scholarly journals Exploration of Blood Lipoprotein and Lipid Fraction Profiles in Healthy Subjects through Integrated Univariate, Multivariate, and Network Analysis Reveals Association of Lipase Activity and Cholesterol Esterification with Sex and Age

Metabolites ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 326
Author(s):  
Yasmijn Balder ◽  
Alessia Vignoli ◽  
Leonardo Tenori ◽  
Claudio Luchinat ◽  
Edoardo Saccenti
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Network Analysis ◽  
Predictive Modeling ◽  
Healthy Subjects ◽  
Blood Donors ◽  
Lipid Fraction ◽  
Strong Association ◽  
Men And Women ◽  
Main Fraction ◽  
Age Dependent

In this study, we investigated blood lipoprotein and lipid fraction profiles, quantified using nuclear magnetic resonance, in a cohort of 844 healthy blood donors, integrating standard univariate and multivariate analysis with predictive modeling and network analysis. We observed a strong association of lipoprotein and lipid main fraction profiles with sex and age. Our results suggest an age-dependent remodulation of lipase lipoprotein activity in men and a change in the mechanisms controlling the ratio between esterified and non-esterified cholesterol in both men and women.

Measuring Mobility of the Metacarpophalangeal Joints II, III, IV, and V in the Dorso-Volar Plane

1984 ◽  
Vol 13 (1) ◽  
pp. 15-20 ◽  
Author(s):  
C Wagner ◽  
D Drescher
Keyword(s):  
Healthy Subjects ◽  
Reliability And Validity ◽  
Repeated Measurements ◽  
Interrater Agreement ◽  
Range Of Movement ◽  
Men And Women ◽  
Examination Method ◽  
Total Range ◽  
Flexion And Extension

An electronic gravity goniometer was developed for determining the passive range of movement of the MCP joints II, III, IV, and V in the dorso-volar plane by the use of preset torques. Test–retest measurements on 23 healthy subjects between the ages of 18 and 57 demonstrated high intrarater and interrater agreement for determining the total range. In the determination of the amounts of flexion and extension the measurement of the flexion was less reliable. There was overall evidence of a declining tendency of reliability from MCP joint II to MCP joint V, probably caused by different reactions of the joints to repeated measurements. The higher total range of the MCP joints in women was principally caused by a higher range of extension. In the case of men and women the range of MCP joint V was noticeably greater than that of the other three joints. The mobility of the four MCP joints correlates relatively closely as a whole, however, in the case of the non-adjacent joints less closely than with the adjacent joints. Reliability and validity of the examination method were balanced against one another with regard to testing of the biomechanical pre-conditions for manual dexterity.

scholarly journals Studies on Spontaneous Platelet Aggregation (PAT III) in Patients with Vascular Disease

1977 ◽  
Author(s):  
H.J. Krzywanek ◽  
K. Breddin
Keyword(s):  
Platelet Aggregation ◽  
Healthy Subjects ◽  
Age Groups ◽  
Arterial Disease ◽  
Peripheral Occlusive Arterial Disease ◽  
Age Dependent ◽  
Patient Groups ◽  
The Difference ◽  
Spontaneous Platelet Aggregation ◽  
Prospective Investigation

Aggregation tests were performed in 345 patients with peripheral occlusive arterial disease (PAD), 274 patients with coronary heart disease (CHD), and 502 diabetics (D). 263 healthy volunteers (N) served as controls. As in previous studies an age dependent increase of strongly enhanced spontaneous platelet aggregation in obviously healthy subjects can be demonstrated, reaching 28% in the 50-59 years’age group. In the various patient groups the incidence of enhanced aggregation is much higher throughout all age groups than in the control s.The overall incidence of missing spontaneous platelet aggregation vs. strongly enhanced aggregation is summarized below. The difference between normals and the various patient groups is significant (X2-test, α<0.0001).A prospective investigation has been started to establish whether enhanced spontaneous platelet aggregation is a risk factor and an early indicator of progressive atherosclerosis.

scholarly journals Induction of superoxide dismutase in leukocytes by paraquat: correlation with age and possible predictor of longevity

Blood ◽  
1990 ◽  
Vol 76 (4) ◽  
pp. 835-841 ◽  
Author(s):  
Y Niwa ◽  
K Ishimoto ◽  
T Kanoh
Keyword(s):  
Superoxide Dismutase ◽  
Healthy Subjects ◽  
Oxygen Species ◽  
Peripheral Blood Leukocytes ◽  
Blood Leukocytes ◽  
Sod Activity ◽  
Elderly Individuals ◽  
Age Dependent ◽  
O2 Production

Reactive oxygen species (ROS) are thought to play a role in the aging process as well as in a number of human diseases states. Superoxide dismutase (SOD), an enzyme that scavenges the superoxide anion (O2-) is constitutively expressed in leukocytes and other tissues. When assayed in peripheral blood leukocytes (PBL), constitutive SOD activity shows little variation among individuals of different ages. We have found that significant induction of SOD activity occurs in PBL incubated in vitro with paraquat, an agent known to cause intracellular O2- production. This induction was found to be highly age dependent; lymphocytes from 36 healthy subjects aged 20 to 40 years showed an increase of 85% +/- 10%, versus an increase of only 8% +/- 1% for lymphocytes from 30 healthy subjects aged 65 to 79 years (P less than 10(-4)). Forty subjects, aged 67 to 73 years, who were healthy at the time of assay of leukocyte SOD induction were followed up 5 years later. Nineteen of these subjects had died; all 19 had shown SOD induction of less than 10% (range, 0% to 7%; mean, 2.4%). In contrast, of the 21 survivors (range, 2.5% to 50%; mean, 21%), 12 had shown SOD induction greater than 10%, and 7 had shown SOD induction greater than or equal to 35% (P less than 10(-3)). Thirteen of the 19 deaths were attributable to malignancy or cerebrocardiovascular disease. Preservation of leukocyte SOD inducibility appears to correlate with longevity in elderly individuals and may be of value in predicting resistance to malignancy or fetal cardiovascular events.

Age-Dependent Increase ofCampylobacter pyloriAntibodies in Blood Donors

1989 ◽  
Vol 24 (1) ◽  
pp. 110-114 ◽  
Author(s):  
T. U. Kosunen ◽  
J. Höök ◽  
H. I. Rautelin ◽  
G. Myllylä
Keyword(s):  
Blood Donors ◽  
Age Dependent

scholarly journals Seroprevalence Study of Anti-HEV IgG among Different Adult Populations in Corsica, France, 2019

2019 ◽  
Vol 7 (10) ◽  
pp. 460 ◽  
Author(s):  
Capai ◽  
Masse ◽  
Gallian ◽  
Souty ◽  
Isnard ◽  
...  
Keyword(s):  
Risk Factors ◽  
General Practice ◽  
Blood Donors ◽  
Adult Population ◽  
Strong Association ◽  
Hepatitis E ◽  
Cross Sectional Study ◽  
Antibody Detection ◽  
P Value ◽  
Cross Sectional

Hepatitis E virus (HEV) is a major cause of acute hepatitis worldwide. In France, hyperendemic areas including Corsica have an anti-HEV Immunoglobulin G (IgG) prevalence higher than 50%. The aim of this study was to determine the seroprevalence of anti-HEV IgG in three adult populations in Corsica and the risk factors associated with antibody detection. Between 2017 and 2019, a total of 930 individuals, including 467 blood donors, 393 students or university staff members and 70 patients from general practice, were tested for the presence of anti-HEV IgG using the Wantai HEV IgG enzyme immunoassay kit and filled a questionnaire. The association between seropositivity and potential risk factors was tested with univariate and multivariate analyses. Out of the 930 samples, 52.3% (486/930) were seropositive—54.4% (254/467) among blood donors, 47.6% (187/393) among university students and 64.3% (45/70) among patients of general practice. Three main risk factors were identified: (i) skinning and butchering (Adjusted Odds Ratio aOR = 2.76, 95% confidence interval [95% CI] [1.51–5.37]; p-value < 10−3), (ii) consumption of a local pork live raw sausage (fittonu) (aOR = 1.95 95% CI [1.45–2.64]; p-value = 10−5), and (iii) increasing age (p-value = 0.003). Seropositivity rates between the different populations were homogeneous after age stratification. This cross-sectional study indicates a high anti-HEV IgG seroprevalence in the Corsican adult population, not significantly different between women and men and increasing with age. This serosurvey also showed homogeneity regarding the exposure to HEV among three different types of populations. Finally, we confirmed the endemicity of Corsica with respect to HEV and identified a strong association between consumption of figatellu/fittonu and the practice of skinning and butchering with the detection of anti-HEV IgG.

scholarly journals The Age-Related Performance Decline in Ironman 70.3

2020 ◽  
Vol 17 (6) ◽  
pp. 2148
Author(s):  
Kristian Jäckel ◽  
Caio Sousa ◽  
Elias Villiger ◽  
Pantelis Nikolaidis ◽  
Beat Knechtle
Keyword(s):  
Age Group ◽  
Men And Women ◽  
Race Time ◽  
Recreational Athletes ◽  
Age Related ◽  
Age Dependent ◽  
Performance Decline ◽  
Sport Events ◽  
Ironman Distance

Although the age-related decline in sport events has been well studied, little is known on such a decline in recreational triathletes for the Half Ironman distance. Indeed, the few existing studies concentrated on specific aspects such as top events, elite groups, some consecutive years, single locations, or age categories instead of analyzing all the data available. Therefore, the aim of the present study was to examine recreational triathletes’ performance in three split disciplines (swimming, cycling, and running) as well as in overall race time by analyzing all data of Half Ironman finishers found on ironman.com (i.e., 690 races; years 2004 through 2018; 206,524 women (24.6%) and 633,576 men (75.4%), in total 840,100 athletes). The age-dependent decline in Half Ironman started earliest in swimming (from the very first age group on) with a smallest age group delta between 35–49 years in men and 40–54 years in women. The performance decline started at 26 and 28 years in men and women for running; at 34 years for men and 35 years for women in cycling; and at 32 years for men and 31 years for women with regard to overall race time. The results may be used by coaches and recreational athletes alike to plan a triathlon career.

scholarly journals Detection of Specific Antibodies against Toscana Virus among Blood Donors in Northeastern Italy and Correlation with Sand Fly Abundance in 2014

2020 ◽  
Vol 8 (2) ◽  
pp. 145 ◽  
Author(s):  
Silvia Morini ◽  
Mattia Calzolari ◽  
Giada Rossini ◽  
Nadia Pascarelli ◽  
Andrea Porcellini ◽  
...  
Keyword(s):  
Blood Donors ◽  
Strong Association ◽  
Immunofluorescence Assay ◽  
Sand Fly ◽  
Seroprevalence Rate ◽  
Toscana Virus ◽  
Serum Samples ◽  
Explanatory Variables ◽  
Northeastern Italy ◽  
Microneutralization Test

Toscana virus (TOSV) is a Phlebovirus transmitted by phlebotomine sand flies and is an important etiological agent of summer meningitis in the Mediterranean basin. Since TOSV infection is often asymptomatic, we evaluated the seroprevalence in blood donors (BDs) in the Bologna and Ferrara provinces (Northeastern Italy)—the areas with the highest and lowest numbers of TOSV neuroinvasive cases in the region, respectively. A total of 1208 serum samples from BDs were collected in April–June 2014 and evaluated for the presence of specific TOSV-IgG by ELISA. The IgG-reactive samples were confirmed by indirect immunofluorescence assay (IIF) and by microneutralization test (MN). Serum samples were defined as positive for anti-TOSV IgG when reactive by ELISA and by at least one second-level test; TOSV seroprevalence was 6.8% in the Bologna province, while no circulation of TOSV was detected in the Ferrara province. Sand fly abundance in 2014 was also estimated by a geographic information system using a generalized linear model applied to a series of explanatory variables. TOSV seroprevalence rate was strongly associated with the sand fly abundance index in each municipality, pointing out the strong association between sand fly abundance and human exposure to TOSV.

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