scholarly journals Prevalence and Determinants of Sex-Specific Dietary Supplement Use in a Greek Cohort

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2857
Author(s):  
Marina O. Rontogianni ◽  
Afroditi Kanellopoulou ◽  
Georgios Markozannes ◽  
Emmanouil Bouras ◽  
Christos Derdemezis ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Dietary Supplement ◽  
Regression Models ◽  
Health Study ◽  
Considerable Proportion ◽  
P Value ◽  
Study Cohort ◽  
Logistic Regression Models ◽  
Supplement Use ◽  
Dietary Supplement Use

We describe the profile of dietary supplement use and its correlates in the Epirus Health Study cohort, which consists of 1237 adults (60.5% women) residing in urban north-west Greece. The association between dietary supplement use and demographic characteristics, lifestyle behaviors, personal medical history and clinical measurements was assessed using logistic regression models, separately for women and men. The overall prevalence of dietary supplement use was 31.4%, and it was higher in women (37.3%) compared to men (22.4%; p-value = 4.2−08). Based on multivariable logistic regression models, dietary supplement use in women was associated with age (positively until middle-age and slightly negatively afterwards), the presence of a chronic health condition (OR = 1.71; 95% CI, 1.18–2.46), lost/removed teeth (OR = 0.52; 95% CI, 0.35–0.78) and diastolic blood pressure (OR per 5 mmHg increase =0.84; 95% CI, 0.73–0.96); body mass index and worse general health status were borderline inversely associated. In men, dietary supplement use was positively associated with being employed (OR = 2.53; 95% CI, 1.21–5.29). A considerable proportion of our sample used dietary supplements, and the associated factors differed between women and men.

The impact of SPY angiography on intraoperative decision making and outcomes for post-mastectomy reconstruction

2019 ◽  
pp. 1-5
Keyword(s):  
Decision Making ◽  
Logistic Regression ◽  
Skin Necrosis ◽  
Regression Models ◽  
Multivariable Analysis ◽  
P Value ◽  
Flap Necrosis ◽  
Single Institution ◽  
Logistic Regression Models ◽  
The Impact

Objective: While the use of intraoperative laser angiography (SPY) is increasing in mastectomy patients, its impact in the operating room to change the type of reconstruction performed has not been well described. The purpose of this study is to investigate whether SPY angiography influences post-mastectomy reconstruction decisions and outcomes. Methods and materials: A retrospective analysis of mastectomy patients with reconstruction at a single institution was performed from 2015-2017.All patients underwent intraoperative SPY after mastectomy but prior to reconstruction. SPY results were defined as ‘good’, ‘questionable’, ‘bad’, or ‘had skin excised’. Complications within 60 days of surgery were compared between those whose SPY results did not change the type of reconstruction done versus those who did. Preoperative and intraoperative variables were entered into multivariable logistic regression models if significant at the univariate level. A p-value <0.05 was considered significant. Results: 267 mastectomies were identified, 42 underwent a change in the type of planned reconstruction due to intraoperative SPY results. Of the 42 breasts that underwent a change in reconstruction, 6 had a ‘good’ SPY result, 10 ‘questionable’, 25 ‘bad’, and 2 ‘had areas excised’ (p<0.01). After multivariable analysis, predictors of skin necrosis included patients with ‘questionable’ SPY results (p<0.01, OR: 8.1, 95%CI: 2.06 – 32.2) and smokers (p<0.01, OR:5.7, 95%CI: 1.5 – 21.2). Predictors of any complication included a change in reconstruction (p<0.05, OR:4.5, 95%CI: 1.4-14.9) and ‘questionable’ SPY result (p<0.01, OR: 4.4, 95%CI: 1.6-14.9). Conclusion: SPY angiography results strongly influence intraoperative surgical decisions regarding the type of reconstruction performed. Patients most at risk for flap necrosis and complication post-mastectomy are those with questionable SPY results.

scholarly journals Assessing Clinical Change in Individuals Exposed to Repetitive Head Impacts: The Repetitive Head Impact Composite Index

2021 ◽  
Vol 12 ◽  
Author(s):  
Charles Bernick ◽  
Guogen Shan ◽  
Lauren Bennett ◽  
Jay Alberts ◽  
Jeffrey Cummings
Keyword(s):  
Logistic Regression ◽  
Regression Models ◽  
Cognitive Testing ◽  
Health Study ◽  
Clinical Change ◽  
Linear Discriminant ◽  
Head Impacts ◽  
Logistic Regression Models ◽  
Repetitive Head Impacts ◽  
Over Time

Background: There is a current lack of any composite measure for the effective tracking and monitoring of clinical change in individuals exposed to repetitive head impacts (RHI). The aim of this study is to create a composite instrument for the purposes of detecting change over time in cognitive and behavioral function in individuals exposed to RHI.Methods: The data to derive the composite instrument came from the Professional Fighters Brain Health Study (PFBHS), a longitudinal study of active and retired professional fighters [boxers and mixed martial arts (MMA) fighters] and healthy controls. Participants in the PFBHS underwent assessment on an annual basis that included computerized cognitive testing and behavioral questionnaires. Multivariate logistic regression models were employed to compare active fighters (n = 117) with controls (n = 22), and retired fighters (n = 26) with controls to identify the predictors that could be used to differentiate the groups over time. In a second step, linear discriminant analysis was performed to derive the linear discriminant coefficients for the three groups by using the predictors from the two separate logistic regression models.Results: The composite scale is a weighted linear value of 12 standardized scores consisting of both current and yearly change scores in domains including: processing speed, choice reaction time, semantic fluency, letter fluency, and Barrett Impulsiveness Scale. Because the weighting of values differed between active and retired fighters, two versions emerged. The mean and standard deviation ratio (MSDR) showed that the new index had better sensitivity compared to the individual measures, with the ratio of MSDR of the new index to that of the existing measures of at least 1.84.Conclusion: With the increasing need for tools to follow individuals exposed to RHI and the potential of clinical trials on the horizon for CTE, the RHICI is poised to serve as an initial approach to a composite clinical measure.

scholarly journals Comparison of a Medication Inventory and a Dietary Supplement Interview in Assessing Dietary Supplement Use in the Hispanic Community Health Study/Study of Latinos

2016 ◽  
Vol 11 ◽  
pp. IMI.S25587
Author(s):  
Keturah R. Faurot ◽  
Anna Maria Siega-Riz ◽  
Paula Gardiner ◽  
Josέ O. Rivera ◽  
Laura A. Young ◽  
...  
Keyword(s):  
Ethnic Minority ◽  
Community Health ◽  
Dietary Supplement ◽  
Health Study ◽  
Minority Populations ◽  
Survey Nonresponse ◽  
Supplement Use ◽  
Hispanic Community ◽  
Ethnic Minority Populations ◽  
Dietary Supplement Use

Although dietary supplement use is common, its assessment is challenging, especially among ethnic minority populations such as Hispanics/Latinos. Using the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) (n = 16,415), this report compares two strategies for capturing dietary supplement use over a 30-day period: a medication-based inventory and a nutrition-based dietary supplement interview. Age-standardized prevalence was calculated across multiple dietary supplement definitions, adjusted with survey/nonresponse weights. The prevalence of dietary supplement use was substantially higher as measured in the dietary supplement interview, compared to the medication inventory: for total dietary supplements (39% vs 26%, respectively), for nonvitamin, nonmineral supplements (24% vs 12%), and for botanicals (9.2% vs 4.5%). Concordance between the two assessments was fair to moderate (Cohen's kappa: 0.31–0.52). Among women, inclusion of botanical teas increased the prevalence of botanical supplement use from 7% to 15%. Supplement assessment that includes queries about botanical teas yields more information about patient supplement use.

scholarly journals Diagnostic Accuracy of Breast Medical Tactile Examiners (MTEs): A Prospective Pilot Study

Breast Care ◽  
2019 ◽  
Vol 14 (1) ◽  
pp. 41-47
Author(s):  
Michael P. Lux ◽  
Julius Emons ◽  
Mayada R. Bani ◽  
Marius Wunderle ◽  
Charlotte Sell ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Predictive Value ◽  
Regression Models ◽  
Clinical Breast Examination ◽  
P Value ◽  
Logistic Regression Models ◽  
Screening Programs ◽  
Suspicious Breast Lesion ◽  
Clinical Breast ◽  
Adjusted Logistic Regression

Background: The usefulness of clinical breast examination (CBE) in general and in breast cancer screening programs has been a matter of debate. This study investigated whether adding vision-impaired medical tactile examiners (MTEs) improves the predictiveness of CBE for suspicious lesions and analyzed the feasibility and acceptability of this approach. Methods: The prospective study included 104 patients. Physicians and MTEs performed CBEs, and mammography and ultrasound results were used as the gold standard. Sensitivity and specificity were calculated and logistic regression models were used to compare the predictive value of CBE by physicians alone, MTEs alone, and physicians and MTEs combined. Results: For CBEs by physicians alone, MTEs alone, and both combined, sensitivity was 71, 82, and 89% and specificity was 55, 45, and 35%, respectively. Using adjusted logistic regression models, the validated areas under the curve were 0.685, 0.692, and 0.710 (median bootstrapped p value (DeLong) = 0.381). Conclusion: The predictive value for a suspicious breast lesion in CBEs performed by MTEs in patients without prior surgery was similar to that of physician-conducted CBEs. Including MTEs in the CBE procedure in breast units thus appears feasible and could be a way of utilizing their skills.

P–256 Time Lapse Imaging (TLI) acquired morphokinetic variables, nucleation errors and cleavage abnormalities are associated with live birth and may aid in de-selection of transfer embryos

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
S Sayed ◽  
M Reigstad ◽  
B M Petersen ◽  
A Schwennicke ◽  
J Wegne. Hausken ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Embryo Transfer ◽  
Live Birth ◽  
Clinical Setting ◽  
Regression Models ◽  
Explanatory Power ◽  
Study Cohort ◽  
Hormonal Stimulation ◽  
Logistic Regression Models

Abstract Study question May the observation by TLI of morphokinetics, nucleation errors and cleavage abnormalities assist in de-selecting embryos before embryo transfer? Summary answer The combine predictive power of the association between the three biomarkers and live birth may aid in embryo de-selection What is known already Morphokinetic parameters and cleavage biomarkers are associated with treatment outcomes following in vitro fertilization (IVF). Nucleation errors observed by TLI have also been associated with IVF outcomes. It is also shown that nucleation error self-repair in pre-implantation embryos occurs, resulting in euploid blastocysts and live births. Biomarkers identified by TLI have been incorporated in developing algorithms to be used in selecting “the embryo” with the best potential for a live birth. However, the few randomized control studies (RCT) have not shown convincingly that TLI significantly improves live birth rate. Study design, size, duration Analyses of TLI data from transferred embryos, cultured in the EmbryoScope TM between June 2012 and August 2018, in a single IVF clinical setting were included. 2082 treatment cycles with Known Implantation Data (KID) for implantation and live birth were included in the analyses. Nucleation errors such as micronucleation, binucleation, and multinucleation were systematically annotated. Cleavage abnormalities such as direct cleavages, rapid and reverse cleavages were annotated for a minimum of 44 hours post insemination. Participants/materials, setting, methods Annotations for cleavage abnormalities, morphokinetic variables and nucleation errors, during a minimum of 44 hours, for 2959 transferred embryos were obtained from the EmbryoScope. The potential negative association between day 2 KID embryo biomarkers and implantation as well as live birth was assessed. The analyses controlled for potential confounding by adjusting for maternal age, infertility diagnosis, BMI, hormonal stimulation regime and insemination method. Main results and the role of chance Preliminary results were obtained regarding biomarkers in the form of nucleation errors, cleavage abnormalities and early embryo morphological attributes. Several of these biomarkers were significantly associated with implantation and live birth. Nucleation errors were associated with substantial decrease in implantation and live birth, but contrary to findings from other studies, none of the recorded nucleation error types precluded live birth. Many morphokinetically defined cleavage abnormalities were also shown to be significantly associated with implantation and live birth, with timings to 2-cells (t2) and second cell cycle (cc2) displaying the most prominent predictions for live birth probability. Within each of the three biomarker groups, logistic regression models with implantation and live birth probability predictions displayed reasonable explanatory power regarding implantation and live birth. Combining all types of biomarkers lead to logistic regression models with substantially higher explanatory power than when the regression models only comprised a single biomarker group. With a study of this size and P values for the basic findings predominantly being highly significant, the role of chance is likely to be limited. The statistical uncertainty may therefore be subordinated to the confounding caused by embryo transfer selection and further by exclusive use of embryos with known implantation Limitations, reasons for caution Only transferred embryos with KID data were analysed and hence the outcome of other embryos is unknown. Our study used mostly day 2 embryos, therefore generalisation up to blastocyst stage is not possible. Our findings apply to our study cohort and may differ from findings in another clinical setting. Wider implications of the findings: Our study provides knowledge about the role of TLI biomarkers and their potential for deselecting embryos for transfer. This will avoid transfer of lower quality embryos with lower chances of live birth. Incorporating such non-invasive de-selection strategies, alongside morphology may contribute to improving IVF outcome. Trial registration number NA

Dietary Supplement Use Among Adult Cancer Survivors in the United States

2019 ◽  
Author(s):  
Mengxi Du ◽  
Jeffrey B. Blumberg ◽  
Zhilei Shan ◽  
Gail Rogers ◽  
Fan Chen ◽  
...  
Keyword(s):  
United States ◽  
Cancer Survivors ◽  
Dietary Supplement ◽  
The United States ◽  
Supplement Use ◽  
Adult Cancer Survivors ◽  
Dietary Supplement Use

scholarly journals Dietary supplement use in elementary school children: a Japanese web-based survey

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Kazue Ishitsuka ◽  
Satoshi Sasaki ◽  
Hidetoshi Mezawa ◽  
Mizuho Konishi ◽  
Maki Igarashi ◽  
...  
Keyword(s):  
Dietary Supplements ◽  
Dietary Supplement ◽  
Sports Participation ◽  
Web Based ◽  
Mineral Supplements ◽  
Supplement Use ◽  
Health Related Behaviors ◽  
Health Related ◽  
Dietary Supplement Use ◽  
Frequency Of Sports Participation

Abstract Background A variety of dietary supplements are commercially available. However, the efficacy and safety of dietary supplement use in children are not well established. Understanding dietary supplement use is important for developing public health policy regarding dietary supplements. This study aimed to investigate the types of dietary supplements used and characteristics of dietary supplement users among Japanese elementary school children. Method We conducted a cross-sectional web-based questionnaire study. Dietary supplement use, socio-demographics, and health-related behaviors were assessed through mother-reported questionnaire. Types of dietary supplements were identified based on ingredient using product barcodes and brand names. Multivariate logistic regression analysis was conducted to investigate the socio-demographics and health-related behaviors associated with supplement use. Results Among 4933 children, 333 (6.8%) were identified as dietary supplement users. The most common supplement was amino acids or protein (1.4%), followed by n–3 fatty acids or fish oil (1.0%), probiotics (1.0%), multivitamins (0.9%), multivitamin-minerals (0.8%), and botanicals (0.8%). Overall, any dietary supplement use was significantly associated with the highest frequency of sports participation (odds ratio [OR], 2.58; 95% confidence interval [CI], 1.65–4.02), highest household income (OR, 1.87; 95% CI, 1.13–3.10), highest maternal educational level (OR, 1.82; 95% CI, 1.31–2.52), and male sex (OR, 1.38; 95% CI, 1.09–1.75). The highest frequency of sports participation was significantly associated with higher odds of use of amino acids or protein (OR, 6.06; 95% CI, 1.78–20.6) and multivitamins (OR, 3.56; 95% CI, 1.11–11.5), compared to the lowest frequency of sports participation. Conclusion This study showed that Japanese children primarily use non-vitamin, non-mineral supplements. Non-vitamin, non-mineral supplements should thus be included in future studies aimed at monitoring dietary supplement use. We also found that dietary supplement use in children was associated with sports participation. Guidelines for dietary supplement use for children, in particular sport participants, are needed.

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