Clinical Significance and Prognostic Value of Hemostasis Parameters in 337 Patients with Acute Infective Endocarditis

(1) Background: The aim of this study was to assess the clinical significance and prognostic role of the main hemostasis parameters in infective endocarditis (IE): prothrombin time as international normalized ratio (PT-INR), activated partial thromboplastin time (aPTT), fibrinogen, D-dimers, platelet count, homocysteine. (2) Methods: We studied 337 patients with IE. Clinical, hemato-chemical and echocardiography parameters were analyzed. Coagulation parameters were measured on admission. (3) Results: D-dimers levels (p = 0.012) and a prolonged PT-INR (p = 0.013) were associated with higher in-hospital mortality, while prolonged aPTT (p = 0.021) was associated with increased 1-year mortality. Staphylococcus aureus (S. aureus) infection (p = 0.003), prosthetic valve endocarditis (PVE) (p = 0.001), surgical indication (p = 0.002) and higher D-dimer levels (p = 0.005) were independent predictors of in-hospital mortality. PVE (p = 0.001), a higher Charlson Comorbidity Index (p = 0.049), surgical indication (p = 0.001) and prolonged aPTT (p = 0.012) were independent predictors of 1-year mortality. Higher levels of D-dimers (p < 0.001) and a shorter aPTT (p < 0.001) were associated with embolic complications of IE. S. aureus etiology was bound to higher D-dimers levels (p < 0.001) and a shorter aPTT (p = 0.006). (4) Conclusions: Elevated D-dimers are associated with a higher risk for in-hospital mortality in IE patients. High D-dimers and a short aPTT are associated with a higher risk for embolic events in IE. A longer aPTT is associated with 1-year mortality.

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The Role of the Coagulase-negative Staphylococci (CoNS) in Infective Endocarditis; A Narrative Review from 2000 to 2020

Current Pharmaceutical Biotechnology ◽

10.2174/1389201021666200423110359 ◽

2020 ◽

Vol 21 (12) ◽

pp. 1140-1153 ◽

Cited By ~ 1

Author(s):

Mohammad A. Noshak ◽

Mohammad A. Rezaee ◽

Alka Hasani ◽

Mehdi Mirzaii

Keyword(s):

Foreign Body ◽

Infective Endocarditis ◽

Prosthetic Valve ◽

Human Life ◽

Prosthetic Valve Endocarditis ◽

Surgical Site Infections ◽

Coagulase Negative Staphylococci ◽

Native Valve ◽

Native Valve Endocarditis

Coagulase-negative staphylococci (CoNS) are part of the microbiota of human skin and rarely linked with soft tissue infections. In recent years, CoNS species considered as one of the major nosocomial pathogens and can cause several infections such as catheter-acquired sepsis, skin infection, urinary tract infection, endophthalmitis, central nervous system shunt infection, surgical site infections, and foreign body infection. These microorganisms have a significant impact on human life and health and, as typical opportunists, cause peritonitis in individuals undergoing peritoneal dialysis. Moreover, it is revealed that these potential pathogens are mainly related to the use of indwelling or implanted in a foreign body and cause infective endocarditis (both native valve endocarditis and prosthetic valve endocarditis) in patients. In general, approximately eight percent of all cases of native valve endocarditis is associated with CoNS species, and these organisms cause death in 25% of all native valve endocarditis cases. Moreover, it is revealed that methicillin-resistant CoNS species cause 60 % of all prosthetic valve endocarditis cases. In this review, we describe the role of the CoNS species in infective endocarditis, and we explicated the reported cases of CoNS infective endocarditis in the literature from 2000 to 2020 to determine the role of CoNS in the process of infective endocarditis.

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Prognostic Role of Paravalvular Spread on Computed Tomography in Suspected Prosthetic Valve Endocarditis

Journal of Thoracic Imaging ◽

10.1097/rti.0000000000000598 ◽

2021 ◽

Vol Publish Ahead of Print ◽

Author(s):

Gurmandeep S. Sandhu ◽

Pratik S. Velangi ◽

Harmeet Kharoud ◽

Prabhjot S. Nijjar

Keyword(s):

Computed Tomography ◽

Prosthetic Valve ◽

Prosthetic Valve Endocarditis ◽

Prognostic Role

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Role of IgG against N-protein of SARS-CoV2 in COVID19 clinical outcomes

Scientific Reports ◽

10.1038/s41598-021-83108-0 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Mayank Batra ◽

Runxia Tian ◽

Chongxu Zhang ◽

Emile Clarence ◽

Camila Sofia Sacher ◽

...

Keyword(s):

Hospital Mortality ◽

Clinical Outcomes ◽

Hospital Admissions ◽

High Concentration ◽

Logistic Regression Models ◽

N Protein ◽

Comorbidity Index ◽

Poor Outcomes ◽

Time Of Admission

AbstractThe Nucleocapsid Protein (N Protein) of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV2) is located in the viral core. Immunoglobulin G (IgG) targeting N protein is detectable in the serum of infected patients. The effect of high titers of IgG against N-protein on clinical outcomes of SARS-CoV2 disease has not been described. We studied 400 RT-PCR confirmed SARS-CoV2 patients to determine independent factors associated with poor outcomes, including Medical Intensive Care Unit (MICU) admission, prolonged MICU stay and hospital admissions, and in-hospital mortality. We also measured serum IgG against the N protein and correlated its concentrations with clinical outcomes. We found that several factors, including Charlson comorbidity Index (CCI), high levels of IL6, and presentation with dyspnea were associated with poor clinical outcomes. It was shown that higher CCI and higher IL6 levels were independently associated with in-hospital mortality. Anti-N protein IgG was detected in the serum of 55 (55%) patients at the time of admission. A high concentration of antibodies, defined as signal to cut off ratio (S/Co) > 1.5 (75 percentile of all measurements), was found in 25 (25%) patients. The multivariable logistic regression models showed that between being an African American, higher CCI, lymphocyte counts, and S/Co ratio > 1.5, only S/Co ratio were independently associated with MICU admission and longer length of stay in hospital. This study recommends that titers of IgG targeting N-protein of SARS-CoV2 at admission is a prognostic factor for the clinical course of disease and should be measured in all patients with SARS-CoV2 infection.

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Clinical significance and prognostic role of hypoxia-induced microRNA 382 in gastric adenocarcinoma

PLoS ONE ◽

10.1371/journal.pone.0223608 ◽

2019 ◽

Vol 14 (10) ◽

pp. e0223608 ◽

Cited By ~ 1

Author(s):

An Na Seo ◽

Yukdong Jung ◽

Hyeonha Jang ◽

Eunhye Lee ◽

Han-Ik Bae ◽

...

Keyword(s):

Clinical Significance ◽

Gastric Adenocarcinoma ◽

Prognostic Role

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The prognostic role of Charlson comorbidity index for critically ill elderly patients

The European Research Journal ◽

10.18621/eurj.451391 ◽

2019 ◽

Author(s):

Abdulkerim Yıldız ◽

Ali Yiğt ◽

Ali Ramazan Benli

Keyword(s):

Elderly Patients ◽

Critically Ill ◽

Charlson Comorbidity Index ◽

Prognostic Role ◽

Comorbidity Index

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Clinical significance and prognostic role of an immune-related gene signature in gastric adenocarcinoma

Aging ◽

10.18632/aging.203266 ◽

2021 ◽

Author(s):

Rui Mao ◽

Kehao Liu ◽

Nana Zhao ◽

Pengsen Guo ◽

Yingxin Wu ◽

...

Keyword(s):

Clinical Significance ◽

Gastric Adenocarcinoma ◽

Gene Signature ◽

Related Gene ◽

Prognostic Role ◽

Immune Related Gene

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Prognostic Role of Admission C-Reactive Protein Level as a Predictor of In-Hospital Mortality in Type-A Acute Aortic Dissection: A Meta-Analysis

Vascular and Endovascular Surgery ◽

10.1177/1538574419858161 ◽

2019 ◽

Vol 53 (7) ◽

pp. 547-557 ◽

Cited By ~ 3

Author(s):

Wan Chin Hsieh ◽

Brandon Michael Henry ◽

Chong Chao Hsieh ◽

Pavel Maruna ◽

Mohamed Omara ◽

...

Keyword(s):

Aortic Dissection ◽

Hospital Mortality ◽

Acute Aortic Dissection ◽

Meta Analysis ◽

Type A ◽

C Reactive Protein ◽

Prognostic Role ◽

Reactive Protein ◽

Increased Risk

Background: Acute aortic dissection (AD) is a lethal vascular disease, accounting for over 90% cases of acute aortic syndrome. Despite advances in understanding associated risk factors, the long-term prognosis for AD patients is still poor. Several prognostic biomarkers have been used for AD as per the IRAD, such as older age (>70 years), onset of chest pain and hypotension, but they are not effective in all patients. Instead, C-reactive protein (CRP) is a consistent inflammatory marker. CRP levels are abnormally increased in AD. However, the prognostic value of serum CRP level in AD remains unclear. Objective: To perform a systematic review and meta-analysis (registration no CRD42017056205) to evaluate whether CRP is a biomarker associated with in-hospital mortality in type-A AD. Methods: PubMed, Web of Science, CNKI, SciELO, and EMBASE were searched for papers published from January 2000 to October 2017 for studies on the prognostic role of CRP at admission in type-A AD patients. Outcome data were extracted and pooled hazard ratios (HRs) were calculated. Results: 18 (N = 2875 patients) studies met the inclusion criteria. Elevated CRP level was associated with a significantly increased risk of in-hospital mortality in patients with type-A AD (HR = 1.15, 95% CI: 1.06-1.25, p = 0.001). The pooled sensitivity of CRP in type-A AD patients was 77% (95% CI 69%–84%, p < 0.001), and the specificity was 72% (95% CI 66%–78%, p < 0.001). Conclusion: Elevated CRP level is significantly associated with increased risks of in-hospital mortality in patients with type-A AD. CRP is a convenient prognostic factor in type-A AD patients.

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