Dermal Drug Delivery of Phytochemicals with Phenolic Structure via Lipid-Based Nanotechnologies

Phenolic compounds are a large, heterogeneous group of secondary metabolites found in various plants and herbal substances. From the perspective of dermatology, the most important benefits for human health are their pharmacological effects on oxidation processes, inflammation, vascular pathology, immune response, precancerous and oncological lesions or formations, and microbial growth. Because the nature of phenolic compounds is designed to fit the phytochemical needs of plants and not the biopharmaceutical requirements for a specific route of delivery (dermal or other), their utilization in cutaneous formulations sets challenges to drug development. These are encountered often due to insufficient water solubility, high molecular weight and low permeation and/or high reactivity (inherent for the set of representatives) and subsequent chemical/photochemical instability and ionizability. The inclusion of phenolic phytochemicals in lipid-based nanocarriers (such as nanoemulsions, liposomes and solid lipid nanoparticles) is so far recognized as a strategic physico-chemical approach to improve their in situ stability and introduction to the skin barriers, with a view to enhance bioavailability and therapeutic potency. This current review is focused on recent advances and achievements in this area.

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Complexation with Hydroxypropyl-gama-Cyclodextrin of Birch Tree Extract Physico-chemical Characterisation of their Binary Products

Revista de Chimie ◽

10.37358/rc.08.6.1854 ◽

2008 ◽

Vol 59 (6) ◽

Cited By ~ 1

Author(s):

Codruta Soica ◽

Cristina A. Dehelean ◽

Valentin Ordodi ◽

Diana Antal ◽

Vicentiu Vlaia

Keyword(s):

Inclusion Complexes ◽

Water Solubility ◽

In Vitro Dissolution ◽

Molar Ratio ◽

Bark Extract ◽

Birch Bark ◽

Preparation Methods ◽

Birch Tree ◽

Physico Chemical

Birch bark contains important pentacyclic triterpens that determine an anticancer, anti-inflammatory and antiviral activity. The compounds can be extracted by simple procedures with organic solvents. The major problem of this type of triterpens is their low water solubility which can be increased by physical procedures like cyclodextrin complexation. The aim of present study was to analyse the products between birch bark extract and hydroxypropyl-g -cyclodextrin. Hydroxypropyl-g -cyclodextrin (HPGCD) was used as a host to improve its solubility in water, via inclusion complex formation. In order to obtain the inclusion complexes, 1:2 molar ratio and two preparation methods (physical mixing, kneading) were used. The inclusion complexes were analyzed by in vitro dissolution tests, thermal analysis and X-ray diffraction.

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Physico-Chemical Characteristics of Sapota (Chikoo) Powder based Value Added Pasta Product using Semolina (Suji) and Maida

Journal of AgriSearch ◽

10.21921/jas.v7i04.19394 ◽

2020 ◽

Vol 7 (04) ◽

Author(s):

SATYA NARAYAN SINGH ◽

RAJESH G BURBADE ◽

HITESH SANCHAVAT ◽

P S PANDIT

Keyword(s):

Bulk Density ◽

Crude Protein ◽

Water Solubility ◽

Value Added ◽

Absorption Capacity ◽

Oil Absorption ◽

Minimum Value ◽

Maximum Value ◽

Physico Chemical ◽

Specific Length

The cereals of today are more nutritious and healthful than ever before. Cereals processing is one of the oldest and the most essential part of all food technologies. Pasta products and noodles have been staple foods since ancient times in many countries all over the world. In this study pasta formulation was substituted with blending sapota powder in different proportions (4 levels i.e. 0%, 10%, 20%, 30%) into semolina and maida flour separately. Pasta products were prepared using eight different formulations and adding water (approximately 31% of total weight) in DOLLY pasta extruder machine. All the samples were evaluated for physical properties: specific length (mm/g), bulk density (kg/m3), specific density (kg/m3) and porosity (%); functional properties: water absorption index (%), water solubility index (%) and oil absorption capacity (ml/g) and nutritional compositions: moisture (%), crude protein (%), fat (%) and carbohydrate (%). Highest specific length 36.20 mm/g was observed for T5 treatment, low bulk density 368.10 kg/m3 was observed for T5 and highest porosity 9.24% was found for T1 treatment. The maximum WAI, WSI values 325.83%, 17.33% respectively was observed for T1 treatment and minimum value of oil absorption capacity 1.06 ml/g for T8 treatment. The moisture content of dried pasta products was found in the range of 6 to 7%. The maximum value of crude protein 13.07% was found for T5 and minimum value 8.81% for T4 treatments. The fat contents were varied from 1.02% to 1.28 %. The maximum value of carbohydrate was 76.20% for T1 and minimum value 65.41% for T8.

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Piroxicam Loading onto Mesoporous Silicas by Supercritical CO2 Impregnation

Molecules ◽

10.3390/molecules26092500 ◽

2021 ◽

Vol 26 (9) ◽

pp. 2500

Author(s):

Marta Gallo ◽

Luca Serpella ◽

Federica Leone ◽

Luigi Manna ◽

Mauro Banchero ◽

...

Keyword(s):

Supercritical Co2 ◽

Water Solubility ◽

Solid Dispersions ◽

Mesoporous Silicas ◽

Incipient Wetness Impregnation ◽

Pore Blocking ◽

Physico Chemical ◽

Adsorption From Solution ◽

First Time ◽

Loading Procedure

Piroxicam (PRX) is a commonly prescribed nonsteroidal anti-inflammatory drug. Its efficacy, however, is partially limited by its low water solubility. In recent years, different studies have tackled this problem and have suggested delivering PRX through solid dispersions. All these strategies, however, involve the use of potentially harmful solvents for the loading procedure. Since piroxicam is soluble in supercritical CO2 (scCO2), the present study aims, for the first time, to adsorb PRX onto mesoporous silica using scCO2, which is known to be a safer and greener technique compared to the organic solvent-based ones. For comparison, PRX is also loaded by adsorption from solution and incipient wetness impregnation using ethanol as solvent. Two different commercial mesoporous silicas are used (SBA-15 and Grace Syloid® XDP), which differ in porosity order and surface silanol population. Physico-chemical analyses show that the most promising results are obtained through scCO2, which yields the amorphization of PRX, whereas some crystallization occurs in the case of adsorption from solution and IWI. The highest loading of PRX by scCO2 is obtained in SBA-15 (15 wt.%), where molecule distribution appears homogeneous, with very limited pore blocking.

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In situ dual crosslinking strategy to improve the physico-chemical properties of thermoplastic starch

Carbohydrate Polymers ◽

10.1016/j.carbpol.2021.118250 ◽

2021 ◽

pp. 118250

Author(s):

Hamed Peidayesh ◽

Abolfazl Heydari ◽

Katarína Mosnáčková ◽

Ivan Chodák

Keyword(s):

Chemical Properties ◽

Thermoplastic Starch ◽

Physico Chemical

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Removal of heavy metal from soil and groundwater by in-situ electrokinetic remediation

Water Science & Technology ◽

10.2166/wst.2000.0586 ◽

2000 ◽

Vol 42 (7-8) ◽

pp. 335-343 ◽

Cited By ~ 4

Author(s):

S. Shiba ◽

S. Hino ◽

Y. Hirata ◽

T. Seno

Keyword(s):

Heavy Metals ◽

Heavy Metal ◽

Electric Potential ◽

Potential Gradient ◽

Electrokinetic Remediation ◽

Contaminated Aquifer ◽

Physico Chemical ◽

Operational Variables ◽

Mass Transport Process

The operational variables of electrokinetic remediation have not been cleared yet, because this method is relatively new and is an innovative technique in the aquifer remediation. In order to investigate the operational variables of the electrokinetic remediation, a mathematical model has been constructed based on the physico chemical mass transport process of heavy metals in pore water of contaminated aquifer. The transport of the heavy metals is driven not only by the hydraulic flow due to the injection of the purge water but also by the electromigration due to the application of the electric potential gradient. The electric potential between anode and cathode is the important operational variable for the electrokinetic remediation. From the numerical simulations with use of this model it is confirmed that the remediation starts from the up stream anode and gradually the heavy metal is transported to the down stream cathode and drawn out through the purge water.

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Some indicators of water quality of the Tamis river

Chemical Industry and Chemical Engineering Quarterly ◽

10.2298/ciceq100712060b ◽

2011 ◽

Vol 17 (1) ◽

pp. 107-115 ◽

Cited By ~ 3

Author(s):

Nada Babovic ◽

Dejan Markovic ◽

Vojkan Dimitrijevic ◽

Dragan Markovic

Keyword(s):

Water Quality ◽

Ph Value ◽

Ammonium Nitrogen ◽

Field Analysis ◽

Total Hardness ◽

Chemical Parameters ◽

Physico Chemical

This paper shows the results obtained in field analysis performed at the Tamis River, starting from the settlement Jasa Tomic - border between Serbia and Romania to Pancevo - confluence of Tamis into the Danube. The Tamis is a 359 km long river rising in the southern Carpathian Mountains. It flows through the Banat region and flows into the Danube near Pancevo. During the years the water quality of the river has severely deteriorated and badly affected the environment and the river ecosystem. In situ measurements enabled determination of physico-chemical parameters of water quality of the Tamis River on every 400 m of the watercourse, such as: water temperature, pH value, electrical conductivity, contents of dissolved oxygen and oxygen saturation. The main reason of higher pollution of Tamis is seen in connection to DTD hydro system. Sampling was performed at 7 points with regard to color, turbidity, total hardness, alkalinity, concentration of ammonium nitrogen, nitrite nitrogen, nitrate nitrogen, iron, chlorides and sulphates in samples. The aim of the present work was to evaluate water quality in the Tamis River taking into account significant pollution, which originates from settlements, industry and agriculture, and to suggest appropriate preventive measures to further pollution decreasing of the river's water.

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Separation of phenols from oils using deep eutectic solvents and ionic liquids

Pure and Applied Chemistry ◽

10.1515/pac-2019-1119 ◽

2020 ◽

Vol 92 (10) ◽

pp. 1717-1731

Author(s):

Yucui Hou ◽

Zhi Feng ◽

Jaime Ruben Sossa Cuellar ◽

Weize Wu

Keyword(s):

Ionic Liquids ◽

Phenolic Compounds ◽

High Efficiency ◽

Deep Eutectic Solvents ◽

Environmentally Benign ◽

Organic Chemical ◽

Environmental Friendliness ◽

Oil Mixtures ◽

Organic Chemical Industry

AbstractPhenolic compounds are important basic materials for the organic chemical industry, such as pesticides, medicines and preservatives. Phenolic compounds can be obtained from biomass, coal and petroleum via pyrolysis and liquefaction, but they are mixtures in oil. The traditional methods to separate phenols from oil using alkaline washing are not environmentally benign. To solve the problems, deep eutectic solvents (DESs) and ionic liquids (ILs) have been developed to separate phenols from oil, which shows high efficiency and environmental friendliness. In this article, we summarized the properties of DESs and ILs and the applications of DESs and ILs in the separation of phenols and oil. There are two ways in which DESs and ILs are used in these applications: (1) DESs formed in situ using different hydrogen bonding acceptors including quaternary ammonium salts, zwitterions, imidazoles and amides; (2) DESs and ILs used as extractants. The effect of water on the separation, mass transfer dynamics in the separation process, removal of neutral oil entrained in DESs, phase diagrams of phenol + oil + extractant during extraction, are also discussed. In the last, we analyze general trends for the separation and evaluate the problematic or challenging aspects in the separation of phenols from oil mixtures.

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Soil physico-chemical characterization in the different soil layers of National Maize Research Program, Rampur, Chitwan, Nepal

Journal of Maize Research and Development ◽

10.3126/jmrd.v3i1.18918 ◽

2018 ◽

Vol 3 (1) ◽

pp. 28-44

Author(s):

Dinesh Khadka ◽

Sushil Lamichhane ◽

Amit P Timilsina ◽

Bandhu R Baral ◽

Kamal Sah ◽

...

Keyword(s):

Research Program ◽

Soil Structure ◽

Sandy Loam ◽

Chemical Properties ◽

Single Layer ◽

Chemical Characterization ◽

Bottom Layer ◽

Soil Parameters ◽

Physico Chemical

Soil pit digging and their precise study is a decision making tool to assess history and future of soil management of a particular area. Thus, the present study was carried out to differentiate soil physico-chemical properties in the different layers of excavated pit of the National Maize Research Program, Rampur, Chitwan, Nepal. Eight pits were dug randomly from three blocks at a depth of 0 to 100 cm. The soil parameters were determined in-situ, and in laboratory for texture, pH, OM, N, P (as P2O5), K (as K2O), Ca, Mg, S, B, Fe, Zn, Cu and Mn of collected soils samples of different layers following standard analytical methods at Soil Science Division, Khumaltar. The result revealed that soil structure was sub-angular in majority of the layers, whereas bottom layer was single grained. The value and chrome of colour was increasing in order from surface to bottom in the majority pits. Similarly, the texture was sandy loam in majority layers of the pits. Moreover, four types of consistence (loose to firm) were observed. Furthermore, mottles and gravels were absent in the majority layers. Likewise, soil was very to moderately acidic in observed layers of majority pits, except bottom layer of agronomy block was slightly acidic. Regarding fertility parameters (OM, macro and micronutrients), some were increasing and vice-versa, while others were intermittent also. Therefore, a single layer is not dominant for particular soil physico-chemical parameters in the farm. In overall, surface layer is more fertile than rest of the layers in all the pits.

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Estimation of the retention behaviour of s-triazine derivatives applying multiple regression analysis of selected molecular descriptors

Acta periodica technologica ◽

10.2298/apt1344229j ◽

2013 ◽

pp. 229-237 ◽

Cited By ~ 1

Author(s):

Lidija Jevric ◽

Sanja Podunavac-Kuzmanovic ◽

Strahinja Kovacevic ◽

Natasa Kalajdzija ◽

Bratislav Jovanovic

Keyword(s):

Dissociation Constant ◽

Water Solubility ◽

Molecular Descriptors ◽

Chemical Properties ◽

Log P ◽

Retention Factors ◽

Solute Retention ◽

Physico Chemical ◽

Hydrophilic Lipophilic Balance ◽

Triazine Derivatives

The estimation of retention factors by correlation equations with physico-chemical properties can be of great helpl in chromatographic studies. The retention factors were experimentally measured by RP-HPTLC on impregnated silica gel with paraffin oil using two-component solvent systems. The relationships between solute retention and modifier concentration were described by Snyder?s linear equation. A quantitative structure-retention relationship was developed for a series of s-triazine compounds by the multiple linear regression (MLR) analysis. The MLR procedure was used to model the relationships between the molecular descriptors and retention of s-triazine derivatives. The physicochemical molecular descriptors were calculated from the optimized structures. The physico-chemical properties were the lipophilicity (log P), connectivity indices (?), total energy (Et), water solubility (log W), dissociation constant (pKa), molar refractivity (MR), and Gibbs energy (GibbsE) of s-triazines. A high agreement between the experimental and predicted retention parameters was obtained when the dissociation constant and the hydrophilic-lipophilic balance were used as the molecular descriptors. The empirical equations may be successfully used for the prediction of the various chromatographic characteristics of substances, with a similar chemical structure.

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