scholarly journals Novel Macrolactams from a Deep-Sea-Derived Streptomyces Species

Marine Drugs ◽  
2020 ◽  
Vol 19 (1) ◽  
pp. 13
Author(s):  
Pei Wang ◽  
Dongyang Wang ◽  
Rongxin Zhang ◽  
Yi Wang ◽  
Fandong Kong ◽  
...  
Keyword(s):  
Deep Sea ◽  
Spectroscopic Analysis ◽  
Fermentation Broth ◽  
Light Conditions ◽  
X Ray Diffraction ◽  
Chemical Methods ◽  
Streptomyces Species ◽  
Deep Sea Sediment ◽  
Streptomyces Sp ◽  
X Ray

Four polyene macrolactams including the previously reported niizalactam C (4), and three new ones, streptolactams A–C (1–3) with a 26-membered monocyclic, [4,6,20]-fused tricyclic and 11,23-oxygen bridged [14,16]-bicyclic skeletons, respectively, were isolated from the fermentation broth of the deep-sea sediment-derived Streptomyces sp. OUCMDZ-3159. Their structures were determined based on spectroscopic analysis, X-ray diffraction analysis, and chemical methods. The abiotic formation of compounds 2 and 4 from compound 1 were confirmed by a series of chemical reactions under heat and light conditions. Compounds 1 and 3 showed a selective antifungal activity against Candida albicans ATCC 10231.

scholarly journals Thioester-Containing Benzoate Derivatives with α-Glucosidase Inhibitory Activity from the Deep-Sea-Derived Fungus Talaromyces indigoticus FS688

Marine Drugs ◽  
2021 ◽  
Vol 20 (1) ◽  
pp. 33
Author(s):  
Mingqiong Li ◽  
Saini Li ◽  
Jinhua Hu ◽  
Xiaoxia Gao ◽  
Yanlin Wang ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Deep Sea ◽  
Spectroscopic Analysis ◽  
X Ray Diffraction ◽  
Docking Analysis ◽  
X Ray ◽  
Structure Activity ◽  
Ic50 Value ◽  
Ic50 Values ◽  
Benzoate Derivatives

Eurothiocins C–H (1–6), six unusual thioester-containing benzoate derivatives, were isolated from the deep-sea-derived fungus Talaromyces indigoticus FS688 together with a known analogue eurothiocin A (7). Their structures were elucidated through spectroscopic analysis and the absolute configurations were determined by X-ray diffraction and ECD calculations. In addition, compound 1 exhibited significant inhibitory activity against α-glucosidase with an IC50 value of 5.4 μM, while compounds 4 and 5 showed moderate effects with IC50 values of 33.6 and 72.1 μM, respectively. A preliminary structure–activity relationship is discussed and a docking analysis was performed.

scholarly journals Bioactive Metabolites from the Deep-Sea-Derived Fungus Diaporthe longicolla FS429

Marine Drugs ◽  
2020 ◽  
Vol 18 (8) ◽  
pp. 381
Author(s):  
Zhaoming Liu ◽  
Yuchan Chen ◽  
Saini Li ◽  
Qinglin Wang ◽  
Caiyun Hu ◽  
...  
Keyword(s):  
Deep Sea ◽  
Spectroscopic Analysis ◽  
Methanol Extract ◽  
Tyrosine Phosphatase ◽  
Bioactive Metabolites ◽  
X Ray Diffraction ◽  
Antiproliferative Effects ◽  
X Ray ◽  
Ic50 Value ◽  
First Time

The chemical investigation of a methanol extract of the deep-sea-derived fungus Diaporthe longicolla FS429 led to the isolation of two novel diterpenoids longidiacids A and B (1 and 2), two new polyketides (3 and 4), two new cytochalasin analogues longichalasins A and B (6 and 8) and three known analogues 5, 7, 9. Their structures were elucidated through comprehensive spectroscopic analysis, while the absolute configurations were established by the comparison of the experimental and quantum chemical calculated ECD spectra. The structure of compound 7 was confirmed through X-ray diffraction for the first time. In the bioassays compound 8 exhibited antiproliferative effects against SF-268, with an IC50 value of 16.44 μM. Moreover, compounds 1 and 8 were detected to inhibit 35.4% and 53.5% of enzyme activity of Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) at a concentration of 50 μM.

scholarly journals Terrosamycins A and B, Bioactive Polyether Ionophores from Streptomyces sp. RKND004 from Prince Edward Island Sediment

Marine Drugs ◽  
2019 ◽  
Vol 17 (6) ◽  
pp. 347 ◽  
Author(s):  
Amanda Sproule ◽  
Hebelin Correa ◽  
Andreas Decken ◽  
Bradley Haltli ◽  
Fabrice Berrué ◽  
...  
Keyword(s):  
Prince Edward Island ◽  
Fermentation Broth ◽  
Antibiotic Activity ◽  
Breast Cancer Cell Lines ◽  
X Ray Diffraction ◽  
Streptomyces Sp ◽  
X Ray ◽  
Methoxy Groups ◽  
The One ◽  
Hydroxy Groups

Terrosamycins A (1) and B (2), two polycyclic polyether natural products, were purified from the fermentation broth of Streptomyces sp. RKND004 isolated from Prince Edward Island sediment. The one strain-many compounds (OSMAC) approach coupled with UPLC-HRMS-based metabolomics screening led to the identification of these compounds. The structure of 1 was determined from analysis of NMR, HRMS, and X-ray diffraction data. NMR experiments performed on 2 revealed the presence of two methoxy groups replacing two hydroxy groups in 1. Like other polyether ionophores, 1 and 2 exhibited excellent antibiotic activity against Gram-positive pathogens. Interestingly, the terrosamycins also exhibited activity against two breast cancer cell lines.

Sem and X-Ray Analysis of Renal and Biliary Calculi

1976 ◽  
Vol 34 ◽  
pp. 306-307
Author(s):  
R. J. Narconis ◽  
G. L. Johnson
Keyword(s):  
Chemical Constituents ◽  
Natural State ◽  
X Ray Diffraction ◽  
Chemical Methods ◽  
X Ray ◽  
Additional Dimension ◽  
Biliary Calculi ◽  
Calculus Formation ◽  
Scanning Electron

Analysis of the constituents of renal and biliary calculi may be of help in the management of patients with calculous disease. Several methods of analysis are available for identifying these constituents. Most common are chemical methods, optical crystallography, x-ray diffraction, and infrared spectroscopy. The application of a SEM with x-ray analysis capabilities should be considered as an additional alternative.A scanning electron microscope equipped with an x-ray “mapping” attachment offers an additional dimension in its ability to locate elemental constituents geographically, and thus, provide a clue in determination of possible metabolic etiology in calculus formation. The ability of this method to give an undisturbed view of adjacent layers of elements in their natural state is of advantage in determining the sequence of formation of subsequent layers of chemical constituents.

scholarly journals Photocurrent density and electrical properties of Bi0.5Na0.5TiO3-BaNi0.5Nb0.5O3 ceramics

2021 ◽  
Author(s):  
Mingqiang Zhong ◽  
Qin Feng ◽  
Changlai Yuan ◽  
Xiao Liu ◽  
Baohua Zhu ◽  
...  
Keyword(s):  
Electrical Properties ◽  
Photovoltaic Effect ◽  
Short Circuit ◽  
Short Circuit Current ◽  
Photocurrent Density ◽  
Open Circuit ◽  
Light Conditions ◽  
X Ray Diffraction ◽  
Solid State Method ◽  
X Ray

AbstractIn this work, the (1−x)Bi0.5Na0.5TiO3-xBaNi0.5Nb0.5O3 (BNT-BNN; 0.00 ⩽ x ⩽ 0.20) ceramics were prepared via a high-temperature solid-state method. The crystalline structures, photovoltaic effect, and electrical properties of the ceramics were investigated. According to X-ray diffraction, the system shows a single perovskite structure. The samples show the normal ferroelectric loops. With the increase of BNN content, the remnant polarization (Pr) and coercive field (Ec) decrease gradually. The optical band gap of the samples narrows from 3.10 to 2.27 eV. The conductive species of grains and grain boundaries in the ceramics are ascribed to the double ionized oxygen vacancies. The open-circuit voltage (Voc) of ∼15.7 V and short-circuit current (Jsc) of ∼1450 nA/cm2 are obtained in the 0.95BNT-0.05BNN ceramic under 1 sun illumination (AM1.5G, 100 mW/cm2). A larger Voc of 23 V and a higher Jsc of 5500 nA/cm2 are achieved at the poling field of 60 kV/cm under the same light conditions. The study shows this system has great application prospects in the photovoltaic field.

scholarly journals Study of Green and Chemical Methods for Synthesis of Nano Spinel MgFe2O4 and its Study on Degradation of Rose Bengal Dye

2020 ◽  
Vol 32 (3) ◽  
pp. 501-507
Author(s):  
Krushitha Shetty ◽  
B.S. Prathibha ◽  
Dinesh Rangappa ◽  
K.S. Anantharaju ◽  
H.P. Nagaswarupa ◽  
...  
Keyword(s):  
Combustion Synthesis ◽  
Rose Bengal ◽  
Sol Gel ◽  
Solution Combustion Synthesis ◽  
X Ray Diffraction ◽  
Solution Combustion ◽  
Chemical Methods ◽  
Transfer Resistance ◽  
X Ray ◽  
Rose Bengal Dye

MgFe2O4 nanoferrites were synthesized by sol-gel and solution combustion synthesis (SCS) methods through green and chemical methods. Green and chemical methods for sol-gel were processed with use of lemon extract and citric acid, respectively. A green and chemical method for solution combustion synthesis was followed by using Phyllanthus acidus leaf extract and urea, respectively. The influence of synthesis approach on the behaviour of prepared nanoferrites were studied using powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM) and UV visible spectroscopy, vast variation in particle size, crystallinity, electrochemical and photocatalytic activity of the nanoferrites synthesized by various methods were witnessed. Powder X-ray diffraction (PXRD) result of prepared nanoferrites acquired by green and chemical approaches clarified phase structure as spinel and the crystalline size found to be around 11-24 nm. The spinel surface morphology was witnessed for the synthesized nanoferrites. The tetrahedral and octahedral sites of the prepared nanoferrites were confirmed by FTIR spectra. MgFe2O4 nanoferrites synthesized by green sol-gel approach exposed superior electrochemical activity by possessing very less charge transfer resistance. The results of EIS were correlated with the photocatalytic degradation of Rose Bengal dye. Photocatalytic property of the prepared nanoferrites was examined for photodegradation of Rose Bengal dye under UV-light.

scholarly journals Dechdigliotoxins A–C, Three Novel Disulfide-Bridged Gliotoxin Dimers from Deep-Sea Sediment Derived Fungus Dichotomomyces cejpii

Marine Drugs ◽  
2019 ◽  
Vol 17 (11) ◽  
pp. 596 ◽  
Author(s):  
Zhaoming Liu ◽  
Zhen Fan ◽  
Zhanghua Sun ◽  
Hongxin Liu ◽  
Weimin Zhang
Keyword(s):  
Tumor Cell ◽  
Quantum Chemical Calculations ◽  
Cell Lines ◽  
Deep Sea ◽  
Quantum Chemical ◽  
Biosynthetic Pathway ◽  
Spectroscopic Analysis ◽  
Tumor Cell Lines ◽  
Disulfide Linkage ◽  
Deep Sea Sediment

Dechdigliotoxins A–C (1–3), which represented the first examples of gliotoxin dimers with an unprecedented exocyclic disulfide linkage, were obtained from a deep-sea derived fungus Dichotomomyces cejpii FS110. The structures of these compounds were elucidated on the basis of spectroscopic analysis and the absolute configurations were unambiguously determined through quantum chemical calculations, as well as DP4+ probability simulations. The proposed biosynthetic pathway suggested 1–3 were generated from unusual L-Phe and D-Ser. All the isolates were evaluated for their cytotoxicity against four tumor cell lines.

Quality control in urinary stone analysis: results of 44 ring trials (1980–2001)

2005 ◽  
Vol 43 (3) ◽  
Author(s):  
Albrecht Hesse ◽  
Rolf Kruse ◽  
Wolf-Jochen Geilenkeuser ◽  
Matthias Schmidt
Keyword(s):  
Quality Control ◽  
Infrared Spectroscopy ◽  
Urinary Stone ◽  
Error Rates ◽  
The Body ◽  
X Ray Diffraction ◽  
Stone Analysis ◽  
Chemical Methods ◽  
X Ray ◽  
Pure Substances

AbstractUrinary stone analysis is the most important diagnostic step after stone removal from the body. The methods employed for these analyses are based on diverse analytical principles. Chemical methods are used for detecting individual ions. Infrared spectroscopy is used for examining molecular structures, and X-ray diffraction for determination of the crystalline structure of a substance. Since 1980, a twice-yearly ring trials quality control survey has been on offer to examine the quality of urinary stone analyses. A summary of the results of 44 ring trials (1980–2001) has been compiled for individual pure substances and binary (two-component) mixtures. On average, 100 laboratories have participated in these ring trials. Initially, over 80% of the participants carried out their analyses using chemical methods. In 2001, this figure decreased to a mere 13%. In contrast, a progressive increase in the use of infrared spectroscopy was observed, up to 79% of all participants employed this method. X-Ray diffraction was only employed in a small number of specialised laboratories (5–9%). The chemical methods produced a very high proportion of errors (6.5–94%) with both the pure substances and binary mixtures, whereas high error rates for infrared spectroscopy and X-ray diffraction were confined to individual substances only. Due to the poor results in the ring trials, the majority of laboratories stopped using chemical analysis, which is now considered to be obsolete. Regarding mixtures, error rates of over 10% also occurred with infrared spectroscopy and X-ray diffraction. Ring trials are indispensable for the quality management of urinary stone analysis.

Comparative Spectroscopic Analysis of Maya Wall Paintings from Ek’Balam, Mexico

2014 ◽  
Vol 1618 ◽  
pp. 63-72 ◽  
Author(s):  
A. Alonso ◽  
N. A. Pérez ◽  
J. L. Ruvalcaba Sil ◽  
E. Casanova ◽  
P. Claes ◽  
...  
Keyword(s):  
Spectroscopic Analysis ◽  
Analytical Techniques ◽  
Archaeological Site ◽  
X Ray Diffraction ◽  
X Ray ◽  
Non Invasive ◽  
Yellow Orange ◽  
Pigment Distribution ◽  
The Rich ◽  
Invasive Techniques

ABSTRACTThe Maya archaeological site of Ek’Balam is located in Yucatán, Mexico. This place is known for its artistic tradition of reliefs modeled in stucco as well as the rich pictorial and hieroglyphic texts. Although the mural played a key role in the artistic program architectural of elite groups, most of these remains have not been studied, either by its incomplete or fragile condition, or by localization in inaccessible substructures.In this study, technical aspects of the mural paintings from rooms 12 and 50 of the main building of the site are addressed by the spectroscopic analysis of its materials. Optical microscopy was used to observe the layers superposition and pigment distribution, while the stucco and rock support were characterized by X-ray Diffraction (XRD) and X-ray Fluorescence (XRF). Moreover, the chromatic palette composed of different colors and tones of red, yellow, orange, green, blue and black were analyzed mainly with non-invasive techniques using Raman and FTIR spectroscopies as well as XRF.The information obtained from the combination of these analytical techniques, allowed a better understanding of the similarities and differences between these two rooms that were built during the last construction stage of the Acropolis. These results were also compared with previous analyses of mural painting of this site and other Maya paintings.

scholarly journals Nanangenines: drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensis

2019 ◽  
Vol 15 ◽  
pp. 2631-2643 ◽  
Author(s):  
Heather J Lacey ◽  
Cameron L M Gilchrist ◽  
Andrew Crombie ◽  
John A Kalaitzis ◽  
Daniel Vuong ◽  
...  
Keyword(s):  
Mammalian Cells ◽  
Biosynthetic Pathway ◽  
Spectroscopic Analysis ◽  
Bioinformatics Analysis ◽  
Biosynthetic Gene Cluster ◽  
In Vitro Activity ◽  
X Ray Diffraction ◽  
X Ray ◽  
Drimane Sesquiterpenoids

Chemical investigation of an undescribed Australian fungus, Aspergillus nanangensis, led to the identification of the nanangenines – a family of seven new and three previously reported drimane sesquiterpenoids. The structures of the nanangenines were elucidated by detailed spectroscopic analysis supported by single crystal X-ray diffraction studies. The compounds were assayed for in vitro activity against bacteria, fungi, mammalian cells and plants. Bioinformatics analysis, including comparative analysis with other acyl drimenol-producing Aspergilli, led to the identification of a putative nanangenine biosynthetic gene cluster that corresponds to the proposed biosynthetic pathway for nanangenines.

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