scholarly journals Multiple External Root Resorption of Teeth as a New Manifestation of Systemic Sclerosis—A Cross-Sectional Study in Japan

2019 ◽  
Vol 8 (10) ◽  
pp. 1628 ◽  
Author(s):  
Memida ◽  
Matsuda ◽  
Kajiya ◽  
Mizuno ◽  
Ouhara ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Root Resorption ◽  
Temporomandibular Disorder ◽  
Mouth Opening ◽  
Digital Ulcers ◽  
Oral Manifestations ◽  
X Rays ◽  
Cross Sectional ◽  
Facial Region ◽  
External Root Resorption

Background: Multiple external root resorption (MERR) has been reported in systemic sclerosis (SSc) patients in Japan and Spain. To establish whether MERR is a new manifestation, we investigated the prevalence of MERR and systemic and oral manifestations to be associated with MERR in patients with SSc. Methods: Root resorption was detected by dental X-rays, panoramagraphy or cone beam computed tomography (CBCT). The prevalence of systemic and oral manifestations was examined by rheumatologists and dentists, respectively. Autoantibodies were investigated using laboratory tests. Results: MERR was detected in four out of the 41 patients (9.8%) who participated in the present study. The prevalence of digital ulcers was significantly higher in patients with MERR (MERR vs non-MERR, 75% vs 16.2%, p < 0.05), whereas that of other systemic manifestations was not. The prevalence of face skin sclerosis (100% vs 10.8%, p < 0.01), calcinosis at the facial region (75% vs 0%, p < 0.01), limited mouth opening (75% vs 18.9% p < 0.05), temporomandibular disorder symptoms (50% vs 2.7%, p < 0.05), and tongue rigidity (75% vs 2.7%, p < 0.05) was significantly higher in patients with MERR. Conclusion: SSc patients with MERR had highly homogenous maxillofacial manifestations. Further clinical and basic studies are needed to elucidate the mechanisms underlying MERR in SSc patients.

Expression of matrix metalloproteinases 2 and 9 in replanted teeth with external root resorption: A cross-sectional study

2021 ◽  
pp. 105194
Author(s):  
Thiago César da Silva Lima ◽  
Roberta Gabriela Amaro ◽  
Letícia Canhestro Machado dos Santos ◽  
Sylvia Cury Coste ◽  
Eduardo Fernandes e Silva ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Root Resorption ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
External Root Resorption

scholarly journals Clinical Bedside Tools to Assess Systemic Sclerosis Vasculopathy: Can digital thermal monitoring and sublingual microscopy identify patients with digital ulcers?

2021 ◽  
pp. jrheum.201234
Author(s):  
Tracy M. Frech ◽  
Zhining Ou ◽  
Angela P. Presson
Keyword(s):  
Systemic Sclerosis ◽  
Vascular Reactivity ◽  
Rank Correlation ◽  
Boundary Region ◽  
Reactivity Index ◽  
Clinical Feature ◽  
Digital Ulcers ◽  
Thermal Monitoring ◽  
Irreversible Damage ◽  
Cross Sectional

Objective Sublingual microscopy assesses systemic sclerosis (SSc) vasculopathy. Digital thermal monitoring (DTM) may identify patients at risk for digital ulcer (DU). The purpose of this analysis was to assess sublingual microscopy and DTM in SSc patients with and with no previous DU in order to determine the utility of these clinical tools. Methods SSc registry patients with clinical data had both DTM and sublingual microscopy on the same day were included in this cross-sectional analysis. DTM quantifies vascular reactivity index (VRI). Sublingual microscopy measures longitudinal red blood cell fraction (RBC fract) and perfused boundary region (PBR). We evaluated the pairwise association between VRI, RBCfract and PBR in a monotonic relationship using Spearman’s rank correlation in the DU subset. Correlation coefficients (rs) and their 95% confidence intervals (CIs) were reported. Results Ninety patients were included; 29 had digital pits and/or active DU and 61 never had a DU. The only significant clinical feature associated with DU was modified Rodnan skin score (p=0.003) with DU being higher. The VRI was lower in patients with DU (p=0.01). The higher RBCfract the lower PBR (rs =- 0.71, 95% CI: -0.86, -0.47, p<0.001). VRI was not associated with RBCfract or PBR (p=0.24 or 0.55, respectively) in the DU patients. Conclusion DTM is a useful tool for assessing SSc-DU. While sublingual microscopy measurements did not significantly correlate to VRI in SSc-DU patients, a longitudinal study may be more helpful in capturing vasculopathy activity prior to possibly irreversible damage.

SAT0327 SEXUAL DYSFUNCTION IN FEMALE SCLERODERMA PATIENTS AND ITS CORRELATION WITH VASCULAR INVOLVEMENT

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1109.1-1109
Author(s):  
Z. Khodamoradi ◽  
M. Nazarinia ◽  
E. Esmaeilzadeh
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Sclerosis ◽  
Sexual Dysfunction ◽  
Vascular Complications ◽  
Vascular Involvement ◽  
P Value ◽  
Case Group ◽  
Digital Ulcers ◽  
Cross Sectional ◽  
Female Patients

Background:Systemic Sclerosis (Scleroderma, SSc) is an autoimmune disorder characterized by multi-organ dysfunction, which ultimately leads to multiple clinical and psychological complications. Among various complications of scleroderma, sexual dysfunction can be named as a major issue in both male and female patients, which has great impact on quality of life of the patients.Objectives:Investigating the sexual dysfunction in scleroderma patients and its relation to their vascular involvements.Methods:A case control study was done on 80 married female scleroderma patients with age between 20-60 years old. Eighty normal individuals adjusted for age, place of living and socioeconomic status were also recruited. Sexual performance in both groups was assessed using FSFI standardized questionnaire, which evaluated it in 6 domains of desire, arousal, lubrication, orgasm, satisfaction, and pain. Micro and macro-vascular involvements of the patients were also determined using Raynaud Condition Score, Echocardiography, physical exam for assessing their digital ulcers and reviewing their medical records for presence of past or present history of renal crisis and thromboembolic events.Results:The total score of FSFI in the case group was significantly lower compared to control one (16.68 ± 6.35, 19.69 ± 6.01, P-value <0.001). The score was significantly lower in all domains of sexual dysfunction except for pain and lubrication. Moreover, the mean score of FSFI was also found to be significantly lower in limited form of the disease compared to diffuse one (14.6 ± 6.9, 18.1 ± 5.5, P-value 0.01). No significant association was found between vascular complications and sexual impairment of the scleroderma patients.Conclusion:This study can be named as the first survey investigating the sexual dysfunction in Iranian female scleroderma patients and assessing its relation with vascular complication of the disease. Thus, it can be a guide for future studies on sexual dysfunction especially in societies with cultural limitations in discussing this issue.References:[1]Bruni C, Raja J, Denton CP, Matucci-Cerinic M. The clinical relevance of sexual dysfunction in systemic sclerosis.Autoimmun Rev2015; 14(12):1111-5. doi: 10.1016/j.autrev.2015.07.016.[2]Puchner R, Sautner J, Gruber J, Bragagna E, Trenkler A, Lang G. et al. High Burden of Sexual Dysfunction in Female Patients with Rheumatoid Arthritis: Results of a Cross-sectional Study.J Rheumatol2019; 46(1):19-26. doi: 10.3899/jrheum.171287.[3]Lin MC, Lu MC, Livneh H, Lai NS, Guo HR, Tsai TY. Factors associated with sexual dysfunction in Taiwanese females with rheumatoid arthritis.BMC Womens Health2017; 17(1):12. doi: 10.1186/s12905-017-0363-5.[4]Frikha F, Masmoudi J, Saidi N, Bahloul Z. Sexual dysfunction in married women with Systemic Sclerosis.Pan Afr Med J2014; 17:82. doi: 10.11604/pamj.2014.17.82.3833.Disclosure of Interests:None declared

scholarly journals Risk of digital ulcers occurrence in systemic sclerosis: a cross-sectional study

2019 ◽  
Vol 59 (1) ◽  
Author(s):  
Alex Magno Coelho Horimoto ◽  
Albert Schiaveto de Souza ◽  
Silvia Helena Rodrigues ◽  
Cristiane Kayser
Keyword(s):  
Systemic Sclerosis ◽  
Cross Sectional Study ◽  
Digital Ulcers ◽  
Sectional Study ◽  
Cross Sectional

Predictive factors of hand radiographic lesions in systemic sclerosis: a prospective study

2010 ◽  
Vol 70 (4) ◽  
pp. 630-633 ◽  
Author(s):  
J Avouac ◽  
G Mogavero ◽  
H Guerini ◽  
J L Drapé ◽  
A Mathieu ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Cox Regression ◽  
Flexion Contracture ◽  
Cox Proportional Hazards ◽  
Vascular Involvement ◽  
Digital Ulcers ◽  
Close Monitoring ◽  
X Rays ◽  
Cox Regression Analysis ◽  
Erosive Arthritis

ObjectiveTo examine the outcomes of hand radiographic x-rays in patients with systemic sclerosis (SSc) and to identify risk factors for the progression of hand radiographic lesions in a prospective cohort.MethodsDual time-point x-rays were systematically performed after a median interval of 5 years (range 4–7 years) in 103 consecutively recruited patients with SSc. Univariate and multivariate Cox proportional hazards models evaluated predictors of progression of hand radiographic lesions.ResultsRadiographic progression of erosive arthritis, acro-osteolysis, calcinosis and flexion contracture occurred in 24, 22, 27 and 18 patients, respectively. Multivariate Cox regression analysis did not identify any predictor of the progression of erosive arthritis. Digital ulcers were shown independently to predict the progression of acro-osteolysis and calcinosis (HR 12.43, 95% CI 1.97 to 88.40 and 3.16, 95% CI 1.22% to 9.43%, respectively). The diffuse cutaneous subset was shown to be an independent predictor of the progression of flexion contracture (HR 7.52, 95% CI 1.21 to 43.93).ConclusionThe results highlight the striking level of hand radiographic lesions in SSc and suggest close monitoring of patients with the diffuse cutaneous subset for the occurrence or worsening of this complication. The results also show that severe peripheral vascular involvement predicts both acro-osteolysis and calcinosis, highlighting their vascular background.

scholarly journals Gender-related Differences in Systemic Sclerosis: A Multicenter Cross-sectional Study from the National Registry of the Italian Society Of Rheumatology

2021 ◽  
pp. jrheum.210794
Author(s):  
Rossella De Angelis ◽  
Dilia Giuggioli ◽  
Gianluigi Bajocchi ◽  
Lorenzo Dagna ◽  
Giovanni Zanframundo ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Demographic Data ◽  
Left Ventricular ◽  
Sicca Syndrome ◽  
Left Ventricular Ejection ◽  
Female Group ◽  
Special Focus ◽  
Digital Ulcers ◽  
Cross Sectional ◽  
Ventricular Ejection Fraction

Objective There is still a great deal to learn about the influence of gender in systemic sclerosis (SSc). In this respect, national registries provide large and homogeneous patient cohorts for analytical studies. We therefore investigated a wide-ranging and well-characterized SSc series with the aim of identifying gender differences in disease expressions, with a special focus on demographic, clinical and serological characteristics. Methods A multicenter SSc cohort of 2,281 patients, 247 men, was recruited in the Italian SPRING (Systemic Sclerosis PRogression INvestiGation) registry. Demographic data, disease manifestations, serological profile and internal organ involvement were compared. Results The overall female/male ratio was 8.2/1. Female/male ratios for limited SSc, diffuse SSc and sine SSc subsets were 8.7/1, 4.9/1, and 10.7/1 respectively. A shorter Raynaud's onset to SSc diagnosis, an increased prevalence of diffuse cutaneous subset, renal crisis, and digital ulcers were found in males, while a significant higher percentage of sicca syndrome, serum ANA, anti-ENA, anti-La/SSB, and anti-CENP-1 was detected in the female group. Males exhibited lower left ventricular ejection fraction, higher prevalence of conduction blocks, arrhythmias, ground glass and honeycombing. Moreover, forced vital capacity and total lung capacity were medially lower in men than in women. Finally, males were more frequently treated with immunosuppressive drugs. Conclusion Our study further supports the presence of several gender-related differences in SSc patients. These differences were pronounced as regards the severity of cutaneous, peripheral vascular and cardiopulmonary involvement for male patients, whereas an increased prevalence of sicca syndrome and a specific autoantibody profile characterize the female gender.

scholarly journals External root resorption of second molars caused by impacted third molars: an observational study in panoramic radiographs

2018 ◽  
Vol 47 (1) ◽  
pp. 25-30
Author(s):  
Jhonatan Thiago LACERDA-SANTOS ◽  
Gélica Lima GRANJA ◽  
Jalber Almeida dos SANTOS ◽  
Julliana Cariry PALHANO-DIAS ◽  
José Cadmo Wanderley Peregrino de ARAÚJO-FILHO ◽  
...  
Keyword(s):  
Root Resorption ◽  
Young Patients ◽  
Third Molar ◽  
Third Molars ◽  
Chi Square ◽  
Cross Sectional ◽  
Exact Test ◽  
Panoramic Radiographs ◽  
Second Molar ◽  
External Root Resorption

Abstract Objective This research investigate the presence of external root resorption (ERR) in second molars caused by impacted third molars in panoramic radiographs, relating to the position of third molars according to classification of Winter, Pell and Gregory. Material and method A cross-sectional, retrospective study using panoramic radiographs obtained from January 2014 to December 2015. The inclusion criterion was the presence of a second molar adjacent to an impacted third molar. Data were analyzed using descriptive and inferential statistics. Pearson's Chi-Square Test and Fisher's Exact Test (p≤0.05) were performed. Result The sample consisted of 584 panoramic radiographs, 356 (60.95%) of women, and 228 (39.05%) of men, the mean age was 25.31 years. The prevalence of ERR was 12.5%, and the group of 14-24 year olds was the most affected (p = 0.46). The presence of ERR was statistically higher in the mandible (42.1%) with p=0.01. The ERR located in the cervical (57.1%) and medium (58.8%) thirds was proportionally higher in the teeth with B2 (p=0.02) and mesio-angular positions (p=0.26). Conclusion The prevalence of ERR in second molars, caused by impacted third molars, was shown to be similar to results found in the literature, with no gender preference, this affects young patients, occurring frequently in mandible teeth, and presents greater severity in the cervical and middle thirds. The B2 and mesio-angular positions were more prone to ERR.

scholarly journals Cancellous bone-like tissue replacement from calcinosis in patients with systemic sclerosis with multiple external root resorption

Bone Reports ◽  
2022 ◽  
pp. 101165
Author(s):  
Takumi Memida ◽  
Shinji Matsuda ◽  
Takashi Nakamoto ◽  
Kazuhisa Ouhara ◽  
Mikihito Kajiya ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Cancellous Bone ◽  
Root Resorption ◽  
Tissue Replacement ◽  
External Root Resorption

scholarly journals Oral manifestations of patients with systemic sclerosis: a meta-analysis for case-controlled studies

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Suhan Zhang ◽  
Junfei Zhu ◽  
Yanshan Zhu ◽  
Xiaochao Zhang ◽  
Ruifang Wu ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Meta Analysis ◽  
Mouth Opening ◽  
Oral Health Status ◽  
Oral Manifestations ◽  
Systemic Complications ◽  
Probing Depth ◽  
Newcastle Ottawa Scale ◽  
Dmft Index ◽  
Interincisor Distance

Abstract Background Systemic sclerosis (SSc) is a multisystem rheumatic disease. Orofacial manifestations are commonly in SSc but maybe usually ignored and overshadowed by other systemic complications. Multiple comparative studies have been conducted to investigate the possible links between SSc and oral manifestations. The present study aimed to investigate the oral health status in patients with SSc. Methods Pubmed, Embase, Web of Science, and Scopus were searched up to July 2020. Following outcomes were evaluated: Probing depth (PD), Attachment loss (AL), Bleeding on probing (BOP), Number or percentage of Sites with PD ≥ 4 mm, Prevalence of periodontitis, Number of teeth, Decayed Teeth, Missing teeth, Filled teeth, DMFT index, and the interincisal distance. Newcastle-Ottawa Scale (NOS) were applied for quality assessment. The statistical analysis was processed using the software STATA. Results 11 eligible studies were included. The maximum interincisor distance was significantly restricted in SSc patients (SMD − 1.061; 95 %CI [− 1.546, − 0.576]; Z = 4.29, P = 0.000).The prevalence of Periodontitis (OR 7.007; 95 %CI [3.529, 13.915]; Z = 5.56, P = 0.000), PD (SMD 3.101; 95 %CI [1.374, 4.829]; Z = 3.52, P = 0.000), AL(SMD 2.584; 95 %CI [0.321, 4.846]; Z = 2.24, P = 0.025), sites with PD ≥ 4mm (SMD 2.071 ; 95 %CI [0.267, 3.875]; Z = 2.25, P = 0.024) and the number of decayed teeth (SMD, 0.186; 95 %CI [0.007, 0.365]; Z = 2.04, P = 0.041) were increased significantly in SSc population in comparison with the controls. Conclusions SSc patients have limited mouth opening, higher periodontitis prevalence, and worse periodontal status, as well as an increased number of decayed teeth. Routinely oral hygiene instruction and initial periodontal treatment is recommended for SSc patients.

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