scholarly journals Regioselective Mercury(I)/Palladium(II)-Catalyzed Single-Step Approach for the Synthesis of Imines and 2-Substituted Indoles

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 4092
Author(s):  
Rsuini U. Gutiérrez ◽  
Mayra Hernández-Montes ◽  
Aarón Mendieta-Moctezuma ◽  
Francisco Delgado ◽  
Joaquín Tamariz
Keyword(s):  
Single Step ◽  
Efficient Synthesis ◽  
One Pot ◽  
Step Process ◽  
Alkyl Derivatives ◽  
Terminal Acetylenes

An efficient synthesis of ketimines was achieved through a regioselective Hg(I)-catalyzed hydroamination of terminal acetylenes in the presence of anilines. The Pd(II)-catalyzed cyclization of these imines into the 2-substituted indoles was satisfactorily carried out by a C-H activation. In a single-step approach, a variety of 2-substituted indoles were also generated via a Hg(I)/Pd(II)-catalyzed, one-pot, two-step process, starting from anilines and terminal acetylenes. The arylacetylenes proved to be more effective than the alkyl derivatives.

CuI/Et2NH-Catalyzed One-Pot Highly Efficient Synthesis of 1,4-Disubstituted 1,2,3-Triazoles in Green Solvent Glycerol

Synthesis ◽  
2018 ◽  
Vol 50 (11) ◽  
pp. 2191-2199 ◽  
Author(s):  
Yongde Zhao ◽  
Shengqiang Guo ◽  
Yang Zhou ◽  
Bencai Dai ◽  
Cuimeng Huo ◽  
...  
Keyword(s):  
Catalytic System ◽  
Sodium Azide ◽  
Room Temperature ◽  
Green Solvent ◽  
Efficient Synthesis ◽  
One Pot ◽  
Highly Efficient ◽  
Three Component Reaction ◽  
Efficient Route ◽  
Terminal Acetylenes

A concise one-pot three-component reaction of organic halides­, terminal acetylenes, and sodium azide provided an efficient route for the synthesis of 1,2,3-triazoles. A variety of 1,2,3-triazoles were prepared in good to excellent yields with green solvent glycerol. This procedure used CuI and diethylamine, which are two easily available reagents as the new catalytic system at room temperature.

A one-pot process for the microwave-assisted synthesis of 7-substituted pyrazolo[1,5-a]pyrimidine

RSC Advances ◽  
2016 ◽  
Vol 6 (4) ◽  
pp. 3301-3306 ◽  
Author(s):  
Ibtissam Bassoude ◽  
Zahira Tber ◽  
El Mokhtar Essassi ◽  
Gérald Guillaumet ◽  
Sabine Berteina-Raboin
Keyword(s):  
Microwave Assisted Synthesis ◽  
Efficient Synthesis ◽  
One Pot ◽  
Step Process ◽  
Microwave Assisted ◽  
Decarboxylation Reaction

An efficient synthesis of 7-substituted pyrazolo[1,5-a]pyrimidines using a one-pot, two-step process via Pd-catalyzed direct CH-arylation followed by a saponification–decarboxylation reaction is reported.

Progress in One-Pot Synthesis of Methyl Isobutyl Ketone Using Multifunctional Layered Based Catalysts

2013 ◽  
Vol 571 ◽  
pp. 169-196
Author(s):  
Nigamananda Das
Keyword(s):  
Methyl Isobutyl Ketone ◽  
Single Step ◽  
Methyl Isobutyl ◽  
Isobutyl Ketone ◽  
One Pot ◽  
Catalytic Systems ◽  
Step Process ◽  
One Pot Synthesis ◽  
Multifunctional Catalysts ◽  
One Step

Methyl isobutyl ketone (MIBK) is one of the most widely produced and used aliphatic ketones worldwide. The one-step MIBK process with no intermediate separation steps using multifunctional catalysts is an important development towards greener organic synthesis and generates tremendous interest among the researcher across the globe. The single step process is facile and more economically viable and has provided opportunity to develop new and improved catalyst systems capable of operating under mild conditions. A widely variety of catalytic systems have been used in one-step process during last three to four decades. The progress in one-pot synthesis of MIBK using different multifunctional catalysts with special reference to layered based catalysts was critically reviewed in this article.

Novel and efficient synthesis of fused spiro piperidone-cyclopropanes from cascade reaction of 1-acylcyclopropanecarboxamides and polarized olefin

2021 ◽  
Author(s):  
Xiao Dan Han ◽  
Gao Liang Peng ◽  
Hui Bin Wang ◽  
lei wu ◽  
Jian Ping Fu ◽  
...  
Keyword(s):  
Cascade Reaction ◽  
Single Step ◽  
Efficient Synthesis ◽  
One Pot ◽  
The One ◽  
Cyclopropane Derivatives

We report here that a series of O-bridged ring fused spiro piperidone-cyclopropane derivatives 3 can be constructed in a single step by the one-pot reaction of 1-acylcyclopropanecarboxamides 1 with polarized...

scholarly journals One-Pot Synthesis of Heavier Group 14 N-Heterocyclic Carbene Using Organosilicon Reductant

Inorganics ◽  
2018 ◽  
Vol 6 (3) ◽  
pp. 69 ◽  
Author(s):  
Ravindra Raut ◽  
Sheikh Amin ◽  
Padmini Sahoo ◽  
Vikas Kumar ◽  
Moumita Majumdar
Keyword(s):  
Alkali Metal ◽  
Reducing Agents ◽  
Single Step ◽  
Reducing Agent ◽  
Metal Salts ◽  
Group 14 ◽  
Reaction Conditions ◽  
One Pot ◽  
Step Process ◽  
One Pot Synthesis

Syntheses of heavier Group 14 analogues of “Arduengo-type” N-heterocyclic carbene majorly involved the use of conventional alkali metal-based reducing agents under harsh reaction conditions. The accompanied reductant-derived metal salts and chances of over-reduced impurities often led to isolation difficulties in this multi-step process. In order to overcome these shortcomings, we have used 1,4-bis-(trimethylsilyl)-1,4-diaza-2,5-cyclohexadiene as a milder reducing agent for the preparation of N-heterocyclic germylenes (NHGe) and stannylenes (NHSn). The reaction occurs in a single step with moderate yields from the mixture of N-substituted 1,4-diaza-1,3-butadiene, E(II) (E(II) = GeCl2·dioxane, SnCl2) and the organosilicon reductant. The volatile byproducts trimethylsilyl chloride and pyrazine could be removed readily under vacuum. No significant over reduction was observed in this process. However, N-heterocyclic silylene (NHSi) could not be synthesized using an even stronger organosilicon reductant under thermal and photochemical conditions.

One-pot production of oxygenated monomers and modified lignin from biomass based on plasma electrolysis

2021 ◽  
Author(s):  
Lusi A ◽  
Harish Radhakrishnan ◽  
hu hui ◽  
Xianglan Bai
Keyword(s):  
Single Step ◽  
Red Oak ◽  
High Quality ◽  
One Pot ◽  
Step Process ◽  
Plasma Electrolysis ◽  
Novel Method ◽  
Modified Lignin

Herein, we report a novel method to obtain oxygenated chemicals and high-quality lignin from biomass in one-pot using a single step process. Plasma electrolysis of red oak was conducted by...

Facile and Efficient Synthesis of New Class of Imidazole Derivatives via One-Pot Multicomponent Reactions in Water

2013 ◽  
Vol 16 (10) ◽  
pp. 788-790
Author(s):  
Zinatossadat Hossaini ◽  
Samereh Seyfi ◽  
Faramarz Rostami-Charati ◽  
Mehdi Ghambarian
Keyword(s):  
Multicomponent Reactions ◽  
Efficient Synthesis ◽  
One Pot ◽  
Imidazole Derivatives ◽  
New Class

Microwave-accelerated Carbon-carbon and Carbon-heteroatom Bond Formation via Multi-component Reactions: A Brief Overview

2020 ◽  
Vol 7 (1) ◽  
pp. 23-39 ◽  
Author(s):  
Kantharaju Kamanna ◽  
Santosh Y. Khatavi
Keyword(s):  
Organic Synthesis ◽  
Bond Formation ◽  
Cycloaddition Reaction ◽  
Nanoparticle Synthesis ◽  
Single Step ◽  
Bioactive Molecules ◽  
One Pot ◽  
Bond Forming ◽  
Material Interest ◽  
Carbon Carbon Bond

Multi-Component Reactions (MCRs) have emerged as an excellent tool in organic chemistry for the synthesis of various bioactive molecules. Among these, one-pot MCRs are included, in which organic reactants react with domino in a single-step process. This has become an alternative platform for the organic chemists, because of their simple operation, less purification methods, no side product and faster reaction time. One of the important applications of the MCRs can be drawn in carbon- carbon (C-C) and carbon-heteroatom (C-X; X = N, O, S) bond formation, which is extensively used by the organic chemists to generate bioactive or useful material synthesis. Some of the key carbon- carbon bond forming reactions are Grignard, Wittig, Enolate alkylation, Aldol, Claisen condensation, Michael and more organic reactions. Alternatively, carbon-heteroatoms containing C-N, C-O, and C-S bond are also found more important and present in various heterocyclic compounds, which are of biological, pharmaceutical, and material interest. Thus, there is a clear scope for the discovery and development of cleaner reaction, faster reaction rate, atom economy and efficient one-pot synthesis for sustainable production of diverse and structurally complex organic molecules. Reactions that required hours to run completely in a conventional method can now be carried out within minutes. Thus, the application of microwave (MW) radiation in organic synthesis has become more promising considerable amount in resource-friendly and eco-friendly processes. The technique of microwaveassisted organic synthesis (MAOS) has successfully been employed in various material syntheses, such as transition metal-catalyzed cross-coupling, dipolar cycloaddition reaction, biomolecule synthesis, polymer formation, and the nanoparticle synthesis. The application of the microwave-technique in carbon-carbon and carbon-heteroatom bond formations via MCRs with major reported literature examples are discussed in this review.

Six-Sided Heptaporphyrin Array: Towards a Nano-Sized Cube

2004 ◽  
Vol 69 (5) ◽  
pp. 996-1008 ◽  
Author(s):  
Steven J. Langford ◽  
Clint P. Woodward
Keyword(s):  
Single Step ◽  
One Pot ◽  
H Nmr ◽  
The Core ◽  
Nmr Techniques ◽  
Axial Vertex

A strategy in preparing a family of hexameric porphyrin cubes based on the interplay of Sn(IV)-O and Ru(II)-N interactions is described. In this first iteration, we have prepared the heptamer [SnIV(TPyP)·(4)2][Ru(CO)(TPP)]6 (4 = (E)-(3-(4-pyridyl)acrylate)) constituting a 5,10,15,20-tetra(4-pyridyl)porphyrin (TPyP) core and 5,10,15,20-tetraphenylporphyrin (TPP) faces and compared its formation by stepwise and "one-pot" strategies where up to nine components are assembled in a single step in a regiospecific manner. In one example, the heptamer is formed around the template [SnIV(TPyP)·(4)2] bearing pyridine groups in which the nitrogens radiate octahedrally along each vertex. The ability to modulate the axial vertex through choice of pyridine is also demonstrated. 1H NMR measurements on [SnIV(TPyP)·(4)2][Ru(CO)(TPP)]6 indicate that the protons on the core template are extremely shielded as a result of the anisotropy of the peripheral porphyrin units. Various NMR techniques, including NOESY experiments, have been used to characterise the heptamer in solution.

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