scholarly journals Functional Foods and Bioactive Compounds: A Review of Its Possible Role on Weight Management and Obesity’s Metabolic Consequences

Medicines ◽  
2019 ◽  
Vol 6 (3) ◽  
pp. 94 ◽  
Author(s):  
Melina Konstantinidi ◽  
Antonios E. Koutelidakis
Keyword(s):  
Weight Management ◽  
Bioactive Compounds ◽  
Obesity Prevention ◽  
Functional Foods ◽  
Scientific Evidence ◽  
Epidemiological Studies ◽  
Lipid Absorption ◽  
Beta Oxidation ◽  
Balanced Diet

Background: Weight management and obesity prevention is a basic aim of health organizations in order to decrease the prevalence of various metabolic disorders. The aim of the present review article was the evaluation of the possible role of functional foods and their bioactive compounds as alternative way to promote weight management and prevent obesity and its metabolic consequences. Methods: Approximately 100 articles were selected from Scopus, PubMed, Google Scholar, and Science Direct, by using relative key words, and based mainly on recent animal, clinical or epidemiological studies. Results: The literature review highlighted the possible effect of specific functional foods such as coffee, green tea, berries, nuts, olive oil, pomegranate, avocado, and ginger. Specific bioactive compounds of those foods—such as caffeine, catechins, gallic acid, anthocyanins, ascorbic acid, polyphenols, oleuropein, capsaicin, and quercetin—may contribute to weight management, obesity prevention, and obesity’s metabolic consequences. The possible mechanisms include effect on satiety, lipid absorption, fatty acids beta oxidation, stimulation of thermogenesis, etc. Conclusions: Functional foods, as part of a balanced diet, could be useful in the direction of weight management and decrease of obesity’s’ metabolic consequences. However, the scientific evidence is unclear and in most cases controversial and more clinical and epidemiological studies are needed in order to further investigate the mechanisms of their possible effect.

scholarly journals Dietary Bioactive Compounds and Human Health and Disease

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 348 ◽  
Author(s):  
Sonia González
Keyword(s):  
Human Health ◽  
Bioactive Compounds ◽  
Scientific Evidence ◽  
Health And Disease ◽  
Nutritional Compounds ◽  
Dietary Bioactive Compounds

In the last century, solid scientific evidence has demonstrated the role of nutritional compounds in the maintenance of health [...]

scholarly journals Analysis of contemporary epidemiological study research design formats on addressing functional food efficacy

2021 ◽  
Vol 1 (12) ◽  
pp. 97
Author(s):  
Pooja Agarwal ◽  
Emma Rutter ◽  
Danik M Martirosyan
Keyword(s):  
Epidemiological Study ◽  
Research Design ◽  
Bioactive Compounds ◽  
Functional Food ◽  
Functional Foods ◽  
Controlled Trial ◽  
Epidemiological Studies ◽  
Review Article ◽  
Cross Sectional ◽  
Study Research

The entirety of this particular review article demonstrates an in-depth analysis of the overall functionality of nutritional functional foods, imperative bioactive compounds, and essential biomarkers within the metabolic pathway and in chronic disease progression. Specifically, this review article assesses the efficacy of a plethora of functional foods and their associated bioactive compounds via the interpretation of epidemiological research studies that were conducted in the following design formats: cohort design, case-control design, cross-sectional design, and randomized controlled trial design. Although there has been a source of ambiguity demonstrated by food scientists and government organizations surrounding what would be the standard definition of functional food, this review article attempts to advocate for a contemporary definition that acknowledges the primary attributes of present-day functional food. Having said this, the main intention of this review article is to help address the necessity of analyzing the overarching efficacy of specific functional foods via the analysis of different retrospective epidemiological studies. Moreover, this review article will acknowledge which specific epidemiological study research design format is most applicable in the evaluation of functional food products within upcoming epidemiological studies. Ultimately, food scientists and nutritionists alike will get the opportunity to develop an all-encompassing contemporary definition for functional food upon the recognition and incorporation of different epidemiological study research design formats in a timely and cost-effective manner. KEYWORDS: Functional food, bioactive compounds, biomarkers, epidemiology, cohort design, case-control design, cross-sectional design, and randomized controlled trial design.

scholarly journals FFC’s Advancement of Functional Food Definition

2018 ◽  
Vol 8 (7) ◽  
pp. 385 ◽  
Author(s):  
Johanna Gur ◽  
Marselinny Mawuntu ◽  
Danik Martirosyan
Keyword(s):  
Bioactive Compounds ◽  
Functional Food ◽  
Functional Foods ◽  
Scientific Evidence ◽  
Psychological Function ◽  
Comprehensive Understanding ◽  
Physiological Mechanisms ◽  
Food Center ◽  
Definition Of ◽  
Improve Health

Background: To create functional food products based on scientific evidence, we must first define functional foods. Previous definitions describe how functional foods improve health and mitigate disease. However, more refined definitions provide a reason for their efficacy–through the activity of bioactive compounds and the measurement of biomarkers, which are the essential tools for gauging the effectiveness of functional foods.Functional foods are generally linked to health promotion. The physiological effects of functional food or bioactive compounds may vary, but their categories of action include physical performance, cognitive, behavioral, and psychological function, organ or system function, and combating chronic disease [1, 2].Therefore, establishing a formal definition for these foods will help bring legitimate functional foods to the market. The addition of bioactive compounds, or biochemical molecules that improve health through the physiological mechanisms, improves the definition of functional foods. As a result, the advancement of the functional food definition by the Functional Food Center (FFC) has developed to provide clarity and a more comprehensive understanding of its meaning. 

Antiplatelet effects of bioactive compounds present in tomato pomace

2021 ◽  
Vol 22 ◽  
Author(s):  
Eduardo Fuentes ◽  
Andrés Trostchansky ◽  
Lívia Mateus Reguengo ◽  
Mario Roberto Maróstica Jr. ◽  
Iván Palomo
Keyword(s):  
Bioactive Compounds ◽  
Epidemiological Studies ◽  
Protective Role ◽  
Tomato Pomace ◽  
Tomato Paste ◽  
Research Outcomes ◽  
Functional Product ◽  
Antithrombotic Effects ◽  
Vegetables And Fruits

Abstract: Cardiovascular diseases (CVD) currently account for nearly half of no communicable diseases. Epidemiological studies have demonstrated the cardiovascular protective role of a diet rich in vegetables and fruits. In this context, our research outcomes have demonstrated the antiplatelet activities of fruits and vegetable extracts widely consumed, among which tomato was highlighted in our lab work. Tomato pomace, a major byproduct of tomato paste production, consists of skin and seeds and is a rich source of bioactive compounds. Tomato pomace has potent antithrombotic effects, even greater than the tomato. Given the large volumes of an industrial generation of tomato pomace, there is an opportunity to use this by-product to obtain a functional product with antiaggregant and antithrombotic properties that could be useful as an additive in health foods and thus prevent CVD. This review will focus on the platelet as the target for the antithrombotic actions exerted by the different bioactive compounds present in tomato pomace.

Role of Diet, Functional Foods, and Nutraceuticals in Brain Disorders

2021 ◽  
pp. 502-525
Author(s):  
Vandana Bharat Patravale ◽  
Shivraj Vasantrao Naik ◽  
Shrikant Ninaji Dhage
Keyword(s):  
Functional Foods ◽  
Epidemiological Studies ◽  
Therapeutic Options ◽  
Brain Disorders ◽  
Brain Disorder ◽  
Safety And Efficacy ◽  
Prevention And Treatment ◽  
Alternative Approaches ◽  
The Brain

This chapter presents an overview of various complementary nutritional approaches for the management of brain disorders. Numerous epidemiological studies emphasize the growing burden of brain disorders worldwide. Due to the complex pathophysiology, lack of precise diagnostic and therapeutic options, there is growing need to have alternative approaches. One important strategy for the prevention and treatment of brain impairment is based on dietary supplements, functional foods, and nutraceuticals. The current chapter illustrates various aspects of available nutritional products for the brain disorder. Considering the recent surge in the nutritional products and as it destined to play an important role in future, existing regulatory framework is explained here which ensures purity, safety, and efficacy of the marketed products.

scholarly journals Comprehensive Analysis and Assessment of the Role of Major Bioactive Compounds Isolated from Justicia Adhatoda Leaves as Potent Antimycobacterial Agents

2022 ◽  
Author(s):  
Smita Mishra ◽  
Manisha Khatri ◽  
Varsha Mehra
Keyword(s):  
Bioactive Compounds ◽  
Ex Vivo ◽  
Scientific Evidence ◽  
Traditional Medicines ◽  
Ancient Times ◽  
Infectious Pathogen ◽  
Justicia Adhatoda ◽  
Global Population

Abstract Tuberculosis (TB) continues to be one of the world's leading causes of death by the infectious pathogen Mycobacterium tuberculosis, which infects one-third of the global population. The emergence of the COVID-19 pandemic made its spread rapid and the treatment task more daunting. With the havoc of infectious disease expansion, traditional medicines have triggered tremendous interest worldwide. However, less availability of scientific evidence still hinders its practical use. In the present study, we evaluated the potential of the traditional medicinal plant, Justicia adhatoda, which has been used to treat respiratory ailments since ancient times. We have successfully isolated and characterized several bioactive compounds viz- Vasicoline, Vasicolinone, Adhatodine, Adhavasine, Aniflorine, and Vasicinone from J. adhatoda plant leaves, including Vasicine as the principal compound, and showed their anti-tubercular activity on nutrient-starved Mycobacterium smegmatis and Mycobacterium bovis. The study also directs their in-vitro and ex-vivo antimycobacterial potential on THP1 macrophages with internalized Mycobacterium. Our study is one of its first kind, where we assessed the synergistic antimycobacterial effect of the isolated compounds with the first-line drug Isoniazid (INH). Their potential role in promoting phagolysosome fusion and apoptosis of M. bovis infected THP1 macrophages is further evaluated.

scholarly journals Calcium intake and the outcome of short-term weight management

2008 ◽  
pp. 237-245
Author(s):  
K Kabrnová-Hlavatá ◽  
V Hainer ◽  
M Gojová ◽  
P Hlavatý ◽  
V Kopský ◽  
...  
Keyword(s):  
Weight Loss ◽  
Weight Management ◽  
Calcium Intake ◽  
Epidemiological Studies ◽  
Fat Free Mass ◽  
Obese Women ◽  
Short Term ◽  
Significant Difference ◽  
Eating Inventory

Experimental and epidemiological studies suggest that calcium intake is inversely related to weight gain. Calcium of dairy origin has been shown to be more effective in promoting weight loss. However, clinical studies yielded controversial results concerning the role of calcium intake in weight change. The aim of this study was to ascertain whether the addition of calcium can affect the outcome of 3-week weight management (WM) with a hypocaloric diet characterized by a decreased calcium intake. Overweight/ obese women (n=67; BMI 32.2±4.1 kg/m2; age 49.1±12.1 years) underwent a 4-week comprehensive WM program. WM included a 7 MJ/day diet resulting in a stable weight during the first week and a 4.5 MJ/day diet with mean daily calcium intake 350 mg during the second to fourth week. Participants were divided into three age- and BMI-matched groups who received placebo or calcium (500 mg/day). Calcium was administered either as carbonate or calcium of dairy origin (Lactoval). There was no significant difference in weight loss in response to WM between the placebo-treated and calcium-treated groups. However, addition of calcium to the diet resulted in a lower hunger score in the Eating Inventory as well as a decrease in plasma resistin levels. Body composition measured by bioimpedance demonstrated that added calcium leads to preservation of fat-free mass. Nevertheless, a greater loss of fatfree mass in the placebo group might be partly due to a greater loss of water.

scholarly journals Hair loss: A review of the role of food bioactive compounds

2019 ◽  
Vol 2 (5) ◽  
pp. 94 ◽  
Author(s):  
Grace Wei ◽  
Danik Martirosyan
Keyword(s):  
Bioactive Compounds ◽  
Rice Bran ◽  
Hair Loss ◽  
Hair Growth ◽  
Functional Foods ◽  
Experimental Studies ◽  
In Vivo Studies ◽  
Current Standard ◽  
The Impact

Background: The impact that hair loss has on an individual's psychological wellness, and subsequent quality of life, is widespread and long lasting. The current standard treatments for hair loss include surgery and medications, ranging from over-the-counter treatments to corticosteroid injections and immunosuppressants. Unfortunately, these current treatments are either expensive, invasive, or have extremely negative side effects. Recently, the role of vitamins, minerals, and functional foods with their associated bioactive compounds, have gained increasing recognition as a potential means to address this issue. Some of these compounds have been shown to decrease the risk of specific forms of hair loss, particularly alopecia, a form of balding that results due from an autoimmune disorder. These include experimental studies using black raspberry extract and egg yolks as well as epidemiological studies using Mediterranean diets and various micronutrients. Other compounds have been shown to promote hair growth on a more general scale, including in vivo studies using rice bran extract and mouse models using red ginseng oil and annurca apple polyphenols. This review identifies key hair growth promoting vitamins, minerals, and functional foods, as well as summarizes the relevant mechanisms of action of these compounds that have been elucidated. Knowledge regarding the effects of these nutriceuticals on reducing hair loss is rapidly expanding. However, it is imperative that further research be done in order to delineate mechanisms of actions for all compounds related to managing and treating hair loss and subsequently integrate these dietary modifications into clinical treatment recommendations for hair loss.Keywords: Hair loss, alopecia, berry extract, mediterranean diet, rice bran, ginseng, annurca apple, thuja orientalis, marine supplement, honey, egg yolk, functional foods, bioactive compounds

Medical management: lifestyle and behavioural changes

ESC CardioMed ◽  
2018 ◽  
pp. 1384-1387
Author(s):  
Nicolas Danchin ◽  
Etienne Puymirat ◽  
Nadia Aissaoui
Keyword(s):  
Lifestyle Modification ◽  
Scientific Evidence ◽  
Saturated Fat ◽  
Epidemiological Studies ◽  
Balanced Diet ◽  
Obesity And Diabetes ◽  
Artery Disease ◽  
Long Term Impact ◽  
Meta Analyses

Numerous epidemiological studies have reported diverse associations between lifestyle and coronary artery disease. Clinical trials assessing the long-term impact of lifestyle modification, however, are scarce, and most of current recommendations are therefore based upon weak scientific evidence. Smoking cessation is a major component of lifestyle adaptation in smokers, and its benefits are not disputed. Regular physical activity is also beneficial, although the optimal amount of physical exercise is uncertain. Regarding nutrition, a balanced diet with increased vegetable and fruit intake, as well as olive oil and nuts are likely to be beneficial; the conventional regimen limiting the amount of saturated fat is not supported by the most recent meta-analyses on the topic. Finally, other lifestyle aspects are important, in particular stress management and addressing specific risk factors such as obesity and diabetes.

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