scholarly journals Utility of Novel Hypochromia and Microcythemia Markers in Classifying Hematological and Iron Status in Male Athletes

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2767 ◽  
Author(s):  
Jadwiga Malczewska-Lenczowska ◽  
Olga Surała ◽  
Joanna Orysiak ◽  
Dariusz Turowski ◽  
Beata Szczepańska ◽  
...  
Keyword(s):  
Binding Capacity ◽  
Iron Status ◽  
Hemoglobin Concentration ◽  
Volume Distribution ◽  
Hemoglobin Content ◽  
Male Athletes ◽  
Iron Depletion ◽  
Distribution Width ◽  
Iron Deficient ◽  
Sports Anemia

In athletes, no reliable indices exist for an unambiguous evaluation of hematological and iron status. Therefore, the utility of some new red blood cell (RBC) parameters was explored in 931 elite male athletes aged 13–35 years. To diagnose iron status, the values of ferritin and soluble transferrin receptor (sTfR), total iron binding capacity (TIBC), and basic blood morphology were determined in blood. The new hematological markers included among others: mean cellular hemoglobin content in reticulocytes (CHr), percentage of erythrocytes (HYPOm) and reticulocytes (HYPOr) with decreased cellular hemoglobin concentration, percentage of erythrocytes (LowCHm) and reticulocytes (LowCHr) with decreased cellular hemoglobin content, mean volume of reticulocytes (MCVr), and percentage of erythrocytes with decreased volume (MICROm). Despite adverse changes in reticulocyte hypochromia indices (CHr, LowCHr, HYPOr; p < 0.001) in the iron depletion state, the area under the receiver operating characteristic curve (AUC-ROC) values calculated for them were relatively low (0.539–0.722). In iron-deficient erythropoiesis (IDE), unfavorable changes additionally concern microcythemia indices in both reticulocytes and erythrocytes (MCVr, MCV, MICROm, and red cell volume distribution width—RDW), with especially high values of AUC-ROC (0.947–0.970) for LowCHm, LowCHr, and CHr. Dilutional sports anemia was observed in 6.1% of athletes. In this subgroup, only hemoglobin concentration (Hb), hematocrit (Hct), and RBC (all dependent on blood volume) were significantly lower than in the normal group. In conclusion, the diagnostic utility of the new hematology indices was not satisfactory for the detection of an iron depletion state in athletes. However, these new indices present high accuracy in the detection of IDE and sports anemia conditions.

Iron Status of Female Runners

1993 ◽  
Vol 3 (2) ◽  
pp. 222-231 ◽  
Author(s):  
Russell R. Pate ◽  
Bonnie J. Miller ◽  
J. Mark Davis ◽  
Chris A. Slentz ◽  
Lisa A. Klingshirn
Keyword(s):  
Serum Ferritin ◽  
Reference Group ◽  
Binding Capacity ◽  
Iron Status ◽  
Hemoglobin Concentration ◽  
Mean Corpuscular Hemoglobin ◽  
Running Activity ◽  
Iron Deficient ◽  
Increased Risk ◽  
Chi Square Analysis

This study was designed to observe iron status and prevalence of iron deficient conditions in adult female habitual runners (n=111) and inactive females of comparable age (n=65). The runners were significantly lower (p<.05) than the reference group in mean serum ferritin (SF), total iron binding capacity, and red blood cell count, but significantly higher (p<.05) in mean corpuscular hemoglobin. The groups did not differ significantly in hemoglobin concentration, hematocrit, serum iron, percent saturation of transfenin, or red cell protoporphyrin. Chi square analysis indicated that iron depletion (SF <20 ng·ml-1) was significantly more prevalent (p<.005) in the runners than in the controls. Anemia was extremely rare in both groups. A multiple regression analysis revealed significant negative associations between serum ferritin and coffeeltea intake (p<.001) and running activity (p<.05). These results indicate that habitual runners, as compared with inactive women, are at increased risk for iron deficient states but that full-blown anemia is a rare consequence of this deficient iron status.

scholarly journals Using Soluble Transferrin Receptor and Taking Inflammation into Account When Defining Serum Ferritin Cutoffs Improved the Diagnosis of Iron Deficiency in a Group of Canadian Preschool Inuit Children from Nunavik

Anemia ◽  
2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Huguette Turgeon O’Brien ◽  
Rosanne Blanchet ◽  
Doris Gagné ◽  
Julie Lauzière ◽  
Carole Vézina
Keyword(s):  
Iron Deficiency ◽  
Transferrin Receptor ◽  
Binding Capacity ◽  
Iron Status ◽  
Transferrin Saturation ◽  
Deficiency Anemia ◽  
Soluble Transferrin Receptor ◽  
Iron Depletion ◽  
Reactive Protein ◽  
Iron Deficient

The prevalence of iron depletion, iron deficient erythropoiesis (IDE), and iron deficiency anemia (IDA) was assessed in preschool Inuit children using soluble transferrin receptor (sTfR) and traditional indicators of iron status while disregarding or taking inflammation into account when defining SF cutoffs. Iron depletion was defined as follows: (1) SF < 15 μg/L regardless of the C-reactive protein (CRP) level and (2) SF < 15 or <50 μg/L with CRP ≤ 5 or >5 mg/L, respectively. IDE corresponded to iron depletion combined with total iron binding capacity > 72 μmol/L and/or transferrin saturation < 16%. Iron depletion and IDE affected almost half of the children when accounting for inflammation, compared to one-third when the SF cutoff was defined regardless of CRP level (P<0.0001). The prevalence of IDE adjusted for inflammation (45.1%) was very similar to the prevalence observed when sTfR was used as a sole marker of IDE (47.4%). The prevalence of anemia was 15%. The prevalence of IDA (IDE + hemoglobin < 110 g/L) was higher when accounting for than when disregarding inflammation (8.0% versus 6.2%,P=0.083). Using sTfR and different SF cutoffs for children with versus without inflammation improved the diagnosis of iron depletion and IDE. Our results confirm that Inuit children are at particularly high risk for iron deficiency.

Effect of exposure to low temperature on normal and iron-deficient subjects

1984 ◽  
Vol 246 (3) ◽  
pp. R380-R383 ◽  
Author(s):  
C. Martinez-Torres ◽  
L. Cubeddu ◽  
E. Dillmann ◽  
G. L. Brengelmann ◽  
I. Leets ◽  
...  
Keyword(s):  
Oxygen Consumption ◽  
Cold Exposure ◽  
Initial Temperature ◽  
Iron Status ◽  
Hemoglobin Concentration ◽  
Normal Subjects ◽  
Plasma Norepinephrine ◽  
Oral Temperature ◽  
The Third ◽  
Iron Deficient

Twenty-one Venezuelan peasants were segregated into three groups on the basis of measurements of iron status: seven normal subjects, six iron-deficient subjects with normal hemoglobin and eight iron-deficient subjects with a hemoglobin concentration of less than 9 g/dl. All subjects were placed in a water bath at an initial temperature of 36 degrees C. The water temperature was then rapidly lowered to 28 degrees C, and observations were made over the period of 1 h. Mean oral temperature of the first group fell 0.2, the second group 0.5, and the third group 0.9 degrees C. Mean plasma norepinephrine levels in both groups of iron-deficient subjects were significantly higher at 36 degrees C and during cold exposure compared with control subjects. Oxygen consumption was also significantly increased in both groups of iron-deficient subjects after cold exposure.

scholarly journals Impacts of Mycoplasma loads and lung lesions on immune and hematological statuses of pigs in an eight-breed cross heterogeneous population

2020 ◽  
Vol 98 (8) ◽  
Author(s):  
Qing Zhang ◽  
Jing Li ◽  
Tao Huang ◽  
Yifeng Zhang ◽  
Wenwu Xu ◽  
...  
Keyword(s):  
Blood Cell ◽  
Neutrophil Count ◽  
Lymphocyte Count ◽  
Hemoglobin Concentration ◽  
Mean Corpuscular Hemoglobin ◽  
Volume Distribution ◽  
Mean Corpuscular Hemoglobin Concentration ◽  
Corpuscular Hemoglobin ◽  
Distribution Width ◽  
Lung Lesions

Abstract Developments of pulmonary diseases, often accompanied by infections of bacteria, severely affect the meat production and welfare of pigs. This study investigated 307 pigs at age of 240 d from an eight-breed cross reared under standardized housing conditions for associations among the extent of lung lesions, bacteria load inferred from 16S rRNA sequencing of bronchoalveolar lavage fluid, as well as 57 immune cells and 25 hematological traits. We showed that the pigs under study suffered substantial and varied lung lesions, and the Mycoplasma is the most associated bacteria genera. At a false discovery rate of 0.05 (FDR &lt; 0.05), the severity of lung lesions were significantly associated with greater CD8+ to CD3+ cell ratio, neutrophil-to-lymphocyte ratio (NLR), and standard deviation of red blood cell volume distribution width (RDW-SD), and lower CD4−CD8−/CD3+, CD3+CD4−CD8−/PBMCs (peripheral blood mononuclear cells) and CD14−CD16−/PBMCs cell ratios, mean corpuscular hemoglobin concentration, lymphocyte count, and lymphocyte count percentage, reflecting an status of inflammation, immune suppression, and hypoxia of the pigs accompanying the progression of the lung lesions. The Mycoplasma abundance showed positive correlations with neutrophil count, neutrophil count percentage, NLR, monocyte count, coefficient of variation in red blood cell volume distribution width , and RDW-SD, and negative correlations with mean corpuscular hemoglobin concentration, lymphocyte count, and lymphocyte count percentage; these correlations are largely consistent with those of lung lesions, supporting the comorbidity of lung lesions and Mycoplasma infection. We also observed nonlinear associations that sharp increases in neutrophil count and neutrophil count percentage occurred only when Mycoplasma abundance raised above the population-average level. The results provide helpful insights into the changes of host immune status in response to Mycoplasma relevant lung diseases in pigs.

scholarly journals Iron Metabolism Modification During Repeated Show Jumping Event in Equine Athletes

2017 ◽  
Vol 17 (1) ◽  
pp. 197-204 ◽  
Author(s):  
Giuseppe Piccione ◽  
Maria Rizzo ◽  
Francesca Arfuso ◽  
Daniele Bruschetta ◽  
Elisabetta Giudice ◽  
...  
Keyword(s):  
Health Status ◽  
Physical Performance ◽  
Binding Capacity ◽  
Iron Status ◽  
Recovery Period ◽  
Hemoglobin Concentration ◽  
Repeated Measure ◽  
Iron Binding ◽  
Iron Binding Capacity ◽  
Show Jumping

Abstract In athletic horse the evaluation of iron status is of great importance to improve physical performance and health status of animal. The aim of this study was to evaluate the changes of iron indices following show jumping. Ten regularly trained Italian Saddlebred horses aged 7-8 years (mean body weight 467±12 kg) were subjected to three days jumping competition. Blood samples were collected at 5 time points: T0 (the day before competitions), T1 (immediately after exercise at day 1), T2 (immediately after exercise at day 2), T3 (immediately after exercise at day 3) and during the recovery period T4 (24 h after day 3). On each blood sample the values of red blood cell (RBC), hemoglobin concentration (Hb), hematocrit (Hct), serum iron, ferritin, transferrin, total iron-binding capacity (TIBC) and unsaturated iron-binding capacity (UIBC) were assessed. One-way repeated measure analysis of variance (ANOVA) showed a statistical significant effect of exercise (P<0.05) on all studied parameters. The application of Bonferroni’s post-hoc comparison showed a statistical significant increase in all studied parameters after exercise. These results provide new information about the changes in iron profile of jumper horse following exercise allowing for better evaluation of the health status and physical performance of this athlete horse.

scholarly journals Effects of Lead on Hemopoeitic and Iron Status in Iraqi Workers at Lead Batteries Factory

2013 ◽  
Vol 10 (2) ◽  
pp. 388-395
Author(s):  
Baghdad Science Journal
Keyword(s):  
Aminolevulinic Acid ◽  
Early Stage ◽  
Binding Capacity ◽  
Iron Status ◽  
Hemoglobin Concentration ◽  
Blood Lead ◽  
Significant Negative Correlation ◽  
Control Group ◽  
Lead Levels ◽  
Iron Binding Capacity

The present study aimed to evaluate the effect of lead exposure on hemopoetic system (through the index delta-Aminolevulinic acid dehydratase ?-ALAD activity & hemoglobin concentration (Hb) ) and on iron status (levels of iron Fe, Ferritin Fr, Total iron binding capacity TIBC, percentage of transferine saturation TF%) in 44 Iraqi worker at lead batteries factory. Workers divided into two groups: smokers(n=21) mean aged (37.33±4.82 year)and non smokers(n=23) mean aged(40.78±7.89 year) and 45 healthy subjects mean aged (33.97±5.08)as control group . Activity of ?-ALAD ratio shows significant decrease (p ? 0.05) ,while Hb and hematocrit Hct were non significant (p ? 0.05) in smoker workers more than non smoker as compared to control . The results show a non significant decrease (p ? 0.05) in the sera levels of iron S.Fe, TS%, Fr in all workers as compared to control , the amount of decreasing for smoker more than non smoker except ferritin levels. A significant increases in the level of TIBC in workers as compared to control, this elevation is more in smoker than non smoker workers. In smoker workers, there was a significant positive correlation between the blood lead levels BLLs and Hb, Hct,TIBC whereas a significant negative correlation was observed between BLLs and S.Fe, TS%. In conclusion, the results of this study reveal the importance of monitoring the level of iron status in smoker peoples who dealing or exposure to lead due to the probability injured with anemia and used ?-ALAD ratio to predict the efficiency of their heme synthesis as a new marker for the diagnosis of early stage of anemia.

scholarly journals Clinical thresholds for diagnosing iron deficiency: comparison of functional assessment of serum ferritin to population based centiles

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Gorkem Sezgin ◽  
Paul Monagle ◽  
Tze Ping Loh ◽  
Vera Ignjatovic ◽  
Monsurul Hoq ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Serum Ferritin ◽  
Age Groups ◽  
Hemoglobin Concentration ◽  
Population Based ◽  
Reference Intervals ◽  
Deficiency Anemia ◽  
Distribution Width ◽  
Iron Deficient ◽  
Lower Limits

Abstract Low serum ferritin is diagnostic of iron deficiency, yet its published lower cut-off values are highly variable, particularly for pediatric populations. Lower cut-off values are commonly reported as 2.5th percentiles, and is based on the variation of ferritin values in the population. Our objective was to determine whether a functional approach based on iron deficient erythropoiesis could provide a better alternative. Utilizing 64,443 ferritin test results from pediatric electronic health records, we conducted various statistical techniques to derive 2.5th percentiles, and also derived functional reference limits through the association between ferritin and erythrocyte parameters: hemoglobin, mean corpuscular volume, mean cell hemoglobin concentration, and red cell distribution width. We find that lower limits of reference intervals derived as centiles are too low for clinical interpretation. Functional limits indicate iron deficiency anemia starts to occur when ferritin levels reach 10 µg/L, and are largely similar between genders and age groups. In comparison, centiles (2.5%) presented with lower limits overall, with varying levels depending on age and gender. Functionally-derived limits better reflects the underlying physiology of a patient, and may provide a basis for deriving a threshold related to treatment of iron deficiency and any other biomarker with functional outcomes.

Red Blood Cell Volume Distribution Width (RDW) in Uraemic Patients on Chronic Haemodialysis

1989 ◽  
Vol 12 (3) ◽  
pp. 170-174 ◽  
Author(s):  
D. Docci ◽  
C. Delvecchio ◽  
C. Gollini ◽  
F. Turci ◽  
L. Baldrati ◽  
...  
Keyword(s):  
Blood Cell ◽  
Cell Volume ◽  
Red Blood Cell ◽  
Iron Status ◽  
Volume Distribution ◽  
Chronic Haemodialysis ◽  
Distribution Width ◽  
Iron Administration ◽  
Parallel Increase ◽  
Normal Individuals

Red blood cell volume distribution width (RDW) was obtained with the Coulter counter in 60 haemodialysis patients and 55 normal individuals. RDW tended to be higher in the former and the degree of increase was to some extent correlated with the underlying nephropathy. Although RDW failed to correlate with conventional tests of iron status, it was observed that iron administration could produce a decrease toward normal in RDW and a parallel increase in haemoglobin when the initial RDW was increased. In contrast, the response to iron was negligible in the patients with normal RDW basally. It was concluded that high RDW is an acceptable indicator of iron deficiency in haemodialysis patients.

scholarly journals Day-to-day variation in iron-status measures in young iron-deplete women

2005 ◽  
Vol 94 (4) ◽  
pp. 551-556 ◽  
Author(s):  
Anita Belza ◽  
Marianne Henriksen ◽  
Annette K Ersbøll ◽  
Shakuntala H Thilsted ◽  
Inge Tetens
Keyword(s):  
Menstrual Cycle ◽  
Observational Studies ◽  
Iron Status ◽  
Venous Blood ◽  
Blood Sampling ◽  
Volume Distribution ◽  
Distribution Width ◽  
Blood Samples ◽  
Significance Level ◽  
True Value

In intervention and observational studies, it is necessary to determine the number of blood samples required to estimate the true value of Fe-status measures. The aim of the present study was to determine the number of days for blood sampling required in order to measure the ‘true value’ of five Fe-status parameters in young Fe-depleted women and to investigate the effect of menstrual cycle on these measures. Twelve women (aged 23–30 years), non-anaemic but with low Fe stores, participated in the study. Venous blood samples were collected under standardised conditions on fifteen non-consecutive days during a 5-week period. All blood samples were analysed for Hb, serum ferritin (SF), serum transferrin receptors (sTfR), red blood cell volume distribution width (RDW) and reticulocytes (RET), and body Fe stores were calculated as the ratio between sTfR and SF. No systematic changes were found in the investigated parameters during the study. When analytical variations were accounted for, the day-to-day variations (CV%) were as follows: Hb 2·9 %, SF 8·2 %, RET 26·0 %, RDW 2·4 % and sTfR 8·1 %. Calculating the ‘true value’ with a 5 % significance level and 80 % power showed that one blood sample was sufficient for Hb, SF, sTfR and RDW, whereas seven blood-sampling days were needed for RET. In this study, no significant differences in Fe status were found across the menstrual cycle. The conclusions from this study are valid for studies conducted under similar strict conditions.

scholarly journals Effect of Maternal Iron Deficiency Anemia on the Iron Store of Newborns in Ethiopia

Anemia ◽  
2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Betelihem Terefe ◽  
Asaye Birhanu ◽  
Paulos Nigussie ◽  
Aster Tsegaye
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Complete Blood Count ◽  
Iron Status ◽  
Hemoglobin Concentration ◽  
Deficiency Anemia ◽  
Iron Store ◽  
Cross Sectional ◽  
Iron Deficient

Iron deficiency anemia among pregnant women is a widespread problem in developing countries including Ethiopia, though its influence on neonatal iron status was inconsistently reported in literature. This cross-sectional study was conducted to compare hematologic profiles and iron status of newborns from mothers with different anemia status and determine correlation between maternal and neonatal hematologic profiles and iron status in Ethiopian context. We included 89 mothers and their respective newborns and performed complete blood count and assessed serum ferritin and C-reactive protein levels from blood samples collected from study participants. Maternal median hemoglobin and serum ferritin levels were 12.2 g/dL and 47.0 ng/mL, respectively. The median hemoglobin and serum ferritin levels for the newborns were 16.2 g/dL and 187.6 ng/mL, respectively. The mothers were classified into two groups based on hemoglobin and serum ferritin levels as iron deficient anemic (IDA) and nonanemic (NA) and newborns of IDA mothers had significantly lower levels of serum ferritin (P=0.017) and hemoglobin concentration (P=0.024). Besides, newborns’ ferritin and hemoglobin levels showed significant correlation with maternal hemoglobin (P=0.018;P=0.039) and ferritin (P=0.000;P=0.008) levels. We concluded that maternal IDA may have an effect on the iron stores of newborns.

Sign in / Sign up

Export Citation Format

Share Document