scholarly journals “Three-Bullets” Loaded Mesoporous Silica Nanoparticles for Combined Photo/Chemotherapy

Nanomaterials ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. 823 ◽  
Author(s):  
André Luiz Tessaro ◽  
Aurore Fraix ◽  
Ana Claudia Pedrozo da Silva ◽  
Elena Gazzano ◽  
Chiara Riganti ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Outer Part ◽  
Green Light ◽  
Biological Evaluation ◽  
Light Sources ◽  
Good Tolerability ◽  
Physiological Conditions ◽  
The Individual

This contribution reports the design, preparation, photophysical and photochemical characterization, as well as a preliminary biological evaluation of mesoporous silica nanoparticles (MSNs) covalently integrating a nitric oxide (NO) photodonor (NOPD) and a singlet oxygen (1O2) photosensitizer (PS) and encapsulating the anticancer doxorubicin (DOX) in a noncovalent fashion. These MSNs bind the NOPD mainly in their inner part and the PS in their outer part in order to judiciously exploit the different diffusion radius of the cytotoxic NO and 1O2. Furthermore this silica nanoconstruct has been devised in such a way to permit the selective excitation of the NOPD and the PS with light sources of different energy in the visible window. We demonstrate that the individual photochemical performances of the photoactive components of the MSNs are not mutually affected, and remain unaltered even in the presence of DOX. As a result, the complete nanoconstruct is able to deliver NO and 1O2 under blue and green light, respectively, and to release DOX under physiological conditions. Preliminary biological results performed using A375 cancer cells show a good tolerability of the functionalized MSNs in the dark and a potentiated activity of DOX upon irradiation, due to the effect of the NO photoreleased.

Recent Advances in Application of Azobenzenes Grafted on Mesoporous Silica Nanoparticles in Controlled Drug Delivery Systems Using Light as External Stimulus

2020 ◽  
Vol 20 (11) ◽  
pp. 1001-1016
Author(s):  
Sandra Ramírez-Rave ◽  
María Josefa Bernad-Bernad ◽  
Jesús Gracia-Mora ◽  
Anatoly K. Yatsimirsky
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
Delivery Systems ◽  
Surface Reactivity ◽  
External Stimulus ◽  
Recent Advances

Hybrid materials based on Mesoporous Silica Nanoparticles (MSN) have attracted plentiful attention due to the versatility of their chemistry, and the field of Drug Delivery Systems (DDS) is not an exception. MSN present desirable biocompatibility, high surface area values, and a well-studied surface reactivity for tailoring a vast diversity of chemical moieties. Particularly important for DDS applications is the use of external stimuli for drug release. In this context, light is an exceptional alternative due to its high degree of spatiotemporal precision and non-invasive character, and a large number of promising DDS based on photoswitchable properties of azobenzenes have been recently reported. This review covers the recent advances in design of DDS using light as an external stimulus mostly based on literature published within last years with an emphasis on usually overlooked underlying chemistry, photophysical properties, and supramolecular complexation of azobenzenes.

Fluorescent spherical mesoporous silica nanoparticles loaded with emodin: Synthesis, cellular uptake and anticancer activity

2021 ◽  
Vol 119 ◽  
pp. 111619
Author(s):  
Paul Jänicke ◽  
Claudia Lennicke ◽  
Annette Meister ◽  
Barbara Seliger ◽  
Ludger A. Wessjohann ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Anticancer Activity ◽  
Silica Nanoparticles ◽  
Cellular Uptake ◽  
Mesoporous Silica Nanoparticles

Exploiting mesoporous silica nanoparticles as versatile drug carriers for several routes of administration

2021 ◽  
Vol 312 ◽  
pp. 110774
Author(s):  
Rafael Miguel Sábio ◽  
Andréia Bagliotti Meneguin ◽  
Aline Martins dos Santos ◽  
Andreia Sofia Monteiro ◽  
Marlus Chorilli
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Carriers ◽  
Routes Of Administration

scholarly journals Cylindrical Microparticles Composed of Mesoporous Silica Nanoparticles for the Targeted Delivery of a Small Molecule and a Macromolecular Drug to the Lungs: Exemplified with Curcumin and siRNA

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 844
Author(s):  
Thorben Fischer ◽  
Inga Winter ◽  
Robert Drumm ◽  
Marc Schneider
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Targeted Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Alveolar Epithelial Cells ◽  
In Vitro Toxicity ◽  
Layer By Layer ◽  
Necrosis Factor Alpha ◽  
Aerodynamic Properties ◽  
Tnf Α

The transport of macromolecular drugs such as oligonucleotides into the lungs has become increasingly relevant in recent years due to their high potency. However, the chemical structure of this group of drugs poses a hurdle to their delivery, caused by the negative charge, membrane impermeability and instability. For example, siRNA to reduce tumour necrosis factor alpha (TNF-α) secretion to reduce inflammatory signals has been successfully delivered by inhalation. In order to increase the effect of the treatment, a co-transport of another anti-inflammatory ingredient was applied. Combining curcumin-loaded mesoporous silica nanoparticles in nanostructured cylindrical microparticles stabilized by the layer-by-layer technique using polyanionic siRNA against TNF-α was used for demonstration. This system showed aerodynamic properties suited for lung deposition (mass median aerodynamic diameter of 2.85 ± 0.44 µm). Furthermore, these inhalable carriers showed no acute in vitro toxicity tested in both alveolar epithelial cells and macrophages up to 48 h incubation. Ultimately, TNF-α release was significantly reduced by the particles, showing an improved activity co-delivering both drugs using such a drug-delivery system for specific inhibition of TNF-α in the lungs.

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