scholarly journals Role of Growth Factors in Cutaneous Wound Healing: A Review

1993 ◽  
Vol 4 (5) ◽  
pp. 729-760 ◽  
Author(s):  
Christopher P. Kiritsy ◽  
Samuel E. Lynch
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Healing Process ◽  
Repair Process ◽  
Wound Healing Process ◽  
Cutaneous Wounds ◽  
Skin Ulcers ◽  
Molecular Events ◽  
Chronic Skin ◽  
Preclinical Animal Models

The well-orchestrated, complex series of events resulting in the repair of cutaneous wounds are, at least in part, regulated by polypeptide growth factors. This review provides a detailed overview of the known functions, interactions, and mechanisms of action of growth factors in the context of the overall repair process in cutaneous wounds. An overview of the cellular and molecular events involved in soft tissue repair is initially presented, followed by a review of widely studied growth factors and a discussion of commonly utilized preclinical animal models. The article concludes with a summary of the preliminary results from human clinical trials evaluating the effects of growth factors in the healing of chronic skin ulcers. Throughout, the interactions among the growth factors in the wound-healing process are emphasized.

Natural, Synthetic and their Combinatorial Nanocarriers Based Drug Delivery System in the Treatment Paradigm for Wound Healing Via Dermal Targeting

2020 ◽  
Vol 26 (36) ◽  
pp. 4551-4568
Author(s):  
Mohammad Kashif Iqubal ◽  
Sadaf Saleem ◽  
Ashif Iqubal ◽  
Aiswarya Chaudhuri ◽  
Faheem Hyder Pottoo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Photodynamic Therapy ◽  
Growth Factors ◽  
Combination Therapy ◽  
Healing Process ◽  
Wound Healing Process ◽  
Wound Site ◽  
Synthetic Drugs ◽  
Treatment Paradigm

A wound refers to the epithelial loss, accompanied by loss of muscle fibers collagen, nerves and bone instigated by surgery, trauma, frictions or by heat. Process of wound healing is a compounded activity of recovering the functional integrity of the damaged tissues. This process is mediated by various cytokines and growth factors usually liberated at the wound site. A plethora of herbal and synthetic drugs, as well as photodynamic therapy, is available to facilitate the process of wound healing. Generally, the systems used for the management of wounds tend to act through covering the ruptured site, reduce pain, inflammation, and prevent the invasion and growth of microorganisms. The available systems are, though, enough to meet these requirements, but the involvement of nanotechnology can ameliorate the performance of these protective coverings. In recent years, nano-based formulations have gained immense popularity among researchers for the wound healing process due to the enhanced benefits they offer over the conventional preparations. Hereupon, this review aims to cover the entire roadmap of wound healing, beginning from the molecular factors involved in the process, the various synthetic and herbal agents, and combination therapy available for the treatment and the current nano-based systems available for delivery through the topical route for wound healing.

scholarly journals Multi-Functional Core-Shell Nanofibers for Wound Healing

Nanomaterials ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1546
Author(s):  
Zhen Li ◽  
Shunqi Mei ◽  
Yajie Dong ◽  
Fenghua She ◽  
Puwang Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Drug Release ◽  
Release Rate ◽  
Healing Process ◽  
Wound Healing Process ◽  
Core Shell ◽  
High Production Rate ◽  
Centrifugal Spinning ◽  
Multiple Drugs

Core-shell nanofibers have great potential for bio-medical applications such as wound healing dressings where multiple drugs and growth factors are expected to be delivered at different healing phases. Compared to monoaxial nanofibers, core-shell nanofibers can control the drug release profile easier, providing sustainable and effective drugs and growth factors for wound healing. However, it is challenging to produce core-shell structured nanofibers with a high production rate at low energy consumption. Co-axial centrifugal spinning is an alternative method to address the above limitations to produce core-shell nanofibers effectively. In this study, a co-axial centrifugal spinning device was designed and assembled to produce core-shell nanofibers for controlling the release rate of ibuprofen and hEGF in inflammation and proliferation phases during the wound healing process. Core-shell structured nanofibers were confirmed by TEM. This work demonstrated that the co-axial centrifugal spinning is a high productivity process that can produce materials with a 3D environment mimicking natural tissue scaffold, and the specific drug can be loaded into different layers to control the drug release rate to improve the drug efficiency and promote wound healing.

scholarly journals Novel formulation approaches for wound healing

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 937-948
Author(s):  
Tanaji D Nandgude ◽  
Syed Nateque Naser
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Cell Types ◽  
Wound Management ◽  
Wound Healing Process ◽  
Anatomic Structure ◽  
Tissue Integrity ◽  
Molecular Events ◽  
Acute Injuries ◽  
Healing Wounds

A wound is damage to the typical anatomic structure. Wound healing is an immediate therapeutic response to injury. It is a creation of the combined response of some cell types towards injury. Wound healing takes place by a sequence of molecular events which cooperate to fix tissue integrity and cell work. In typical healthy individual under ordinary conditions, these physiological events take place smoothly. Though sometimes, these molecular events are arrested, this brings about in struggle to heal. There is an assortment of approaches for the way toward managing and controlling both acute injuries (acute wounds) and ceaseless non-mending wounds (chronic non-healing wounds). The principal objective of these two cases is to achieve better-wound healing. Ideal formulations of wound healing should not only enhance the healing process but also reduce pain, infection and loss of electrolytes, proteins and liquids from the injury. A broad scope of items typically introduced with target various parts of the wound healing process depends on numerous types of wounds and novel polymers utilised for the conveyance of medications to both acute and ceaseless injuries. These include alginate, hydrocolloids, hydrofibers, polyurethane, and hydrogels. This article gives particular importance to different novel approaches in the management of wound healing. This review draws out the data and hopes to provide understanding into traditional, current and imminent techniques and methods for wound management.

Acceleration of the healing process of full-thickness wounds using hydrophilic chitosan–silica hybrid sponge in a porcine model

2018 ◽  
Vol 32 (8) ◽  
pp. 1011-1023 ◽  
Author(s):  
Ji-Ung Park ◽  
Seol-Ha Jeong ◽  
Eun-Ho Song ◽  
Juha Song ◽  
Hyoun-Ee Kim ◽  
...  
Keyword(s):  
Wound Healing ◽  
Surface Characterization ◽  
Porcine Model ◽  
Healing Process ◽  
Synergetic Effect ◽  
Wound Healing Process ◽  
Cutaneous Wounds ◽  
Chemical Coupling

In this study, we evaluated the surface characterization of a novel chitosan–silica hybridized membrane and highlighted the substantial role of silica in the wound environment. The chemical coupling of chitosan and silica resulted in a more condensed network compared with pure chitosan, which was eventually able to stably maintain its framework, particularly in the wet state. In addition, we closely observed the wound-healing process along with the surface interaction between chitosan–silica and the wound site using large-surface-area wounds in a porcine model. Our evidence indicates that chitosan–silica exerts a synergetic effect of both materials to promote a remarkable wound-healing process. In particular, the silica in chitosan–silica accelerated wound closure including wound contraction, and re-epithelialization via enhancement of cell recruitment, epidermal maturity, neovascularization, and granulation tissue formation compared with pure chitosan and other commercial dressing materials. This advanced wound dressing material may lead to effective treatment for problematic cutaneous wounds and can be further applied for human skin regeneration.

scholarly journals Development and use of biomaterials as wound healing therapies

2019 ◽  
Vol 7 ◽  
Author(s):  
Rachael Zoe Murray ◽  
Zoe Elizabeth West ◽  
Allison June Cowin ◽  
Brooke Louise Farrugia
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Healing Process ◽  
Wound Dressings ◽  
Wound Healing Process ◽  
Skin Substitutes ◽  
Vast Number ◽  
Recent Advances ◽  
Future Direction

Abstract There is a vast number of treatments on the market for the management of wounds and burns, representing a multi-billion dollar industry worldwide. These include conventional wound dressings, dressings that incorporate growth factors to stimulate and facilitate the wound healing process, and skin substitutes that incorporate patient-derived cells. This article will review the more established, and the recent advances in the use of biomaterials for wound healing therapies, and their future direction.

Wound Care

2018 ◽  
pp. 27-40
Author(s):  
Amit Ramjit ◽  
Saad Shebrain
Keyword(s):  
Wound Healing ◽  
Wound Care ◽  
Healing Process ◽  
Repair Process ◽  
Wound Healing Process ◽  
Invasive Procedures ◽  
Previous Trauma ◽  
Life Threatening ◽  
History Of ◽  
Patient At Risk

The skin and subcutaneous tissues protect the body from the external environment. Invasive procedures compromise the skin, necessitating these structures to heal which restores their protective function. Skin undergoes a systematic physiologic and predictable repair process. However, pathological conditions such as infection result in abnormal wound healing, which requires the healthcare provider to monitor the wound-healing process closely. Failure in wound healing can place the patient at risk for deeper infection, life-threatening complications such as necrotizing fasciitis (NF), and cosmetically unacceptable wounds. Abnormal healing outcomes, such as a history of keloid or hypertrophic scarring from previous trauma or invasive procedures, give the clinician clues to managing additional procedures properly. Knowledge of wound care techniques such as dressings allows the clinician to manage wounds properly during the repair process.

scholarly journals TERAPI LARVA PADA LUKA KRONIS TERBUKA

2015 ◽  
Vol 7 (1) ◽  
Author(s):  
Sunny Wangko
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Chronic Wound ◽  
Healing Process ◽  
Bioactive Molecules ◽  
Wound Management ◽  
Wound Healing Process ◽  
Beneficial Effects ◽  
Infected Wounds ◽  
Larval Therapy

Abstract: The usage of larvae in wound treatment has been known across the centuries in different countries. However, larval therapy is offered when the conventional therapy has failed in the management of chronic, infected wounds. Concerning the larval therapy, it was presumed that the wound healing was due to the mechanical debridement effect of the larval movement and of their hooks. To date, a variety of study reports reveals that there are several beneficial effects of the larval therapy, inter alia: secretion/excretion of larvae contains enzymes, growth factors, and cytokines that collaborate in the wound healing process. The bioactive molecules in the secretion/excretion of the larvae has to be further studied and to be developed, therefore, they can be applied in the wound management efficiently and economically. Keywords: larval therapy, chronic wound, healing process.     Abstrak: Walaupun pemanfaatan larva pada luka kronis telah sangat lama dikenal di berbagai negara, terapi larva umumnya digunakan bila terapi konvensional telah gagal. Awalnya diduga bahwa efek debridemen mekanis oleh gerakan larva dan kaitnya yang paling berperan. Dewasa ini, laporan berbagi studi telah mengungkapkan bahwa larva menyekresi dan menyintesis berbagai bahan baik berupa enzim, sitokin, dan growth factors yang turut berperan dalam proses penyembuhan luka. Adanya molekul bioaktif dalam ekskresi dan sekresi larva perlu diteliti dan dikembangkan agar dapat diaplikasikan dengan lebih efisien dan ekonomis. Kata kunci: terapi larva, luka kronis, penyembuhan luka.

scholarly journals Growth Factors, Reactive Oxygen Species, and Metformin—Promoters of the Wound Healing Process in Burns?

2021 ◽  
Vol 22 (17) ◽  
pp. 9512
Author(s):  
Daniela Miricescu ◽  
Silviu Constantin Badoiu ◽  
Iulia-Ioana Stanescu-Spinu ◽  
Alexandra Ripszky Totan ◽  
Constantin Stefani ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Wound Healing ◽  
Growth Factors ◽  
Healing Process ◽  
Reactive Oxygen ◽  
Burn Injuries ◽  
Wound Healing Process ◽  
Oxygen Species ◽  
Clotting Factors ◽  
Major Health Problem

Burns can be caused by various factors and have an increased risk of infection that can seriously delay the wound healing process. Chronic wounds caused by burns represent a major health problem. Wound healing is a complex process, orchestrated by cytokines, growth factors, prostaglandins, free radicals, clotting factors, and nitric oxide. Growth factors released during this process are involved in cell growth, proliferation, migration, and differentiation. Reactive oxygen species are released in acute and chronic burn injuries and play key roles in healing and regeneration. The main aim of this review is to present the roles of growth factors, reactive oxygen species, and metformin in the healing process of burn injuries.

scholarly journals Synthesis of keratin spray from chicken feathers for biomedical applications

2021 ◽  
Vol 3 (2) ◽  
pp. 18-22
Author(s):  
Mohamed Saad Bala ◽  
Liyana Maryam ◽  
Basma Yahya Alashwal ◽  
Arun Gupta ◽  
Triveni Soubam ◽  
...  
Keyword(s):  
Wound Healing ◽  
Inductively Coupled Plasma ◽  
Ph Value ◽  
Wound Care ◽  
Healing Process ◽  
Optical Emission ◽  
Repair Process ◽  
Emission Spectrometry ◽  
Wound Healing Process ◽  
Chicken Feathers

There is a pressing need to develop wound healing spray that can utilize it for the treatment of skin rebuilding. Wound healing involves the regeneration and tissue repair process with the sequence of molecular and cellular measures that ensue the onset of a tissue lesion to reestablish the damaged tissue. This study aimed to produce the best formulation of keratin-based wound spray which was prepared by varying of the keratin concentration to suit for human nature skin and can be promoted for the wound healing process. A wound-healing bouquet was prepared with keratin as the primary substituent mixed with 2-phenyl ethanol, methyl lactate, and methyl propanediol to rejuvenate the skin effectively. The keratin has been extracted from chicken feathers which have high levels of protein source. Keratinocytes containing keratin migrate from the wound edges to cover the wound during the remedial process. The samples are characterized by Fourier Transform Infrared Spectroscopy (FTIR) to determine the functional groups and Inductively Coupled Plasma-Optical Emission Spectrometry (ICP-OES) for heavy metal analysis. The characteristics of keratin-based wound spray from chicken feather made it an effective wound care product. The pH value of the formulation possesses a little acidic nature (pH 5.56) where is considered an appropriate nature to prevent the growth of bacteria. This wound healing spray gives a suitable domain of cure efficiency to the injured region as they have ideal levels of pH.

scholarly journals The Role of MSC in Wound Healing, Scarring and Regeneration

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1729
Author(s):  
Raquel Guillamat-Prats
Keyword(s):  
Wound Healing ◽  
Wound Repair ◽  
Therapeutic Potential ◽  
Healing Process ◽  
Repair Process ◽  
Skin Wound ◽  
Wound Healing Process ◽  
Matrix Remodeling ◽  
Skin Wound Healing ◽  
Tissue Repair And Regeneration

Tissue repair and regeneration after damage is not completely understood, and current therapies to support this process are limited. The wound healing process is associated with cell migration and proliferation, extracellular matrix remodeling, angiogenesis and re-epithelialization. In normal conditions, a wound will lead to healing, resulting in reparation of the tissue. Several risk factors, chronic inflammation, and some diseases lead to a deficient wound closure, producing a scar that can finish with a pathological fibrosis. Mesenchymal stem/stromal cells (MSCs) are widely used for their regenerative capacity and their possible therapeutically potential. Derived products of MSCs, such as exosomes or extravesicles, have shown a therapeutic potential similar to MSCs, and these cell-free products may be interesting in clinics. MSCs or their derivative products have shown paracrine beneficial effects, regulating inflammation, modifying the fibroblast activation and production of collagen and promoting neovascularization and re-epithelialization. This review describes the effects of MSCs and their derived products in each step of the wound repair process. As well, it reviews the pre-clinical and clinical use of MSCs to benefit in skin wound healing in diabetic associated wounds and in pathophysiological fibrosis.

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