Metal-Ceramic Beads Based on Niobium and Alumina Produced by Alginate Gelation

Full metal-ceramic composite beads containing different amounts of niobium and alumina, particularly 100 vol% alumina, 100 vol% niobium, and 95/5 vol% niobium/alumina, were produced by the alginate gelation process. The suspension for bead fabrication contained sodium alginate as gelling agent and was added dropwise into a calcium chloride solution to trigger the consolidation process. After debinding in air, sintering of the composite beads was performed under inert atmosphere. Samples in green and sintered state were analyzed by digital light microscopy and scanning electron microscopy equipped with energy dispersive X-ray spectroscopy. Investigations by mercury intrusion porosimetry revealed that pure alumina beads featured smaller pores compared to composite beads, although the open porosities were comparable. The fracture strength was evaluated on single beads. Contrary to the pure alumina, the composite beads showed a clear plastic deformation. Pure niobium beads showed a ductile behavior with very large deformations. XRD analyses revealed the presence of calcium hexaluminate and beta-alumina as minor phases in the alumina beads, while the composite ones contained about 25 wt% of impurities. The impurities comprised NbO arising from the oxidation, and β-Nb2C, from the reaction with the residual sodium alginate.

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U(VI) adsorption by sodium alginate/graphene oxide composite beads in water

Journal of Radioanalytical and Nuclear Chemistry ◽

10.1007/s10967-021-07598-y ◽

2021 ◽

Author(s):

Dianxin Li ◽

Peng Zhang ◽

Yiqing Yang ◽

Yuqi Huang ◽

Tao Li ◽

...

Keyword(s):

Graphene Oxide ◽

Sodium Alginate ◽

Oxide Composite ◽

Composite Beads

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DESIGN, OPTIMIZATION & IN-VITRO EVALUATION OF SODIUM ALGINATE BASED IN-SITU GEL OF RANITIDINE HYDROCHLORIDE IN ULCER TREATMENT

International Journal of Pharmaceutical and Biological Science Archive ◽

10.32553/ijpba.v9i1.178 ◽

2021 ◽

Vol 9 (1) ◽

Author(s):

Sanket Kumar ◽

Mahesh Singh ◽

Babulal Patel

Keyword(s):

Peptic Ulcer ◽

Drug Release ◽

Sodium Alginate ◽

Gelling Agent ◽

Cross Linking ◽

Physical Interaction ◽

In Situ Gel ◽

Ranitidine Hydrochloride ◽

Ulcer Treatment

Peptic ulcer, it is the most common type of stomach disease, according to the American Gastroenterology Association. “We know that ulcers occur because there has been a disruption in the balance of factors that injure the digestive tract and those factors that protect it from injury,” The present investigation deal with the formulation, optimization and evaluation of sodium alginate based in situ gel of ranitidine hydrochloride (R-HCl) in ulcer treatment. The in-situ formulation are homogenous liquid when administration orally and become gel at the contact site. The evaluation of the formulation is dependent upon accurate results obtained by analytical method used during the study. Accurate results require the use of standard and a calibration procedure. Hence, standard plots of Ranitidine hydrochloride were prepared in (0.1N HCL, pH 1.2) solutions. Two, sodium alginate and calcium carbonate used as a polymer and cross-linking agent respectively in the formulation of in-situ gel. From the IR studies it may be concluded that the drug and carriers used undergo physical interaction there is no chemical change, and thus the gelling agent, cross-linking agent and other excipient is suitable for formulation of in-situ gel of ranitidine hydrochloride. Indicate that the formulation, DKF9 which was prepared by the Sodium alginate (2 gm) with Ranitidine Hydrochloride showed minimum drug release (sustained drug release) after 8 hrs. It can be concluded that the In-situ gel was beneficial for delivering the drug which needs sustained release to achieve the slow action. Keywords: In-situ gel, Peptic Ulcer, Ranitidine Hydrochloride (R-HCl), Sodium alginate.

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DESIGN, DEVELOPMENT, AND EVALUATION OF AN ION-ACTIVATED OPHTHALMIC IN SITU GEL OF MOXIFLOXACIN HYDROCHLORIDE

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2019.v12i3.28086 ◽

2019 ◽

pp. 94-103

Author(s):

GIRISH KONDALKAR ◽

ASISH DEV

Keyword(s):

Drug Release ◽

Sodium Alginate ◽

Statistical Models ◽

Bacterial Infections ◽

Gelling Agent ◽

Design Development ◽

Sustained Drug Release ◽

Exchange Method ◽

In Situ Gelling

Objective: The objective of this study was to develop an in situ ophthalmic gel of an anti-infective drug, moxifloxacin (MOX) hydrochloride (HCL), for sustained ocular delivery for the treatment of bacterial infections of the eye. Method: In the present work the in situ gelling systems were prepared by ion exchange method with the help of various concentrations of gelling agent gelrite (0.08 g, 0.1 g and 0.12 g) and sodium alginate (0.6 g, 0.8 g and 1 g) as viscosity enhancer were added in the formulation; 9 formulations were prepared according to 32 factorial designs and evaluated. The responses were analyzed for the analysis of variance using Design-Expert version 10 software. Statistical models were generated for each response parameter. Results: Optimized formulation batch F7 (0.12% gelrite and 0.6% sodium alginate) was liquid before addition of simulated tear fluid (STF) and underwent rapid gelation on addition of STF and had given 84.05% cumulative drug release; the formulation was found to be clear, having good in situ gelling capacity, good antibacterial efficacy, having drug content 99.75%; optimized formulation was sterile and showed sustained drug release over 8 h period as compared to marketed eye drop. Conclusions: From the above results, we can concluded that 32 full factorial design and statistical models can be successfully used to optimize the formulations, and it was concluded that the trial batch F7 (0.12% gelrite and 0.6% sodium alginate) is the best formula (percentage cumulative drug release over 84.05%) and it is possible to formulate in situ ophthalmic gels of MOX HCL using gelrite in combination with sodium alginate for the treatment of various bacterial infections of the eyes.

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Optimization of Water Fraction Gel Formula of Binahong Leaf (Anredera cordifolia (Ten.) Steen) With Gelling Agent of Sodium Alginate and Carboxymethyl Chitosan Combination

Majalah Obat Tradisional ◽

10.22146/mot.36604 ◽

2018 ◽

Vol 23 (3) ◽

pp. 97

Author(s):

Citra Ariani Edityaningrum ◽

Kintoko Kintoko ◽

Feby Zulien ◽

Lina Widiyastuti

Keyword(s):

Sodium Alginate ◽

Carboxymethyl Chitosan ◽

T Test ◽

Gelling Agent ◽

Physical Parameters ◽

Water Fraction ◽

Lattice Design ◽

Alginate Concentration ◽

Significant Difference ◽

Optimum Formula

Water fraction of binahong (Anredera cordifolia (Ten.) Steen) leaf has been proven to heal ulcus diabetic. In order to make the use easier and more practical, in this study the water fraction of binahong leaves is formulated in gel preparation form. This study was conducted to obtain a comparison of the amount of sodium alginate and carboxymethyl chitosan as gelling agent to produce gel that meets the good physical requirements. The method used to determine the amount of comparison of sodium alginate and carboxymethyl chitosan is to use Simplex Lattice Design (SLD). Eight variations of gel formula are designed with the ratio of sodium alginate: carboxymethyl chitosan as follows: F1 (0:3% w/w), F2 (0:3% w/w), F3 (0.75:2.25% w/w), F4 (1.5:1.5 % w/w), F5 (1.5:1.5% w/w), F6 (2.25:0.75% w/w), F7 (3:0% w/w), F8 (3:0% w/w). Physical parameters observed included pH, viscosity, dispersion, and adherence. Data obtained compared with the actual conducted by researchers using one sample test t-test with 95% confidence level. Based on the results of the study, increased sodium alginate concentration can increase viscosity and adhesiveness and decrease the pH and spreadability of the gel. One sample t-test analysis shows that there is no significant difference between predicted parameter value and actual result so SLD equation can be used to construct gel formula of water fraction of binahong leaf. The conclusion is a combination of sodium alginate 1.546% w/w and carboxymethyl chitosan 1.454% w/w yield gel optimum. Physical parameter response of optimum formula is pH 5.86; viscosity 2000 cps; spreadability of 21,96 cm2; and adhesiveness of 19,81 seconds.

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THE PREPARATION OF COMPOSITE MATERIALS BASED ON MAGNETITE NANOPARTICLES AND SODIUM ALGINATE FOR WASTE WATER PURIFICATION

Contemporary Materials ◽

10.7251/comen1601083a ◽

2016 ◽

Vol 7 (1) ◽

Author(s):

Ayse Z. Aroguz ◽

Vesna Teofilović ◽

Sinem Karademir ◽

Ljiljana Tanasić ◽

Sibel Aydogan ◽

...

Keyword(s):

Waste Water ◽

Composite Materials ◽

Sodium Alginate ◽

Water Purification ◽

Magnetite Nanoparticles ◽

Low Cost ◽

Chemical Precipitation ◽

Layer By Layer ◽

Paper Manufacturing ◽

Composite Beads

The use of synthetic chemical dyes in various industries, including plastics, paper manufacturing, cloth dyeing, printing and leather treatment, has increased considerably over the last years, resulting in the release of dye-containing effluents into the aquatic and soil ecosystems. There are many techniques to remove the waste after dying process (coagulation, chemical precipitation, reverse osmosis, extraction, filtration, biological treatment and adsorption). The releasing of dyes from many industrial plants is environmentally hazardous. The most important goal for the waste water purification is to find the low-cost adsorbents with high selectivity and long life. In our study, an effort has been made to prepare efficient composite materials for dyes removal from aqueous solution based on medium molecular weights deacetylated chitin i.e. poly(D-glucosamine) and a bio-degradable nontoxic anionic polysaccharide sodium alginate filled with magnetite nanoparticles. Alginate composite beads coated with poly(D-glucosamine) were prepared using layer-by-layer (LbL) deposition method. During the adsorption process the concentrations of dyes in solution waste were determined according to the general spectrophotometer method.

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FORMULATION OPTIMIZATION AND EVALUATION OF TINIDAZOLE IN-SITU

Journal of Biomedical and Pharmaceutical Research ◽

10.32553/jbpr.v10i2.856 ◽

2021 ◽

Vol 10 (2) ◽

pp. 20-26

Author(s):

Yaduwanshi Payal ◽

Goswami Anindya ◽

Malviya Neelesh

Keyword(s):

Factorial Design ◽

Sodium Alginate ◽

Dosage Form ◽

Sodium Citrate ◽

The Body ◽

Gelling Agent ◽

Formulation Optimization ◽

Full Factorial ◽

32 Full Factorial Design

The study deals with formulation optimization and evaluation of tinidazole gel by using sodium alginate as gelling agent calcium chloride, sodium citrate were used as cross linking agent. The polymeric solution of drug is in solution form before it administered to the body. But after administration when it comes in contact with acidic pH it’s converted into gel form and the drug tinidazole released from the dosage form constantly and slowly. The formulation is effective for the treatment of gastric ulcer because of Helicobacter pylori. 32 full factorial design were used for the optimization of the formulation 12 trial batches were prepared and 9 factorial design batches in which 2 factor 3 level factorial design were used for the optimization. The concentration of sodium alginate, were taken in 3 level low, medium, high and the prepared formulation were evaluated.

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Ultrasound Phantom Using Sodium Alginate as a Gelling Agent

Journal of Ultrasound in Medicine ◽

10.1002/jum.14252 ◽

2017 ◽

Vol 36 (11) ◽

pp. 2345-2353 ◽

Cited By ~ 1

Author(s):

Minoru Aoyagi ◽

Tomomi Hiraguri

Keyword(s):

Sodium Alginate ◽

Gelling Agent ◽

Ultrasound Phantom

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CP Ti Fabricated by Low Temperature Extrusion of HDH Powder: Application in Dentistry

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.704.351 ◽

2016 ◽

Vol 704 ◽

pp. 351-359 ◽

Cited By ~ 7

Author(s):

Martin Balog ◽

Josko Viskic ◽

Peter Krizik ◽

Zdravko Schauperl ◽

Mateja Snajdar ◽

...

Keyword(s):

Base Material ◽

Cost Effective ◽

Cold Isostatic Pressing ◽

Fatigue Performance ◽

Consolidation Process ◽

Metal Base ◽

Cost Effective Approach ◽

Metal Ceramic ◽

Cp Ti ◽

Iso 14801

Powder metallurgy (PM) commercial purity titanium (CP Ti) was fabricated and studied, with an aim of utilization for dental application. PM CP Ti was manufactured using a cost effective approach, where affordable hydrogenation–dehydrogenation (HDH) process Ti 99.4 wt.% powder was consolidated via the following sequence of PM techniques: cold isostatic pressing, warm vacuum pressing at 420 °C and warm direct extrusion at 500 °C. The paper presents the first studies on processing, microstructure, testing of mechanical properties, fatigue performance and bonding strength with different veneer coatings. By employed consolidation process sound material with low porosity (1.5%) and sustained oxygen content (0.21 wt.%) was attained. The tensile properties obtained for PM CP Ti (UTS = 701 MPa, YS0.2 = 512 MPa, ε = 13 %) were improved over to those for cast / milled CP Ti Grade 4 reference, the material commonly used in dentistry. Tested using the ISO 14801 standard for dental implants, the samples machined from PM CP Ti showed fatigue performance similar to CP Ti Grade 4. PM CP Ti used as a metal base material in restoration metal – ceramic systems showed very good bond strength with three commercially available veneering ceramics and complied with the ISO 9693 standard. Within the limitations of this paper, the preliminary results demonstrated that performance of economic PM CP Ti is equal or superior to CP Ti Grade 4 reference material and it can be used in prosthodontics.

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