scholarly journals Frontiers in Bioengineering and Biotechnology: Plant Nanoparticles for Anti-Cancer Therapy

Vaccines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 830
Author(s):  
Erum Shoeb ◽  
Uzma Badar ◽  
Srividhya Venkataraman ◽  
Kathleen Hefferon
Keyword(s):  
Drug Delivery ◽  
Cancer Research ◽  
Cancer Therapy ◽  
Plant Virus ◽  
Biomedical Applications ◽  
Plant Viruses ◽  
Naturally Occurring ◽  
Anti Cancer ◽  
Diagnostic Agents ◽  
Stimuli Response

Naturally occurring viral nanomaterials have gained popularity owing to their biocompatible and biodegradable nature. Plant virus nanoparticles (VNPs) can be used as nanocarriers for a number of biomedical applications. Plant VNPs are inexpensive to produce, safe to administer and efficacious as treatments. The following review describes how plant virus architecture facilitates the use of VNPs for imaging and a variety of therapeutic applications, with particular emphasis on cancer. Examples of plant viruses which have been engineered to carry drugs and diagnostic agents for specific types of cancer are provided. The drug delivery system in response to the internal conditions is known as stimuli response, recently becoming more applicable using plant viruses based VNPs. The review concludes with a perspective of the future of plant VNPs and plant virus-like particles (VLPs) in cancer research and therapy.

scholarly journals Stereocomplex Polylactide for Drug Delivery and Biomedical Applications: A Review

Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 2846
Author(s):  
Seung Hyuk Im ◽  
Dam Hyeok Im ◽  
Su Jeong Park ◽  
Justin Jihong Chung ◽  
Youngmee Jung ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Drug Carrier ◽  
Micelle Formation ◽  
Weak Stability ◽  
Critical Fields ◽  
Physical Strength ◽  
Anti Cancer

Polylactide (PLA) is among the most common biodegradable polymers, with applications in various fields, such as renewable and biomedical industries. PLA features poly(D-lactic acid) (PDLA) and poly(L-lactic acid) (PLLA) enantiomers, which form stereocomplex crystals through racemic blending. PLA emerged as a promising material owing to its sustainable, eco-friendly, and fully biodegradable properties. Nevertheless, PLA still has a low applicability for drug delivery as a carrier and scaffold. Stereocomplex PLA (sc-PLA) exhibits substantially improved mechanical and physical strength compared to the homopolymer, overcoming these limitations. Recently, numerous studies have reported the use of sc-PLA as a drug carrier through encapsulation of various drugs, proteins, and secondary molecules by various processes including micelle formation, self-assembly, emulsion, and inkjet printing. However, concerns such as low loading capacity, weak stability of hydrophilic contents, and non-sustainable release behavior remain. This review focuses on various strategies to overcome the current challenges of sc-PLA in drug delivery systems and biomedical applications in three critical fields, namely anti-cancer therapy, tissue engineering, and anti-microbial activity. Furthermore, the excellent potential of sc-PLA as a next-generation polymeric material is discussed.

scholarly journals Surface Modification of Bacterial Cellulose for Biomedical Applications

2022 ◽  
Vol 23 (2) ◽  
pp. 610
Author(s):  
Teresa Aditya ◽  
Jean Paul Allain ◽  
Camilo Jaramillo ◽  
Andrea Mesa Restrepo
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Surface Modification ◽  
Bacterial Cellulose ◽  
Biomedical Applications ◽  
Human Tissues ◽  
Naturally Occurring ◽  
Microstructure And Mechanical Properties

Bacterial cellulose is a naturally occurring polysaccharide with numerous biomedical applications that range from drug delivery platforms to tissue engineering strategies. BC possesses remarkable biocompatibility, microstructure, and mechanical properties that resemble native human tissues, making it suitable for the replacement of damaged or injured tissues. In this review, we will discuss the structure and mechanical properties of the BC and summarize the techniques used to characterize these properties. We will also discuss the functionalization of BC to yield nanocomposites and the surface modification of BC by plasma and irradiation-based methods to fabricate materials with improved functionalities such as bactericidal capabilities.

scholarly journals Advances of Microneedles in Biomedical Applications

Molecules ◽  
2021 ◽  
Vol 26 (19) ◽  
pp. 5912
Author(s):  
Jie Xu ◽  
Danfeng Xu ◽  
Xuan Xuan ◽  
Huacheng He
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Minimally Invasive ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Wound Repair ◽  
Delivery Systems ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
Different Shapes

A microneedle (MN) is a painless and minimally invasive drug delivery device initially developed in 1976. As microneedle technology evolves, microneedles with different shapes (cone and pyramid) and forms (solid, drug-coated, hollow, dissolvable and hydrogel-based microneedles) have been developed. The main objective of this review is the applications of microneedles in biomedical areas. Firstly, the classifications and manufacturing of microneedle are briefly introduced so that we can learn the advantages and fabrications of different MNs. Secondly, research of microneedles in biomedical therapy such as drug delivery systems, diagnoses of disease, as well as wound repair and cancer therapy are overviewed. Finally, the safety and the vision of the future of MNs are discussed.

Gold nanospheres and nanorods for anti-cancer therapy: comparative studies of fabrication, surface-decoration, and anti-cancer treatments

Nanoscale ◽  
2020 ◽  
Vol 12 (28) ◽  
pp. 14996-15020
Author(s):  
Wei Mao ◽  
Young Ju Son ◽  
Hyuk Sang Yoo
Keyword(s):  
Gold Nanoparticles ◽  
Cancer Therapy ◽  
Cancer Therapeutics ◽  
Drug Carriers ◽  
Gold Nanospheres ◽  
Cancer Treatments ◽  
Anti Cancer ◽  
Diagnostic Agents ◽  
Irradiation Therapy ◽  
Surface Decoration

Various gold nanoparticles have been explored as cancer therapeutics because they can be widely engineered for use as efficient drug carriers and diagnostic agents, and in photo-irradiation therapy.

Multifunctional Mesoporous Silica Nanoparticles for Cancer Therapy and Imaging

2019 ◽  
Vol 26 (31) ◽  
pp. 5745-5763 ◽  
Author(s):  
Fahima Dilnawaz
Keyword(s):  
Drug Delivery ◽  
Surface Modification ◽  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Structural Characteristics ◽  
Mesoporous Silica Nanoparticles ◽  
Synthetic Methods ◽  
Promising Tool ◽  
Stimuli Response

Background: Cancer is a widespread disease and has a high mortality rate. Popular conventional treatment encompasses chemotherapy, radiation and surgical resection. However, these treatments impart lots of toxicity problems to the patients mostly due to their non-selectiveness nature, which invokes drug resistances and severe side-effects. Objectives: In this regard, nanotechnology has claimed to be a smart technology that provides the system with the ability to target drugs to the specific sites. With the use of nanotechnology, various nanomaterials that are widely used as a drug delivery vehicle are created for biomedical applications. Amongst variously diversified nanovehicles, mesoporous silica nanoparticles (MSNs) have attracted enormous attention due to their structural characteristics, great surface areas, tunable pore diameters, good thermal and chemical stability, excellent biocompatibility along with ease of surface modification. Furthermore, the drug release from MSNs can be tailored through various stimuli response gatekeeper systems. The ordered structure of MSNs is extremely suitable for loading of the high amount of drug molecules with controlled delivery for targeting the cancer tissues via enhanced permeability and retention effect or further with surface modification, it can also be actively targeted by various ligands. Methods: The review article emphases the common synthetic methods and current advancement of MSNs usages for stimuli response drug delivery, immunotherapy as well as the theranostic ability for cancer. Conclusion: Although MSNs are becoming the promising tool for more efficient and safer cancer therapy, however, additional translational studies are required to explore its multifunctional ability in a clinical setting.

Synthesis and Applications of Hydrogels in Cancer Therapy

2020 ◽  
Vol 20 (12) ◽  
pp. 1431-1446
Author(s):  
Anchal Singhal ◽  
Niharika Sinha ◽  
Pratibha Kumari ◽  
Manoushikha Purkayastha
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Cancer Therapy ◽  
Mechanical Strength ◽  
Biomedical Applications ◽  
Three Dimensional ◽  
Polymer Chains ◽  
Human Tissues ◽  
Methods Of Synthesis

: Hydrogels are water-insoluble, hydrophilic, cross-linked, three-dimensional networks of polymer chains having the ability to swell and absorb water but do not dissolve in it, that comprise the major difference between gels and hydrogels. The mechanical strength, physical integrity and solubility are offered by the crosslinks. The different applications of hydrogels can be derived based on the methods of their synthesis, response to different stimuli, and their different kinds. Hydrogels are highly biocompatible and have properties similar to human tissues that make it suitable to be used in various biomedical applications, including drug delivery and tissue engineering. The role of hydrogels in cancer therapy is highly emerging in recent years. In the present review, we highlighted different methods of synthesis of hydrogels and their classification based on different parameters. Distinctive applications of hydrogels in the treatment of cancer are also discussed.

scholarly journals A Promising Biocompatible Platform: Lipid-Based and Bio-Inspired Smart Drug Delivery Systems for Cancer Therapy

2018 ◽  
Vol 19 (12) ◽  
pp. 3859 ◽  
Author(s):  
Min Kim ◽  
Seung-Hae Kwon ◽  
Jung Choi ◽  
Aeju Lee
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery Systems ◽  
Controlled Drug Release ◽  
Research Area ◽  
Delivery Systems ◽  
Cancer Therapies ◽  
Smart Systems ◽  
Tumor Microenvironments ◽  
Anti Cancer

Designing new drug delivery systems (DDSs) for safer cancer therapy during pre-clinical and clinical applications still constitutes a considerable challenge, despite advances made in related fields. Lipid-based drug delivery systems (LBDDSs) have emerged as biocompatible candidates that overcome many biological obstacles. In particular, a combination of the merits of lipid carriers and functional polymers has maximized drug delivery efficiency. Functionalization of LBDDSs enables the accumulation of anti-cancer drugs at target destinations, which means they are more effective at controlled drug release in tumor microenvironments (TMEs). This review highlights the various types of ligands used to achieve tumor-specific delivery and discusses the strategies used to achieve the effective release of drugs in TMEs and not into healthy tissues. Moreover, innovative recent designs of LBDDSs are also described. These smart systems offer great potential for more advanced cancer therapies that address the challenges posed in this research area.

scholarly journals Hyaluronic Acid Nanoparticles as Nanomedicine for Treatment of Inflammatory Diseases

Pharmaceutics ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 931 ◽  
Author(s):  
N.Vijayakameswara Rao ◽  
Jun Gi Rho ◽  
Wooram Um ◽  
Pramod Kumar EK ◽  
Van Quy Nguyen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Biomedical Applications ◽  
Therapeutic Agent ◽  
Inflammatory Responses ◽  
Inflammatory Diseases ◽  
Biological Functions ◽  
Wide Range ◽  
Diagnostic Agents ◽  
Long Acting

Owing to their unique biological functions, hyaluronic acid (HA) and its derivatives have been explored extensively for biomedical applications such as tissue engineering, drug delivery, and molecular imaging. In particular, self-assembled HA nanoparticles (HA-NPs) have been used widely as target-specific and long-acting nanocarriers for the delivery of a wide range of therapeutic or diagnostic agents. Recently, it has been demonstrated that empty HA-NPs without bearing any therapeutic agent can be used therapeutically for the treatment of inflammatory diseases via modulating inflammatory responses. In this review, we aim to provide an overview of the significant achievements in this field and highlight the potential of HA-NPs for the treatment of inflammatory diseases.

scholarly journals Effect of Flow-Induced Shear Stress in Nanomaterial Uptake by Cells: Focus on Targeted Anti-Cancer Therapy

Cancers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1916 ◽  
Author(s):  
Samar Shurbaji ◽  
Gulsen G. Anlar ◽  
Essraa A. Hussein ◽  
Ahmed Elzatahry ◽  
Huseyin C. Yalcin
Keyword(s):  
Shear Stress ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Cancer Cell ◽  
Cell Mechanics ◽  
Normal Tissue ◽  
Biomedical Applications ◽  
Shear Stresses ◽  
Anti Cancer

Recently, nanomedicines have gained a great deal of attention in diverse biomedical applications, including anti-cancer therapy. Being different from normal tissue, the biophysical microenvironment of tumor cells and cancer cell mechanics should be considered for the development of nanostructures as anti-cancer agents. Throughout the last decades, many efforts devoted to investigating the distinct cancer environment and understanding the interactions between tumor cells and have been applied bio-nanomaterials. This review highlights the microenvironment of cancer cells and how it is different from that of healthy tissue. We gave special emphasis to the physiological shear stresses existing in the cancerous surroundings, since these stresses have a profound effect on cancer cell/nanoparticle interaction. Finally, this study reviews relevant examples of investigations aimed at clarifying the cellular nanoparticle uptake behavior under both static and dynamic conditions.

Sign in / Sign up

Export Citation Format

Share Document