scholarly journals Dietary Antioxidant Capacity Promotes a Protective Effect against Exacerbated Oxidative Stress in Women Undergoing Adjuvant Treatment for Breast Cancer in a Prospective Study

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4324
Author(s):  
Luiza Kuhnen Reitz ◽  
Jaqueline Schroeder ◽  
Giana Zarbato Longo ◽  
Brunna Cristina Bremer Boaventura ◽  
Patrícia Faria Di Pietro
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Prospective Study ◽  
Antioxidant Capacity ◽  
Adjuvant Treatment ◽  
Lipid Hydroperoxides ◽  
Antioxidant Power ◽  
Dietary Antioxidant ◽  
Increased Risk ◽  
Dietary Antioxidant Capacity

Breast cancer (Bca) is the most common type of cancer among women worldwide, and oxidative stress caused by adjuvant treatment may be decreased by antioxidant intake. The aim of this study is to investigate the associations between Dietary antioxidant Capacity (DaC) and oxidation and antioxidant biomarkers in women undergoing adjuvant treatment (AT) for Bca. This prospective study had a sample of 70 women (52.2 ± 10.7 y). DaC (mmol/g) was calculated using nutritional data obtained from a Food Frequency Questionnaire, and blood was collected to measure the oxidation and antioxidant biomarkers at baseline (T0), and after AT (T1). Carbonylated protein levels were inversely associated with DaC at T1 (p = 0.004); women showed an increased risk of having increment on lipid hydroperoxides and thiobarbituric acid reactive substances (TBARS), and decrement on ferric reducing antioxidant power (FRAP) and reduced glutathione after AT, in response to lowered DaC (p < 0.05). Carbonylated proteins, TBARS and FRAP levels remained stable between the periods for women at the 3rd DaC tertile at T1, differentiating them from those at the 1st tertile, who showed negative changes in these biomarkers (p < 0.04). DaC may be beneficial for women undergoing AT for Bca, since it promoted a reduction in oxidative stress.

scholarly journals Overweight Women with Breast Cancer on Chemotherapy Have More Unfavorable Inflammatory and Oxidative Stress Profiles

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3303
Author(s):  
Letícia L. D. Santos ◽  
Isis D. D. Custódio ◽  
Alinne T. F. Silva ◽  
Izabella C. C. Ferreira ◽  
Eduarda C. Marinho ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Nutritional Status ◽  
Dietary Inflammatory Index ◽  
Overweight Women ◽  
Inflammatory Index ◽  
Dietary Antioxidant ◽  
Stress Profiles ◽  
And Oxidative Stress ◽  
Dietary Antioxidant Capacity

Chronic inflammation and redox imbalance are strongly influenced by diet and nutritional status, and both are risk factors for tumor development. This prospective study aimed to explore the associations between inflammatory and antioxidant markers and nutritional status in women with breast cancer undergoing chemotherapy. The women were evaluated at three times: T0, after the infusion of the first cycle; T1, after infusion of the intermediate cycle; and T2, after the infusion of the last chemotherapy cycle. The consumption of antioxidant nutrients and the Total Dietary Antioxidant Capacity reduced between T0 and T2 and the Dietary Inflammatory Index scores increased throughout the chemotherapy. Blood samples taken at the end of the chemotherapy showed lower levels of glutathione reductase and reduced glutathione, with greater quantification of the transcripts for Interleukin-6 and Tumor Necrosis Factor α. It should be emphasized that the Total Dietary Antioxidant Capacity is lower and the Dietary Inflammatory Index is higher in the group of overweight patients at the end of the follow-up, besides showing lower levels of the redox status, especially the plasma levels of glutathione reductase (p = 0.039). In addition, trends towards higher transcriptional levels of cytokines in peripheral blood were observed more often in overweight women than in non-overweight women. In this study of 55 women with breast cancer, nine (16%) with metastases, diet became more pro-inflammatory with fewer antioxidants during the chemotherapy. Briefly, we have shown that chemotherapy is critical for high-risk overweight women due to their reduced intake of antioxidant nutrients, generating greater inflammatory and oxidative stress profiles, suggesting the adoption of healthier dietary practices by women with breast cancer throughout their chemotherapy.

Total dietary antioxidant capacity, individual antioxidant intake and breast cancer risk: The Rotterdam study

2014 ◽  
Vol 136 (9) ◽  
pp. 2178-2186 ◽  
Author(s):  
Athanasios Pantavos ◽  
Rikje Ruiter ◽  
Edith F. Feskens ◽  
Catherine E. de Keyser ◽  
Albert Hofman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Antioxidant Capacity ◽  
Rotterdam Study ◽  
Dietary Antioxidant ◽  
Antioxidant Intake ◽  
Dietary Antioxidant Capacity

scholarly journals LINE-1 methylation levels, a biomarker of weight loss in obese subjects, are influenced by dietary antioxidant capacity

Redox Report ◽  
2016 ◽  
Vol 21 (2) ◽  
pp. 67-74 ◽  
Author(s):  
Marcos Garcia-Lacarte ◽  
Fermin I. Milagro ◽  
Maria A. Zulet ◽  
J. Alfredo Martinez ◽  
Maria L. Mansego
Keyword(s):  
Weight Loss ◽  
Antioxidant Capacity ◽  
Dietary Antioxidant ◽  
Obese Subjects ◽  
Dietary Antioxidant Capacity

scholarly journals Dietary Antioxidant Capacity and Its Association with Preeclampsia

2017 ◽  
Vol 6 (1) ◽  
pp. 47 ◽  
Author(s):  
Mahdiyeh Sheikhi ◽  
Elham Sharifi-Zahabi ◽  
Zamzam Paknahad
Keyword(s):  
Antioxidant Capacity ◽  
Dietary Antioxidant ◽  
Dietary Antioxidant Capacity

PSXV-27 Late-Breaking: Evaluation of antioxidant capacity in receiving beef calves challenged with lipopolysaccharide (LPS)

2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 381-382
Author(s):  
Samantha N Barker ◽  
Treylr Jackson ◽  
John Richeson ◽  
Jeff A Carroll ◽  
Nicole C Burdick-Sanchez ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Capacity ◽  
Repeated Measures ◽  
Colorimetric Assay ◽  
Post Challenge ◽  
Antioxidant Power ◽  
Blood Samples ◽  
Endotoxin Challenge ◽  
Beef Calves ◽  
Lps Challenge

Abstract The objective of this study was to evaluate antioxidant capacity in plasma of beef calves challenged with LPS. Following an initial feeding period of 40 d, steers (n = 32; 379 kg ± 30.7) were transported to the Livestock Issues Research Unit’s Bovine Immunology Research and Development Complex and challenged intravenously with LPS (0.25 µg/kg BW) on d 41. Blood samples were collected via jugular catheter at -2, 0, 2, 4, 6, 8, 10, 12, 18, 24, 36 and 48 h relative to the LPS challenge at 0 h. Blood samples were processed to isolate plasma for indicators of oxidative stress with a colorimetric assay to determine ferric reducing antioxidant power (FRAP) values via concentration of ferrous iron (µM). Data were analyzed as repeated measures using the GLIMMIX procedure of SAS. Antioxidant values did vary with time (P &lt; 0.001) being greater (P &lt; 0.05) at -2, 0, 2, 36, and 48 h. Antioxidant capacity was reduced at 6 and 8 h (P &lt; 0.05), with the least FRAP value observed at 8 h post-challenge. Antioxidant capacity increased (P &lt; 0.05) again at 10 h, showing similar (P &gt; 0.05) concentrations to those observed at 4 h. By 24 h post-challenge, plasma FRAP values increased (P &lt; 0.05) similar to initial values at -2, 0, and 2 h. It can be inferred that oxidative stress contributes to reduced antioxidant capacity, ultimately interfering with animal growth and productivity. While these values reflect the oxidative stress response to an acute endotoxin challenge, and a subsequent recovery returning to homeostasis within 24 to 48 h, they may also correlate with other physiological and immunological indicators associated with an acute endotoxin challenge.

scholarly journals Evaluation of Salivary and Serum Total Antioxidant Capacity and Lipid Peroxidation in Postmenopausal Women

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Fatemeh Zovari ◽  
Hadi Parsian ◽  
Ali Bijani ◽  
Ameneh Moslemnezhad ◽  
Atena Shirzad
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Antioxidant Capacity ◽  
Postmenopausal Women ◽  
Total Antioxidant Capacity ◽  
Premenopausal Women ◽  
Control Group ◽  
Antioxidant Power ◽  
Whole Saliva ◽  
Total Antioxidant

Objective. In menopause, reduction of estrogen hormone affects oxidative stress process in serum. Oxidative stress in saliva plays a significant role in the pathogenesis of oral diseases. The aim of this study was to investigate the total antioxidant capacity and lipid peroxidation in the serum and saliva of premenopausal and postmenopausal women. Methods. In this case control study, 50 postmenopausal women (case group) and 48 premenopausal women (control group) were selected. The unstimulated whole saliva and serum of the postmenopausal and premenopausal women were collected. The total antioxidant capacity (TAC) of the saliva and serum was measured by ferric reducing antioxidant power (FRAP). Also, malondialdehyde (MDA) was measured by thiobarbituric acid reactive substance (TBARS) method for serum and saliva. Then, the obtained data were analyzed by SPSS 17, whereby Mann–Whitney test and Spearman’s correlation test were used. P < 0.05 was considered statistically significant. Results. The postmenopausal group had significantly lower mean serum TAC and higher mean serum MDA than the control group ( P < 0 < 001 and P < 0.01 , respectively). The mean salivary TAC and MDA, however, did not differ significantly between the case and control group ( P = 0.64 and P = 0.08 , respectively). Conclusion. In postmenopausal women, with elevation of serum MDA and reduction of serum TAC, the extent of serum oxidative stress grows, but MDA and TAC levels of saliva do not change.

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