scholarly journals Flaxseed Lignans as Important Dietary Polyphenols for Cancer Prevention and Treatment: Chemistry, Pharmacokinetics, and Molecular Targets

2019 ◽  
Vol 12 (2) ◽  
pp. 68 ◽  
Author(s):  
S. Franklyn De Silva ◽  
Jane Alcorn
Keyword(s):  
Cancer Prevention ◽  
Treatment Strategies ◽  
Molecular Targets ◽  
Evidence Base ◽  
Food Sources ◽  
Effective Prevention ◽  
Biological Targets ◽  
Dietary Polyphenols ◽  
Flaxseed Lignans ◽  
Prevention And Treatment

Cancer causes considerable morbidity and mortality across the world. Socioeconomic, environmental, and lifestyle factors contribute to the increasing cancer prevalence, bespeaking a need for effective prevention and treatment strategies. Phytochemicals like plant polyphenols are generally considered to have anticancer, anti-inflammatory, antiviral, antimicrobial, and immunomodulatory effects, which explain their promotion for human health. The past several decades have contributed to a growing evidence base in the literature that demonstrate ability of polyphenols to modulate multiple targets of carcinogenesis linking models of cancer characteristics (i.e., hallmarks and nutraceutical-based targeting of cancer) via direct or indirect interaction or modulation of cellular and molecular targets. This evidence is particularly relevant for the lignans, an ubiquitous, important class of dietary polyphenols present in high levels in food sources such as flaxseed. Literature evidence on lignans suggests potential benefit in cancer prevention and treatment. This review summarizes the relevant chemical and pharmacokinetic properties of dietary polyphenols and specifically focuses on the biological targets of flaxseed lignans. The consolidation of the considerable body of data on the diverse targets of the lignans will aid continued research into their potential for use in combination with other cancer chemotherapies, utilizing flaxseed lignan-enriched natural products.

scholarly journals Combinatorial Epigenetics Impact of Polyphenols and Phytochemicals in Cancer Prevention and Therapy

2019 ◽  
Vol 20 (18) ◽  
pp. 4567 ◽  
Author(s):  
Arora ◽  
Sharma ◽  
Tollefsbol
Keyword(s):  
Cancer Prevention ◽  
Biological Properties ◽  
Food Sources ◽  
Cancer Society ◽  
Dietary Polyphenols ◽  
Treatment And Prevention ◽  
Increased Risk ◽  
Mirnas Expression ◽  
Dose Dependent ◽  
Prevention And Therapy

Polyphenols are potent micronutrients that can be found in large quantities in various food sources and spices. These compounds, also known as phenolics due to their phenolic structure, play a vital nutrient-based role in the prevention of various diseases such as diabetes, cardiovascular diseases, neurodegenerative diseases, liver disease, and cancers. However, the function of polyphenols in disease prevention and therapy depends on their dietary consumption and biological properties. According to American Cancer Society statistics, there will be an expected rise of 23.6 million new cancer cases by 2030. Due to the severity of the increased risk, it is important to evaluate various preventive measures associated with cancer. Relatively recently, numerous studies have indicated that various dietary polyphenols and phytochemicals possess properties of modifying epigenetic mechanisms that modulate gene expression resulting in regulation of cancer. These polyphenols and phytochemicals, when administrated in a dose-dependent and combinatorial-based manner, can have an enhanced effect on epigenetic changes, which play a crucial role in cancer prevention and therapy. Hence, this review will focus on the mechanisms of combined polyphenols and phytochemicals that can impact various epigenetic modifications such as DNA methylation and histone modifications as well as regulation of non-coding miRNAs expression for treatment and prevention of various types of cancer.

miRNAs in Cancer Prevention and Treatment and as Molecular Targets for Natural Product Anticancer Agents

2013 ◽  
Vol 13 (5) ◽  
pp. 519-541 ◽  
Author(s):  
Biyun Qian ◽  
Subhasree Nag ◽  
Yuliang Su ◽  
Sukesh Voruganti ◽  
Jiang-Jiang Qin ◽  
...  
Keyword(s):  
Cancer Prevention ◽  
Natural Product ◽  
Anticancer Agents ◽  
Molecular Targets ◽  
Prevention And Treatment

scholarly journals Integrated Medicine for Chemotherapy-Induced Peripheral Neuropathy

2021 ◽  
Vol 22 (17) ◽  
pp. 9257
Author(s):  
Chih-Hung Tsai ◽  
Yuan-Ho Lin ◽  
Yung-Sheng Li ◽  
Trung-Loc Ho ◽  
Le Huynh Hoai Thuong ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Peripheral Neuropathy ◽  
Recent Progress ◽  
Therapeutic Strategy ◽  
Treatment Strategies ◽  
Common Side Effect ◽  
Integrated Medicine ◽  
Effective Prevention ◽  
Effective Strategies ◽  
Prevention And Treatment

Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of typical chemotherapeutics among cancer survivors. Despite the recent progress, the effective prevention and treatment strategies for CIPN remain limited. Better understanding of the pathogenesis of CIPN may provide new niches for developing a new ideal therapeutic strategy. This review summarizes the current understanding of CIPN and current recommendations along with completed/active clinical trials and aims to foster translational research to improve the development of effective strategies for managing CIPN.

scholarly journals Analysis SARS-CoV-2 Genomes of G20 Areas on Phylogeny Tree, t-SNE based on Machine Learning

2020 ◽  
Author(s):  
Renyang Liu ◽  
Mu Qiao ◽  
Alima ◽  
Jeffrey Zheng ◽  
Wei Zhou
Keyword(s):  
Public Health ◽  
Machine Learning ◽  
Phylogenetic Tree ◽  
Treatment Strategies ◽  
Gene Sequences ◽  
Effective Prevention ◽  
Multiple Resources ◽  
The World ◽  
Prevention And Treatment ◽  
Epidemiological Characteristics

Abstract The new coronavirus disease (COVID-19) broke out earlier in Wuhan, and the plague spread rapidly from multiple resources of different countries. COVID-19 has caused millions of diagnosed people worldwide, causing many deaths and posing a severe threat to public health in countries around the world. Facing this urgent situation, in-depth research on the emerging SARS-CoV-2 to understand the related pathogenic mechanism and epidemiological characteristics is urgent. This type of activity would be useful to determine its origin to formulate effective prevention and treatment strategies for affected patients.This paper adopts t-SNE based on machine learning to draw a phylogenetic tree from collected genomic sequences to analyze G20 countries’ samples. The phylogenetic tree of the generating mechanism was described, and intermediate results were illustrated. The results of this research showed that viruses in many countries have similar or similar relationships among the gene sequences.

Another look at dietary polyphenols: challenges in cancer prevention and treatment

2021 ◽  
Vol 28 ◽  
Author(s):  
Roberto Arrigoni ◽  
Andrea Ballini ◽  
Luigi Santacroce ◽  
Stefania Cantore ◽  
Angelo Inchingolo ◽  
...  
Keyword(s):  
Side Effects ◽  
Protective Effect ◽  
Cancer Prevention ◽  
Fruit And Vegetables ◽  
Dietary Polyphenols ◽  
Metabolic Interaction ◽  
The World ◽  
Prevention And Treatment ◽  
Prevention And Therapy

: Cancer is a pathology that impacts in a profound manner people all over the world. The election strategy against cancer often uses chemotherapy and radiotherapy, which more often than not can present many side effects and not always reliable efficacy. By contrast, it is widely known that a diet rich in fruit and vegetables has a protective effect against cancer insurgence and development. Polyphenols are generally believed to be responsible for those beneficial actions, at least partially. In this review, we highlight the metabolic interaction between polyphenols and our metabolism and discuss their potential for anticancer prevention and therapy.

Nanoencapsulated dietary polyphenols for cancer prevention and treatment: successes and challenges

Nanomedicine ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. 1147-1162 ◽  
Author(s):  
Shams Tabrez ◽  
Nasimudeen R Jabir ◽  
Vaqar Mustafa Adhami ◽  
Mohammad Imran Khan ◽  
Mohammed Moulay ◽  
...  
Keyword(s):  
Cancer Prevention ◽  
Therapeutic Potential ◽  
Epigallocatechin Gallate ◽  
Systemic Delivery ◽  
Dietary Polyphenols ◽  
Prevention And Treatment ◽  
In Vivo Animal Models ◽  
Successes And Challenges

Many dietary polyphenols have been investigated for their therapeutic potential either as single agents or in combinations. Despite the significant anticancer potential of these polyphenols in in vitro cell culture and in vivo animal models, their clinical applications have been limited because of challenges such as ineffective systemic delivery, stability and low bioavailability. Nanoencapsulation of these polyphenols could prolong circulation, improve localization, enhance efficacy and reduce the chances of multidrug resistance. This review summarized the use of various polyphenols especially epigallocatechin gallate, quercetin, curcumin and resveratrol as nanoformulations for cancer prevention and treatment. Despite some success, more research is warranted to design a nanoencapsulated combination of polyphenols, effective in in vitro, in vivo and human systems.

scholarly journals Ursolic acid in cancer prevention and treatment: Molecular targets, pharmacokinetics and clinical studies

2013 ◽  
Vol 85 (11) ◽  
pp. 1579-1587 ◽  
Author(s):  
Muthu K. Shanmugam ◽  
Xiaoyun Dai ◽  
Alan Prem Kumar ◽  
Benny K.H. Tan ◽  
Gautam Sethi ◽  
...  
Keyword(s):  
Cancer Prevention ◽  
Ursolic Acid ◽  
Clinical Studies ◽  
Molecular Targets ◽  
Prevention And Treatment

scholarly journals Anthocyanins and Human Health—A Focus on Oxidative Stress, Inflammation and Disease

Antioxidants ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 366 ◽  
Author(s):  
Hollie Speer ◽  
Nathan M. D’Cunha ◽  
Natalie I. Alexopoulos ◽  
Andrew J. McKune ◽  
Nenad Naumovski
Keyword(s):  
Oxidative Stress ◽  
Treatment Strategies ◽  
Food Sources ◽  
Cardiometabolic Health ◽  
Physiological Effects ◽  
Beneficial Effects ◽  
Age Related ◽  
The Everyday ◽  
Prevention And Treatment ◽  
Apoptotic Effects

Consumption of anthocyanins (ACNs), due to their antioxidant, anti-inflammatory and anti-apoptotic effects, has been proposed for the prevention and treatment of several different diseases and conditions. ACNs are recognized as one of the leading nutraceuticals for prolonging health benefits through the attenuation of oxidative stress, and inflammatory or age-related diseases. Increased consumption of ACNs has the potential to attenuate the damage ensuing from oxidative stress, inflammation, enhance cardiometabolic health, and delay symptoms in predisposed neuropathology. A myriad of evidence supports ACN consumption as complementary or standalone treatment strategies for non-communicable diseases (NCDs) including obesity, diabetes, cardiovascular disease (CVD), neurodegenerative diseases, as well as, more recently, for the modulation of gut bacteria and bone metabolism. While these findings indicate the beneficial effects of ACN consumption, their food sources differ vastly in ACN composition and thus potentially in their physiological effects. Consumption of foods high in ACNs can be recommended for their potential beneficial health effects due to their relatively easy and accessible addition to the everyday diet.

Lactoferrin ameliorates pathological cardiac hypertrophy related to mitochondrial quality control in aged mice

2021 ◽  
Author(s):  
Lishan Huang ◽  
Ruiyu Chen ◽  
Libin Liu ◽  
Yu Zhou ◽  
Zhou Chen
Keyword(s):  
Quality Control ◽  
Cardiovascular Diseases ◽  
Cardiac Hypertrophy ◽  
Myocardial Hypertrophy ◽  
Treatment Strategies ◽  
The Elderly ◽  
Mitochondrial Quality Control ◽  
Effective Prevention ◽  
Pathological Cardiac Hypertrophy ◽  
Prevention And Treatment

Pathological myocardial hypertrophy, which lacks effective prevention and treatment strategies, makes the elderly susceptible to various cardiovascular diseases. Based on the beneficial attributes of lactoferrin in aging-related diseases, we aimed...

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