scholarly journals The 115 Years Old Multicomponent Bargellini Reaction: Perspectives and New Applications

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 558
Author(s):  
Marta Serafini ◽  
Ilaria Murgia ◽  
Mariateresa Giustiniano ◽  
Tracey Pirali ◽  
Gian Cesare Tron
Keyword(s):  
Organic Chemistry ◽  
Knowledge Sharing ◽  
Multicomponent Reaction ◽  
Review Article ◽  
Chronological Order ◽  
New Applications

Despite its uniqueness, the Bargellini multicomponent reaction remains barely known by the most part of chemists. This can be ascribed to the fact that this transformation has not been adequately reviewed in the classic books of named reactions in organic chemistry. Nevertheless, several works on this reaction have been carried out over the years, many of them were written in Italian in the period 1929–1966. In this review article we extensively cover, in a chronological order, the most important applications of the Bargellini reaction reported to date, with the hope that this knowledge-sharing will help chemists to properly use this multicomponent transformation and imagine novel reactivities based on it.

Silver-assisted syntheses of fused five-membered N-heterocycles

2021 ◽  
Vol 25 ◽  
Author(s):  
Navjeet Kaur ◽  
Neha Ahlawat ◽  
Yamini Verma ◽  
Pooja Grewal ◽  
Pranshu Bhardwaj ◽  
...  
Keyword(s):  
Organic Chemistry ◽  
Heterocyclic Compounds ◽  
Stereoselective Synthesis ◽  
Review Article ◽  
Highly Efficient ◽  
Work Up ◽  
Detailed Work

: The metal-mediated formation of heterocycles is one of the most emerging and essential strategies in organic chemistry. The reactions utilized previously to synthesize heterocycles were less familiar to the scientists due to their detailed work-up, expensive nature, and complex operations. The silver-assisted cyclic reactions are highly efficient for both regioselective and stereoselective synthesis of five-membered fused N-heterocyclic compounds. The applications of silver in the preparation of five-membered fused N-heterocyclic compounds are covered in this review article.

scholarly journals Recent Advances in Enzymatic and Chemoenzymatic Cascade Processes

Catalysts ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 1258
Author(s):  
Noelia Losada-Garcia ◽  
Zaida Cabrera ◽  
Paulina Urrutia ◽  
Carla Garcia-Sanz ◽  
Alicia Andreu ◽  
...  
Keyword(s):  
Organic Chemistry ◽  
Solid Phase ◽  
Cascade Reactions ◽  
Review Article ◽  
The Novel ◽  
Enzyme Cascade ◽  
Cascade Processes ◽  
Novel Strategy ◽  
Substantial Interest

Cascade reactions have been described as efficient and universal tools, and are of substantial interest in synthetic organic chemistry. This review article provides an overview of the novel and recent achievements in enzyme cascade processes catalyzed by multi-enzymatic or chemoenzymatic systems. The examples here selected collect the advances related to the application of the sequential use of enzymes in natural or genetically modified combination; second, the important combination of enzymes and metal complex systems, and finally we described the application of biocatalytic biohybrid systems on in situ catalytic solid-phase as a novel strategy. Examples of efficient and interesting enzymatic catalytic cascade processes in organic chemistry, in the production of important industrial products, such as the designing of novel biosensors or bio-chemocatalytic systems for medicinal chemistry application, are discussed

scholarly journals Proteomics and Metabolomics for Cystic Fibrosis Research

2020 ◽  
Vol 21 (15) ◽  
pp. 5439 ◽  
Author(s):  
Nara Liessi ◽  
Nicoletta Pedemonte ◽  
Andrea Armirotti ◽  
Clarissa Braccia
Keyword(s):  
Cystic Fibrosis ◽  
Biomarker Discovery ◽  
State Of The Art ◽  
Review Article ◽  
Future Scenarios ◽  
Transmembrane Conductance Regulator ◽  
Transmembrane Conductance ◽  
Post Translational Modifications ◽  
New Applications ◽  
Cystic Fibrosis Transmembrane

The aim of this review article is to introduce the reader to the state-of-the-art of the contribution that proteomics and metabolomics sciences are currently providing for cystic fibrosis (CF) research: from the understanding of cystic fibrosis transmembrane conductance regulator (CFTR) biology to biomarker discovery for CF diagnosis. Our work particularly focuses on CFTR post-translational modifications and their role in cellular trafficking as well as on studies that allowed the identification of CFTR molecular interactors. We also show how metabolomics is currently helping biomarker discovery in CF. The most recent advances in these fields are covered by this review, as well as some considerations on possible future scenarios for new applications.

scholarly journals Reviewing Magnetic Particle Preparation: Exploring the Viability in Biosensing

Sensors ◽  
2020 ◽  
Vol 20 (16) ◽  
pp. 4596
Author(s):  
Daniel Kappe ◽  
Laila Bondzio ◽  
Joris Swager ◽  
Andreas Becker ◽  
Björn Büker ◽  
...  
Keyword(s):  
Magnetic Particles ◽  
Magnetic Particle ◽  
Size Range ◽  
Particle System ◽  
Microfluidic Channel ◽  
Review Article ◽  
Particle Systems ◽  
Heusler Compound ◽  
Particle Preparation ◽  
New Applications

In this review article, we conceptually investigated the requirements of magnetic nanoparticles for their application in biosensing and related them to example systems of our thin-film portfolio. Analyzing intrinsic magnetic properties of different magnetic phases, the size range of the magnetic particles was determined, which is of potential interest for biosensor technology. Different e-beam lithography strategies are utilized to identify possible ways to realize small magnetic particles targeting this size range. Three different particle systems from 500 μm to 50 nm are produced for this purpose, aiming at tunable, vertically magnetized synthetic antiferromagnets, martensitic transformation in a single elliptical, disc-shaped Heusler Ni50Mn32.5Ga17.5 particle and nanocylinders of Co2MnSi-Heusler compound. Perspectively, new applications for these particle systems in combination with microfluidics are addressed. Using the concept of a magnetic on–off ratchet, the most suitable particle system of these three materials is validated with respect to magnetically-driven transport in a microfluidic channel. In addition, options are also discussed for improving the magnetic ratchet for larger particles.

Review on Synthesis of Bio-active Coumarin-fused Heterocyclic Molecules

2020 ◽  
Vol 24 (22) ◽  
pp. 2566-2587
Author(s):  
Geetika Patel ◽  
Subhash Banerjee
Keyword(s):  
Organic Chemistry ◽  
Heterocyclic Compounds ◽  
Multistep Method ◽  
Review Article ◽  
Literature Survey ◽  
Research Articles ◽  
One Pot ◽  
Physiochemical Properties ◽  
Heterocyclic Molecules ◽  
The Individual

The literature survey reveals that the individual coumarin and heterocyclic molecules have biological and pharmaceutical activities. Moreover, integrated coumarinfused heterocyclic compounds have shown interesting biological and physiochemical properties and thus, designing and development of coumarin-fused heterocyclic molecules are of great interest in the field of synthetic organic chemistry. Several coumarin-fused heterocyclic molecules have been synthesized by using different strategies such as multistep method, one-pot multi-component protocol, coupling and condensation method. The wide applications of integrated coumarin-fused heterocyclic molecules stimulated interest among researchers to develop different methodologies for the synthesis of novel fused molecules. As a consequence, several research articles, papers and review articles have been published in the literature. In this review article, we have presented various methods for the synthesis of different class of coumarin-fused heterocyclic molecules and their applications in chemical, optical, pharmaceutical and other useful applications.

Ionic Liquid Promoted Eco-friendly and Efficient Synthesis of Six-membered Npolyheterocycles

2018 ◽  
Vol 15 (8) ◽  
pp. 1124-1146 ◽  
Author(s):  
Navjeet Kaur
Keyword(s):  
Organic Chemistry ◽  
Ionic Liquid ◽  
Ionic Liquids ◽  
Organic Solvents ◽  
Review Article ◽  
Environmentally Benign ◽  
Wide Range ◽  
Catalyzed Reactions ◽  
Metal Catalyzed ◽  
Reaction Media

Background: The synthesis of N-polyheterocycles by environmentally benign method is highly attractive but challenging proposition. New strategies have been developed for the preparation of polycyclic heterocycles in the last decades. In this review article, the synthesis of nitrogen containing six-membered polycyclic heterocyclic compounds is presented with the application of ionic liquids. This contribution focuses on the literature related to the total synthesis of six-membered N-polyheterocycles. Objective: Ionic liquids not only acted as environmentally benign reaction media but also as catalysts which afforded the very promising replacements of traditional molecular solvents in organic chemistry due to their stability, non-flammability, non-volatility and ease of recyclability. Ionic liquids are utilized in metal catalyzed reactions in place of organic solvents in the last years. It has attracted considerable attention in recent years. Ionic liquids acted as alternatives of organic solvents and these ILs are environment friendly. Conclusion: In the area of green chemistry ionic liquid assisted synthesis is a very promising technique which afforded a flexible platform for the formation of heterocycles. The influence of ILs on the development of efficient and new synthetic protocols over the last decade for the construction of N-polyheterocycles is featured in this review article. These synthetic strategies will continue to attract more attention and will find a wide range of applications in organic synthesis. In conclusion, ionic liquids assisted syntheses have become an efficient and powerful tool in organic chemistry quickly.

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