scholarly journals Lipid Nanoparticles Loaded with Selected Iridoid Glycosides as Effective Components of Hydrogel Formulations

Materials ◽  
2021 ◽  
Vol 14 (15) ◽  
pp. 4090
Author(s):  
Marta Dąbrowska ◽  
Izabela Nowak
Keyword(s):  
Shelf Life ◽  
Raw Materials ◽  
Iridoid Glycosides ◽  
Lipid Nanoparticles ◽  
Transepidermal Water Loss ◽  
In Vivo Studies ◽  
Lipid Nanocarriers ◽  
Product Effectiveness ◽  
Shelf Life Stability

One possibility of improving active ingredient penetration into deeper skin layers to enhance the cosmetic product effectiveness, is the application of lipid nanoparticles. The aim of the study presented in this paper was to evaluate the potential of hydrogel formulations enriched with iridoid glycosides-loaded lipid nanoparticles. Lipid nanocarriers were produced using an emulsification-ultrasonication method based on multiple emulsions. The encapsulation efficiency was determined at the level of 89% and 77% for aucubin and catalpol, respectively. The next stage was the incorporation of the obtained dispersions of lipid nanoparticles into hydrogel formulations, followed by determination of their physicochemical properties, shelf-life stability, and application properties (in vivo tests). The introduction of lipid nanoparticles increased the stabilization of the consistency of the obtained hydrogel formulations, and was confirmed by viscosity measurements. No effect of lipid nanoparticle incorporation on shelf-life stability of the hydrogels was detected. In vivo studies showed improvements in moisture content of the epidermis, transepidermal water loss, skin topography, and macrorelief parameters. In particular, a synergistic effect of the active ingredients and lipid nanoparticles on the anti-wrinkle effect, moisturizing effect, and regeneration of the protective barrier of the stratum corneum was evidenced. The attractiveness of aucubin and catalpol as cosmetic raw materials in hydrogel formulations was evidenced, especially when the iridoid glycosides were applied in the form of lipid nanoparticles.

Phytochemistry and Pharmacology of the Genus Pedicularis Used in Traditional Chinese Medicine

2014 ◽  
Vol 42 (05) ◽  
pp. 1071-1098 ◽  
Author(s):  
Mao-Xing Li ◽  
Xi-Rui He ◽  
Rui Tao ◽  
Xinyuan Cao
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Chemical Constituents ◽  
Iridoid Glycosides ◽  
In Vivo Studies ◽  
Chemical Components ◽  
Wide Range ◽  
Phenylpropanoid Glycosides

In the present review, the literature data on the chemical constituents and biological investigations of the genus Pedicularis are summarized. Some species of Pedicularis have been widely applied in traditional Chinese medicine. A wide range of chemical components including iridoid glycosides, phenylpropanoid glycosides (PhGs), lignans glycosides, flavonoids, alkaloids and other compounds have been isolated and identified from the genus Pedicularis. In vitro and in vivo studies indicated some monomer compounds and extracts from the genus Pedicularis have been found to possess antitumor, hepatoprotective, anti-oxidative, antihaemolysis, antibacterial activity, fatigue relief of skeletal muscle, nootropic effect and other activities.

scholarly journals Progress to Improve Oral Bioavailability and Beneficial Effects of Resveratrol

2019 ◽  
Vol 20 (6) ◽  
pp. 1381 ◽  
Author(s):  
Adele Chimento ◽  
Francesca De Amicis ◽  
Rosa Sirianni ◽  
Maria Sinicropi ◽  
Francesco Puoci ◽  
...  
Keyword(s):  
Solid Dispersions ◽  
Aqueous Solubility ◽  
In Vivo Studies ◽  
Beneficial Effects ◽  
Lipid Nanocarriers ◽  
Methodological Approaches ◽  
Neuroprotective Actions ◽  
Synthetic Derivatives

Resveratrol (3,5,4′-trihydroxystilbene; RSV) is a natural nonflavonoid polyphenol present in many species of plants, particularly in grapes, blueberries, and peanuts. Several in vitro and in vivo studies have shown that in addition to antioxidant, anti-inflammatory, cardioprotective and neuroprotective actions, it exhibits antitumor properties. In mammalian models, RSV is extensively metabolized and rapidly eliminated and therefore it shows a poor bioavailability, in spite it of its lipophilic nature. During the past decade, in order to improve RSV low aqueous solubility, absorption, membrane transport, and its poor bioavailability, various methodological approaches and different synthetic derivatives have been developed. In this review, we will describe the strategies used to improve pharmacokinetic characteristics and then beneficial effects of RSV. These methodological approaches include RSV nanoencapsulation in lipid nanocarriers or liposomes, nanoemulsions, micelles, insertion into polymeric particles, solid dispersions, and nanocrystals. Moreover, the biological results obtained on several synthetic derivatives containing different substituents, such as methoxylic, hydroxylic groups, or halogens on the RSV aromatic rings, will be described. Results reported in the literature are encouraging but require additional in vivo studies, to support clinical applications.

Lipid nanoparticles enhance the absorption of cyclosporine A through the gastrointestinal barrier: In vitro and in vivo studies

2016 ◽  
Vol 500 (1-2) ◽  
pp. 154-161 ◽  
Author(s):  
Melissa Guada ◽  
Beatriz Lasa-Saracíbar ◽  
Hugo Lana ◽  
Maria del Carmen Dios-Viéitez ◽  
Maria J. Blanco-Prieto
Keyword(s):  
Cyclosporine A ◽  
Lipid Nanoparticles ◽  
In Vivo Studies ◽  
Gastrointestinal Barrier

Brain delivery of camptothecin by means of solid lipid nanoparticles: Formulation design, in vitro and in vivo studies

2012 ◽  
Vol 439 (1-2) ◽  
pp. 49-62 ◽  
Author(s):  
Susana Martins ◽  
Ingunn Tho ◽  
Isolde Reimold ◽  
Gert Fricker ◽  
Eliana Souto ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
In Vivo Studies ◽  
Brain Delivery ◽  
Formulation Design ◽  
Solid Lipid

scholarly journals High anticancer efficacy of solid lipid nanoparticles containing Zataria multiflora essential oil against breast cancer and melanoma cell lines

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Alireza Valizadeh ◽  
Ali Asghar Khaleghi ◽  
Ghazaal Roozitalab ◽  
Mahmoud Osanloo
Keyword(s):  
Breast Cancer ◽  
Essential Oil ◽  
Solid Lipid Nanoparticles ◽  
Entrapment Efficiency ◽  
Lipid Nanoparticles ◽  
In Vivo Studies ◽  
Zataria Multiflora ◽  
Anticancer Efficacy ◽  
Solid Lipid

Abstract Background The cancer burden is rising rapidly worldwide, and it annually causes about 8.8 million deaths worldwide. Due to chemical drugs’ side effects and the emergence of resistance, the development of new green drugs has received much attention. We aimed to investigate whether solid-lipid nanoparticles containing essential oil of Zataria multiflora (ZMSLN) enhanced the anticancer efficacy of the essential oil against breast cancer (MDA-MB-468) and melanoma (A-375) cells. Results ZMSLN was prepared by the high-pressure homogenizer method; particle size 176 ± 8 nm, polydispersity index 0.22 ± 0.1, entrapment efficiency 67 ± 5%. The essential oil showed a dose-dependent antiproliferative effect on MDA-MB-468 and A-375 cells at all examined concentrations (75, 150, 300, 600, and 1200 μg/mL). Interestingly, after treating both cells with 75 μg/mL of ZMSLN, their viabilities were reduced to under 13%. Conclusion The finding showed that ZMSLN had a distinct antiproliferative efficacy; it could thus be considered a green anticancer candidate for further in vivo and in vivo studies.

Recent advances in metabolomic analyses of berry fruits and their in vivo metabolites

2021 ◽  
pp. 1-23
Author(s):  
Gizem Catalkaya ◽  
Elwira Sieniawska ◽  
Magdalena Maciejewska-Turska ◽  
Guoyin Kai ◽  
Esra Capanoglu
Keyword(s):  
Biological Activity ◽  
Systems Biology ◽  
Food Intake ◽  
Raw Materials ◽  
Analytical Techniques ◽  
In Vivo Studies ◽  
Food Research ◽  
Living Organisms ◽  
Berry Fruits

Metabolomics, one of the most recent additions to the systems biology toolkit, has been used to study the metabolism and physiology of living organisms. In the field of food research, metabolomics has lately gained popularity as a technique for determining the quality, processing, and safety of raw materials and final food products, as well as for identifying biomarkers linked to food intake and disease. This review aimed to provide an overview of the current understanding of the analytical techniques used for metabolomics and their application to berries with a special emphasis on the in vivo studies. Specifically, identification of biomarkers of biological activity and in vivo metabolites of berries using metabolomics approach is covered.

scholarly journals From Cosmetics to Innovative Cosmeceuticals—Non-Woven Tissues as New Biodegradable Carriers

Cosmetics ◽  
2021 ◽  
Vol 8 (3) ◽  
pp. 65
Author(s):  
Pierfrancesco Morganti ◽  
Gianluca Morganti ◽  
Alessandro Gagliardini ◽  
Alka Lohani
Keyword(s):  
Raw Materials ◽  
Physiological Activity ◽  
Well Being ◽  
In Vivo Studies ◽  
Active Ingredients ◽  
Sustainable Technologies ◽  
New Class ◽  
Medicinal Value

Due to pollution and climate-change fear, further increased by the COVID19 pandemic, consumers are looking for body and mind health by the request of more effective and safe products, including the anti-aging skincare cosmeceuticals.. The term “cosmeceuticals” was coined in 1962 as a fusion of cosmetic and pharmaceutical to cover a new class of products able to achieve aesthetic and drug-like benefits. They not only improve the skin’s appearance, but also treat different dermatological conditions, through a physiological activity, shown by in vitro and in vivo studies. This new category of cosmetics should contain no recognized drugs, but nonetheless have medicinal value. Consumers, in fact, are looking for products able to regenerate the skin and maintain not only a youthful appearance together with well-ness and well-being, but preserving the environment also. Consequently, they are searching for cosmetics and food made with high-quality natural ingredients, packaged with biodegradable materials and realized by sustainable technologies, possibly at zero waste. Consumers, in fact, are afraid of the pollution and plastics invading lands and oceans, causing many frequent disasters on our planet. New and smart tissues and films, made by polysaccharides and natural active ingredients, are proposed as innovative cosmeceuticals. These non-woven tissues, embedded by micro/nano complexes of chitin and lignin encapsulating different active ingredients, could represent a new category of vehicles that are characterized for their high effectiveness and safeness. Moreover, they do not induce allergic nor sensitizing phenomena, being biodegradable; skin- and environmentally friendly; and free of preservatives, emulsifiers, colors, fragrances and any kind of chemicals. Last but not least, polysaccharides, chitin and lignin may be obtained from industrial and agro-forestry waste, safeguarding the natural raw materials for the future generations.

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