1778 women). The anthropometric index, lipid profile, fasting blood glucose and SUA levels were measured. Male and female participants were grouped according to the quartiles of SUA level separately. Multiple logistic regression analyses were performed to evaluate the association of SUA quartiles with MetS and its components. Results The overall prevalence of hyperuricemia and MetS was 29.7% and 2%, respectively. Multiple logistic regression analysis revealed that compared with the lowest 2 quartiles of SUA together, the highest quartile showed an association with the prevalence of MetS and high triglyceride in males, and OR (95% CI) were 3.438(1.090-10.841) and 4.364(2.133–8.930) respectively after adjustments confounding factors. In terms of abdominal obesity, compared with the lowest 2 quartiles of SUA together, the OR (95% CI) was 1.976(1.128–3.459) for those in the third quartile and 1.766(1.020–3.057) for those in the highest quartile after adjustments confounding factors in females. Conclusions This study suggested a significant positive relationship between SUA and MetS and its components among young adults. Hence, routine measurement of SUA is recommended to prevent hyperuricemia and its related complications.

Download Full-text

The association between low carbohydrate diet score and metabolic syndrome among Iranian adults

Public Health Nutrition ◽

10.1017/s1368980021003074 ◽

2021 ◽

pp. 1-25

Author(s):

Zohreh Sadat Sangsefidi ◽

Elnaz Lorzadeh ◽

Azadeh Nadjarzadeh ◽

Masoud Mirzaei ◽

Mahdieh Hosseinzadeh

Keyword(s):

Metabolic Syndrome ◽

Abdominal Obesity ◽

Hdl Cholesterol ◽

Health Study ◽

Dietary Intakes ◽

Carbohydrate Diet ◽

Cross Sectional ◽

Low Carbohydrate Diet ◽

Low Carbohydrate ◽

Low Hdl

Abstract Objective: Assessing relationship between low carbohydrate diet (LCD) score and metabolic syndrome (Mets) in Iranian adults. Design: Cross-sectional study Setting: Yazd Health Study and Taghzieh Mardom-e-Yazd study. Participants: Data of 2074 participants were used. Dietary intakes were assessed by a validated semi-quantitative food frequency questionnaire. LCD score was calculated for each person by summing up the assigned scores to deciles of energy percentages from macronutrients. Mets was evaluated using National Cholesterol Education Program Adult Treatment Panel III. Eventually, association between LCD score and Mets was examined using logistic regression. Results: Total Mets prevalence was approximately 40.5%. After adjustment for confounders, subjects in the higher quartile of LCD score had a significant lower chance of Mets versus lower quartile among all participants (Q4 versus Q1: OR: 0.68, 95% CI: 0.50-0.92) and separately in men (Q4 versus Q1: OR: 0.54, 95% CI: 0.34-0.86) and women (Q2 versus Q1: OR: 0.53, 95% CI: 0.34-0.82). Furthermore, more LCD adherence in men reduced abdominal obesity by 47% (Q3 versus Q1OR: 0.53, 95% CI: 0.28-0.99). Low HDL cholesterol was also observed both in the highest quartile of LCD score in all participants (OR: 0.74, 95% CI: 0.56-0.99) and separately in men (OR: 0.63, 95% CI: 0.40-0.98) versus the first quartile. Conclusions: More adherence to LCD might be related to lower chance of Mets and some of its components such as low HDL cholesterol and abdominal obesity specially in men. Further studies are required to confirm the findings.

Download Full-text

Relationships between Subclinical Hypothyroidism and Metabolic Syndrome and Vitamin D Status in Korean Adults: Korea National Health and Nutrition Examination Survey 2013-2015

Korean Journal of Health Promotion ◽

10.15384/kjhp.2020.20.1.10 ◽

2020 ◽

Vol 20 (1) ◽

pp. 10-15

Author(s):

You-Lee Kim ◽

A-Lum Han ◽

Sae-Ron Shin

Keyword(s):

Metabolic Syndrome ◽

Vitamin D ◽

Regression Analysis ◽

Multiple Regression Analysis ◽

Multiple Regression ◽

National Health ◽

Subclinical Hypothyroidism ◽

Nutrition Examination Survey ◽

Vitamin D Status ◽

Health And Nutrition

Background: Many studies have established the association between overt hypothyroidism and metabolic syndrome (MS). However, the relationship between subclinical hypothyroidism (SCH) and MS varies from study to study. This study aimed to investigate associations between SCH and components of MS and vitamin D status in Korean adults.Methods: Using data from the 6th Korea National Health and Nutrition Examination Survey (2013-2015), chi-squared tests and t-tests were used to explore relationships between thyroid hormones and components of MS and vitamin D status. Multiple regression analysis was undertaken to assess relationships between SCH and components of MS and vitamin D.Results: Systolic blood pressure and fasting glucose were significantly higher in the euthyroid (EUT) group than in the SCH group, and vitamin D status was significantly lower in the SCH group than EUT. However, in multiple regression analysis, SCH presented no significant association with components of MS or vitamin D status even after adjusting for age, sex, drinking, and smoking.Conclusions: In Korean adults, there is no significant association between SCH and MS or vitamin D.

Download Full-text