scholarly journals The Radiation Sterilization of Ertapenem Sodium in the Solid State

Molecules ◽  
2019 ◽  
Vol 24 (16) ◽  
pp. 2944
Author(s):  
Karolina Kilińska ◽  
Judyta Cielecka-Piontek ◽  
Robert Skibiński ◽  
Daria Szymanowska ◽  
Andrzej Miklaszewski ◽  
...  
Keyword(s):  
Solid State ◽  
Physicochemical Properties ◽  
High Performance ◽  
Degradation Products ◽  
Radiation Sterilization ◽  
Scanning Calorimetry ◽  
Beam Radiation ◽  
Promising Alternative ◽  
Ft Ir ◽  
First Time

For the first time, the influence of ionising radiation on the physicochemical properties of ertapenem in solid state was studied. During our studies, we evaluated the possibility of applying radiosterilization to obtain sterile ertapenem. Spectroscopic (Fourier Transform Infrared (FT-IR)), thermal (differential scanning calorimetry (DSC), chromatography (High-Performance Liquid Chromatography (HPLC) and HPLC-MS), and X-ray powder diffraction (XRPD) studies shown that irradiation of ertapenem with the 25 kGy, the dose required to achieve sterility, does not change the physicochemical properties of the studied compound. The antimicrobial activity of ertapenem irradiated with the dose of 25 kGy was only reduced for one species. Based on the received results, we can conclude that radiostelization is a promising alternative method of obtaining sterile ertapenem. In our studies, ertapenem was also exposed to e-beam radiation with a dose of 400 kGy. It was determined that two novel degradation products that are structurally differently to degradants formed during hydrolysis and thermolysis.

scholarly journals The Radiostability of Meropenem Trihydrate in Solid State

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2738 ◽  
Author(s):  
Karolina Kilińska ◽  
Judyta Cielecka-Piontek ◽  
Robert Skibiński ◽  
Daria Szymanowska ◽  
Andrzej Miklaszewski ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Solid State ◽  
Physical Stability ◽  
Chemical Degradation ◽  
Beam Radiation ◽  
Promising Alternative ◽  
X Ray ◽  
Lactam Ring ◽  
Ft Ir ◽  
Hydroxyethyl Group

The influence of ionising radiation on the physicochemical properties of meropenem trihydrate in solid state was studied for doses of e-beam radiation: 25 kGy and 400 kGy. In the first part of our studies, we evaluated the possibility of applying radiosterilization to obtain sterile meropenem. No changes for meropenem irradiated with a dose of 25 kGy, the dose required to attain sterility, was confirmed in the results of spectroscopic (FT-IR), thermal (DSC, TGA) and X-ray powder diffraction (XRPD) studies. The radiation dose of 25 kGy produces no more than about 1500 ppm of radical defects. The chromatographic studies of irradiated meropenem in solutions did not show any chemical degradation. Moreover, the antimicrobial activity of meropenem irradiated with the dose of 25 kGy was unchanged. Based on the received results, we can conclude that radiostelization is a promising, alternative method for obtaining sterile meropenem. In the second part of the research, meropenem was exposed to e-beam radiation at the 400 kGy dose rate. It was confirmed, that reducing of antimicrobial activity could be connected with the degradation of β-lactam ring and changes in the trans-hydroxyethyl group. Apart from chemical changes, changes in the physical stability of irradiated meropenem (400 kGy) was also observed.

scholarly journals Effect of Solid Forms on Physicochemical Properties of Valnemulin

Crystals ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 675 ◽  
Author(s):  
Jinbo Ouyang ◽  
Jian Chen ◽  
Limin Zhou ◽  
Fangze Han ◽  
Xin Huang
Keyword(s):  
Organic Acids ◽  
Physicochemical Properties ◽  
Excess Enthalpy ◽  
Vapor Sorption ◽  
Dynamic Vapor Sorption ◽  
Scanning Calorimetry ◽  
Intrinsic Dissolution ◽  
X Ray ◽  
Ft Ir ◽  
Scanning Electron

To improve the physicochemical properties of valnemulin (VLM), different solid forms formed by VLM and organic acids, including tartaric acid (TAR), fumaric acid (FUM), and oxalic acid (OXA), were successfully prepared and characterized by using differential scanning calorimetry (DSC), scanning electron microscope (SEM), X-ray powder diffraction (XRPD), and Fourier-transform infrared spectroscopy (FT-IR). The excess enthalpy Hex between VLM and other organic acids was calculated by COSMOthermX software and was used to evaluate the probability of forming multi-component solids between VLM and organic acids. By thermal analysis, it was confirmed that multi-component solid forms of VLM were thermodynamically more stable than VLM itself. Through dynamic vapor sorption (DVS) experiments, it was found that three multi-component solid forms of VLM had lower hygroscopicity than VLM itself. Furthermore, the intrinsic dissolution rate of VLM and its multi-component forms was determined in one kind of acidic aqueous medium by using UV-vis spectrometry. It was found that the three multi-component solid forms of VLM dissolved faster than VLM itself.

A Si/Ge nanocomposite prepared by a one-step solid-state metathesis reaction and its enhanced electrochemical performance

2015 ◽  
Vol 3 (21) ◽  
pp. 11199-11202 ◽  
Author(s):  
Ning Lin ◽  
Liangbiao Wang ◽  
Jianbin Zhou ◽  
Jie Zhou ◽  
Ying Han ◽  
...  
Keyword(s):  
Solid State ◽  
Electrochemical Performance ◽  
High Performance ◽  
Metathesis Reaction ◽  
One Step ◽  
First Time ◽  
Enhanced Electrochemical Performance

High-performance Si/Ge anodes are prepared through a one-step solid-state metathesis reaction between Mg2Si and GeO2 for the first time.

scholarly journals Synthesis of V2O3/C composites with different morphologies by a facile route and phase transition properties of the compounds

2014 ◽  
Vol 32 (2) ◽  
pp. 236-242 ◽  
Author(s):  
Yifu Zhang ◽  
Nannan Wang ◽  
Yuting Huang ◽  
Chi Huang ◽  
Xiao Mei ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Phase Transition ◽  
Hydrothermal Route ◽  
Scanning Calorimetry ◽  
Transmission Electron ◽  
Facile Hydrothermal Route ◽  
Potential Applications ◽  
Subsequent Calcination ◽  
Ft Ir ◽  
First Time

AbstractV2O3 and amorphous carbon composites (V2O3/C composites) with different morphologies (e.g. nanospheres, nanorods and nanosheets) were, for the first time, successfully synthesized by a facile hydrothermal route and subsequent calcination. The as-obtained samples were characterized by X-ray powder diffraction (XRD), energy dispersive spectrometery (EDS), elemental analysis (EA), Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The morphology of V2O3/C composites could be easily controlled by varying the reaction time, and, as a result, V2O3/C composites with nanospheres, nanorods and nanosheets were selectively synthesized. Furthermore, the phase transition property of V2O3/C composites was measured by differential scanning calorimetry (DSC), suggesting that V2O3/C composites exhibit the phase transition similar to V2O3, which could expand the potential applications of materials related to V2O3 in the future.

scholarly journals Solid state and sub-cooled liquid vapour pressures of cyclic aliphatic dicarboxylic acids

2010 ◽  
Vol 10 (10) ◽  
pp. 23017-23043 ◽  
Author(s):  
A. M. Booth ◽  
W. J. Montague ◽  
M. H. Barley ◽  
D. O. Topping ◽  
G. McFiggans ◽  
...  
Keyword(s):  
Solid State ◽  
Dicarboxylic Acids ◽  
Estimation Methods ◽  
Melting Points ◽  
Straight Chain ◽  
Scanning Calorimetry ◽  
Knudsen Effusion ◽  
Knudsen Effusion Mass Spectrometry ◽  
First Time ◽  
Selection Of

Abstract. Knudsen Effusion Mass Spectrometry (KEMS) has been used to measure for the first time the solid state vapour pressures of a series of aliphatic cyclic dicarboxylic acids with increasing ring size. Additionally the atmospherically important compounds; cis-pinonic acid and levoglucosan were also measured. Differential Scanning Calorimetry (DSC) was used to measure melting points, enthalpies and entropies of fusion, which were used to determine sub-cooled liquid vapour pressures for the compounds. The sub-cooled liquid vapour pressure of straight chain, branched and cyclic dicarboxylic acids was compared to a selection of estimation methods.

scholarly journals Differential Degradation and Detoxification of an Aromatic Pollutant by Two Different Peroxidases

2017 ◽  
Author(s):  
Aysha Hamad Alneyadi ◽  
Iltaf Shah ◽  
Synan F. AbuQamar ◽  
Syed Salman Ashraf
Keyword(s):  
Organic Pollutants ◽  
High Performance ◽  
Degradation Products ◽  
Low Molecular Weight ◽  
Optimum Conditions ◽  
Reaction Conditions ◽  
Toxicological Evaluation ◽  
Sulforhodamine B ◽  
Optimum Reaction ◽  
First Time

Enzymatic degradation of organic pollutants is a new and promising remediation approach. Peroxidases are one of the most commonly used classes of enzymes to degrade organic pollutants. However, it is generally assumed that all peroxidases behave similarly and produce similar degradation products. In this study, we conducted detailed studies of the degradation of a model aromatic pollutant, Sulforhodamine B dye (SRB dye), using two peroxidases—soybean peroxidase (SBP) and chloroperoxidase (CPO). Our results show that these two related enzymes had different optimum conditions (pH, temperature, H2O2 concentration...etc.) for efficiently degrading SRB dye. High-performance liquid chromatography and LC-mass spectrometry analyses confirmed that both SBP and CPO transformed the SRB dye into low molecular weight intermediates. While most of the intermediates produced by the two enzymes were the same, the CPO treatment produced at least one different intermediate. Furthermore, toxicological evaluation using lettuce (Lactuca sativa) seeds demonstrated that the SBP-based treatment was able to eliminate the phytotoxicity of SRB dye, but the CPO-based treatment did not. Our results show, for the first time, that while both of these related enzymes can be used to efficiently degrade organic pollutants, they have different optimum reaction conditions and may not be equally efficient in detoxification of organic pollutants.

New Strategy toward Novel Hyperbranched Phenol-Formaldehyde Resin: Synthesis, Characterization and Curing Study

2007 ◽  
Vol 29-30 ◽  
pp. 177-180
Author(s):  
Samaresh Ghosh
Keyword(s):  
Phenol Formaldehyde ◽  
Flow Behavior ◽  
Phenol Formaldehyde Resin ◽  
Formaldehyde Resin ◽  
Scanning Calorimetry ◽  
Elemental Analyses ◽  
New Strategy ◽  
Ft Ir ◽  
First Time ◽  
Tof Ms

Novel hyperbranched phenol-formaldehyde (HBPF) resin 1 has been prepared for the first time. Thorough characterizations (FT-IR, NMR, HPLC, MALDI-TOF MS and elemental analyses and rheological flow behavior) were performed to ascertain the structure of HBPF 1. The condensationcuring event of HBPF with diglycidylether of bisphenol-A (DGEBA) has been studied by differential scanning calorimetry (DSC) technique.

Poly(aryl Imino Sulphone)s as Novel High Performance Polymers

2011 ◽  
Vol 217-218 ◽  
pp. 1159-1164
Author(s):  
Guan Jun Chang ◽  
Lin Zhang ◽  
Run Xiong Lin
Keyword(s):  
High Performance ◽  
Condensation Polymerization ◽  
Scanning Calorimetry ◽  
Aromatic Diamines ◽  
Good Thermal Stability ◽  
High Performance Polymers ◽  
Amination Reaction ◽  
Aryl Amination ◽  
Palladium Catalyzed ◽  
Ft Ir

Poly(aryl imino sulphone)s (PAIS) as novel high-performance polymers have been obtained by the condensation polymerization of 4,4'-dibromodiphenyl solfone with different primary aromatic diamines via Palladium-catalyzed aryl amination reaction. The structure of polymers synthesized was characterized by means of FT-IR, NMR spectroscopy and elemental analysis, the results showed an agreement with the proposed structure. Differential scanning calorimetry (DSC) and thermal analysis (TG) measurements showed that polymers possessed high glass transition temperature (Tg>145°C) and good thermal stability with high decomposition temperatures (TD>450°C). These novel polymers also exhibited good mechanical behaviors and good solubility.

High-performance, ultra-flexible and transparent embedded metallic mesh electrodes by selective electrodeposition for all-solid-state supercapacitor applications

2017 ◽  
Vol 5 (19) ◽  
pp. 9032-9041 ◽  
Author(s):  
Yan-Hua Liu ◽  
Jian-Long Xu ◽  
Su Shen ◽  
Xin-Lei Cai ◽  
Lin-Sen Chen ◽  
...  
Keyword(s):  
Solid State ◽  
High Performance ◽  
Low Cost ◽  
Processing Methods ◽  
Electrodeposition Process ◽  
Metallic Mesh ◽  
Film Processing ◽  
First Time ◽  
Supercapacitor Applications

High-performance, ultra-flexible and transparent embedded metallic mesh electrodes were fabricatedvialow-cost selective electrodeposition process combined with inverted film-processing methods for the first time. Flexible and transparent all-solid-state supercapacitors were thus successfully constructed.

Preparation of Gentamicin Sulfate Nanoparticles using Eudragit RS-100 and Evaluation of Their Physicochemical Properties

2021 ◽  
Author(s):  
Ladan Nejati ◽  
Nader Shakiba Maram ◽  
Amanollah Zarei Ahmady
Keyword(s):  
Physicochemical Properties ◽  
Aminoglycoside Antibiotic ◽  
Critical Research ◽  
Scanning Calorimetry ◽  
Eudragit Rs ◽  
Gentamicin Sulfate ◽  
Ft Ir ◽  
Physical Interactions ◽  
Polymer Stabilized ◽  
Double Emulsification

Improving permeability and absorption of drugs are critical research challenges in pharmaceutical science. Gentamicin sulfate is an aminoglycoside antibiotic, which is very active against gram-negative bacteria; however, it has very poor bioavailability. This study aimed to prepare gentamicin nanoparticles with the intention of increased bioavailability. Accordingly, Eudragit RS-100 nanoparticles loaded with gentamicin sulfate were prepared by the double emulsification and solvent evaporation method, a proper technique for encapsulating hydrophilic molecules. Nanoparticles’ suspensions with polymer to drug ratios of 1:1 ([Formula: see text] and 2:1 ([Formula: see text]) were prepared, lyophilized and evaluated for their production yield, physicochemical properties and morphology. The mean particle size was 195.67[Formula: see text]nm and 228[Formula: see text]nm for [Formula: see text] and [Formula: see text], respectively. The formulations’ loading efficiencies were relatively high (85.73 for [Formula: see text] and 85.20 for [Formula: see text]). The nanoparticles’ surface charge (+40.5[Formula: see text]mV) was sufficient to inhibit their aggregation and facilitate the nanoparticles’ absorption through the gastrointestinal tract. The results of differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FT-IR) revealed that drug and polymer stabilized each other by physical interactions between their functional groups. Both formulations presented an initial burst drug release of nearly 20% after 30[Formula: see text]min in phosphate buffer (pH = 7.4). After 24[Formula: see text]h, [Formula: see text] did not release the drug completely, while [Formula: see text] released the whole drug. Overall, nanoparticles with proper characteristics were obtained. This study puts forward the necessity of conducting further research in order to explore the intestinal absorption of these nanoparticles and the possibility of being utilized for oral administration of gentamicin sulfate.

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