scholarly journals Pulmonary Delivery of Curcumin and Beclomethasone Dipropionate in a Multicomponent Nanosuspension for the Treatment of Bronchial Asthma

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1300
Author(s):  
Luca Casula ◽  
Francesco Lai ◽  
Elena Pini ◽  
Donatella Valenti ◽  
Chiara Sinico ◽  
...  
Keyword(s):  
Size Distribution ◽  
Beclomethasone Dipropionate ◽  
Water Solubility ◽  
Pulmonary Delivery ◽  
Long Term Stability ◽  
Inhalation Delivery ◽  
Inflammatory Mechanism ◽  
Three Samples ◽  
Aerodynamic Parameters ◽  
Next Generation Impactor

Curcumin has shown a potential extraordinary activity as an add-on ingredient in asthma treatment, due to its immunomodulatory and anti-inflammatory mechanism of action. However, its low water solubility and bioavailability lead to a poor therapeutic effect, which can be overcome by its formulation as nanocrystals. The aim of this study was to prepare a multicomponent formulation for the delivery of curcumin (CUR) and beclomethasone dipropionate (BDP) into the lungs as water-based nanosuspensions (NS). Single component formulations (CUR-NS, BDP-NS) and a multicomponent formulation (CUR+BDP-NS) were prepared through a wet ball media milling technique, using P188 as a non-toxic stabilizer. Characterization was carried out in terms of size, size distribution, zeta potential, nanocrystals morphology, and solid-state properties. Moreover, the inhalation delivery efficiency was studied with Next Generation Impactor (NGI, Apparatus E Ph. Eu). CUR-NS was optimized and showed a long-term stability and improved nanocrystals apparent solubility. The three formulations exhibited a nanocrystal mean diameter in the range of 200–240 nm and a homogenous particle size distribution. Aggregation or sedimentation phenomena were not observed in the multicomponent formulation on 90 days storage at room temperature. Finally, the nebulization tests of the three samples showed optimal aerodynamic parameters and MMAD < 5 µm.

Investigating the influence of aromatic moieties on the formulation of hydrophobic natural products and drugs in poly(2-oxazoline) based amphiphiles

2018 ◽  
Author(s):  
Robert Luxenhofer ◽  
Michael M Lübtow ◽  
Lukas Hahn ◽  
Thomas Lorson ◽  
Rainer Schobert
Keyword(s):  
Natural Products ◽  
Small Molecules ◽  
Water Solubility ◽  
Drug Loading ◽  
High Drug ◽  
Long Term Stability ◽  
Aromatic Content ◽  
Important Interaction ◽  
Amorphous Structures ◽  
High Drug Loading

Many natural compounds with interesting biomedical properties share one physicochemical property, namely a low water solubility. Polymer micelles are, among others, a popular means to solubilize hydrophobic compounds. The specific molecular interactions between the polymers and the hydrophobic drugs are diverse and recently it has been discussed that macromolecular engineering can be used to optimize drug loaded micelles. Specifically, π-π stacking between small molecules and polymers has been discussed as an important interaction that can be employed to increase drug loading and formulation stability. Here, we test this hypothesis using four different polymer amphiphiles with varying aromatic content and various natural products that also contain different relative amounts of aromatic moieties. While in the case of paclitaxel, having the lowest relative content of aromatic moieties, the drug loading decreases with increasing relative aromatic amount in the polymer, the drug loading of curcumin, having a much higher relative aromatic content, is increased. Interestingly, the loading using schizandrin A, a dibenzo[a,c]cyclooctadiene lignan with intermediate relative aromatic content is not influenced significantly by the aromatic content of the polymers employed. The very high drug loading, long term stability, the ability to form stable highly loaded binary coformulations in different drug combinations, small sized formulations and amorphous structures in all cases, corroborate earlier reports that poly(2-oxazoline) based micelles exhibit an extraordinarily high drug loading and are promising candidates for further biomedical applications. The presented results underline that the interaction between the polymers and the incorporated small molecules are complex and must be investigated in every specific case.<br>

Bentonite granulates as a seals for mobile flood barriers

2021 ◽  
Vol 11 (4) ◽  
pp. 16-23
Author(s):  
Piotr Wrona ◽  
Wojciech Panna ◽  
Stanisław Lipiński ◽  
Maciej Woźniak
Keyword(s):  
Comparative Analysis ◽  
Size Distribution ◽  
Raw Materials ◽  
Test Stand ◽  
Three Samples

Bentonites and other smectite raw materials are widely used in many industries. The authors of the study analyzed the suitability of swelling granulates for their use as a seals in mobile flood barriers. For this purpose, a comparative analysis of the swelling and granulation parameters of three samples available on the market was performed. This results was compared with a macroscopic swelling test, which was realized on the specially prepared test stand. The carried out research shows that not only the content of the swelling minerals – mainly smectite – affect on the sealing of the system, but also they are determine by granules size distribution and the type of smectite.

scholarly journals Synthesis and Characterization of Stearic Acid-Beclomethasone Dipropionate Conjugates with the Potential for Improving Loading Capacity in Lipid-based Nanoparticles

2021 ◽  
Author(s):  
Shishuai Dang ◽  
Zhengwei Huang ◽  
Ying Huang ◽  
Xin Pan ◽  
Chuanbin Wu
Keyword(s):  
Drug Delivery ◽  
Stearic Acid ◽  
Beclomethasone Dipropionate ◽  
Drug Loading ◽  
Pulmonary Delivery ◽  
Dynamics Simulation ◽  
Loading Capacity ◽  
Technology Platform ◽  
New Type ◽  
Model Drug

<p>Lipid-based nanoparticles (LBNs) are a new type of nanoparticulate drug delivery system, which have been gradually shown broad prospects in pulmonary drug delivery systems. However, the main disadvantage of these LBNs for inhalable drugs with limited lipophilicity is the low encapsulation capacity. Herein, this study anticipates establishing a technology platform to improve the loading capacity of low lipophilicity drugs in LBNs, for the therapy of lung diseases. A proof-of-concept was carried out using Beclomethasone dipropionate (BDP) as a model drug. BDP was conjugated with stearic acid (SA), a kind of the lipid matrix for LBN. The conjugate was characterized and the interactions between the conjugate and SA were investigated by molecular dynamics simulation. It is expected that the drug loading capacity of weak-lipophilic drugs in LBN can be increased by establishing the technology platform, and the application of LBNs in pulmonary delivery can be broadened.</p>

Incorporation of Beclomethasone Dipropionate into Polyethylene Glycol-Diacyl Lipid Micelles as a Pulmonary Delivery System

2012 ◽  
Vol 73 (2) ◽  
pp. 90-105 ◽  
Author(s):  
Mohanad Naji Sahib ◽  
Yusrida Darwis ◽  
Kok Khiang Peh ◽  
Shaymaa Abdalwahed Abdulameer ◽  
Yvonne Tze Fung Tan
Keyword(s):  
Polyethylene Glycol ◽  
Delivery System ◽  
Beclomethasone Dipropionate ◽  
Pulmonary Delivery ◽  
Lipid Micelles

scholarly journals Synthesis and Characterization of Stearic Acid-Beclomethasone Dipropionate Conjugates with the Potential for Improving Loading Capacity in Lipid-based Nanoparticles

2021 ◽  
Author(s):  
Shishuai Dang ◽  
Zhengwei Huang ◽  
Ying Huang ◽  
Xin Pan ◽  
Chuanbin Wu
Keyword(s):  
Drug Delivery ◽  
Stearic Acid ◽  
Beclomethasone Dipropionate ◽  
Drug Loading ◽  
Pulmonary Delivery ◽  
Dynamics Simulation ◽  
Loading Capacity ◽  
Technology Platform ◽  
New Type ◽  
Model Drug

<p>Lipid-based nanoparticles (LBNs) are a new type of nanoparticulate drug delivery system, which have been gradually shown broad prospects in pulmonary drug delivery systems. However, the main disadvantage of these LBNs for inhalable drugs with limited lipophilicity is the low encapsulation capacity. Herein, this study anticipates establishing a technology platform to improve the loading capacity of low lipophilicity drugs in LBNs, for the therapy of lung diseases. A proof-of-concept was carried out using Beclomethasone dipropionate (BDP) as a model drug. BDP was conjugated with stearic acid (SA), a kind of the lipid matrix for LBN. The conjugate was characterized and the interactions between the conjugate and SA were investigated by molecular dynamics simulation. It is expected that the drug loading capacity of weak-lipophilic drugs in LBN can be increased by establishing the technology platform, and the application of LBNs in pulmonary delivery can be broadened.</p>

scholarly journals Physicochemical Properties and Resistant Starch Content of Corn Tortilla Flours Refrigerated at Different Storage Times

Foods ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 469
Author(s):  
Isela Rojas-Molina ◽  
Monsserrat Mendoza-Avila ◽  
María de los Ángeles Cornejo-Villegas ◽  
Alicia Del Real-López ◽  
Eric Rivera-Muñoz ◽  
...  
Keyword(s):  
Particle Size ◽  
Particle Size Distribution ◽  
Physicochemical Properties ◽  
Size Distribution ◽  
Resistant Starch ◽  
Water Solubility ◽  
Corn Starch ◽  
Starch Content ◽  
Type I ◽  
Corn Tortilla

The tortilla is a foodstuff that has a short shelf-life, causing great losses to the industry. The objective of this work was to evaluate, for the first time, the physicochemical properties and resistant starch (RS) content of flours. These were obtained from nixtamalized corn tortillas made with traditional and industrial (commercial) methods, stored at 4 °C for 7, 15, and 30 days. The flours were characterized by measuring particle size distribution, color, water absorption index (WAI), water solubility index (WSI), viscosity, calcium, and RS content. Additionally, chemical proximate analysis, scanning electron microscopy (SEM), and thermal analysis were conducted. Storage at 4 °C increased the friability of tortillas and shifted the particle size distribution toward a greater content of coarse particles in corn tortilla flours. The commercial corn tortilla flours showed higher WAI and WSI values than the traditional corn tortilla flours. On the other hand, the traditional corn tortilla flours exhibited higher RS content values than commercial corn tortilla flours as well as peak viscosity. X-ray diffractograms revealed the presence of amylose-lipid complexes (RS5) in experimental samples. The thermograms evidenced three endotherms corresponding to corn starch gelatinization and melting of type I and type II amylose–lipid complexes.

THE FREEZING POINTS OF HIGH PURITY METALS AS PRECISION TEMPERATURE STANDARDS: II. AN INVESTIGATION OF THE FREEZING TEMPERATURES OF ZINC, CADMIUM, AND TIN

1957 ◽  
Vol 35 (9) ◽  
pp. 1086-1106 ◽  
Author(s):  
E. H. McLaren
Keyword(s):  
High Purity ◽  
Freezing Temperature ◽  
Pressure Effects ◽  
Platinum Resistance ◽  
Long Term Stability ◽  
Melting Temperatures ◽  
Three Samples ◽  
Zinc Cadmium ◽  
Precision Temperature ◽  
Freezing Temperatures

An investigation of freezing and melting temperatures with platinum resistance thermometry on high purity zinc, cadmium, and tin has been carried out. Using appropriate techniques, plateaus of essentially constant (< ±0.0001 °C.) temperature with durations of over 1 hour are readily obtained on the cooling curves of these metals. For series of freezes on particular samples, the standard deviations of the respective plateau temperatures were found to be of the order of ±0.0002 °C. It was not possible to distinguish among the plateau temperatures of three samples selected from different distillation batches of New Jersey S.P. zinc. Evidence is presented on the long term stability ([Formula: see text] years) of the plateau freezing temperature of S.P. zinc determined with six standard thermometers. The pressure effects on the freezing temperatures were found to be 0.0043 °C, 0.0062 °C, and 0.0033 °C. per atmosphere for zinc, cadmium, and tin respectively.Thermal analysis of these high purity metals reveals alloy structures and other features associated with nucleation, coring, and annealing phenomena; typical thermal curves are shown.

scholarly journals Particles Released by Abused Prismatic Ni-rich Automotive Lithium-ion Batteries

2020 ◽  
Vol 15 ◽  
Keyword(s):  
Heavy Metal ◽  
Particulate Matter ◽  
Lithium Ion Batteries ◽  
Size Distribution ◽  
Cell Mass ◽  
Lithium Ion ◽  
Element Content ◽  
Minimum Size ◽  
Three Samples ◽  
Nickel Copper

The particulate matter released by lithium-ion batteries during eruption and combustion caused by thermal runaway may contain heavy metal pollution elements. The aim of this study is to reveal four heavy metal element content and size distribution of particulate matter released by abused prismatic Ni-rich automotive lithium-ion batteries. A fully charged commercial 50 Ah Li(Ni0.6Mn0.2Co0.2)O2 cell was triggered by heating in a sealed chamber at nitrogen environment. The particulate matter with size being below 500 μm were divided into three samples using sieves. Four soil pollution elements, including nickel, copper, zinc, chromium, were detected, and sizes were analyzed. The results show that all these four elements are found, and nickel and copper are found in all samples. Among the four elements, Ni had the largest mass percentage, followed by Cu, Zn and Cr. These particulate matter account for 1.7% of the cell mass, with the minimum size and median size being approximately 1.45 μm and 162.9 um. The element content reveals the pollution from LIBs and the size distribution provides a basis for the design of the particle filter pore.

Sign in / Sign up

Export Citation Format

Share Document