Antipyretic Plants: An Updated Review

2020 ◽  
Vol 16 (1) ◽  
pp. 4-12
Author(s):  
Vandana Garg ◽  
Rohit Dutt
Keyword(s):  
Side Effects ◽  
Body Temperature ◽  
Medicinal Plants ◽  
Inflammatory Mediators ◽  
Review Paper ◽  
The Body ◽  
Hypothalamic Area ◽  
Antipyretic Activity ◽  
Disease States ◽  
Elevated Body Temperature

Background: Fever, is known as pyrexia, may occur due to infection, inflammation, or any tissue damage and disease states. Normally, the infected or damaged tissue initiates the enhanced formation of pro-inflammatory mediators like cytokines which further increases the synthesis of prostaglandin E2 (PgE2) near the hypothalamic area and thereby trigger the hypothalamus to elevate the body temperature. Objective: Antipyretics are the agents which reduce the elevated body temperature. The most commonly used antipyretic agent, paracetamol, may be fatal due to its side effects. Methods: In this review paper, Chemical Abstracts, Google Scholar, PubMed, and Science Direct were the sources for the published article to collect information regarding antipyretic activity. Results: This review compiles the antipyretic plants that may be useful to treat fever due to various diseases. Conclusion: These medicinal plants could be good alternatives for traditional allopathic antipyretics.

Antipyretic Activity of the Root Extracts of Xylocarpus

2019 ◽  
Vol 9 (3) ◽  
pp. 35-38
Author(s):  
Ganesh Kumar Y ◽  
Pranitha D ◽  
Phaneendra D ◽  
Madhava Reddy Ch
Keyword(s):  
Mechanisms Of Action ◽  
Prostaglandin Synthesis ◽  
The Body ◽  
Human Race ◽  
Pharmacological Activities ◽  
Standard Drug ◽  
Root Extracts ◽  
Antipyretic Activity ◽  
Inhibition Of Prostaglandin Synthesis ◽  
Elevated Body Temperature

Various types of conditions exist in the body that causes fever and pain. Drugs that are used to treat fever are called antipyretics, and those are usually prescribed to treat elevated body temperature. But those drugs result in many other side effects like ulcers, perforations, bleedings and obstructions, which make their use questionable and limiting. Medicinal plants are used in the treatment of diseases from the starting of the human race and the process; they had been subjected to rigorous investigations and tests to establish a scientific proof and validation of the various pharmacological activities and their respective mechanisms of action in treating the herbs. Considering the anti-inflammatory properties of the plant, Xylocarpus mekongesis was investigated for its antipyretic activity in yeast method and 3doses out of which 00mg/kg body weight showed a better activity compared to the standard drug and other extracts too. The mechanism of action was similar to the paracetamol action that is inhibition of prostaglandin synthesis.

CLASSIFICATION OF HUMAN FACIAL AND AURAL TEMPERATURE USING NEURAL NETWORKS AND IR FEVER SCANNER: A RESPONSIBLE SECOND LOOK

2005 ◽  
Vol 05 (01) ◽  
pp. 165-190 ◽  
Author(s):  
E. Y. K. NG ◽  
COLIN CHONG ◽  
G. J. L. KAW
Keyword(s):  
Neural Network ◽  
Body Temperature ◽  
False Negative ◽  
The Body ◽  
Body Core Temperature ◽  
Thermal Imager ◽  
Facial Skin ◽  
Thermal Imagers ◽  
Cardinal Symptom ◽  
Elevated Body Temperature

Severe Acute Respiratory Syndrome (SARS) is a highly infectious disease caused by a coronavirus. Screening to detect potential SARS infected subject with elevated body temperature plays an important role in preventing the spread of SARS. The use of infrared (IR) thermal imaging cameras has thus been proposed as a non-invasive, speedy, cost-effective and fairly accurate means for mass blind screening of potential SARS infected persons. Infrared thermography provides a digital image showing temperature patterns. This has been previously utilized in the detection of inflammation and nerve dysfunctions. It is believed that IR cameras may potentially be used to detect subjects with fever, the cardinal symptom of SARS and avian influenza. The accuracy of the infrared system can, however, be affected by human, environmental, and equipment variables. It is also limited by the fact that the thermal imager measures the skin temperature and not the body core temperature. Thus, the use of IR thermal systems at various checkpoints for mass screening of febrile persons is scientifically unjustified such as what is the false negative rate and most importantly not to create false sense of security. This paper aims to study the effectiveness of infrared systems for its application in mass blind screening to detect subjects with elevated body temperature. For this application, it is critical for thermal imagers to be able to identify febrile from normal subjects accurately. Minimizing the number of false positive and false negative cases improves the efficiency of the screening stations. False negative results should be avoided at all costs, as letting a SARS infected person through the screening process may result in potentially catastrophic results. Hitherto, there is lack of empirical data in correlating facial skin with body temperature. The current work evaluates the correlations (and classification) between the facial skin temperatures to the aural temperature using the artificial neural network approach to confirm the suitability of the thermal imagers for human temperature screening. We show that the Train Back Propagation and Kohonen self-organizing map (SOM) can form an opinion about the type of network that is better to complement thermogram technology in fever diagnosis to drive a better parameters for reducing the size of the neural network classifier while maintaining good classification accuracy.

Endodontic Materials: Reactor Response

1988 ◽  
Vol 2 (1) ◽  
pp. 25-28 ◽  
Author(s):  
I.A. Mjör
Keyword(s):  
Side Effects ◽  
Review Paper ◽  
Defense Mechanism ◽  
The Body ◽  
Endodontic Treatment ◽  
Bridge Formation ◽  
Per Se ◽  
Apical Area

This discussion of a review paper on endodontic materials focuses on the need for standardization of this group of materials, including clinical and biological investigations. It was concluded that the search for endodontic materials that are both adhesive to dentin and insoluble must continue. When such materials become available, the defense mechanism of the body would take care of the healing per se. This approach as well as techniques and materials which induce dentin bridge formation in the apical area were considered feasible for improving endodontic treatment. The need to report side-effects of endodontic materials was stressed, and it was suggested that such reports should be mandatory for clinicians and for manufacturers of endodontic materials.

scholarly journals Global Economic Impacts of COVID 19 to Increase the Protection of Society By Using Thermal Imaging Cameras to Measure the Temperature of Human Body

2021 ◽  
Vol 92 ◽  
pp. 01031
Author(s):  
Ladislav Mariš ◽  
Veronika Adamová
Keyword(s):  
Body Temperature ◽  
Preventive Measures ◽  
Economic Impacts ◽  
Value Added ◽  
Preventive Measure ◽  
The Body ◽  
Manufacturing Companies ◽  
Temperature Measuring ◽  
Expected Benefits ◽  
Elevated Body Temperature

Research background: In 2020, a pandemic of COVID-19 has started. One of the symptoms is that a person has an elevated body temperature. One of the preventive measures against the spread of COVID-19 is the body temperature measuring. But this does not immediately mean, that person´s elevated body temperature indicates the presence of COVID-19. It also does not mean, that a person with COVID-19 must have fever. In generally, there is accepted a preventive measure to measure a body temperature, that can help to detect an infected person. The demands for body temperature measuring devices has increased. One of these devices is the thermal security cameras (TSC). Purpose of the article: The aim of this paper is to point out the increased use of the TSC during the global pandemic of COVID-19. At the same time, it is necessary to point out the real benefits of using these devices in relation to global trend and significant economic impacts on society. Methods: The analysis of available materials and data of the implementation of the TCS in relation to COVID-19 crisis. There are case studies elaborated on two manufacturing companies with different approaches to the implementation of preventive measures. Findings & Value added: Firstly, the increased demand for protecting and preventive measures have an impact on the extreme increase in prices for these technologies compared to the pre-pandemic period. Secondly, accepted protecting and safety measures, such as TSC, do not have the expected benefits in relation to COVID-19.

scholarly journals Antipyretic Activity of Gudduchi (-Tinospora cordifolia)- A Review

2021 ◽  
pp. 125-128
Author(s):  
K. A. Haseena ◽  
Neha Gadgil ◽  
Snigdha Das Mandal
Keyword(s):  
Body Temperature ◽  
Medicinal Plants ◽  
Tissue Damage ◽  
Therapeutic Agents ◽  
Tinospora Cordifolia ◽  
Antipyretic Activity ◽  
Indian Medicinal Plants

Pyrexia is defined as elevation of body temperature. It is a response due to tissue damage, inflammation, alignancy etc. Fever is associated with symptoms of lethargy, depression, anorexia, sleepiness etc. In Ayurveda, many drugs are attributed with jwaragna property. Among these described drugs gudduchi (Tinospora cordifolia) has the best antipyretic activity. Indian medicinal plants and their derivatives are having invaluable source of therapeutic agents to treat various disorders. Nowadays, many drugs have been developed from plants which are active against a number of diseases.

scholarly journals UJI AKTIVITAS ANTIPIRETIK EKSTRAK DAUN SISIK NAGA(Pyrrosia piloselloides (L.) M.G. Price) TERHADAP TIKUS PUTIH (Rattus norvegicus) JANTAN GALUR WISTAR YANG DIINDUKSI PEPTON 5%

2018 ◽  
Vol 15 (01) ◽  
pp. 22
Author(s):  
Ratna Widyasari ◽  
Dina Yuspitasari ◽  
Fadli Fadli ◽  
Athiah Masykuroh ◽  
Winda Tahuhiddah
Keyword(s):  
Body Temperature ◽  
Rattus Norvegicus ◽  
Test Group ◽  
Negative Control ◽  
The Body ◽  
Control Group ◽  
Antipyretic Activity ◽  
White Rats ◽  
Infra Red ◽  
Pyrrosia Piloselloides

INTISARI  Demam adalah keadaan ketika suhu tubuh meningkat melebihi suhu tubuh normal. Demam terjadi karena pelepasan  pirogen  dari dalam leukosit yang sebelumnya telah terangsang oleh pirogen  eksogen yang dapat berasal dari mikroorganisme atau merupakan suatu hasil reaksi imunologik yang tidak berdasarkan suatu infeksi. Sementara itu, banyak  negara telah mengembangkan pengobatan menggunakan herbal. Salah satu usaha yang dilakukan adalah dengan penggunaan obat tradisional. Penelitian ini bertujuan untuk membuktikan bahwa daun Sisik Naga (Pyrrosia piloselloides  (L.) M.G Price) dengan konsentrasi 0,062%, 0,125% dan 0,25% memiliki aktivitas antipiretik dengan menggunakan penginduksi demam  Pepton  5%. Penelitian ini merupakan penelitian eksperimental dengan Rancang Acak Lengkap (RAL). Pengukuran suhu rektal tikus menggunakan termometer  infra red. Hewan uji dibagi menjadi 5 kelompok yaitu kelompok kontrol negatif (suspensi Na-CMC 1%), kelompok kontrol positif (suspensi parasetamol) dan kelompok uji yaitu pemberian ekstrak daun sisik naga 0,062%, 0,125% dan 0,25%. Data yang diperoleh dianalisis dengan  menggunakan uji anova dan uji LSD (Least Significant Different). Hasil dari penelitian ini bahwa ekstrak daun sisik naga (Pyrrosia piloselloides  (L.) M.G Price) konsentrasi 0,25% mempunyai aktivitas antipiretik pada tikus putih (Rattus norvegicus) jantan galur wistar. Kata kunci: Antipiretik, Daun Sisik Naga (Pyrrosia piloselloides (L.) M.G Price), Pepton 5%   ABSTRACT  A fever is a condition when the body temperature rises beyond the normal body temperature. Fever occurs due to the release of pyrogytes from within leukocytes that have previously been stimulated by exogenous pyrogens that may originate from microorganisms or are a result of immunologic reactions that are not based on an infection. Meanwhile, many countries have developed treatments using herbs. One of the efforts done is with the use of traditional medicine. This study aims to prove that the leaves of the Dragon Scales (Pyrrosia piloselloides (L.) M.G Price) with concentrations of 0.062%, 0.125% and 0.25% have antipyretic activity using Pepton fever induction 5%. This research is an experimental research with Completely Random Design (RAL). Rectal temperature measurements of mice using infra red thermometer. Test animals were divided into 5 groups: negative control group (1% Na-CMC suspension), positive control group (paracetamol suspension) and the test group were 0.062%, 0.125% and 0.25%. The data obtained were analyzed using anova test and LSD (Least Significant Different) test. The results of this study showed that the extract of leaf scales (Pyrrosia piloselloides (L.) M.G Price) concentrations of 0.25% had antipyretic activity in white rats (Rattus norvegicus) male wistar strain. Keywords: Antipyretics, Leaf Scales Dragon (Pyrrosia piloselloides (L.) M.G Price), Pepton 5%

Role of Peroxisome Proliferated Activated Receptor gamma (PPARγ) in Different Disease States: Recent Updates

2020 ◽  
Vol 27 ◽  
Author(s):  
Suvadeep Mal ◽  
Ashish Ranjan Dwivedi ◽  
Vijay Kumar ◽  
Naveen Kumar ◽  
Bhupinder Kumar ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Side Effects ◽  
Ppar Gamma ◽  
Review Article ◽  
The Body ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Disease States ◽  
Ppar Ligands

: Peroxisome proliferator-activated receptor (PPAR), a ligand dependant transcription factor, is a member of nuclear receptor superfamily. PPAR exists in three isoforms i.e. PPAR alpha (PPARα), PPAR beta (PPARβ), and PPAR gamma (PPARγ). These are multi-functional transcription factor and help in regulating inflammation, diabetes type 2, lipid concentration in the body, metastasis, and tumor growth or angiogenesis. Activation of PPARγ causes inhibition of growth of cultured human breast, gastric, lung, prostate, and other cancer cells. PPARγ is mainly involved in fatty acid storage, glucose metabolism, and homeostasis and adipogenesis regulation. A large number of natural and synthetic ligands bind to PPARγ and modulate its activity. Ligands such as thiazolidinedione, troglitazone, rosiglitazone, pioglitazone effectively bind to PPARγ however, most of these were found to display severe side effects such as hepatotoxicity, weight gain, cardiovascular complications and bladder tumor. Now the focus is shifted towards the development of dual-acting or pan PPAR ligands. The current review article describes the functions and role of PPARγ in various disease states. In addition, recently reported PPARγ ligands and pan PPAR ligands were discussed in detail. It is envisaged that the present review article may help in the development of potent PPAR ligands with no or minimal side effects.

scholarly journals Plectranthus scutellarioides (L.) Reduces the Rectal Temperature of Diphteria-Pertussis-Tetanus Vaccine-Induced Mice

2019 ◽  
Vol 4 (2) ◽  
pp. 27
Author(s):  
Yudha Prabowo ◽  
Nyi M. Saptarini ◽  
Sri A. Sumiwi ◽  
Jutti Levita ◽  
Imam A. Wicaksono ◽  
...  
Keyword(s):  
Body Temperature ◽  
Rectal Temperature ◽  
The Body ◽  
Antipyretic Effect ◽  
Arabic Gum ◽  
Antipyretic Activity ◽  
Scientific Exploration ◽  
Tetanus Vaccine ◽  
Anti Oxidant ◽  
Dpt Vaccine

The pharmacological activities of Plecranthus sp include anti-oxidant, antimicrobial, inhibition on cyclooxygenase (COX) and xanthine oxidase, and cytotoxic activity. The aim of this work was to study the antipyretic activity of P. scutellarioides (L.) extract on animal model. Twenty seven Swiss Webster male mice were divided into nine groups and were pyrexia-induced by using 0.1 ml of diphteria-pertussis-tetanus (DPT) vaccine. Their body temperature was measured every 60 minutes. After 4 hours of DPT vaccine injection, the mice were treated with (I) Arabic gum suspension (PGA) 2%; (II) paracetamol 16.25 mg/kg BW; (III) paracetamol 32.5 mg/kg BW; (IV) paracetamol 65 mg/kg BW; (V) paracetamol 130 mg/kg BW; (VI) P. scutellarioides extract 70 mg/kg BW; (VII) P. scutellarioides extract 140 mg/kg BW; (VIII) P. scutellarioides extract 280 mg/kg BW; (IX) P. scutellarioides extract 560 mg/kg BW. Data were analyzed using SPSS 21. Result showed that the body temperature of the mice started to rise at 2.5 hours and reached its peak at 4 hours after vaccine induction. The P. scutellarioides extract dose 280 mg/kg of BW indicated an 80.47% decrease (α= 0.05) compared to paracetamol dose 130 mg/kg of BW which decreases 85.43% of the animals’ fever. Interestingly, higher dose of the extract indicated a decrease in the antipyretic effect. We concluded that P. scutellarioides might possess antipyretic activity which started as early as 5 hours post vaccine-induced and was maintained for 3 hours. This plant needs further scientific exploration Keywords: Diphteria-pertusis-tetanus vaccine, anti-pyretic, rectal temperature, Webster mice  

BODY TEMPERATURE AS A NEW PREDICTOR OF MORTALITY IN HEAD TRAUMA PATIENTS

2019 ◽  
Vol 3 (1) ◽  
pp. 37
Author(s):  
Nor Hayatunnisa ◽  
Rismia Agustina ◽  
Oski Illiandri
Keyword(s):  
Body Temperature ◽  
Trauma Patient ◽  
Head Trauma ◽  
Psychosocial Functioning ◽  
Sampling Technique ◽  
The Body ◽  
P Value ◽  
Trauma Patients ◽  
Risk Of Mortality ◽  
Elevated Body Temperature

Head trauma is a neurological emergency that has fairly complex impacts such as physical, cognitive, psychosocial functioning, temporary care. Sixty-five percent of patients with head trauma experience elevated body temperature. Any increase in body temperature by 1 ℃ can have a 5% effect on brain blood flow which lead patients to mortality. Nurses are responsible for patients who experience increased body temperature, especially in providing professional nursing care. The purpose of this research is to know the correlation of body with mortality of head trauma patient at RSUD Ulin Banjarmasin. This research uses non probability sampling method with consecutive sampling technique. The study was conducted in December 2017-January 2018 using an observation sheet. The data analysis shows the p value of 0.003 <0.05 which indicates that H0 is rejected means there is a correlation between the body and the mortality of the head trauma patient at Ulin Banjarmasin Hospital. The higher the patient's body temperature the more likely it is to be at risk of mortality.

scholarly journals Cutting Edge of Herbal Drugs over Allopathic Drugs in Clinical Treatment of Rheumatoid Arthritis

2018 ◽  
Vol 4 (1) ◽  
pp. 43-50
Author(s):  
Dr. Vrish Dhwaj Ashwlayan ◽  
Saurabh Nimesh
Keyword(s):  
Rheumatoid Arthritis ◽  
Side Effects ◽  
Medicinal Plants ◽  
The Body ◽  
World Population ◽  
First Line ◽  
Primary Health ◽  
The People ◽  
Herbal Medicinal ◽  
Day By Day

Rheumatoid arthritis (RA) is a chronic inflammatory and systemic auto immune disease, affecting people predominantly between the ages of 20-60 years with unpredictable course. About 1% of the world's population is afflicted by rheumatoid arthritis and is two to three times more common in women than men. This is a long lasting disease that can affect joints in any part of the body, most commonly the hands, wrists, and knees. Popularity of medicinal plants is increasing day by day due to side effects of allopathic medicines. Herbal medicinal plants have been used as major sources of cure of human diseases since time immemorial. Today, one fourth of world population depends on traditional medicine and 80% of the population relies on indigenous herbal medicinal plants. Even today most of the people lives in different developing countries depend on the plant derived medicines for the first line of primary health care because of least or no side effects.

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