scholarly journals New O-Aryl-Carbamoyl-Oxymino-Fluorene Derivatives with MI-Crobicidal and Antibiofilm Activity Enhanced by Combination with Iron Oxide Nanoparticles

Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 3002
Author(s):  
Ilinca Margareta Vlad ◽  
Diana Camelia Nuță ◽  
Robert Viorel Ancuceanu ◽  
Miron Teodor Caproiou ◽  
Florea Dumitrascu ◽  
...  

Antimicrobial resistance is one of the major public health threats at the global level, urging the search for new antimicrobial molecules. The fluorene nucleus is a component of different bioactive compounds, exhibiting diverse pharmacological actions. The present work describes the synthesis, chemical structure elucidation, and bioactivity of new O-aryl-carbamoyl-oxymino-fluorene derivatives and the contribution of iron oxide nanoparticles to enhance the desired biological activity. The antimicrobial activity assessed against three bacterial and fungal strains, in suspension and biofilm growth state, using a quantitative assay, revealed that the nature of substituents on the aryl moiety are determinant for both the spectrum and intensity of the inhibitory effect. The electron-withdrawing inductive effect of chlorine atoms enhanced the activity against planktonic and adhered Staphylococcus aureus, while the +I effect of the methyl group enhanced the anti-fungal activity against Candida albicans strain. The magnetite nanoparticles have substantially improved the antimicrobial activity of the new compounds against planktonic microorganisms. The obtained compounds, as well as the magnetic core@shell nanostructures loaded with these compounds have a promising potential for the development of novel antimicrobial strategies.

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Madhu Bala Sathyanarayanan ◽  
Reneta Balachandranath ◽  
Yuvasri Genji Srinivasulu ◽  
Sathish Kumar Kannaiyan ◽  
Guruprakash Subbiahdoss

Microbial biofilms on biomaterial implants or devices are hard to eliminate by antibiotics due to their protection by exopolymeric substances that embed the organisms in a matrix, impenetrable for most antibiotics and immune-cells. Application of metals in their nanoparticulated form is currently considered to resolve bacterial infections. Gold and iron-oxide nanoparticles are widely used in different medical applications, but their utilisation to eradicate biofilms on biomaterials implants is novel. Here, we studied the effect of gold and iron oxide nanoparticles on Staphylococcus aureus and Pseudomonas aeruginosa biofilms. We report that biofilm growth was reduced at higher concentrations of gold and iron-oxide nanoparticles compared to absence of nanoparticles. Thus nanoparticles with appropriate concentration could show significant reduction in biofilm formation.


2019 ◽  
Vol 15 ◽  
pp. 70-77 ◽  
Author(s):  
Vaikundamoorthy Ramalingam ◽  
Pandurangan Dhinesh ◽  
Subramaniam Sundaramahalingam ◽  
Rajendran Rajaram

2020 ◽  
Vol 46 (8) ◽  
pp. 10942-10951 ◽  
Author(s):  
Sidra Khan ◽  
Zaheer H. Shah ◽  
Saira Riaz ◽  
Naveed Ahmad ◽  
Shumaila Islam ◽  
...  

2020 ◽  
Vol 11 (2) ◽  
Author(s):  
Aleksandra Šmitran ◽  
Dijana Jelić ◽  
Sanja Pržulj ◽  
Savka Vračević ◽  
Dragana Gajić ◽  
...  

Last decade is designated as the postantibiotic era due to increasing number of resistant and multiresistant strains of microorganisms, which developed resistance to one or more antibiotics. Antimicrobial resistance becomes a global health problem. This phenomenon of antimicrobial resistance will undoubtedly affect the efficiency and use of antibiotics in the future. Science and technological development are committed to researching and developing new antibiotics that will satisfy the missing criteria and address the problem of antimicrobial resistance. One of the possible solutions lies in nanotechnologies. Nanoparticles have been isolated as one of the most promising substances on which microorganisms rarely or even develop mechanisms of resistance. The nanoparticles may be in conjunction with already existing antibiotics structures and contribute to the improvement of physicochemical properties in order to successfully overcome the mechanism of antimicrobial resistance. By designing nanoparticles with proper physicochemical and biochemical characteristics we determine their application. The aim of this research is to dope synthesized iron oxide nanoparticles with copper ions in order to test their antimicrobial activity and to evaluate their use as potential antimicrobial agent. Extracts of green tea and ascorbic acid were used as reduction agent for the iron oxide nanoparticles doped with Cu. The antimicrobial activity of the synthesized nanoparticles on the isolates Acinetobacter baumannii and methicillin resistant Staphylococcus aureus (MRSA) was performed by the agar well diffusion method. Synthesized iron oxide nanoparticles showed activity against Acinetobacter baumannii with inhibition zone around 12 mm. Photocatalytical activity was also evaluated by UV/VIS spectrophotometry. Samples doped with copper showed much better photocatalytical performances.


2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Simona Liliana Iconaru ◽  
Alina Mihaela Prodan ◽  
Philippe Le Coustumer ◽  
Daniela Predoi

The glycerol iron oxide nanoparticles (GIO-NPs) were obtained by an adapted coprecipitation method. The X-ray diffraction (XRD) studies demonstrate that GIO-NPs were indexed into the spinel cubic lattice with a lattice parameter of 0.835 nm. The refinement of XRD spectra indicated that no other phases except maghemite were detected. The adsorption of glycerol on iron oxide nanoparticles was investigated by Fourier transform infrared (FTIR) spectroscopy. On the other hand, this work implicated the use of GIO-NPs in antibacterial studies. The results indicate that, in the case ofP. aeruginosa  1397biofilms, at concentrations from 0.01 mg/mL to 0.625 mg/mL, the glycerol iron oxide inhibits the ability of this strain to develop biofilms on the inert substratum.


Antibiotics ◽  
2018 ◽  
Vol 7 (2) ◽  
pp. 46 ◽  
Author(s):  
Laís Arias ◽  
Juliano Pessan ◽  
Ana Vieira ◽  
Taynara Lima ◽  
Alberto Delbem ◽  
...  

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