scholarly journals Innovative Delivery Systems Loaded with Plant Bioactive Ingredients: Formulation Approaches and Applications

Plants ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1238
Author(s):  
Anastasia Kyriakoudi ◽  
Eleni Spanidi ◽  
Ioannis Mourtzinos ◽  
Konstantinos Gardikis
Keyword(s):  
Biological Activity ◽  
Bioactive Compounds ◽  
Broad Spectrum ◽  
Delivery Systems ◽  
Future Trends ◽  
Gastrointestinal Digestion ◽  
Pharmaceutical Applications ◽  
Wide Range ◽  
Bioactive Ingredients ◽  
The Stability

Plants constitute a rich source of diverse classes of valuable phytochemicals (e.g., phenolic acids, flavonoids, carotenoids, alkaloids) with proven biological activity (e.g., antioxidant, anti-inflammatory, antimicrobial, etc.). However, factors such as low stability, poor solubility and bioavailability limit their food, cosmetics and pharmaceutical applications. In this regard, a wide range of delivery systems have been developed to increase the stability of plant-derived bioactive compounds upon processing, storage or under gastrointestinal digestion conditions, to enhance their solubility, to mask undesirable flavors as well as to efficiently deliver them to the target tissues where they can exert their biological activity and promote human health. In the present review, the latest advances regarding the design of innovative delivery systems for pure plant bioactive compounds, extracts or essential oils, in order to overcome the above-mentioned challenges, are presented. Moreover, a broad spectrum of applications along with future trends are critically discussed.

scholarly journals The Influence of In Vitro Gastrointestinal Digestion on the Chemical Composition and Antioxidant and Enzyme Inhibitory Capacities of Carob Liqueurs Obtained with Different Elaboration Techniques

Antioxidants ◽  
2019 ◽  
Vol 8 (11) ◽  
pp. 563 ◽  
Author(s):  
Raquel Rodríguez-Solana ◽  
Natacha Coelho ◽  
Antonio Santos-Rufo ◽  
Sandra Gonçalves ◽  
Efrén Pérez-Santín ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Alcoholic Beverage ◽  
Total Phenolic ◽  
Gastrointestinal Digestion ◽  
Antidiabetic Therapy ◽  
Wide Range ◽  
Production Techniques ◽  
Inhibitory Potential ◽  
The Stability

Carob liqueur is a traditional Mediterranean alcoholic beverage obtained via a wide range of production techniques contributing to the different organoleptic attributes of the final product. The aim of this research was to evaluate the stability of the chemical composition and biological capacities (antioxidant and enzyme inhibition) under in vitro simulated gastrointestinal digestion of liqueurs prepared by flavouring the fig spirit with carob pulp by maceration, distillation, percolation, or aqueous and hydro-alcoholic infusions. For this purpose, the phenolic and furanic compositions, the total phenolic (TPC) and flavonoid (TFC) contents, antioxidant capacity (AC), and enzyme inhibitory potential against acethylcholinesterase, tyrosinase, α-glucosidase and α-amylase enzymes were evaluated. The content of gallic acid decreased after gastrointestinal digestion, while TPC, TFC, and AC significantly increased after each digestion phase. Overall, no significantly different enzyme inhibitions (p < 0.05) were observed among digested liqueurs, with moderate inhibition against acethylcholinesterase and tyrosinase (enzymes related with neurodegenerative diseases), and potent and low inhibitory capacities for α-glucosidase and α-amylase, respectively (ideal conditions employed in antidiabetic therapy). The study indicates that hydro-alcoholic infusion and maceration were the most appropriate methods to obtain liqueurs with higher values of the aforementioned parameters and safe levels of toxic furanics.

scholarly journals Impact of high-pressure processing on the stability and bioaccessibility of bioactive compounds in Clementine mandarin juice and its cytoprotective effect on Caco-2 cells

2020 ◽  
Vol 11 (10) ◽  
pp. 8951-8962
Author(s):  
Antonio Cilla ◽  
María J. Rodrigo ◽  
Begoña De Ancos ◽  
Concepción Sánchez-Moreno ◽  
M. Pilar Cano ◽  
...  
Keyword(s):  
High Pressure ◽  
Bioactive Compounds ◽  
High Pressure Processing ◽  
Cytoprotective Effect ◽  
Gastrointestinal Digestion ◽  
Cytoprotective Activity ◽  
The Stability ◽  
Mandarin Juices ◽  
Mandarin Juice

HPP can be recommended as a suitable technology to retain or indeed increase antioxidant bioactives and their cytoprotective activity in Clementine mandarin juices after gastrointestinal digestion.

scholarly journals Algae Bioactive Constituents and Possible Role During COVID-19 Pandemic (A review)

2021 ◽  
Vol 30 (2) ◽  
pp. 16-22
Author(s):  
Sayed Rashad ◽  
Ghadir El-Chaghaby
Keyword(s):  
Bioactive Compounds ◽  
Biological Activities ◽  
Biologically Active ◽  
Bioactive Constituents ◽  
Algae Biomass ◽  
Synthetic Drugs ◽  
Pharmaceutical Applications ◽  
Active Chemical ◽  
Wide Range ◽  
Algal Products

Nowadays, the use of natural bio-products in pharmaceuticals is gaining popularity as safe alternatives to chemicals and synthetic drugs. Algal products are offering a pure, healthy and sustainable choice for pharmaceutical applications. Algae are photosynthetic microorganisms that can survive in different environmental conditions. Algae have many outstanding properties that make them excellent candidate for use in therapeutics. Algae grow in fresh and marine waters and produce in their cells a wide range of biologically active chemical compounds. These bioactive compounds are offering a great source of highly economic bio-products. The present review discusses the phytochemical and bioactive compounds present in algae biomass and their potent biological activities. The review focuses on the use of alga in therapy and their pharmaceutical applications with special reference to the possible preventive and therapeutic role of algae against COVID-19.

scholarly journals A Comprehensive Review of Cancer MicroRNA Therapeutic Delivery Strategies

Cancers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1852 ◽  
Author(s):  
Alexis Forterre ◽  
Hiroaki Komuro ◽  
Shakhlo Aminova ◽  
Masako Harada
Keyword(s):  
Extracellular Vesicle ◽  
Delivery Systems ◽  
Chemical Structures ◽  
Therapeutic Delivery ◽  
Molecular Oncology ◽  
Physiological Processes ◽  
Cancer Pathogenesis ◽  
Wide Range ◽  
Cancer Types ◽  
The Stability

In the field of molecular oncology, microRNAs (miRNAs) and their role in regulating physiological processes and cancer pathogenesis have been a revolutionary discovery over the last decade. It is now considered that miRNA dysregulation influences critical molecular pathways involved in tumor progression, invasion, angiogenesis and metastasis in a wide range of cancer types. Hence, altering miRNA levels in cancer cells has promising potential as a therapeutic intervention, which is discussed in many other articles in this Special Issue. Some of the most significant hurdles in therapeutic miRNA usage are the stability and the delivery system. In this review, we cover a comprehensive update on the challenges and strategies for the development of therapeutic miRNA delivery systems that includes virus-based delivery, non-viral delivery (artificial lipid-based vesicles, polymer-based or chemical structures), and recently emerged extracellular vesicle (EV)-based delivery systems.

scholarly journals Engineering Size and Structure of Particles in Novel Modified-Release Delivery Systems

2019 ◽  
Vol 22 ◽  
pp. 150-170
Author(s):  
QianQian Dong ◽  
Xiao Zheng ◽  
MiaoMiao Zhou ◽  
Fei Wu ◽  
YanLong Hong ◽  
...  
Keyword(s):  
Delivery Systems ◽  
Taste Masking ◽  
Core Shell ◽  
Coating Film ◽  
Particle Engineering ◽  
Modified Release ◽  
Functional Coating ◽  
Wide Range ◽  
Development And Utilization ◽  
The Stability

Particle engineering has become a hot topic in the field of modified-release delivery systems during last decades. It has a wide range of pharmaceutical applications and is a bridge linking between drugs and drug delivery systems. Particles are an important part of many dosage forms and viewed as a carrier of drugs. Their size, shape, crystalline form, and structure directly affect the stability and releasing pattern of drugs. Engineering size or modifying particles by forming porous, core-shell, or skeleton structures can realize the development and utilization of functionally modified release systems (including fast-release systems, sustained-release systems, and targeted-release systems). However, there are certain problems in the practical application, such as bitter taste and coating damage. Combining with some polymer or lipid materials to form core-shell or embedded structures is considered as the key to taste masking. And, using cushioning agents is proven to be effective in preserving the integrity of the functional coating film of multiparticulates during tableting. To sum up, this review, from a particle engineering point, expounds the influence of different factors on the functionality of particles and offers some useful comments and suggestions for industry personnel.

Lipids as Delivery Systems to Improve the Biological Activity of Bioactive Ingredients

2011 ◽  
Vol 7 (3) ◽  
pp. 160-169 ◽  
Author(s):  
Carlos F. Torres ◽  
Diana Martin ◽  
Guzman Torrelo ◽  
Victor Casado ◽  
Oscar Fernandez ◽  
...  
Keyword(s):  
Biological Activity ◽  
Delivery Systems ◽  
Bioactive Ingredients

scholarly journals Formulasi dan uji stabilitas sediaan lulur dari rimpang kunyit (Curcuma longa linn)

2019 ◽  
Vol 10 (2) ◽  
pp. 52-58
Author(s):  
Rani Prabandari
Keyword(s):  
Biological Activity ◽  
Vitamin C ◽  
Essential Oils ◽  
Traditional Medicine ◽  
Broad Spectrum ◽  
Curcuma Longa ◽  
The Body ◽  
Yellow Substance ◽  
The Stability

ABSTRACT Lulur is a type of cosmetics made from flowers and other plant ingredients that are very useful for maintaining beauty, health, smoothness and brightness of the skin of the body. Lulur can help clean the dirt that sticks to the skin due to the influence of weather and pollution factors so that the skin becomes healthy, clean and beautiful. The contents of the substance include turmeric: curcuminoid which consists of curcumin, desmetoksikumin and bisdesmetoksikurkumin and other beneficial substances, such as volatile essential oils of oil, fat, carbohydrates, protein, starch, vitamin C, iron, phosphorus, and calcium. Curcumin is a yellow substance contained by turmeric, on average 10.29%, has broad spectrum biological activity including antihepototoxic, antibacterial and antioxidant so that turmeric is able to be used for traditional medicine both to maintain health and skin beauty of the body, The method used is study experimental scrubs and tested the stability of scrubs containing turmeric rhizome powder. The best scrubs are formula 1 which uses the ratio of turmeric powder to light brown scrub, homogeneous and perfectly fused body scrub, has a pH of 5, spread of 10,321 cm2, has a viscosity consistency of 99,000 mPa.s and adhesion for 4 seconds.   Keywords: formulations, scrubs, turmeric.    

Sign in / Sign up

Export Citation Format

Share Document