Challenges in the Diagnosis of Magnesium Status

Magnesium is a critical mineral in the human body and is involved in ~80% of known metabolic functions. It is currently estimated that 60% of adults do not achieve the average dietary intake (ADI) and 45% of Americans are magnesium deficient, a condition associated with disease states like hypertension, diabetes, and neurological disorders, to name a few. Magnesium deficiency can be attributed to common dietary practices, medications, and farming techniques, along with estimates that the mineral content of vegetables has declined by as much as 80–90% in the last 100 years. However, despite this mineral’s importance, it is poorly understood from several standpoints, not the least of which is its unique mechanism of absorption and sensitive compartmental handling in the body, making the determination of magnesium status difficult. The reliance on several popular sample assays has contributed to a great deal of confusion in the literature. This review will discuss causes of magnesium deficiency, absorption, handling, and compartmentalization in the body, highlighting the challenges this creates in determining magnesium status in both clinical and research settings.

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Effect of Magnesium Deficiency and Excess on Renal Tubular Potassium Transport in the Rat

Clinical Science ◽

10.1042/cs0600549 ◽

1981 ◽

Vol 60 (5) ◽

pp. 549-554 ◽

Cited By ~ 4

Author(s):

S. L. Carney ◽

N. L. M. Wong ◽

J. H. Dirks

Keyword(s):

Magnesium Deficiency ◽

Distal Tubule ◽

Fractional Excretion ◽

The Body ◽

Control Group ◽

Potassium Excretion ◽

Potassium Homeostasis ◽

Dietary Magnesium ◽

Magnesium Status ◽

Total Body

1. Dietary magnesium deficiency is commonly associated with significant potassium depletion although the mechanisms responsible are unknown. Because the kidney has an important role in both magnesium and potassium homeostasis, clearance and micropuncture experiments were performed on thyroparathyroidectomized magnesium-deficient, normal and hypermagnesaemic rats to study the effect of body magnesium status on renal potassium handling. 2. Dietary magnesium restriction that reduced total-body magnesium by 30% did not alter renal potassium excretion despite a 10% reduction in total-body potassium. Graded magnesium infusions increased the fractional excretion of potassium in both magnesium-depleted and normal rats. However, the increase in the dietary depleted group was significantly less than in the control group (5-10 and then 13% compared with 7-19 and then 28% respectively). These changes in urine potassium excretion followed alterations in distal-tubule function. Parathyroid hormone did not alter potassium excretion in any of the experimental groups in contrast with its effect on magnesium excretion. 3. These data support the concept of distal tubular control of renal potassium homeostasis. The body magnesium status appears to exert some control over cellular potassium content and to alter indirectly distal-tubule potassium excretion.

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Gender determination of caucasoid hair using image analysis

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100146928 ◽

1993 ◽

Vol 51 ◽

pp. 216-217

Author(s):

T.B. Ball ◽

W.M. Hess

Keyword(s):

Image Analysis ◽

Cross Sections ◽

Scalp Hair ◽

The Body ◽

Equivalent Diameter ◽

Cross Sectional ◽

Hair Samples ◽

Length Width ◽

Morphological Differences

It has been demonstrated that cross sections of bundles of hair can be effectively studied using image analysis. These studies can help to elucidate morphological differences of hair from one region of the body to another. The purpose of the present investigation was to use image analysis to determine whether morphological differences could be demonstrated between male and female human Caucasian terminal scalp hair.Hair samples were taken from the back of the head from 18 caucasoid males and 13 caucasoid females (Figs. 1-2). Bundles of 50 hairs were processed for cross-sectional examination and then analyzed using Prism Image Analysis software on a Macintosh llci computer. Twenty morphological parameters of size and shape were evaluated for each hair cross-section. The size parameters evaluated were area, convex area, perimeter, convex perimeter, length, breadth, fiber length, width, equivalent diameter, and inscribed radius. The shape parameters considered were formfactor, roundness, convexity, solidity, compactness, aspect ratio, elongation, curl, and fractal dimension.

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Determination of Lead Content in Red Colored Lipsticks from Mandalay Market by Flame Atomic Absorption Spectrophotometer

Myanmar Health Sciences Research Journal ◽

10.34299/mhsrj.30.03.0045 ◽

2018 ◽

Vol 30 (3) ◽

pp. 167-173

Keyword(s):

Sampling Procedure ◽

The Body ◽

Lead Content ◽

Social Psychological ◽

Allowable Limit ◽

Flame Atomic Absorption ◽

Therapeutic Benefits ◽

Flame Atomic Absorption Spectrophotometer ◽

Exposure Levels

Red colored lipstick is the most widely used cosmetic product. Although lipstick gives a lot of social, psychological and therapeutic benefits, it may harm the consumers. Because some lipsticks contain a considerable amount of heavy metal especially lead. Lead is being used in lipstick mainly for the pigments required to obtain needed colors. Lead accumulates in the body over time and lead-containing lipstick applied several times a day, every day, combined with lead in water and other sources, could add up to significant exposure levels. Therefore, this study was aimed to determine lead content in red colored lipsticks from market. This study was laboratorybased, analytical study by using 25 lipstick samples. Red colored lipsticks were bought from Mandalay Market by random sampling procedure and they were completely coded to avoid the bias. Then, lead content in coded samples was determined by Flame AAS according to International Conference on Harmonization (ICH) guideline. Lead contents of 88% of the lipsticks samples were more than specified limit (20 ppm) of Food and Drug Administration, United States. All of them, lead content was highest in counterfeit lipsticks group. Among the tested lipstick samples, lipstick with lowest lead content was LE-RL 01 (15.74 ppm) and the lipstick with highest lead content was CF-RL 01(60.09 ppm). In conclusion, lead contents of red colored lipsticks (22 out of 25) from market samples were higher than allowable limit (20 ppm).

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Fast Method for the Determination of Residual Solvents in Radiopharmaceutical Products

Revista de Chimie ◽

10.37358/rc.17.4.5526 ◽

2017 ◽

Vol 68 (4) ◽

pp. 666-670 ◽

Cited By ~ 1

Author(s):

Mirela Mihon ◽

Catalin Stelian Tuta ◽

Alina Catrinel Ion ◽

Dana Niculae ◽

Vasile Lavric

Keyword(s):

Gas Chromatography ◽

Control Method ◽

Limit Of Detection ◽

The Body ◽

Biologically Active ◽

Injection Technique ◽

Fast Method ◽

Residual Solvent ◽

Residual Solvents

The aim of this work was the development and validation of a fast analytical method to determine the residual solvents content in radiopharmaceuticals such as: 18F-Fluorodeoxyglucose (18F-FDG), 18F-Fluoroestradiol (18F-FES), 18F-Fluorothymidine (18F-FLT),18F-Fluoromisonidazole (18F-FMISO). Radiopharmaceuticals are radioactive preparations for medical purposes used in nuclear medicine as tracers in diagnostic imaging and treatment of certain diseases. Positron Emission Tomography (PET) is a medical imaging technique that consists in introducing into the body of a small amount of a biologically active chemical compound labelled with a short lived positron-emitting radioisotope (18F, 11C, 68Ga). Residual solvents are critical impurities in radiopharmaceuticals that can affect labelling, stability and physicochemical properties of drugs. Therefore, the determination of these solvents is essential for quality control of radiopharmaceuticals. Validation of the control method for residual solvents by gas chromatography is referred by the European Pharmacopoeia using a special injection technique (head space). The parameters of the method, which comply with International Conference on Harmonization guidelines, are: accuracy, precision, linearity, limit of detection, limit of quantification and robustness. The proposed method (direct gas chromatography injection) proved to be linear, precise, accurate and robust. Good linearity was achieved for all the solvents and correlation coefficients (R2) for each residual solvent were found more than 0.99.

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Antipyretic Plants: An Updated Review

Current Bioactive Compounds ◽

10.2174/1573407215666190401151844 ◽

2020 ◽

Vol 16 (1) ◽

pp. 4-12

Author(s):

Vandana Garg ◽

Rohit Dutt

Keyword(s):

Side Effects ◽

Body Temperature ◽

Medicinal Plants ◽

Inflammatory Mediators ◽

Review Paper ◽

The Body ◽

Hypothalamic Area ◽

Antipyretic Activity ◽

Disease States ◽

Elevated Body Temperature

Background: Fever, is known as pyrexia, may occur due to infection, inflammation, or any tissue damage and disease states. Normally, the infected or damaged tissue initiates the enhanced formation of pro-inflammatory mediators like cytokines which further increases the synthesis of prostaglandin E2 (PgE2) near the hypothalamic area and thereby trigger the hypothalamus to elevate the body temperature. Objective: Antipyretics are the agents which reduce the elevated body temperature. The most commonly used antipyretic agent, paracetamol, may be fatal due to its side effects. Methods: In this review paper, Chemical Abstracts, Google Scholar, PubMed, and Science Direct were the sources for the published article to collect information regarding antipyretic activity. Results: This review compiles the antipyretic plants that may be useful to treat fever due to various diseases. Conclusion: These medicinal plants could be good alternatives for traditional allopathic antipyretics.

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Magnesium: Biochemistry, Nutrition, Detection, and Social Impact of Diseases Linked to Its Deficiency

Nutrients ◽

10.3390/nu13041136 ◽

2021 ◽

Vol 13 (4) ◽

pp. 1136

Author(s):

Diana Fiorentini ◽

Concettina Cappadone ◽

Giovanna Farruggia ◽

Cecilia Prata

Keyword(s):

Social Impact ◽

Magnesium Deficiency ◽

Serum Magnesium ◽

Serum Levels ◽

Point Of View ◽

Magnesium Concentration ◽

Multiple Perspectives ◽

Dietary Reference Values ◽

Magnesium Status ◽

Total Body

Magnesium plays an important role in many physiological functions. Habitually low intakes of magnesium and in general the deficiency of this micronutrient induce changes in biochemical pathways that can increase the risk of illness and, in particular, chronic degenerative diseases. The assessment of magnesium status is consequently of great importance, however, its evaluation is difficult. The measurement of serum magnesium concentration is the most commonly used and readily available method for assessing magnesium status, even if serum levels have no reliable correlation with total body magnesium levels or concentrations in specific tissues. Therefore, this review offers an overview of recent insights into magnesium from multiple perspectives. Starting from a biochemical point of view, it aims at highlighting the risk due to insufficient uptake (frequently due to the low content of magnesium in the modern western diet), at suggesting strategies to reach the recommended dietary reference values, and at focusing on the importance of detecting physiological or pathological levels of magnesium in various body districts, in order to counteract the social impact of diseases linked to magnesium deficiency.

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