scholarly journals Multi-Functional Core-Shell Nanofibers for Wound Healing

Nanomaterials ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1546
Author(s):  
Zhen Li ◽  
Shunqi Mei ◽  
Yajie Dong ◽  
Fenghua She ◽  
Puwang Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Drug Release ◽  
Release Rate ◽  
Healing Process ◽  
Wound Healing Process ◽  
Core Shell ◽  
High Production Rate ◽  
Centrifugal Spinning ◽  
Multiple Drugs

Core-shell nanofibers have great potential for bio-medical applications such as wound healing dressings where multiple drugs and growth factors are expected to be delivered at different healing phases. Compared to monoaxial nanofibers, core-shell nanofibers can control the drug release profile easier, providing sustainable and effective drugs and growth factors for wound healing. However, it is challenging to produce core-shell structured nanofibers with a high production rate at low energy consumption. Co-axial centrifugal spinning is an alternative method to address the above limitations to produce core-shell nanofibers effectively. In this study, a co-axial centrifugal spinning device was designed and assembled to produce core-shell nanofibers for controlling the release rate of ibuprofen and hEGF in inflammation and proliferation phases during the wound healing process. Core-shell structured nanofibers were confirmed by TEM. This work demonstrated that the co-axial centrifugal spinning is a high productivity process that can produce materials with a 3D environment mimicking natural tissue scaffold, and the specific drug can be loaded into different layers to control the drug release rate to improve the drug efficiency and promote wound healing.

Natural, Synthetic and their Combinatorial Nanocarriers Based Drug Delivery System in the Treatment Paradigm for Wound Healing Via Dermal Targeting

2020 ◽  
Vol 26 (36) ◽  
pp. 4551-4568
Author(s):  
Mohammad Kashif Iqubal ◽  
Sadaf Saleem ◽  
Ashif Iqubal ◽  
Aiswarya Chaudhuri ◽  
Faheem Hyder Pottoo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Photodynamic Therapy ◽  
Growth Factors ◽  
Combination Therapy ◽  
Healing Process ◽  
Wound Healing Process ◽  
Wound Site ◽  
Synthetic Drugs ◽  
Treatment Paradigm

A wound refers to the epithelial loss, accompanied by loss of muscle fibers collagen, nerves and bone instigated by surgery, trauma, frictions or by heat. Process of wound healing is a compounded activity of recovering the functional integrity of the damaged tissues. This process is mediated by various cytokines and growth factors usually liberated at the wound site. A plethora of herbal and synthetic drugs, as well as photodynamic therapy, is available to facilitate the process of wound healing. Generally, the systems used for the management of wounds tend to act through covering the ruptured site, reduce pain, inflammation, and prevent the invasion and growth of microorganisms. The available systems are, though, enough to meet these requirements, but the involvement of nanotechnology can ameliorate the performance of these protective coverings. In recent years, nano-based formulations have gained immense popularity among researchers for the wound healing process due to the enhanced benefits they offer over the conventional preparations. Hereupon, this review aims to cover the entire roadmap of wound healing, beginning from the molecular factors involved in the process, the various synthetic and herbal agents, and combination therapy available for the treatment and the current nano-based systems available for delivery through the topical route for wound healing.

scholarly journals Development and use of biomaterials as wound healing therapies

2019 ◽  
Vol 7 ◽  
Author(s):  
Rachael Zoe Murray ◽  
Zoe Elizabeth West ◽  
Allison June Cowin ◽  
Brooke Louise Farrugia
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Healing Process ◽  
Wound Dressings ◽  
Wound Healing Process ◽  
Skin Substitutes ◽  
Vast Number ◽  
Recent Advances ◽  
Future Direction

Abstract There is a vast number of treatments on the market for the management of wounds and burns, representing a multi-billion dollar industry worldwide. These include conventional wound dressings, dressings that incorporate growth factors to stimulate and facilitate the wound healing process, and skin substitutes that incorporate patient-derived cells. This article will review the more established, and the recent advances in the use of biomaterials for wound healing therapies, and their future direction.

scholarly journals TERAPI LARVA PADA LUKA KRONIS TERBUKA

2015 ◽  
Vol 7 (1) ◽  
Author(s):  
Sunny Wangko
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Chronic Wound ◽  
Healing Process ◽  
Bioactive Molecules ◽  
Wound Management ◽  
Wound Healing Process ◽  
Beneficial Effects ◽  
Infected Wounds ◽  
Larval Therapy

Abstract: The usage of larvae in wound treatment has been known across the centuries in different countries. However, larval therapy is offered when the conventional therapy has failed in the management of chronic, infected wounds. Concerning the larval therapy, it was presumed that the wound healing was due to the mechanical debridement effect of the larval movement and of their hooks. To date, a variety of study reports reveals that there are several beneficial effects of the larval therapy, inter alia: secretion/excretion of larvae contains enzymes, growth factors, and cytokines that collaborate in the wound healing process. The bioactive molecules in the secretion/excretion of the larvae has to be further studied and to be developed, therefore, they can be applied in the wound management efficiently and economically. Keywords: larval therapy, chronic wound, healing process.     Abstrak: Walaupun pemanfaatan larva pada luka kronis telah sangat lama dikenal di berbagai negara, terapi larva umumnya digunakan bila terapi konvensional telah gagal. Awalnya diduga bahwa efek debridemen mekanis oleh gerakan larva dan kaitnya yang paling berperan. Dewasa ini, laporan berbagi studi telah mengungkapkan bahwa larva menyekresi dan menyintesis berbagai bahan baik berupa enzim, sitokin, dan growth factors yang turut berperan dalam proses penyembuhan luka. Adanya molekul bioaktif dalam ekskresi dan sekresi larva perlu diteliti dan dikembangkan agar dapat diaplikasikan dengan lebih efisien dan ekonomis. Kata kunci: terapi larva, luka kronis, penyembuhan luka.

scholarly journals Growth Factors, Reactive Oxygen Species, and Metformin—Promoters of the Wound Healing Process in Burns?

2021 ◽  
Vol 22 (17) ◽  
pp. 9512
Author(s):  
Daniela Miricescu ◽  
Silviu Constantin Badoiu ◽  
Iulia-Ioana Stanescu-Spinu ◽  
Alexandra Ripszky Totan ◽  
Constantin Stefani ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Wound Healing ◽  
Growth Factors ◽  
Healing Process ◽  
Reactive Oxygen ◽  
Burn Injuries ◽  
Wound Healing Process ◽  
Oxygen Species ◽  
Clotting Factors ◽  
Major Health Problem

Burns can be caused by various factors and have an increased risk of infection that can seriously delay the wound healing process. Chronic wounds caused by burns represent a major health problem. Wound healing is a complex process, orchestrated by cytokines, growth factors, prostaglandins, free radicals, clotting factors, and nitric oxide. Growth factors released during this process are involved in cell growth, proliferation, migration, and differentiation. Reactive oxygen species are released in acute and chronic burn injuries and play key roles in healing and regeneration. The main aim of this review is to present the roles of growth factors, reactive oxygen species, and metformin in the healing process of burn injuries.

scholarly journals Role of Growth Factors in Cutaneous Wound Healing: A Review

1993 ◽  
Vol 4 (5) ◽  
pp. 729-760 ◽  
Author(s):  
Christopher P. Kiritsy ◽  
Samuel E. Lynch
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Healing Process ◽  
Repair Process ◽  
Wound Healing Process ◽  
Cutaneous Wounds ◽  
Skin Ulcers ◽  
Molecular Events ◽  
Chronic Skin ◽  
Preclinical Animal Models

The well-orchestrated, complex series of events resulting in the repair of cutaneous wounds are, at least in part, regulated by polypeptide growth factors. This review provides a detailed overview of the known functions, interactions, and mechanisms of action of growth factors in the context of the overall repair process in cutaneous wounds. An overview of the cellular and molecular events involved in soft tissue repair is initially presented, followed by a review of widely studied growth factors and a discussion of commonly utilized preclinical animal models. The article concludes with a summary of the preliminary results from human clinical trials evaluating the effects of growth factors in the healing of chronic skin ulcers. Throughout, the interactions among the growth factors in the wound-healing process are emphasized.

scholarly journals Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing

2021 ◽  
Vol 22 (3) ◽  
pp. 1408
Author(s):  
Luis Castillo-Henríquez ◽  
Jose Castro-Alpízar ◽  
Mary Lopretti-Correa ◽  
José Vega-Baudrit
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Drug Release ◽  
Inflammatory Response ◽  
Bacterial Infections ◽  
Healing Process ◽  
Solution Temperature ◽  
Wound Healing Process ◽  
Thermal Stimulus ◽  
Responsive Polymers

Innate and adaptive immune responses lead to wound healing by regulating a complex series of events promoting cellular cross-talk. An inflammatory response is presented with its characteristic clinical symptoms: heat, pain, redness, and swelling. Some smart thermo-responsive polymers like chitosan, polyvinylpyrrolidone, alginate, and poly(ε-caprolactone) can be used to create biocompatible and biodegradable scaffolds. These processed thermo-responsive biomaterials possess 3D architectures similar to human structures, providing physical support for cell growth and tissue regeneration. Furthermore, these structures are used as novel drug delivery systems. Locally heated tumors above the polymer lower the critical solution temperature and can induce its conversion into a hydrophobic form by an entropy-driven process, enhancing drug release. When the thermal stimulus is gone, drug release is reduced due to the swelling of the material. As a result, these systems can contribute to the wound healing process in accelerating tissue healing, avoiding large scar tissue, regulating the inflammatory response, and protecting from bacterial infections. This paper integrates the relevant reported contributions of bioengineered scaffolds composed of smart thermo-responsive polymers for drug delivery applications in wound healing. Therefore, we present a comprehensive review that aims to demonstrate these systems’ capacity to provide spatially and temporally controlled release strategies for one or more drugs used in wound healing. In this sense, the novel manufacturing techniques of 3D printing and electrospinning are explored for the tuning of their physicochemical properties to adjust therapies according to patient convenience and reduce drug toxicity and side effects.

Bilirubin modulated cytokines, growth factors and angiogenesis to improve cutaneous wound healing process in diabetic rats

2016 ◽  
Vol 30 ◽  
pp. 137-149 ◽  
Author(s):  
Mahendra Ram ◽  
Vishakha Singh ◽  
Sanjay Kumawat ◽  
Vinay Kant ◽  
Surendra Kumar Tandan ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Healing Process ◽  
Diabetic Rats ◽  
Wound Healing Process ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound

scholarly journals Growth Factors in Wound Healing – A Review

2021 ◽  
Vol 14 (3) ◽  
pp. 1469-1480
Author(s):  
Lalitha Vaidyanathan
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Synergistic Effects ◽  
Wound Care ◽  
Healing Process ◽  
Future Research ◽  
Wound Healing Process ◽  
Signaling Mechanisms ◽  
Process Understanding ◽  
Incomplete Healing

The review is an overview of the features of growth factors involved in cellular signaling mechanisms regulating the wound healing process. Understanding the insights of this mechanism is significant for opening therapeutic and research avenues in wound healing. The review highlights the synergistic functioning of most of the growth factors which would enhance the possibility of these factors being the targets for wound care therapy.The significance of the onset and resolution of inflammation in the healing process is better understood clinically and a range of recombinant growth factors to combat this condition have been identified and used to accelerate healing process.The chemotactic and growth regulating factors act as triggers that take the cellular and biochemical components through the inflammation, proliferation, epithelialization, angiogenesis and tissue remodeling phases. Clinical conditions that create alteration in expression of these factors lead to slow and incomplete healing. The review emphasizes on the clinical use of synthetic and recombinant growth factors whose synergistic effects are remarkable. The review covers the specific signaling mechanisms involved in the regulation of these growth factor expressions, specifically the PI3K/AKT, RAS/MAP and JAK pathways; these could be potential targets for future research expansions in this field.

scholarly journals Nanohybrids for Wound Healing Application

2021 ◽  
pp. 121-133
Keyword(s):  
Wound Healing ◽  
Drug Release ◽  
Clay Minerals ◽  
Healing Process ◽  
Bacterial Activity ◽  
Material Surface ◽  
Wound Healing Process ◽  
Oxygen Species ◽  
Vital Factor

The microfluidics-delivered nanohybrids invest the framework with an arranged course from wound discovery, receptive oxygen species rummaging and drug release. The drug release conduct mirrors the dynamic wound healing process, hence rendering an upgraded bio-mimetic regeneration. The properties of nanomaterials that are 1– 100 nm in size can be controlled to influence their capacities while connecting with biomaterials and biomedicines. Among the different sorts of nanomaterials, the clay minerals are universal in soils and viewed as protected materials for use in medicinal applications. Anti-bacterial activity is a vital factor for wound healing. Re-epithelization happens amid wound healing and includes the expansion of keratinocytes and the separation of fibroblasts. Ongoing improvements in nanotechnology for blending nanometer-estimate materials may give a chance to empowering viable wound healing because of material surface collaboration with cells and tissue.

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