scholarly journals Multifunctional Nanofibrous Dressing with Antimicrobial and Anti-Inflammatory Properties Prepared by Needle-Free Electrospinning

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1527
Author(s):  
Laura Victoria Schulte-Werning ◽  
Anjanah Murugaiah ◽  
Bhupender Singh ◽  
Mona Johannessen ◽  
Rolf Einar Engstad ◽  
...  
Keyword(s):  
Local Treatment ◽  
Antimicrobial Effect ◽  
Absorption Capacity ◽  
Wound Dressings ◽  
Infection Rates ◽  
Active Ingredients ◽  
Beta Glucan ◽  
Anti Inflammatory ◽  
High Absorption ◽  
Successful Production

An active wound dressing should address the main goals in wound treatment, which are improved wound healing and reduced infection rates. We developed novel multifunctional nanofibrous wound dressings with three active ingredients: chloramphenicol (CAM), beta-glucan (βG) and chitosan (CHI), of which βG and CHI are active nanofiber-forming biopolymers isolated from the cell walls of Saccharomyces cerevisiae and from shrimp shells, respectively. To evaluate the effect of each active ingredient on the nanofibers' morphological features and bioactivity, nanofibers with both βG and CHI, only βG, only CHI and only copolymers, polyethylene oxide (PEO) and hydroxypropylmethylcellulose (HPMC) were fabricated. All four nanofiber formulations were also prepared with 1% CAM. The needle-free NanospiderTM technique allowed for the successful production of defect-free nanofibers containing all three active ingredients. The CAM-containing nanofibers had a burst CAM-release and a high absorption capacity. Nanofibers with all active ingredients (βG, CHI and CAM) showed a concentration-dependent anti-inflammatory activity, while maintaining the antimicrobial activity of CAM. The promising anti-inflammatory properties, together with the high absorption capacity and antimicrobial effect, make these multifunctional nanofibers promising as dressings in local treatment of infected and exuding wounds, such as burn wounds.

Novel tissue engineering scaffolds as wound dressings loaded with Alkannins/Shikonins as active ingredients

2019 ◽  
Author(s):  
AS Arampatzis ◽  
K Theodoridis ◽  
E Aggelidou ◽  
KN Kontogiannopoulos ◽  
I Tsivintzelis ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Wound Dressings ◽  
Active Ingredients ◽  
Tissue Engineering Scaffolds

Antiproliferative Effects of Pterodon pubescens Extract and Isolated Diterpenes in HaCaT Cells

Planta Medica ◽  
2020 ◽  
Author(s):  
Rosanna Tarkany Basting ◽  
Ilza Maria de Oliveira Sousa ◽  
Veronika Butterweck ◽  
Mary Ann Foglio
Keyword(s):  
Cell Migration ◽  
Methyl Ester ◽  
Local Treatment ◽  
Time Lapse ◽  
Molecular Structures ◽  
Brdu Incorporation ◽  
Hacat Cells ◽  
Antiproliferative Effects ◽  
Anti Inflammatory ◽  
Incorporation Assay

Abstract Pterodon pubescens fruits are popularly used because of their analgesic and anti-inflammatory actions, which are attributed to the isolated compounds with a vouacapan skeleton. This work aimed to evaluate the antiproliferative and anti-inflammatory effects of a P. pubescens fruit dichloromethane extract and the vouacapan diterpene furan isomerʼs mixture (1 : 1) (6α-hydroxy-7β-acetoxy-vouacapan-17β-oate methyl ester and 6α-acetoxy-7β-hydroxy-vouacapan-17β-oate methyl ester isomers) in HaCaT cells using the cell migration and the BrDU incorporation assay. Levels of IL-8 were measured by ELISA after TNF-α stimulation. HPLC/DAD analysis of the extract revealed the expressive presence of vouacapan diterpene furan isomerʼs mixture. P. pubescens extract (1.5625 – 25 µg/mL) and vouacapan diterpene furan isomerʼs mixture (3.125 – 50 µM) inhibited cell proliferation as indicated by a decreased BrdU-incorporation. For the evaluation of cell migration, time-lapse microscopy was used. P. pubescens presented inhibition on cell migration at all concentrations tested (3.125 – 12.5 µg/mL), whereas for the VDFI mixture, the inhibition was only observed at the highest concentrations (12.5 and 25 µM) tested. Furthermore P. pubescens extract and vouacapan diterpene furan isomerʼs mixture significantly decreased IL-8 levels. Our results showed antiproliferative and anti-inflammatory effects on HaCaT cells treated with the extract and the vouacapan isomerʼs mixture, without affecting cell viability. These activities could be attributed to the voucapan molecular structures. In conclusion, topical products developed of P. pubescens extract or the voucapan isomerʼs mixture should be further studied as a potential product for local treatment against hyperproliferative lesions as in psoriasis vulgaris, representing an alternative treatment approach.

Oxy+ (arthrospira) and its medicinal importance: an appraisal

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Md Anzar Alam ◽  
Mohd Aleemuddin Quamri ◽  
Muzafar Din Ahmad Bhat ◽  
Siddiqui Aafreen ◽  
Ghulamuddin Sofi
Keyword(s):  
Linoleic Acid ◽  
Dietary Supplement ◽  
Autoimmune Disorders ◽  
Natural Source ◽  
Sulfated Polysaccharides ◽  
Active Ingredients ◽  
Pharmacological Activities ◽  
Anti Inflammatory ◽  
Obesity Hypertension

AbstractOxy+ is a natural source of arthrospira found in nature, used as a dietary supplement and manufactured in Aruba for lifefactors. Arthrospira contains good quality of proteins, sulfated polysaccharides, γ-linoleic acid, along with an array of carotene and phytopigments, vitamins, and minerals which are reported to be antioxidant, immunomodulator, antihyperglycemic, antidyslipidemic, cardioprotective, hepatoprotective, antiviral, anticancerous, antihypertensive, anti-inflammatory, analgesic, neuroprotective and renoprotective activities. Several studies have shown arthrospira, and active ingredients of it revealed various pharmacological activities. It can be used for the management of various ailments such as diabetes, dyslipidemia, obesity, hypertension, cancer, arthritis, osteoarthritis, autoimmune disorders, etc. This review attempts to explore the hidden benefits of Oxy+ (arthrospira).

Understanding the unique interaction of amine-containing ionic compounds with SO2 for high absorption capacity

RSC Advances ◽  
2013 ◽  
Vol 3 (48) ◽  
pp. 25944 ◽  
Author(s):  
Hyunjoo Lee ◽  
Young Mee Jung ◽  
Keun Im Lee ◽  
Hoon Sik Kim ◽  
Ho Seok Park
Keyword(s):  
Absorption Capacity ◽  
Ionic Compounds ◽  
High Absorption

scholarly journals Capture of Acidic Gases from Flue Gas by Deep Eutectic Solvents

Processes ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 1268
Author(s):  
Yan Wang ◽  
Shuhang Ren ◽  
Yucui Hou ◽  
Weize Wu
Keyword(s):  
Hydrogen Bond ◽  
Flue Gas ◽  
Deep Eutectic Solvents ◽  
Absorption Capacity ◽  
Physical Interaction ◽  
Co2 Absorption ◽  
Physicochemical Interaction ◽  
Acidic Gases ◽  
New Strategies ◽  
High Absorption

Up to now, many kinds of deep eutectic solvents (DESs) were investigated for the capture of acidic gases from flue gases. In this review, non-functionalized and functionalized DESs, including binary and ternary DESs, for SO2, CO2 and NO capture, are summarized based on the mechanism of absorption, physical interaction or chemical reaction. New strategies for improving the absorption capacity are introduced in this review. For example, a third component can be introduced to form a ternary DES to suppress the increase in viscosity and improve the CO2 absorption capacity. DESs, synthesized with halogen salt hydrogen bond acceptors (HBAs) and functionalized hydrogen bond donors (HBDs), can be used for the absorption of SO2 and NO with high absorption capacities and low viscosities after absorption, due to physicochemical interaction between gases and DESs. Emphasis is given to introducing the absorption capacities of acidic gases in these DESs, the mechanism of the absorption, and the ways to enhance the absorption capacity.

Enhanced scavenging of a minor component from mixtures of two immiscible liquids by hollow polymer microgels

2022 ◽  
Author(s):  
Mikhail V. Anakhov ◽  
Rustam A. Gumerov ◽  
Igor Potemkin
Keyword(s):  
Minor Component ◽  
Absorption Capacity ◽  
Immiscible Liquids ◽  
A Minor ◽  
Soft Nanoparticles ◽  
High Absorption

Hollow soft nanoparticles are known to be highly perspective containers with high absorption capacity of various substances. In particular, this feature can be applied in terms of solvents separation on...

Collagen Wound Dressings with Anti-Inflammatory Activity

2012 ◽  
Vol 555 (1) ◽  
pp. 271-279 ◽  
Author(s):  
M. G. Albu ◽  
M. Ferdes ◽  
D. A. Kaya ◽  
M. V. Ghica ◽  
I. Titorencu ◽  
...  
Keyword(s):  
Wound Dressings ◽  
Inflammatory Activity ◽  
Anti Inflammatory

scholarly journals Possibilities of using allogeneic mesenchymal stem cells and wound dressings based on aliphatic copolyamide in microautodermoplasty

2020 ◽  
Vol 8 (2) ◽  
pp. 185-196
Author(s):  
Vasily A. Gordienko ◽  
Evgenii V. Zinoviev ◽  
Denis V. Kostyakov ◽  
Marat S. Asadulaev ◽  
Anton S. Shabunin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Clinical Medicine ◽  
Medical Science ◽  
Local Treatment ◽  
Treatment Algorithm ◽  
Wound Dressings ◽  
Results Of Treatment ◽  
Healing Index ◽  
Treatment Of Wounds

Background. The treatment of victims with wound defects is an urgent problem of clinical medicine that doctors of various specialties, mainly surgeons and traumatologists, must face. Regardless of the etiology of the traumatic agent, the wound process is always subjected to fundamental pathophysiological processes. Despite the advances made by medical science in the local treatment of wounds (cell technology, modern wound coverings, and others), surgical procedures remain the main methods, and the search for new techniques to optimize reparative regeneration continues. This ongoing search indicates the absence of a universal algorithm for treating such defects. This lack of a universal treatment algorithm is of particular importance for assisting victims with extensive defects, which often leads to a shortage of donor resources. Aim. The aim of this study was to increase the efficiency of microautodermoplasty due to the use of allogeneic mesenchymal stem cells and wound dressings based on aliphatic copolyamide. Materials and methods. This paper presents the results of an experimental study involving 50 rats. All animals were divided into groups considering the choice of the method of the local treatment. The experimental wound was modeled according to its original technique. The evaluation of the effectiveness of the analyzed methods was performed using planimetric and histological research methods, and by calculating the healing index. Results. The most effective methods for treating experimental wounds using microautodermoplasty (MADP) are wound dressings based on aliphatic copolyamide (CoPA) and adipogenic mesenchymal stem cells (AMSC). By 28 days of treatment after performing MADP + CoPA wound dressings + AMSC, it was possible to reduce the defect area by 16 times compared with the control, and the healing index was the maximum value among all methods 12.5 units. The high regenerative potential was also confirmed by the results of the histological examination. The worst results were found in the MADP group with AMSK that did not cover the wounds with skin or wound dressing. Conclusion. The introduction of the analyzed methods into clinical practice will improve the results of treatment of patients with wound defects of various etiologies.

Xenon analgesia in children with extensive wounds

2021 ◽  
pp. 52-57
Author(s):  
V. G. Bagaev ◽  
N. G. Rauschenbach ◽  
V. A. Mitish ◽  
P. V. Medinsky ◽  
V. G. Amcheslavsky ◽  
...  
Keyword(s):  
Rating Scale ◽  
Numerical Rating Scale ◽  
Local Treatment ◽  
Mean Value ◽  
Wound Dressings ◽  
Severe Injuries ◽  
Relieve Pain ◽  
Xenon Concentration ◽  
Numerical Rating ◽  
Ramsay Scale

Purpose. To assess the effectiveness of sub-narcotic concentrations of xenon in the local treatment of extensive wounds in children with severe injuries.Material and methods. 14 patients (average age 9.3 ± 4.0 years) with extensive wounds were taken into the trial. 67 dressings in them were done with 30 % xenon and oxygen. Pain intensity was assessed by the numerical rating scale of pain (NRSp) (1–10 points); sedation depth – by Ramsay scale (1–6 points) and BIS index.Results. Inhalations of 30 % xenon with oxygen during wound dressings reduced the intensity of pain from Me 3.67 (1.2; 6.0) to Me 2.0 (1.0; 3.3) points by NRSp scale (p < 0.05); after sedanalgesia, it increased again to Me 3.0 (1.0; 5.3). Analgesia with 30 % xenon was effective in 55 (82.0 %) dressings; in 8 (11.9 %) patients with trauma, xenon concentration was increased to 50 %, and in 4 (5.9 %) cases 50 % xenon was added with Fentanyl 1–2 mcg/kg. The depth of sedation assessed by the Ramsay scale decreased (p < 0.05) from 6.0 (5.6; 6.0) to 3.1 (2.2; 4.5) points; after sedanalgesia it increased to Me 5.0 (4.5; 5.4) points. At the same time, the mean value of BIS index decreased (p < 0.05) from 97.5 ± 1.5 to 86.5 ± 5.0 U; after dressing, it rapidly increased to 93.0 ± 2.1 U. During dressings, 82 % of children were calm, had contact with a doctor. Afterwards, their sleep was restored, their mood improved.Conclusion. Sedanalgesia with xenon in sub-narcotic concentrations is an effective technique to relieve pain during treatment of extensive wounds in children.

Management of skin disease

2010 ◽  
pp. 4731-4740
Author(s):  
Rod Sinclair
Keyword(s):  
Salicylic Acid ◽  
Benzoyl Peroxide ◽  
Active Ingredient ◽  
Plaque Psoriasis ◽  
Skin Disease ◽  
Topical Therapy ◽  
Local Treatment ◽  
Skin Disorders ◽  
Topical Treatments ◽  
Anti Inflammatory

Topical therapy employs a vehicle (ointments, creams, lotions, gels) to deliver an active ingredient to the skin, to provide a protective barrier, or to hydrate and moisturize the skin. There are many types of topical treatments, including (1) antipruritics, e.g. calamine, are used to relieve itching; (2) keratolytics, e.g. salicylic acid, urea, are used to remove hyperkeratotic skin; (3) tars act by reducing the thickness of the epidermis; (4) corticosteroids have anti-inflammatory and immunosuppressive effects that are useful in treating many skin disorders; (5) calcipotriol (an analogue of 1,25-dihydroxycholecalciferol) reduces epidermal proliferation and is used in local treatment of plaque psoriasis; (6) retinoids influence immune function and have some anti-inflammatory activity and are used in acne; (7) antiseptics, e.g. benzoyl peroxide, chlorhexidine; (8) antifungal agents; (9) sunscreens; (10) anaesthetics/analgesics....

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