The Importance of Sex Differences on Outcome after Major Trauma: Clinical Outcome in Women Versus Men

Purpose: The purpose of this study was to evaluate epidemiological and clinically relevant sex-related differences in polytraumatized patients at a Level 1 Trauma Center. Methods: 646 adult patients (210 females and 436 males) who were classified as polytraumatized (at the point of admission) and treated at our Level I Trauma Center were reviewed and included in this study. Demographic data as well as mechanism of injury, injury severity, injury pattern, frequency of preclinical intubation, hemodynamic variables on admission, time of mechanical ventilation and of intensive care unit (ICU) treatment, as well as the incidence of acute respiratory distress syndrome (ARDS), multi organ failure (MOF), and mortality were extracted and analyzed. Results: A total of 210 female and 436 male patients formed the basis of this report. Females showed a higher mean age (44.6 vs. 38.3 years; p < 0.0001) than their male counterparts. Women were more likely to be injured as passengers or by suicidal falls whereas men were more likely to suffer trauma as motorcyclists. Following ICU treatment, female patients resided significantly longer at the casualty ward than men (27.1 days vs. 20.4 days, p = 0.013) although there was no significant difference regarding injury severity, hemodynamic variables on admission, and incidence of MOF, ARDS, and mortality. Conclusion: The positive correlation of higher age and longer in-hospital stay in female trauma victims seems to show women at risk for a prolonged in-hospital rehabilitation time. A better understanding of the impact of major trauma in women (but also men) will be an important component of efforts to improve trauma care and long-term outcome.

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P027 Assessment of physical activity in Juvenile Idiopathic Arthritis

Rheumatology ◽

10.1093/rheumatology/keab722.019 ◽

2021 ◽

Vol 60 (Supplement_5) ◽

Author(s):

B Ben Ouahma ◽

W Triki ◽

K Maatallah ◽

H Ferjani ◽

D Ben Nessib ◽

...

Keyword(s):

Physical Activity ◽

Juvenile Idiopathic Arthritis ◽

Demographic Data ◽

Functional Limitations ◽

Unknown Origin ◽

Full Potential ◽

Term Outcome ◽

Long Term Outcome ◽

School Sports ◽

The Impact

Abstract Background Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in childhood, grouping together different diseases characterized by arthritis of unknown origin with onset before age of 16 years. JIA may cause functional impairment and a limited exercise capacity thus a reduced time engaged in physical activity. The aim of the study was to describe participation in physical activity among children with JIA. Methods We conducted a descriptive retrospective study including 23 patients with JIA according to the classification criteria of the International League of Associations for Rheumatology ILAR. Demographic data were collected. All patients answered a questionnaire referring to physical activity. Results The mean age of our patients was 16 years old with a sex ratio of 3. The education level was distributed as follows: 8,7% were in elementary school and 21,7% were in high school. Only 4,3% of the children were participating in high loading sports. Twenty-one per cent of the children reported spending >3 h per week in physical activity during leisure time. Participation in compulsory school-educational physical activity was reported in 43,5% of the children and 26,1% reported full participation. Full exemption from school sports was reported in 46.5% of cases and it was mostly associated with functional limitations. Exercise therapy was prescribed in 26.1% of patients and it was mainly swimming. The impact of physical activity on symptoms was divided into 43,5% of the children who reported an aggravation, 8,7% who reported an improvement and 34,8% who didn't report any change. Conclusion Physical activity in childhood is important to acquire knowledge and behavioral skills in order to maintain an active lifestyle. A special attention to children with JIA is required in order to promote their full potential of social interaction and improve long-term outcome.

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664 The ICON Trauma Study: The Impact of the COVID-19 Lockdown on Major Trauma Workload in the UK

British Journal of Surgery ◽

10.1093/bjs/znab134.074 ◽

2021 ◽

Vol 108 (Supplement_2) ◽

Author(s):

A Adiamah ◽

A i Thompson ◽

C Lewis-Lloyd ◽

E Dickson ◽

L Blackburn ◽

...

Keyword(s):

Major Trauma ◽

Injury Severity ◽

Multivariable Analysis ◽

Similar Time ◽

Historical Cohort ◽

Risk Of Mortality ◽

Major Trauma Centre ◽

Increased Risk ◽

Significant Difference ◽

The Impact

Abstract Introduction Anecdotal evidence suggest a direct impact of the SARS-COV-2-pandemic on presentation and severity of major trauma. Method This observational study from a UK Major Trauma Centre matched a cohort of patients admitted during a 10-week period of the SARS-CoV-2-pandemic (09/03/2020 to 18/05/2020) to a historical cohort admitted during a similar time period in 2019 (11/03/2019 to 20/05/2019). Demographic differences, injury method and severity were compared using Fisher’s and Chi-squared tests. Multivariable logistic regression examined the associated factors predicting 30-day mortality. Results Of 642 patients, 405 and 237 were in the 2019 and 2020 cohorts respectively. 1.69%(4/237) of the 2020 cohort tested SARS-CoV-2 positive. There was a 41.5% decrease in trauma admissions in 2020. The 2020 cohort was older (median 46 vs.40 years), more comorbid and frailer (p < 0.0015). There was a significant difference in injury method with a decrease in vehicle related trauma, but an increase in falls. There was a 2-fold increased risk of mortality in the 2020 cohort that in adjusted models, was explained by higher injury severity and frailty. Positive SARS-CoV-2 status was not associated with increased mortality on multivariable analysis. Conclusions Patients admitted during the SARS-CoV-2-pandemic were older, frailer, more co-morbid and had an increased risk of mortality.

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The Impact of American College of Surgeons Trauma Center Designation and Outcomes after Early Thoracotomy: A National Trauma Databank Analysis

The American Surgeon ◽

10.1177/000313481207800123 ◽

2012 ◽

Vol 78 (1) ◽

pp. 36-41 ◽

Cited By ~ 5

Author(s):

Marko Bukur ◽

Bernardino Castelo Branco ◽

Kenji Inaba ◽

Ramon Cestero ◽

Leslie Kobayashi ◽

...

Keyword(s):

Trauma Center ◽

Injury Severity ◽

Trauma Patients ◽

National Trauma ◽

Level Ii ◽

Pressure Time ◽

Significant Difference ◽

American College Of Surgeons ◽

Level I ◽

The Impact

Trauma centers are designated by the American College of Surgeons (ACS) into four different levels based on resources, volume, and scientific and educational commitment. The purpose of this study was to evaluate the relationship between ACS center designation and outcomes after early thoracotomy for trauma. The National Trauma Databank (v. 7.0) was used to identify all patients who required early thoracotomy. Demographics, clinical data, and outcomes were extracted. Patients were categorized according to ACS trauma center designation. Multivariate logistic regression was used to evaluate the impact of ACS trauma center designation on mortality. From 2002 to 2006, 1834 (77.4%) patients were admitted to a Level I ACS verified trauma center, 474 (20.0%) to a Level II, and 59 (3.6%) to a Level III/IV facility. After adjusting for differences between the groups, there were no significant differences in mortality (overall: 53.3% for Level I, 63.1% for Level II, and 52.5% for Level III/IV, adjusted P = 0.417; or for patients arriving in cardiac arrest: 74.9% vs 87.1% vs 85.0%, P = 0.261). Subgroup analysis did not show any significant difference in survival irrespective of mechanism of injury. Glasgow Coma Scale score # 8, Injury Severity Score >16, no admission systolic blood pressure, time from admission to thoracotomy, and nonteaching hospitals were found to be independent predictors of death. For trauma patients who have sustained injuries requiring early thoracotomy, ACS trauma center designation did not significantly impact mortality. Nonteaching institutions however, were independently associated with poorer outcomes after early thoracotomy. These findings may have important implications in educational commitment of institutions. Further prospective evaluation of these findings is warranted.

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The ICON Trauma Study: the impact of the COVID-19 lockdown on major trauma workload in the UK

European Journal of Trauma and Emergency Surgery ◽

10.1007/s00068-020-01593-w ◽

2021 ◽

Author(s):

Alfred Adiamah ◽

◽

Amari Thompson ◽

Christopher Lewis-Lloyd ◽

Edward Dickson ◽

...

Keyword(s):

Major Trauma ◽

Injury Severity ◽

Care Delivery ◽

Mechanism Of Injury ◽

Historical Cohort ◽

Risk Of Mortality ◽

Major Trauma Centre ◽

Increased Risk ◽

Significant Difference ◽

The Impact

Abstract Background The global pandemic caused by SARS-CoV-2 has impacted population health and care delivery worldwide. As information emerges regarding the impact of “lockdown measures” and changes to clinical practice worldwide; there is no comparative information emerging from the United Kingdom with regard to major trauma. Methods This observational study from a UK Major Trauma Centre matched a cohort of patients admitted during a 10-week period of the SARS-CoV-2-pandemic (09/03/2020–18/05/2020) to a historical cohort of patients admitted during a similar time period in 2019 (11/03/2019–20/05/2019). Differences in demographics, Clinical Frailty Scale, SARS-CoV-2 status, mechanism of injury and injury severity were compared using Fisher’s exact and Chi-squared tests. Univariable and multivariable logistic regression analyses examined the associated factors that predicted 30-days mortality. Results A total of 642 patients were included, with 405 in the 2019 and 237 in the 2020 cohorts, respectively. 4/237(1.69%) of patients in the 2020 cohort tested positive for SARS-CoV-2. There was a 41.5% decrease in the number of trauma admissions in 2020. This cohort was older (median 46 vs 40 years), had more comorbidities and were frail (p < 0.0015). There was a significant difference in mechanism of injury with a decrease in vehicle related trauma, but an increase in falls. There was a twofold increased risk of mortality in the 2020 cohort which in adjusted multivariable models, was explained by injury severity and frailty. A positive SARS-CoV-2 status was not significantly associated with increased mortality when adjusted for other variables. Conclusion Patients admitted during the COVID-19 pandemic were older, frailer, more co-morbid and had an associated increased risk of mortality.

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The management of Hemorrhoidal Disease by Dearterialization and Mucopexy.

Reviews on Recent Clinical Trials ◽

10.2174/1574887115666200506091306 ◽

2020 ◽

Vol 15 ◽

Author(s):

Veronica De Simone ◽

Francesco Litta ◽

Angelo Parello ◽

Paola Campennì ◽

Raffaele Orefice ◽

...

Keyword(s):

Postoperative Management ◽

Term Outcome ◽

Long Term Outcome ◽

Doppler Probe ◽

Minimally Invasive Surgical ◽

Bowel Movements ◽

Excessive Strain ◽

Life Threatening ◽

Hemorrhoidal Prolapse ◽

The Impact

: Several minimally invasive surgical procedures have been recently developed to treat hemorrhoids without any excision. About 25 years ago, a non-excisional procedure providing doppler-guided ligation of the hemorrhoidal arteries has been proposed - named “hemorrhoidal dearterialization”. The original technique has been modified over the years, and indications were expanded. In particular, a plication of the redundant and prolapsing mucosa/submucosa of the rectum (named “mucopexy”) has been introduced to treat hemorrhoidal prolapse, without excision of the hemorrhoidal piles. At present, the THD® Doppler procedure is one of the most used techniques to treat hemorrhoids. Aim of this technique is to realize a target dearterialization, using a Doppler probe with the final purpose to reduce the arterial overflow to the hemorrhoidal piles. In case of associated hemorrhoidal prolapse, a mucopexy is performed together with Doppler-guided dearterialization. The entity and circumferential extension of the hemorrhoidal prolapse guides the mucopexy, which can be considered tailored to a single patient; the dearterialization should be considered mandatory. Advantages of this surgical technique are the absence of serious and life-threatening postoperative events, chronic complications, and limited recurrence risks. The impact of the procedure on the anorectal physiology is negligible. However, a careful postoperative management is mandatory to avoid complications and to guarantee an improved long-term outcome. Therefore, regular physiologic bowel movements, excessive strain at the defecation and strong physical activity are advisable.

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Influenza With an Infiltrate: Investigating the New Community-Acquired Pneumonia Guidelines

Infection Control and Hospital Epidemiology ◽

10.1017/ice.2020.884 ◽

2020 ◽

Vol 41 (S1) ◽

pp. s302-s302

Author(s):

Amanda Barner ◽

Lou Ann Bruno-Murtha

Keyword(s):

Demographic Data ◽

Retrospective Chart Review ◽

Vaccination Rate ◽

Community Acquired Pneumonia ◽

Teaching Hospitals ◽

Antibiotic Prescribing ◽

Supporting Evidence ◽

Radiographic Findings ◽

Significant Difference ◽

The Impact

Background: The Infectious Diseases Society of America released updated community-acquired pneumonia (CAP) guidelines in October 2019. One of the recommendations, with a low quality of supporting evidence, is the standard administration of antibiotics in adult patients with influenza and radiographic evidence of pneumonia. Procalcitonin (PCT) is not endorsed as a strategy to withhold antibiotic therapy, but it could be used to de-escalate appropriate patients after 48–72 hours. Radiographic findings are not indicative of the etiology of pneumonia. Prescribing antibiotics for all influenza-positive patients with an infiltrate has significant implications for stewardship. Therefore, we reviewed hospitalized, influenza-positive patients at our institution during the 2018–2019 season, and we sought to assess the impact of an abnormal chest x-ray (CXR) and PCT on antibiotic prescribing and outcomes. Methods: We conducted a retrospective chart review of all influenza-positive admissions at 2 urban, community-based, teaching hospitals. Demographic data, vaccination status, PCT levels, CXR findings, and treatment regimens were reviewed. The primary outcome was the difference in receipt of antibiotics between patients with a negative (<0.25 ng/mL) and positive PCT. Secondary outcomes included the impact of CXR result on antibiotic prescribing, duration, 30-day readmission, and 90-day mortality. Results: We reviewed the medical records of 117 patients; 43 (36.7%) received antibiotics. The vaccination rate was 36.7%. Also, 11% of patients required intensive care unit (ICU) admission and 84% received antibiotics. Moreover, 109 patients had a CXR: 61 (55.9%) were negative, 29 (26.6%) indeterminate, and 19 (17.4%) positive per radiologist interpretation. Patients with a positive PCT (OR, 12.7; 95% CI, 3.43–60.98; P < .0007) and an abnormal CXR (OR, 7.4; 95% CI, 2.9–20.1; P = .000003) were more likely to receive antibiotics. There was no significant difference in 30-day readmission (11.6% vs 13.5%; OR, 0.89; 95% CI, 0.21–3.08; P = 1) and 90-day mortality (11.6% vs 5.4%; OR, 2.37; 95% CI, 0.48–12.75; P = .28) between those that received antibiotics and those that did not, respectively. Furthermore, 30 patients (62.5%) with an abnormal CXR received antibiotics and 21 (43.7%) had negative PCT. There was no difference in 30-day readmission or 90-day mortality between those that did and did not receive antibiotics. Conclusions: Utilization of PCT allowed selective prescribing of antibiotics without impacting readmission or mortality. Antibiotics should be initiated for critically ill patients and based on clinical judgement, rather than for all influenza-positive patients with CXR abnormalities.Funding: NoneDisclosures: None

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Independent Predictors of Mortality in Torso Trauma Injuries

Journal of Clinical Medicine ◽

10.3390/jcm9103202 ◽

2020 ◽

Vol 9 (10) ◽

pp. 3202

Author(s):

Roberto Bini ◽

Caterina Accardo ◽

Stefano Granieri ◽

Fabrizio Sammartano ◽

Stefania Cimbanassi ◽

...

Keyword(s):

Trauma Center ◽

Injury Severity ◽

Demographic Data ◽

Trauma Patients ◽

Related Condition ◽

Predictors Of Mortality ◽

Risk Of Death ◽

Therapeutic Procedures ◽

Torso Trauma ◽

Enhanced Computed Tomography

Noncompressible torso injuries (NCTIs) represent a trauma-related condition with high lethality. This study’s aim was to identify potential prediction factors of mortality in this group of trauma patients at a Level 1 trauma center in Italy. Materials and Methods: A total of 777 patients who had sustained a noncompressible torso injury (NCTI) and were admitted to the Niguarda Trauma Center in Milan from 2010 to 2019 were included. Of these, 166 patients with a systolic blood pressure (SBP) <90 mmHg were considered to have a noncompressible torso hemorrhage (NCTH). Demographic data, mechanism of trauma, pre-hospital and in-hospital clinical conditions, diagnostic/therapeutic procedures, and survival outcome were retrospectively recorded. Results: Among the 777 patients, 69% were male and 90.2% sustained a blunt trauma with a median age of 43 years. The comparison between survivors and non-survivors pointed out a significantly lower pre-hospital Glasgow coma scale (GCS) and SBP (p < 0.001) in the latter group. The multivariate backward regression model identified age, pre-hospital GCS and injury severity score (ISS) (p < 0.001), pre-hospital SBP (p = 0.03), emergency department SBP (p = 0.039), performance of torso contrast enhanced computed tomography (CeCT) (p = 0.029), and base excess (BE) (p = 0.008) as independent predictors of mortality. Conclusions: Torso trauma patients who were hemodynamically unstable in both pre- and in-hospital phases with impaired GCS and BE had a greater risk of death. The detection of independent predictors of mortality allows for the timely identification of a subgroup of patients whose chances of survival are reduced.

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Traumatic Liver Injury in Hong Kong: The Management Strategy and Outcome

Hong Kong Journal of Emergency Medicine ◽

10.1177/102490790901600403 ◽

2009 ◽

Vol 16 (4) ◽

pp. 208-216 ◽

Cited By ~ 1

Author(s):

CN Chong ◽

YS Cheung ◽

KF Lee ◽

TH Rainer ◽

BSP Lai

Keyword(s):

Hong Kong ◽

Liver Injury ◽

Hospital Stay ◽

Injury Severity ◽

Road Traffic ◽

Demographic Data ◽

Operative Management ◽

Concomitant Injuries ◽

Significant Difference ◽

Non Operative Management

Introduction Management of liver injury is challenging and evolving. The aim of this article is to review the outcome of traumatic liver injury in Chinese people in Hong Kong. Materials & methods Records of 40 patients with hepatic injury who received treatment at the Prince of Wales Hospital between December 2000 and May 2005 were reviewed. Demographic data, severity of liver injury, Injury Severity Score (ISS), haemodynamic status and Glasgow Coma Scale (GCS) score on admission, investigations made, concomitant injuries, management scheme, and outcome of patients were analysed. Results There were 23 male and 17 female patients with a mean age of 31.3 (SD=15.4) years. Road traffic accident was the most common injury mechanism (65%). Half of the patients were treated by non-operative management (NOM). None of them required surgery during subsequent management. Patients in the operative management (OM) group had a significantly higher ISS (p=0.026), but there was no significant difference in the mortality rate between the OM and NOM groups. Patients with stable haemodynamic status and who were treated non-operatively had a significantly shorter hospital stay (p=0.006). High grade liver injury (OR=8.0, 95% CI=1.2 to 53.8, p=0.03) and ISS greater than 25 (OR=21.6, 95% CI=2.0 to 225.3, p=0.01) were independent risk factors for mortality on multivariate analysis. Conclusions Non-operative management of liver injury can be safely accomplished in haemodynamically stable patients, with the possible benefit of a shorter hospital stay.

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Dermatofibrosarcoma Protuberans Treated at a Single Institution: A Surgical Disease With a High Cure Rate

Journal of Clinical Oncology ◽

10.1200/jco.2005.02.5122 ◽

2005 ◽

Vol 23 (30) ◽

pp. 7669-7675 ◽

Cited By ~ 141

Author(s):

Marco Fiore ◽

Rosalba Miceli ◽

Chiara Mussi ◽

Salvatore Lo Vullo ◽

Luigi Mariani ◽

...

Keyword(s):

Reconstructive Surgery ◽

Residual Disease ◽

Dermatofibrosarcoma Protuberans ◽

Distant Metastases ◽

Local Relapse ◽

Primary Group ◽

Low Grade ◽

Term Outcome ◽

Long Term Outcome ◽

Significant Difference

Purpose Dermatofibrosarcoma protuberans (DFSP) is a rare, low-grade, cutaneous sarcoma with autocrine overproduction of the platelet-derived growth factor (PDGF) β-chain from gene rearrangement as a key pathogenetic factor, now susceptible of molecular-targeted therapy. The aim of this retrospective analysis was to explore the outcome of patients with primary or recurrent DFSP. Patients and Methods Two hundred eighteen patients surgically treated at the Istituto Nazionale per lo studio e la cura dei Tumori (Milan, Italy) over 20 years were reviewed. Local relapse, distant metastasis, and survival were studied. Results One hundred thirty-six patients (62.4%) presented with a primary DFSP, while 82 patients (37.6%) had a recurrent disease. In the primary group, margins were microscopically positive in 11.8%, while in the recurrent group they were positive in 14.6% (P =.613). In the primary group, patients undergoing re-excision after inadequate previous surgery had residual disease in 62% of cases. Reconstructive surgery was needed in 30%, significantly more frequently in patients with a recurrence or a head and neck tumor. The crude cumulative incidence of local relapses was 4% at 10 years, and 2% at 10 years for distant metastases. No significant difference was found between primary and recurrent patients, as well as between positive and negative margins. Conclusion This being one of the largest mono-institutional series of DFSP, we confirm that long-term outcome is excellent, in terms of both local and distant control, after a wide excision with negative margins. Reconstructive surgery is often needed. Novel medical therapies will be of use in a limited subgroup of patients.

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