scholarly journals Fatty Acids Composition of Blood Cell Membranes and Peripheral Inflammation in the PREDIMED Study: A Cross-Sectional Analysis

Nutrients ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 576 ◽  
Author(s):  
Jananee Muralidharan ◽  
Christopher Papandreou ◽  
Aleix Sala-Vila ◽  
Nuria Rosique-Esteban ◽  
Montserrat Fitó ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Blood Cell ◽  
Inflammatory Markers ◽  
Cell Membranes ◽  
Cross Sectional ◽  
Negatively Associated ◽  
Cross Sectional Analysis ◽  
Ifn Γ ◽  
Sectional Analysis ◽  
Predimed Study

There is limited evidence from epidemiological studies for the inflammatory or anti-inflammatory properties of fatty acids in blood cell membranes. Therefore, this study examined associations between baseline (n = 282) and 1-year (n = 143) changes in the levels of fatty acids in blood cell membranes with circulating inflammatory markers in older adults at high cardiovascular risk. The data for this cross-sectional analysis was obtained from a case-control study within the PREDIMED study. Linear regression with elastic net penalty was applied to test associations between measured fatty acids and inflammatory markers. Several fatty acids were associated with interferon-γ (IFNγ) and interleukins (ILs) IL-6, IL-8, and IL-10 at baseline and additionally also with IL-1b at 1 year. Omega-6 fatty acids were consistently positively associated with pro-inflammatory IL-6 and IL-8 at baseline. Omega-3 fatty acids including C20:5n3 and C18:3n3 were negatively associated with IFN-γ at 1 year. It is interesting to note that the cis and trans forms of C16:1n7 at 1 year were oppositely associated with the inflammatory markers. C16:1n7trans was negatively associated with IFN-γ, IL-6, IL-8, IL-10, and IL-1b, whereas C16:1n7cis was positively associated with IL-1b. This study adds to the growing body of evidence suggesting potential differences in inflammatory or anti-inflammatory properties of fatty acids in blood cell membranes.

Time From Smoking Cessation and Inflammatory Markers: New Evidence From a Cross-Sectional Analysis of ELSA-Brasil

2017 ◽  
Vol 19 (7) ◽  
pp. 852-858 ◽  
Author(s):  
Flávia Soares Peres ◽  
Sandhi Maria Barreto ◽  
Lidyane V. Camelo ◽  
Antonio Luiz P. Ribeiro ◽  
Pedro Guatimosim Vidigal ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Inflammatory Markers ◽  
Cross Sectional ◽  
Cross Sectional Analysis ◽  
Sectional Analysis ◽  
New Evidence

The role of LCPUFA-ω3 on the obesity-associated hyperandrogenemia of pubertal girls: secondary analysis of a randomized clinical trial

2020 ◽  
Vol 33 (3) ◽  
pp. 347-354
Author(s):  
Mardia Guadalupe López-Alarcón ◽  
Víctor Saúl Vital-Reyes ◽  
Francisco Iván Hernández-Hernández ◽  
Jorge Maldonado-Hernández
Keyword(s):  
Clinical Trial ◽  
Fatty Acids ◽  
Longitudinal Analysis ◽  
Secondary Analysis ◽  
Free Testosterone ◽  
Total Testosterone ◽  
Cross Sectional ◽  
Cross Sectional Analysis ◽  
Sectional Analysis

AbstractIntroductionHyperandrogenism (HA), either clinical or biochemical, is associated with obesity in adolescent girls. Long chain polyunsaturated fatty acids ω3 (LCPUFA-ω3) play protective roles in some obesity-associated morbidities, but their contribution to preventing HA is unclear. Our aim was to examine the potential positive relationships between erythrocyte LCPUFA-ω3, with or without supplementation, and hyperandrogenemia.MethodsSecondary analysis of a clinical trial that was conducted previously to analyze the effect of LCPUFA-ω3 on insulin resistance and body weight. Here, we present a cross-sectional analysis of 180 girls with obesity, and a longitudinal analysis of 117 girls who completed a 3-month supplementation period (57 LCPUFA-ω3 [DO3] and 60 placebo [DP)]). Dehydroepiandrosterone sulfate (DHEAS), total testosterone (TT) and steroid hormone binding globulin (SHBG) were measured with chemiluminescence; free testosterone (FT) was calculated. Erythrocyte fatty acids were determined by gas chromatography. Non-parametric statistics was used for analysis.ResultsIn cross-sectional analysis, age (odds ratio [OR] = 1.35; 95% confidence interval [CI] = 1.03, 1.78; p = 0.027), insulin (OR = 1.05; 95% CI: 1.00, 1.10; p = 0.018), and erythrocytes eicosapentaenoic acid (EPA) (OR = 0.04; 95% CI: 0.01, 0.65; p = 0.012) were predictors of hyperandrogenemia (FT >0.63 ng/mL). In longitudinal analysis, EPA, adiponectin and SHBG increased, while FT decreased, in the DO3 group (p < 0.05). The risk of hyperandrogenemia at the end of follow-up was predicted by basal hyperandrogenemia (OR = 18.16, 95% CI: 5.37, 61.4; p < 0.001) and by increases in EPA (OR = 0.40; 95% CI: 0.01, 0.65; p = 0.06 marginal significance).ConclusionsOur results suggest a preventive role of EPA on the risk for hyperandrogenemia in girls with obesity, but further studies are needed to demonstrate a benefit.

scholarly journals Fish Consumption and Omega-3 Polyunsaturated Fatty Acids in Relation to Depressive Episodes: A Cross-Sectional Analysis

PLoS ONE ◽  
2010 ◽  
Vol 5 (5) ◽  
pp. e10530 ◽  
Author(s):  
Anna Liisa Suominen-Taipale ◽  
Timo Partonen ◽  
Anu W. Turunen ◽  
Satu Männistö ◽  
Antti Jula ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Fish Consumption ◽  
Omega 3 ◽  
Cross Sectional ◽  
Cross Sectional Analysis ◽  
Sectional Analysis ◽  
Depressive Episodes

scholarly journals Low Blood Long Chain Omega-3 Fatty Acids in UK Children Are Associated with Poor Cognitive Performance and Behavior: A Cross-Sectional Analysis from the DOLAB Study

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e66697 ◽  
Author(s):  
Paul Montgomery ◽  
Jennifer R. Burton ◽  
Richard P. Sewell ◽  
Thees F. Spreckelsen ◽  
Alexandra J. Richardson
Keyword(s):  
Fatty Acids ◽  
Cognitive Performance ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Cross Sectional ◽  
Cross Sectional Analysis ◽  
And Behavior ◽  
Sectional Analysis ◽  
Long Chain
Sign in / Sign up

Export Citation Format

Share Document