scholarly journals Flavivirus: From Structure to Therapeutics Development

Life ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 615
Author(s):  
Rong Zhao ◽  
Meiyue Wang ◽  
Jing Cao ◽  
Jing Shen ◽  
Xin Zhou ◽  
...  
Keyword(s):  
Future Development ◽  
Viral Proteins ◽  
Antiviral Drugs ◽  
Positive Polarity ◽  
Virus Infections ◽  
Enveloped Viruses ◽  
African Lineage ◽  
The Past ◽  
Therapeutic Drugs ◽  
Therapeutics Development

Flaviviruses are still a hidden threat to global human safety, as we are reminded by recent reports of dengue virus infections in Singapore and African-lineage-like Zika virus infections in Brazil. Therapeutic drugs or vaccines for flavivirus infections are in urgent need but are not well developed. The Flaviviridae family comprises a large group of enveloped viruses with a single-strand RNA genome of positive polarity. The genome of flavivirus encodes ten proteins, and each of them plays a different and important role in viral infection. In this review, we briefly summarized the major information of flavivirus and further introduced some strategies for the design and development of vaccines and anti-flavivirus compound drugs based on the structure of the viral proteins. There is no doubt that in the past few years, studies of antiviral drugs have achieved solid progress based on better understanding of the flavivirus biology. However, currently, there are no fully effective antiviral drugs or vaccines for most flaviviruses. We hope that this review may provide useful information for future development of anti-flavivirus drugs and vaccines.

scholarly journals Approved Antiviral Drugs over the Past 50 Years

2016 ◽  
Vol 29 (3) ◽  
pp. 695-747 ◽  
Author(s):  
Erik De Clercq ◽  
Guangdi Li
Keyword(s):  
Protease Inhibitors ◽  
Antiviral Drugs ◽  
Nucleoside Analogues ◽  
Virus Infections ◽  
Reverse Transcriptase Inhibitors ◽  
Entry Inhibitors ◽  
The Past ◽  
Polymerase Inhibitors ◽  
Acyclic Nucleoside ◽  
Acyclic Nucleoside Phosphonate

SUMMARYSince the first antiviral drug, idoxuridine, was approved in 1963, 90 antiviral drugs categorized into 13 functional groups have been formally approved for the treatment of the following 9 human infectious diseases: (i) HIV infections (protease inhibitors, integrase inhibitors, entry inhibitors, nucleoside reverse transcriptase inhibitors, nonnucleoside reverse transcriptase inhibitors, and acyclic nucleoside phosphonate analogues), (ii) hepatitis B virus (HBV) infections (lamivudine, interferons, nucleoside analogues, and acyclic nucleoside phosphonate analogues), (iii) hepatitis C virus (HCV) infections (ribavirin, interferons, NS3/4A protease inhibitors, NS5A inhibitors, and NS5B polymerase inhibitors), (iv) herpesvirus infections (5-substituted 2′-deoxyuridine analogues, entry inhibitors, nucleoside analogues, pyrophosphate analogues, and acyclic guanosine analogues), (v) influenza virus infections (ribavirin, matrix 2 protein inhibitors, RNA polymerase inhibitors, and neuraminidase inhibitors), (vi) human cytomegalovirus infections (acyclic guanosine analogues, acyclic nucleoside phosphonate analogues, pyrophosphate analogues, and oligonucleotides), (vii) varicella-zoster virus infections (acyclic guanosine analogues, nucleoside analogues, 5-substituted 2′-deoxyuridine analogues, and antibodies), (viii) respiratory syncytial virus infections (ribavirin and antibodies), and (ix) external anogenital warts caused by human papillomavirus infections (imiquimod, sinecatechins, and podofilox). Here, we present for the first time a comprehensive overview of antiviral drugs approved over the past 50 years, shedding light on the development of effective antiviral treatments against current and emerging infectious diseases worldwide.

Changes in the Teacher Training and Qualification in Bulgaria

2019 ◽  
Vol 7 (3) ◽  
pp. 3-23
Author(s):  
Viara Gyurova
Keyword(s):  
Teacher Education ◽  
Teacher Training ◽  
20Th Century ◽  
Future Development ◽  
Training System ◽  
Development System ◽  
The Past ◽  
Teacher Qualification

Since the beginning of the last decade of the past 20th century, Bulgaria has entered a new, complex stage of its development, with many reforms. Education and teacher training reforms are influenced by the global and European trends, as well as by the national changes (political, economical, social, and technological). The author analyses the main characteristics of the changed teacher training system and teacher qualification and development system. Some of the challenges and directions of the transformation and future development of the teacher education and qualification in Bulgaria are discussed.

Nucleosides and Nucleoside Analogues as Emerging Antiviral Drugs

2020 ◽  
Vol 17 ◽  
Author(s):  
Mohamed Ibrahim Elzagheid
Keyword(s):  
Significant Role ◽  
Mode Of Action ◽  
Crucial Role ◽  
Viral Infections ◽  
Antiviral Drugs ◽  
Review Article ◽  
Nucleoside Analogues ◽  
The Past ◽  
Nucleoside Drugs

: Nucleosides and their analogues have been in use for many years and have become essential for treating patients with viral infections. Many additional nucleoside drugs have been approved over the past decades. This strongly demonstrates how important these compounds are and the crucial role they play. Given that a significant amount of research and literature has been documented regarding nucleoside analogues, this review article mainly focuses the discussion on nucleosides and nucleoside analogous that have proven to play significant role or be emerging in the treatment of known viral infections. This covers the names, structures, applications, toxicity, and mode of action of relevant nucleoside analogues.

Clinical use of Antiviral Drugs

1987 ◽  
Vol 21 (5) ◽  
pp. 399-405 ◽  
Author(s):  
Milap C. Nahata
Keyword(s):  
Influenza A ◽  
Viral Infections ◽  
Antiviral Agent ◽  
Antiviral Drugs ◽  
Investigational Drug ◽  
Virus Infections ◽  
Herpes Encephalitis ◽  
Herpes Simplex Viruses ◽  
Varicella Zoster ◽  
Syncytial Virus

Remarkable progress has been made in antiviral chemotherapy. Six approved antiviral drugs are now available for the treatment of various viral infections. Trifluridine, idoxuridine and vidarabine are all effective in patients with herpes keratitis; trifluridine is preferred due to its low toxicity. Acyclovir is the drug of choice in patients with infections due to herpes simplex viruses, including genital herpes, herpes encephalitis, and neonatal herpes, and infections due to varicella-zoster virus. Amantadine is the only drug currently available for prophylaxis and treatment of influenza A, but an investigational drug, rimantadine, appears to be equally effective and less toxic than amantadine. Ribavirin is the most recently approved antiviral agent for the treatment of respiratory syncytial virus infections. Numerous antiviral drugs are being studied in patients with acquired immunodeficiency syndrome. Although currently available drugs have improved our ability to manage a variety of viral illnesses, much needs to be learned about specific dosage guidelines based on the studies of pharmacokinetics, pharmacodynamics, potential adverse effects and viral resistance, and the role of combination therapy to optimize therapy.

scholarly journals Revitalising Naxi dongba as a ‘pictographic’ vernacular script

2019 ◽  
Vol 3 (1) ◽  
pp. 53-67
Author(s):  
Duncan Poupard
Keyword(s):  
Future Development ◽  
Yunnan Province ◽  
Writing System ◽  
Writing Systems ◽  
Traditional Role ◽  
The Past ◽  
The Future ◽  
English Translations ◽  
Standard Chinese

A script can be a window into a language and all the culture contained within it. China’s minority peoples have a multitude of scripts, but many are in danger of falling out of use, a decline spurred by the adoption and promotion of standard Chinese across the country. Nevertheless, efforts are being made to preserve minority writing systems. This article reveals how the primarily logographic Naxi dongba script (often labelled the world’s ‘last living pictographs’), used in China’s southwestern Yunnan province to record the Naxi language, can be practically used as a modern writing system alongside its more widely known traditional role as a means of recording religious rites, and what exactly separates these two styles of writing. The efforts that have been made to achieve the goal of modernisation over the past decades are reviewed, including the longstanding attempts at Unicode encoding. I make some suggestions for the future development of the script, and employ plenty of examples from recent publications, alongside phonetic renderings and English translations. It is hoped that overall awareness of this unique script can be raised, and that it can develop into a vernacular script with everyday applications.

New challenges in viral hepatitis

Gut ◽  
2012 ◽  
Vol 61 (Suppl 1) ◽  
pp. i1-i5 ◽  
Author(s):  
David Thomas ◽  
Fabien Zoulim
Keyword(s):  
Viral Hepatitis ◽  
Hepatitis Virus ◽  
Virus Infections ◽  
The Past ◽  
Treatment And Prevention ◽  
Introductory Article ◽  
Key Issues ◽  
New Challenges ◽  
Reliable Methods ◽  
Remarkable Progress

Over the past few decades there has been remarkable progress in viral hepatitis. Beginning with discovery of the viral agents, we now have reliable methods to diagnose and monitor all hepatitis virus infections, as well significant advances in treatment and prevention. Nonetheless, important challenges remain. This supplement to Gut looks forward to the next generation of challenges in the field of viral hepatitis, and this introductory article highlights several key issues.

Seismic anisotropy

Geophysics ◽  
2001 ◽  
Vol 66 (1) ◽  
pp. 40-41 ◽  
Author(s):  
Leon Thomsen
Keyword(s):  
Future Development ◽  
Seismic Data ◽  
Seismic Anisotropy ◽  
Practical Interest ◽  
Exploration And Exploitation ◽  
Principal Reason ◽  
The Past ◽  
High Level ◽  
Effective Use

The topic of seismic anisotropy in exploration and exploitation has seen a great deal of progress in the past decade‐and‐a‐half. The principal reason for this is the increased (and increasing) quality of seismic data, of the processing done to it, and of the interpretation expected from it. No longer an academic subject of little practical interest, it is now often viewed as one of the crucial factors which, if not taken into account, severely hampers our effective use of the data. The following brief overview is not intended to be exhaustive, since any such attempt would surely be incomplete. However, it does provide a high‐level survey of the advances seen (at the end of this period) to be important by one who was closely involved, and it directly extrapolates this history to predict the future development of the topic.

Introduction: Current perspectives on positive polarity

Linguistics ◽  
2018 ◽  
Vol 56 (2) ◽  
pp. 283-300
Author(s):  
Mingya Liu ◽  
Gianina Iordăchioaia
Keyword(s):  
Internal Structure ◽  
Negative Polarity ◽  
Positive Polarity ◽  
Negative Polarity Items ◽  
Theoretical Concepts ◽  
Polarity Items ◽  
The Past ◽  
Linguistic Research ◽  
Semantics And Pragmatics ◽  
Different Sources

Abstract Polarity sensitivity has been an established key topic of linguistic research for more than half a century. The study of polarity phenomena can be extremely revealing about the internal structure of a language, as they usually involve an interaction at the interface between syntax, semantics and pragmatics. In the past, most attention was paid to negative polarity items. However, recent years have witnessed a growing interest in positive polarity items. As a continuation of this trend, this issue collects four papers dedicated to positive polarity items, which enrich the empirical domain with novel observations from different languages and appeal to diverse theoretical concepts such as scalarity and presupposition in their modeling of positive polarity. The results show that positive polarity is a distributional phenomenon that has different sources and most likely cannot be modeled in a unifying way, although there may be subsets of positive polarity items that allow unifying accounts.

scholarly journals Endemic and emerging acute virus infections in Indonesia: an overview of the past decade and implications for the future

2018 ◽  
Vol 44 (4) ◽  
pp. 487-503 ◽  
Author(s):  
Wesley de Jong ◽  
Musofa Rusli ◽  
Soerajja Bhoelan ◽  
Sofie Rohde ◽  
Fedik A. Rantam ◽  
...  
Keyword(s):  
Virus Infections ◽  
The Past ◽  
The Future

Social tourism in Mexico: evolution, challenges and future development.

2021 ◽  
pp. 18-29
Author(s):  
Adriana E. Estrada-González
Keyword(s):  
Future Development ◽  
Complex Environment ◽  
The Past ◽  
Definition Of

Abstract This chapter aims to understand the complex environment surrounding social tourism in Mexico. It first provides a discussion regarding the definition of social tourism, followed by an analysis of social tourism in Mexico and its development in the past 45 years. The chapter concludes by presenting policies and initiatives related to social tourism.

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