scholarly journals Inverse Association of Plasma Molybdenum with Metabolic Syndrome in a Chinese Adult Population: A Case-Control Study

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4544
Author(s):  
Ben Li ◽  
Yue Huang ◽  
Cheng Luo ◽  
Xiaolin Peng ◽  
Yang Jiao ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Lower Risk ◽  
Case Control Study ◽  
Adult Population ◽  
Case Control ◽  
Essential Elements ◽  
Inverse Association ◽  
Chinese Adult ◽  
Multiple Covariates ◽  
Control Study

Molybdenum has been found to be associated with metabolic disorders. However, the relationship between molybdenum and metabolic syndrome (MetS) is still unclear. A large case-control study was conducted in a Chinese population from the baseline of Ezhou-Shenzhen cohort. A total of 5356 subjects were included with 2678 MetS and 2678 controls matched by sex and age (±2 years). Medians (IQRs) of plasma molybdenum concentrations were 1.24 μg/L for MetS cases and 1.46 μg/L for controls. After adjustment for multiple covariates, the odds ratio (OR) and 95% confidence intervals (CIs) for MetS were 1.00 (reference), 0.71 (0.59–0.84), 0.56 (0.46–0.68), and 0.47 (0.39–0.58) across quartiles of plasma molybdenum, and per SD increment of log-transformed molybdenum was associated with a 23% lower risk of MetS. In the spline analysis, the risk of MetS and its components decreased steeply with increasing molybdenum and followed by a plateau when the cutoff point was observed around 2.0 μg/L. The dose-dependent relationship of molybdenum with MetS remained consistent when considering other essential elements in the Bayesian kernel machine regression (BKMR) model. In our study, higher plasma molybdenum was significantly associated with a lower risk of MetS, as well as its components, in a dose-response manner.

scholarly journals High erythrocyte levels of the n-6 polyunsaturated fatty acid linoleic acid are associated with lower risk of subsequent rheumatoid arthritis in a southern European nested case–control study

2018 ◽  
Vol 77 (7) ◽  
pp. 981-987 ◽  
Author(s):  
Paola de Pablo ◽  
Dora Romaguera ◽  
Helena L Fisk ◽  
Philip C Calder ◽  
Anne-Marie Quirke ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Linoleic Acid ◽  
Erythrocyte Membrane ◽  
Lower Risk ◽  
Case Control Study ◽  
Case Control ◽  
Inverse Association ◽  
Total N ◽  
Nested Case Control ◽  
Control Study

ObjectivesFindings relating to dietary intake of n-3 polyunsaturated fatty acids (PUFA) and risk of rheumatoid arthritis (RA) are mixed. Erythrocyte membrane PUFA is an accurate objective biomarker of PUFA status; however, there are little data on erythrocyte membrane PUFA and risk of RA. The objective was therefore to compare erythrocyte membrane PUFA between pre-RA individuals and matched controls from a population-based sample, and specifically to test the hypothesis that higher levels of longer chain n-3 PUFA are associated with lower risk of RA.MethodsThe European Prospective Investigation into Cancer and Nutrition (EPIC) is a large European prospective cohort study of apparently healthy populations. We undertook a nested case–control study by identifying RA cases with onset after enrolment (pre-RA) in four EPIC cohorts in Italy and Spain. Confirmed pre-RA cases were matched with controls by age, sex, centre, and date, time and fasting status at blood collection. Conditional logistic regression analysis was used to estimate associations of PUFA with the development of RA, adjusting for potential confounders including body mass index, waist circumference, education level, physical activity, smoking status and alcohol intake.ResultsThe study analysed samples from 96 pre-RA subjects and 258 matched controls. In this analysis, the median time to diagnosis (defined as time between date of blood sample and date of diagnosis) was 6.71 years (range 0.8–15). A significant inverse association was observed with n-6 PUFA linoleic acid (LA) levels and pre-RA in the fully adjusted model (highest tertile: OR 0.29; 95% CI 0.12 to 0.75; P for trend 0.01). No association was observed with any individual n-3 PUFA, total n-3 PUFA or total n-3:n-6 ratio.ConclusionsErythrocyte levels of the n-6 PUFA LA were inversely associated with risk of RA, whereas no associations were observed for other n-6 or n-3 PUFA. Further work is warranted to replicate these findings and to investigate if lower LA levels are a bystander or contributor to the process of RA development.

scholarly journals Association of cystatin C levels with metabolic syndrome incidence: a nested case-control study with propensity score matching

2021 ◽  
Vol 49 (1) ◽  
pp. 030006052098631
Author(s):  
Tengfei Yang ◽  
Dongmei Pei
Keyword(s):  
Metabolic Syndrome ◽  
Propensity Score ◽  
Physical Examination ◽  
Propensity Score Matching ◽  
Case Control Study ◽  
Case Control ◽  
Chinese Adults ◽  
Biochemical Profiles ◽  
Nested Case Control ◽  
Control Study

Objective Metabolic syndrome (MetS) involves multiple metabolic disorders and seriously affects human health. Identification of key biological factors associated with MetS incidence is therefore important. We explored the association between MetS and the biochemical profiles of Chinese adults in Shenyang City in a nested case-control study. Methods We included adult participants who underwent physical examination at our hospital for 2 consecutive years. Participants’ biochemical profiles and other MetS components were tested and monitored continuously. Propensity score matching was used to adjust confounding factors between participants with and without MetS. We analyzed the association between incidence of MetS and the biochemical profiles of participants. Results Of 5702 participants who underwent physical examination between 1 January 2017 and 1 December 2018, 538 had confirmed newly developed MetS. After successfully matching 436 pairs of participants, mean cystatin C (Cys-C) level was significantly higher in the MetS group than in the non-MetS group. Logistic regression analysis indicated that age (years) and γ-glutamate transpeptidase, creatinine, uric acid, and Cys-C levels were significantly associated with MetS incidence; among these, the odds ratio of Cys-C was highest (3.03; 95% confidence interval, 1.02–9.00). Conclusions Cys-C levels were significantly associated with the incidence of MetS among Chinese adults.

scholarly journals Inflammatory Biomarkers Predictive of Metabolic Syndrome in a Nigerian Population: A Case-Control Study

2020 ◽  
Vol 6 (4) ◽  
pp. 382-390
Author(s):  
EN Adejumo ◽  
OA Adejumo ◽  
OA Ogundahunsi
Keyword(s):  
Metabolic Syndrome ◽  
Case Control Study ◽  
Inflammatory Marker ◽  
Characteristic Curve ◽  
Area Under The Curve ◽  
Case Control ◽  
Control Group ◽  
Necrosis Factor Alpha ◽  
Hs Crp ◽  
Control Study

Background: Inflammation is linked to the aetiopathogenesis of Metabolic syndrome (MetS). Objective: To assess the ability of high sensitivity C-Reactive Protein (hs-CRP), Tumour Necrosis Factor-alpha (TNFα) and Interleukin-6 (IL-6) to predict MetS. Methods: A case-control study involving 123 subjects with MetS (cases) and age-matched 123 subjects. without MetS (controls) was conducted. The levels of TNFα, IL-6, and hs-CRP between independent groups were compared. The Receiver Operative Characteristic Curve was used to assess the ability of inflammatory markers to discriminately identify MetS. Results: The mean age of the case and control groups was 49.9±0.9 years and 48.1±1.1 years (p = 0.274) respectively. The median levels of TNFα, IL-6 and hS-CRP were significantly higher among the cases than the control group in both genders (p <0.001). There was a significant increase in the serum values of the markers with increasing components of MetS (p <0.001). The Area Under the Curve of TNFα, IL-6 and hs-CRP was > 0.9 in both males and females. Conclusion: TNFα, IL-6, and hs-CRP identified MetS. There is a need for further studies to determine the inflammatory marker most predictive of MetS.

scholarly journals Inverse association between Helicobacter pylori infection and childhood asthma in Greece: a case-control study

GERMS ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 182-187 ◽  
Author(s):  
Christina Tsigalou ◽  
Theocharis G Konstantinidis ◽  
Dimitrios Cassimos ◽  
Alexandros Karvelas ◽  
Anastasia Grapsa ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Childhood Asthma ◽  
Case Control Study ◽  
Case Control ◽  
Helicobacter Pylori Infection ◽  
Inverse Association ◽  
Control Study
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