The Potential of High Voltage Discharges for Green Solvent Extraction of Bioactive Compounds and Aromas from Rosemary (Rosmarinus officinalis L.)—Computational Simulation and Experimental Methods

Rosemary (Rosmarinus officinalis L.) is a Mediterranean medicinal and aromatic plant widely used due to valuable bioactive compounds (BACs) and aromas. The aim of the study was to evaluate the extraction of intracellular compounds from rosemary combining experimental procedure by means of high voltage electrical discharge (HVED), with a theoretical approach using two computational simulation methods: conductor-like screening model for real solvents and Hansen solubility parameters. The optimal HVED parameters were as follows: frequency 100 Hz, pulse width 400 ns, gap between electrodes 15 mm, liquid to solid ratio 50 mL/g, voltage 15 and 20 kV for argon, and 20 and 25 kV for nitrogen gas. Green solvents were used, water and ethanol (25% and 50%). The comparison was done with modified conventional extraction (CE) extracted by magnetic stirring and physicochemical analyses of obtained extracts were done. Results showed that HVED extracts in average 2.13-times higher total phenol content compared to CE. Furthermore, nitrogen, longer treatment time and higher voltage enhanced higher yields in HVED extraction. HVED was confirmed to have a high potential for extraction of BACs from rosemary. The computational stimulation methods were confirmed by experimental study, ethanol had higher potential of solubility of BACs and aromas from rosemary compared to water.

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High Voltage Electrical Discharges as an Alternative Extraction Process of Phenolic and Volatile Compounds from Wild Thyme (Thymus serpyllum L.): In Silico and Experimental Approaches for Solubility Assessment

Molecules ◽

10.3390/molecules25184131 ◽

2020 ◽

Vol 25 (18) ◽

pp. 4131

Author(s):

Marinela Nutrizio ◽

Gianpiero Pataro ◽

Daniele Carullo ◽

Serena Carpentieri ◽

Luisa Mazza ◽

...

Keyword(s):

Volatile Compounds ◽

High Voltage ◽

Extraction Process ◽

Solubility Parameters ◽

Total Phenolic ◽

Green Solvents ◽

Hansen Solubility Parameters ◽

Wild Thyme ◽

Thymus Serpyllum ◽

Physical Changes

The objective of this study was to evaluate the potential of green solvents for extractions of bioactive compounds (BACs) and essential oils from wild thyme (Thymus serpyllum L.) using theoretical and experimental procedures. Theoretical prediction was assessed by Hansen solubility parameters (HSPs) and conductor-like screening model for realistic solvents (COSMO-RS), to predict the most suitable solvents for extraction of BACs. An experimental procedure was performed by nonthermal technology high voltage electrical discharge (HVED) and it was compared with modified conventional extraction (CE). Obtained extracts were analyzed for chemical and physical changes during the treatment. Theoretical results for solution of BACs in ethanol and water, as green solvents, were confirmed by experimental results, while more accurate data was given by COSMO-RS assessment than HSPs. Results confirmed high potential of HVED for extraction of BACs and volatile compounds from wild thyme, in average, 2.03 times higher yield of extraction in terms of total phenolic content was found compared to CE. The main phenolic compound found in wild thyme extracts was rosmarinic acid, while the predominant volatile compound was carvacrol. Obtained extracts are considered safe and high-quality source reach in BACs that could be further used in functional food production.

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A tool for identifying green solvents for printed electronics

Nature Communications ◽

10.1038/s41467-021-24761-x ◽

2021 ◽

Vol 12 (1) ◽

Author(s):

Christian Larsen ◽

Petter Lundberg ◽

Shi Tang ◽

Joan Ràfols-Ribé ◽

Andreas Sandström ◽

...

Keyword(s):

High Performance ◽

Printed Electronics ◽

Solubility Parameters ◽

Electrochemical Cells ◽

Large Set ◽

Green Solvents ◽

Green Solvent ◽

Hansen Solubility Parameters ◽

Light Emitting

AbstractThe emerging field of printed electronics uses large amounts of printing and coating solvents during fabrication, which commonly are deposited and evaporated within spaces available to workers. It is in this context unfortunate that many of the currently employed solvents are non-desirable from health, safety, or environmental perspectives. Here, we address this issue through the development of a tool for the straightforward identification of functional and “green” replacement solvents. In short, the tool organizes a large set of solvents according to their Hansen solubility parameters, ink properties, and sustainability descriptors, and through systematic iteration delivers suggestions for green alternative solvents with similar dissolution capacity as the current non-sustainable solvent. We exemplify the merit of the tool in a case study on a multi-solute ink for high-performance light-emitting electrochemical cells, where a non-desired solvent was successfully replaced by two benign alternatives. The green-solvent selection tool is freely available at: www.opeg-umu.se/green-solvent-tool.

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Hansen Solubility parameters and Green Solvents for Organic Photovoltaics

International Journal of Advances in Scientific Research and Engineering ◽

10.31695/ijasre.2018.32842 ◽

2018 ◽

Vol 4 (10) ◽

pp. 119-128

Author(s):

Defaru Negera ◽

Teketel Yohannes

Keyword(s):

Organic Photovoltaics ◽

Solubility Parameters ◽

Green Solvents ◽

Hansen Solubility Parameters ◽

Hansen Solubility

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Deep eutectic solvents for antiepileptic drug phenytoin solubilization: thermodynamic study

Scientific Reports ◽

10.1038/s41598-021-03212-z ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Hemayat Shekaari ◽

Mohammed Taghi Zafarani-Moattar ◽

Masumeh Mokhtarpour ◽

Saeid Faraji

Keyword(s):

Deep Eutectic Solvents ◽

Isentropic Compressibility ◽

Solubility Parameters ◽

Pharmaceutical Sciences ◽

Green Solvents ◽

Hansen Solubility Parameters ◽

Solvent Interactions ◽

Meyer Equation ◽

Isobaric Expansion ◽

Selection Of

AbstractThermodynamic investigations provide information about the solute-solvent interactions in the selection of the proper solvent for different fields of pharmaceutical sciences. Especially, the study of antiepileptic drugs in solutions (ethanol/co-solvent) has been a subject of interest owing to their effect in the systems using interaction with a number of important biological membranes. This work focuses on the measurement of density and speed of sound of the phenytoin (PTH) in ethanol/deep eutectic solvents (choline chloride:ethylene glycol, and choline chloride:glycerol) solutions as the innovative class of green solvents at temperature range (288.15 to 318.15) K. It was determined Hansen solubility parameters for assessment of PTH interactions in the solvent media. Some thermophysical parameters including apparent molar volumes Vϕ, apparent molar isobaric expansion $$E_\varphi^0$$ E φ 0 , and Hepler’s constant, apparent molar isentropic compressibility κφ were obtained and calculated using these data. To correlate the Vϕ and κφ values, the Redlich-Meyer equation was used to calculate the number of quantities containing standard partial molar volume and partial molar isentropic compressibility. Finally, $$\Delta \delta$$ Δ δ values showed a strong interaction between PTH and solvent (ethanol/DES (ChCl:EG)). The thermodynamic analysis of the studied system also plays a crucial role in the pharmaceutical industry.

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Optimization of MAE for the Separation of Nicotine and Phenolics from Tobacco Waste by Using the Response Surface Methodology Approach

Molecules ◽

10.3390/molecules26144363 ◽

2021 ◽

Vol 26 (14) ◽

pp. 4363

Author(s):

Marija Banožić ◽

Ines Banjari ◽

Ivana Flanjak ◽

Mate Paštar ◽

Jelena Vladić ◽

...

Keyword(s):

Bioactive Compounds ◽

Treatment Time ◽

Value Added ◽

Extraction Yield ◽

Total Phenol Content ◽

Promising Alternative ◽

Industrial Processing ◽

Nicotine Content ◽

Maximum Extraction ◽

Tobacco Waste

This study intends to valorize by-products of the industrial processing of tobacco to obtain nicotine and phenolics as value-added compounds. Three influential parameters of the microwave-assisted extraction-MAE (temperature, treatment time, and solvent/solid ratio) were studied for the optimization of the extraction protocol for tobacco leaves and three types of waste—scrap, dust, and midrib, respectively. Nicotine was the dominant bioactive compound in all extracts, ranging from 1.512 to 5.480% in leaves, 1.886 to 3.709% in scrap, 2.628 to 4.840% dust, and 0.867 to 1.783% in midrib extracts. Five phenolic compounds were identified and quantified, predominated by chlorogenic acid and rutin. Additionally, total phenol content and antioxidant activity were determined using spectrophotometric assays. Optimization was performed in two aspects: to obtain a maximum extraction yield with minimum nicotine content and to obtain a maximum extraction yield with maximum nicotine content. These findings demonstrate that tobacco waste is a valuable source of bioactive compounds and MAE can be a promising alternative technique to obtain extracts rich in targeted bioactive compounds, especially nicotine.

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