scholarly journals Modestly Elevated Serum Procalcitonin Levels in Patients with Rheumatoid Arthritis Free of Active Infection

Medicina ◽  
2020 ◽  
Vol 56 (10) ◽  
pp. 545
Author(s):  
Khai-Jing Ng ◽  
Hui-Chun Yu ◽  
Hsien-Yu Huang Tseng ◽  
Chia-Wen Hsu ◽  
Ming-Chi Lu
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Linear Regression Analysis ◽  
Elevated Serum ◽  
Multiple Linear Regression Analysis ◽  
Healthy Controls ◽  
Active Infection ◽  
The Difference ◽  
Relationship Of ◽  
The Relationship

Background and objectives: To investigate the serum procalcitonin (PCT) levels among patients with rheumatoid arthritis (RA) without active infection compared with healthy controls and to understand the relationship of PCT with RA disease activity, and treatment received by patients. Materials and Methods: Patients aged 20 years and above with clinician-confirmed diagnosis of RA and healthy volunteers were included during regular outpatient visits, and those with active infection symptoms and signs were excluded. RA disease activity was measured using the Disease Activity Score-28 for Rheumatoid Arthritis with erythrocyte sedimentation rate (DAS28-ESR). Medications received by the patients were also recorded. Results: A total of 623 patients with RA and 87 healthy subjects were recruited in this study. The mean PCT were significantly higher in patients with RA (6.90 ± 11.81 × 10−3 ng/mL) compared with healthy controls (1.70 ± 6.12 × 10−3 ng/mL) (p < 0.001) and the difference remained statistically significant after adjusting for age and sex. In addition, multiple linear regression analysis showed that a lower rank-transformed PCT serum level was significantly correlated with the use of biologics (p = 0.017) and a high DAS28-ESR score (p = 0.028) in patients with RA. Conclusion: Patients with RA have a significantly higher serum PCT levels compared with healthy controls. The use of biologics and an active RA disease activity were associated with a lower level of PCT in patients with RA. Further investigation is required to determine the optimal cutoff value of PCT among patients with RA and its association with disease activity and biologic usage.

scholarly journals AB0256 INCREASED SERUM PROCALCITONIN CONCENTRATION IN PATIENTS WITH RHEUMATOID ARTHRITIS FREE OF ACTIVE INFECTION

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1427.1-1427
Author(s):  
K. J. Ng ◽  
K. Y. Huang ◽  
C. H. Tung ◽  
M. C. Lu ◽  
N. S. Lai
Keyword(s):  
Rheumatoid Arthritis ◽  
Bacterial Infection ◽  
Disease Activity ◽  
Proinflammatory Cytokines ◽  
Linear Regression Analysis ◽  
Manuscript Preparation ◽  
Biologic Agent ◽  
Healthy Controls ◽  
Active Infection ◽  
Age And Sex

Background:Rheumatoid arthritis (RA) is the most common inflammatory arthritis, affecting 0.5-1% of the general population worldwide. Patients with RA are often in a relatively immunocompromised status. Previous study have evaluated procalcitonin (PCT) application among autoimmune and autoinflammatory diseases for the diagnosis of systemic bacterial infection (1, 2) To date, the correlation of baseline PCT levels and RA disease activities, different treatment, or the expression of proinflammatory cytokines in patients with RA remained unknown.Objectives:To investigate the baseline PCT levels among patients with RA without active infection compared with healthy controls and to understand the relationship of PCT with RA disease activity, treatment received by patients, and the expression of proinflammatory cytokines.Methods:Patients aged 20 years and above, with clinician-confirmed diagnosis of RA were included during regular outpatient visits. RA disease activity was measured using the DAS28-ESR.Results:A total of 623 patients with RA and 40 healthy subjects were recruited in this study. The mean PCT were significantly higher in patients with RA (6.90 ± 11.81 * 10-3ng/mL) compared with healthy controls (1.14 ± 3.26 * 10-3ng/mL) (p = 0.002). After adjusted for age and sex, the PCT levels remain significantly elevated in patients with RA (p = 0.001). PCT was not significantly correlated with biologic agent, age, sex, disease duration, disease activity, C-reactive protein, conventional synthetic disease-modifying antirheumatic drugs (csDMARD), and comorbidities. Multiple linear regression analysis showed that PCT was inversely associated with the expression of IL-1β (B = −0.883; CI 95% −1.388, −0.378, p = 0.001) and IFN-α (B = −1.197; CI 95% −2.153, −0.242, p = 0.014) after adjusted for age and sex.Conclusion:Patients with RA have significantly higher baseline PCT compared with healthy controls. The treatment received by patients with RA did not affect the level of PCT. Further investigation is required to determine the optimal cutoff value of PCT among patients with RA before applying it in daily clinical practice.References:[1]Scire CA, Cavagna L, Perotti C, Bruschi E, Caporali R, Montecucco C. Diagnostic value of procalcitonin measurement in febrile patients with systemic autoimmune diseases. Clin Exp Rheumatol. 2006;24(2):123−8.[2]Delevaux I, Andre M, Colombier M, Albuisson E, Meylheuc F, Begue RJ, et al. Can procalcitonin measurement help in differentiating between bacterial infection and other kinds of inflammatory processes? Ann Rheum Dis. 2003;62(4):337−40.Acknowledgments:The authors gratefully acknowledge Dr. Malcolm Koo for advice on statistical analysis and manuscript preparation.Disclosure of Interests:None declared

Elevated Serum Glucose-6-Phosphate Isomerase Correlates with Histological Disease Activity and Clinical Improvement After Initiation of Therapy in Patients with Rheumatoid Arthritis

2010 ◽  
Vol 37 (12) ◽  
pp. 2452-2461 ◽  
Author(s):  
LIE DAI ◽  
LANG-JING ZHU ◽  
DONG-HUI ZHENG ◽  
YING-QIAN MO ◽  
XIU-NING WEI ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Demographic Data ◽  
Elevated Serum ◽  
Serum Marker ◽  
Serum Glucose ◽  
Healthy Controls ◽  
Synovitis Score ◽  
Initiation Of Therapy ◽  
Activity Indices

Objective.To determine serum glucose-6-phosphate isomerase (GPI) concentrations in patients with rheumatoid arthritis (RA), and to test whether they correlate with objective measures of disease activity.Methods.Sera from 116 patients with RA, 69 patients with non-RA rheumatic diseases, and 101 healthy controls were analyzed. Levels of soluble serum GPI were measured by ELISA. Histological disease activity was determined with the synovitis score in synovial needle biopsies from 58 of the 116 patients with RA. Thirty-one of the 58 synovium samples were stained for CD68, CD3, CD20, CD38, CD79a, and CD34 by immunohistochemistry. Demographic data were collected, as well as serological and clinical variables that indicate RA disease activity, for Spearman correlation analysis.Results.Serum GPI level correlated positively with the synovitis score (r = 0.278, p = 0.034). Significantly higher soluble GPI levels were detected in the RA sera compared with sera from healthy controls and the non-RA disease controls (2.25 ± 2.82 vs 0.03 ± 0.05 and 0.19 ± 0.57 μg/ml, respectively; p < 0.0001). The rate of serum GPI positivity was significantly higher in the RA patients than in the non-RA disease controls (64.7% vs 10.1%; p < 0.0001). Spearman analysis showed no significant correlation between serum GPI level and Disease Activity Score in 28 joints at baseline. After initiation of antirheumatic treatments, GPI levels decreased significantly (2.81 ± 3.12 vs 1.44 ± 2.09 μg/ml; p = 0.016), paralleling improvement of the disease activity indices.Conclusion.Elevated serum GPI may be involved in the synovitis of RA and may prove useful as a serum marker for disease activity of RA.

scholarly journals The Influence of the Application of Marketing Mix on the Purchase Decision of Prospective Consumers of Grand Cempaka Housing

2020 ◽  
Author(s):  
Gesang Sudrajad ◽  
J.E Sutanto
Keyword(s):  
Regression Analysis ◽  
Data Analysis ◽  
Quantitative Methods ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Marketing Mix ◽  
Marketing Strategies ◽  
Purchase Decision ◽  
Relationship Of ◽  
The Relationship

The purpose of this study was to examine the effect of simultaneous and partial marketing mix on the purchase decision of prospective consumers of Grand Cempaka Housing.This research uses quantitative methods, and is a survey research from the types of explanatory research whose focus is placed on relational research: studying the relationship of variables. The object of research is the residents of Pasuruan City and the sample in this study is the Prospective Consumer of Grand Cempaka Housing. Data analysis uses multiple linear regression analysis methods.The results of the analysis show that Products, Prices, Places and Promotions simultaneously have a significant effect on the Decision of Purchasing Prospective Consumers of Grand Cempaka Housing. This shows that the marketing mix is one of the marketing strategies that should be considered so that the implementation of the marketing strategy can run successfully because the elements in the marketing mix influence each other. Variables in the marketing mix which include Products, Prices, Places and Promotions partially have a significant effect on the Decision of Purchasing Prospective Consumers of Grand Cempaka Housing. Keywords: marketing mix; purchase decision; property; housing

Disability and Principal Lifetime Occupation in the Elderly

1996 ◽  
Vol 43 (4) ◽  
pp. 317-324 ◽  
Author(s):  
Cristina Geroldi ◽  
Giovanni B. Frisoni ◽  
Renzo Rozzini ◽  
Marco Trabucchi
Keyword(s):  
Linear Regression Analysis ◽  
The Elderly ◽  
Multiple Linear Regression Analysis ◽  
Cognitive Status ◽  
Community Dwelling ◽  
Complete Disappearance ◽  
Italian Population ◽  
White Collar Workers ◽  
The Difference ◽  
Relationship Of

This study addresses the relationship of disability with principal lifetime occupation in the elderly. Daily function, cognitive, and physical health variables were assessed in an Italian population of 524 community-dwelling elders aged seventy and over. Farmers had 1.4 (95% C.I.: 0.6 to 2.2) instrumental daily functions lost higher than white-collar workers. Adjustment for age, education, and financial dissatisfaction with multiple linear regression analysis decreased the difference to a still significant figure of 0.9 (95% C.I.: 0.1 to 1.7). On the contrary, adjustment only for cognitive status resulted in complete disappearance of the association [0.2 functions lost (95% C.I.: −0.5 to 0.9)]. The data indicate that greater disability in the most disadvantaged occupational groups may be due to poorer cognition.

THE RELATIONSHIP OF PLASMA AND SERUM VISCOSITY TO DISEASE ACTIVITY AND SMOKING HABIT IN RHEUMATOID ARTHRITIS

Rheumatology ◽  
1984 ◽  
Vol 23 (1) ◽  
pp. 15-19 ◽  
Author(s):  
J. G. LARKIN ◽  
G. D. O. LOWE ◽  
R. D. STURROCK ◽  
C. D. FORBES
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Smoking Habit ◽  
Relationship Of ◽  
The Relationship

scholarly journals Keputusan Pembelian Melalui Situs Belanja Online terhadap Perilaku Konsumtif Masyarakat dalam Perspektif Ekonomi Islam

2019 ◽  
Vol 3 (2) ◽  
pp. 132-147
Author(s):  
Muhammad Ridwan ◽  
Isnaini Harahap ◽  
Pangeran Harahap
Keyword(s):  
Statistical Tests ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Purchasing Decisions ◽  
Economic Perspective ◽  
Consumption Behavior ◽  
Islamic Economic ◽  
Consumptive Behavior ◽  
Relationship Of ◽  
The Relationship

This study aims to determine the relationship between purchasing decisions, products, prices, services and risks to consumer consumption behavior in Islamic economic perspective The study will observe Lazada Application Users in Medan. The method used is a quantitative approach using multiple linear regression analysis, with statistical tests. The study found that partially there is a relationship of purchase decision to consumptive behavior by 2.013 or 20.13%. Product to consumptive behavior by 2,137 or 21,37%. Price to consumptive behavior by -2.637 or -26.37%. Service to consumptive behavior by 2,893 or 28,93%. Risk to consumptive behavior by 2.043 or 20.43%. Partially there is a relationship between purchasing decisions, products, prices, services and risks to consumer behavior.

scholarly journals Financing needs and financial management practices of banana (Musa balbisiana) farmers in Inopacan, Leyte

2018 ◽  
pp. 107-123
Author(s):  
Pauline Caintic ◽  
Analita Salabao ◽  
Marlon Tambis
Keyword(s):  
Regression Analysis ◽  
Financial Planning ◽  
Financial Management ◽  
Management Practices ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Pests And Diseases ◽  
The Status ◽  
Relationship Of ◽  
The Relationship

This study investigated the financing needs and the financial management practices of banana farmers in Inopacan, Leyte, the relationship between financial management practices to profitability and the relationship of the various socio-demographic variables to the relevant financial management practices. The relevant financial management practices considered in this study were those found to be significantly related to profitability. Results showed that limited capital for labor and the occurrence of pests and diseases particularly bugtok, which is caused by a bacterium called Ralstonia solanacearum, were among the major problems expressed by the banana farmers that need financing. Financial management practices such as monitoring the status of loan and financial planning and budgeting were widely practiced by the farmers. Out of the 25 farmer-respondents who availed of loan, 21 of them monitored the status of their loans. More than half of them also practiced financial planning and budgeting of their income and loan. The multiple linear regression analysis revealed that monitoring financial budgets and comparing farm profitability with that of other farms or benchmarking are significantly and positively related to profitability. The logistic regression analysis showed significant relationships of household size and being able to avail credit with the relevant financial management practices. The results imply that farmers who have more household members and who have availed of credit are more likely to monitor financial budgets and/or compare profitability with other farms.

scholarly journals THE RELATIONSHIP BETWEEN BALANCE AND FLEXIBILITY WITH ABILITY OF DOLLYO CHAGI KICK IN TAEKWONDO ATHLETES IN DENPASAR

2021 ◽  
Vol 9 (2) ◽  
pp. 94
Author(s):  
Ferdi Alkindi ◽  
Made Hendra Satria Nugraha ◽  
Ni Komang Ayu Juni Antari ◽  
I Made Winarsa Ruma
Keyword(s):  
Significant Relationship ◽  
Random Sampling ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Cross Sectional ◽  
A Value ◽  
Cross Sectional Design ◽  
Relationship Of ◽  
The Relationship ◽  
Cluster Random Sampling

Taekwondo is one of the popular martial arts for the young, teenagers, and adults. One of the kicks that are often used and effective to attack opponents in a match is the Dollyo Chagi kick. Balance and flexibility have an important role in creating optimal kick. To determine the relationship between balance and flexibility with ability of dollyo chagi kick in taekwondo athletes in Denpasar. This study was an observational study using a cross sectional design. The study was conducted 4 days at 4 dojang in Denpasar. Sampling was carried out using the cluster random sampling, with a total of 64 subjects participating in 12-16 years. Based on the Spearman rho non parametric analysis test obtained a weak and significant relationship between balance with the ability of dollyo chagi kick, with a value of p=0.034 (p<0.05), and also obtained a moderate and significant relationship between flexibility with the dollyo chagi kick ability, with a value of p=0.008 (p<0.05). Multiple linear regression analysis test was conducted to determine the relationship of balance and fleksibility with the dollyo chagi kick ability and obtain a value of p=0.001 (p<0.05) and a correlation value (R) of 0.469. Keyword: dollyo chagi kick, balance, flexibility.

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