scholarly journals Multifunctional and Self-Healable Intelligent Hydrogels for Cancer Drug Delivery and Promoting Tissue Regeneration In-Vivo

Polymers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 2680
Author(s):  
Elham Pishavar ◽  
Fatemeh Khosravi ◽  
Mahshid Naserifar ◽  
Erfan Rezvani Ghomi ◽  
Hongrong Luo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Cancer Therapy ◽  
Regenerative Medicine ◽  
Cell Biology ◽  
Drug Delivery Systems ◽  
Drug Loading ◽  
Delivery Systems ◽  
Cancer Drug ◽  
Self Healing

Regenerative medicine seeks to assess how materials fundamentally affect cellular functions to improve retaining, restoring, and revitalizing damaged tissues and cancer therapy. As potential candidates in regenerative medicine, hydrogels have attracted much attention due to mimicking of native cell-extracellular matrix (ECM) in cell biology, tissue engineering, and drug screening over the past two decades. In addition, hydrogels with a high capacity for drug loading and sustained release profile are applicable in drug delivery systems. Recently, self-healing supramolecular hydrogels, as a novel class of biomaterials, are being used in preclinical trials with benefits such as biocompatibility, native tissue mimicry, and injectability via a reversible crosslink. Meanwhile, the localized therapeutics agent delivery is beneficial due to the ability to deliver more doses of therapeutic agents to the targeted site and the ability to overcome post-surgical complications, inflammation, and infections. These highly potential materials can help address the limitations of current drug delivery systems and the high clinical demand for customized drug release systems. To this aim, the current review presents the state-of-the-art progress of multifunctional and self-healable hydrogels for a broad range of applications in cancer therapy, tissue engineering, and regenerative medicine.

Chitosan-based Polymer Matrix for Pharmaceutical Excipients and Drug Delivery

2019 ◽  
Vol 26 (14) ◽  
pp. 2502-2513 ◽  
Author(s):  
Md. Iqbal Hassan Khan ◽  
Xingye An ◽  
Lei Dai ◽  
Hailong Li ◽  
Avik Khan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Drug Carrier ◽  
Drug Loading ◽  
Delivery Systems ◽  
Cancer Drug ◽  
Release Mechanism ◽  
Innovative Drug ◽  
Pharmaceutical Excipients ◽  
Weight Variation

The development of innovative drug delivery systems, versatile to different drug characteristics with better effectiveness and safety, has always been in high demand. Chitosan, an aminopolysaccharide, derived from natural chitin biomass, has received much attention as one of the emerging pharmaceutical excipients and drug delivery entities. Chitosan and its derivatives can be used for direct compression tablets, as disintegrant for controlled release or for improving dissolution. Chitosan has been reported for use in drug delivery system to produce drugs with enhanced muco-adhesiveness, permeation, absorption and bioavailability. Due to filmogenic and ionic properties of chitosan and its derivative(s), drug release mechanism using microsphere technology in hydrogel formulation is particularly relevant to pharmaceutical product development. This review highlights the suitability and future of chitosan in drug delivery with special attention to drug loading and release from chitosan based hydrogels. Extensive studies on the favorable non-toxicity, biocompatibility, biodegradability, solubility and molecular weight variation have made this polymer an attractive candidate for developing novel drug delivery systems including various advanced therapeutic applications such as gene delivery, DNA based drugs, organ specific drug carrier, cancer drug carrier, etc.

Lipid-Coated Nanosized Drug Delivery Systems For An Effective Cancer Therapy

2020 ◽  
Vol 17 ◽  
Author(s):  
Ozge Esim ◽  
Canan Hascicek
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Cancer Treatment ◽  
Drug Delivery Systems ◽  
Polymeric Nanoparticles ◽  
Drug Loading ◽  
Delivery Systems ◽  
Inorganic Nanoparticles ◽  
Coated Nanoparticle

: Currently, despite many active compounds have been introduced to the treatment, cancer remains one of the most vital causes of mortality and reduced quality of life. Conventional cancer treatments may have undesirable consequences due to the continuously differentiating, dynamic and heterogeneous nature of cancer. Recent advances in the field of cancer treatment have promoted the development of several novel nanoformulations. Among them, the lipid coated nanosized drug delivery systems have gained an increasing attention by the researchers in this field owing to the attractive properties such as high stability and biocompatibility, prolonged circulation time, high drug loading capacity and superior in vivo efficacy. They possess the advantages of both the liposomes and polymeric nanoparticles which makes them a chosen one in the field of drug delivery and targeting. Core-shell type lipid-coated nanoparticle systems, which provide the most prominent advantages of both liposomes such as biocompatibility and polymeric/inorganic nanoparticles such as mechanic properties, offer a new approach to cancer treatment. This review discusses design and production procedures used to prepare lipid-coated nanoparticle drug delivery systems, their advantages and multifunctional role in cancer therapy and diagnosis, as well as the applications they have been used in.

scholarly journals Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy

Pharmaceutics ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 298 ◽  
Author(s):  
Nataša Avramović ◽  
Boris Mandić ◽  
Ana Savić-Radojević ◽  
Tatjana Simić
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery Systems ◽  
High Efficiency ◽  
Drug Loading ◽  
Delivery Systems ◽  
Chemotherapeutic Agents ◽  
Cancer Tissue ◽  
Specific Chemical ◽  
Control Drug

Conventional chemotherapy is the most common therapeutic method for treating cancer by the application of small toxic molecules thatinteract with DNA and causecell death. Unfortunately, these chemotherapeutic agents are non-selective and can damage both cancer and healthy tissues, producing diverse side effects, andthey can have a short circulation half-life and limited targeting. Many synthetic polymers have found application as nanocarriers of intelligent drug delivery systems (DDSs). Their unique physicochemical properties allow them to carry drugs with high efficiency, specificallytarget cancer tissue and control drug release. In recent years, considerable efforts have been made to design smart nanoplatforms, including amphiphilic block copolymers, polymer-drug conjugates and in particular pH- and redox-stimuli-responsive nanoparticles (NPs). This review is focused on a new generation of polymer-based DDSs with specific chemical functionalities that improve their hydrophilicity, drug loading and cellular interactions.Recentlydesigned multifunctional DDSs used in cancer therapy are highlighted in this review.

scholarly journals Lipid-Based Drug Delivery Systems in Regenerative Medicine

Materials ◽  
2021 ◽  
Vol 14 (18) ◽  
pp. 5371
Author(s):  
Nina Filipczak ◽  
Satya Siva Kishan Yalamarty ◽  
Xiang Li ◽  
Muhammad Muzamil Khan ◽  
Farzana Parveen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Stem Cells ◽  
Regenerative Medicine ◽  
Drug Delivery Systems ◽  
Local Environment ◽  
Delivery Systems ◽  
The Body ◽  
Innovative Drug ◽  
Natural Healing

The most important goal of regenerative medicine is to repair, restore, and regenerate tissues and organs that have been damaged as a result of an injury, congenital defect or disease, as well as reversing the aging process of the body by utilizing its natural healing potential. Regenerative medicine utilizes products of cell therapy, as well as biomedical or tissue engineering, and is a huge field for development. In regenerative medicine, stem cells and growth factor are mainly used; thus, innovative drug delivery technologies are being studied for improved delivery. Drug delivery systems offer the protection of therapeutic proteins and peptides against proteolytic degradation where controlled delivery is achievable. Similarly, the delivery systems in combination with stem cells offer improvement of cell survival, differentiation, and engraftment. The present review summarizes the significance of biomaterials in tissue engineering and the importance of colloidal drug delivery systems in providing cells with a local environment that enables them to proliferate and differentiate efficiently, resulting in successful tissue regeneration.

Nanocarrier-based Drug Delivery System for Cancer Therapeutics: A Review of the Last Decade

2020 ◽  
Vol 27 ◽  
Author(s):  
Muhammad Sohail ◽  
Wenna Guo ◽  
Zhiyong Li ◽  
Hui Xu ◽  
Feng Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Cancer Therapy ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Research Progress ◽  
Cancer Drug ◽  
Conventional Chemotherapy ◽  
Anti Cancer ◽  
Cancer Drug Delivery

: In recent years, due to the shortcomings of conventional chemotherapy, such as poor bioavailability, low treatment index and unclear side effects, the focus of cancer research has shifted to new nanocarriers of chemotherapeutic drugs. By using biodegradable materials, nanocarriers generally have the advantages of good biocompatibility, low side effects, targeting, controlled release profile, and improved efficacy. And more to the point, nanocarrier based anti-cancer drug delivery systems clearly show the potential to overcome the problems associated with conventional chemotherapy. In order to promote the deepening of research and development in this field, we herein summarized and analyzed various nanocarrier based drug delivery systems for cancer therapy, including the concepts, types, characteristics and preparation methods. The active and passive targeting mechanisms of cancer therapy were also included, along with a brief introduction of the research progress of nanocarriers used for anti-cancer drug delivery in the past decade.

Review paper: Critical Issues in Tissue Engineering: Biomaterials, Cell Sources, Angiogenesis, and Drug Delivery Systems

2011 ◽  
Vol 26 (4) ◽  
pp. 383-417 ◽  
Author(s):  
Hojjat Naderi ◽  
Maryam M. Matin ◽  
Ahmad Reza Bahrami
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Cell Biology ◽  
Drug Delivery Systems ◽  
Materials Science ◽  
Three Dimensional ◽  
Time Frame ◽  
Delivery Systems ◽  
Critical Issues ◽  
Cell Sources

Tissue engineering is a newly emerging biomedical technology, which aids and increases the repair and regeneration of deficient and injured tissues. It employs the principles from the fields of materials science, cell biology, transplantation, and engineering in an effort to treat or replace damaged tissues. Tissue engineering and development of complex tissues or organs, such as heart, muscle, kidney, liver, and lung, are still a distant milestone in twenty-first century. Generally, there are four main challenges in tissue engineering which need optimization. These include biomaterials, cell sources, vascularization of engineered tissues, and design of drug delivery systems. Biomaterials and cell sources should be specific for the engineering of each tissue or organ. On the other hand, angiogenesis is required not only for the treatment of a variety of ischemic conditions, but it is also a critical component of virtually all tissue-engineering strategies. Therefore, controlling the dose, location, and duration of releasing angiogenic factors via polymeric delivery systems, in order to ultimately better mimic the stem cell niche through scaffolds, will dictate the utility of a variety of biomaterials in tissue regeneration. This review focuses on the use of polymeric vehicles that are made of synthetic and/or natural biomaterials as scaffolds for three-dimensional cell cultures and for locally delivering the inductive growth factors in various formats to provide a method of controlled, localized delivery for the desired time frame and for vascularized tissue-engineering therapies.

Nanoclay-based drug delivery systems and their therapeutic potentials

2020 ◽  
Vol 8 (33) ◽  
pp. 7335-7351 ◽  
Author(s):  
Nafeesa Khatoon ◽  
Mao Quan Chu ◽  
Chun Hui Zhou
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Gene Therapy ◽  
Cancer Therapy ◽  
Clay Minerals ◽  
Drug Delivery Systems ◽  
Drug Carriers ◽  
Delivery Systems

Natural and modified nanostructured clay minerals as drug carriers and support matrices for drug delivery, cancer therapy, gene therapy, and tissue engineering.

Chitosan-based inks for 3D printing and bioprinting

2021 ◽  
Author(s):  
Mohsen Taghizadeh ◽  
Ali Taghizadeh ◽  
Mohsen Khodadadi Yazdi ◽  
Payam Zarrintaj ◽  
Florian J. Stadler ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
3D Printing ◽  
Regenerative Medicine ◽  
Biomedical Engineering ◽  
Drug Delivery Systems ◽  
Delivery Systems

3D printing gave biomedical engineering great potential to mimic native tissues, accelerated regenerative medicine, and enlarged capacity of drug delivery systems; thus, advanced biomimetic functional biomaterial developed by 3D-printing for tissue engineering demands.

Supramolecular Nanomedicine Derived from Cucurbit[7]uril-Conjugated Nano-Graphene Oxide for Multi-modality Cancer Therapy

2021 ◽  
Author(s):  
Yuan-Fu Ding ◽  
Cheryl Kwong ◽  
Shengke Li ◽  
Yating Pan ◽  
Jianwen Wei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Cancer Therapy ◽  
Surface Functionalization ◽  
Drug Delivery Systems ◽  
Drug Loading ◽  
Delivery Systems ◽  
Π Stacking ◽  
Nano Graphene

Nano-graphene oxide (NGO) has attracted increasing attentions as advanced drug delivery systems. However, the current surface functionalization and drug-loading of NGO either relies on π−π stacking that is limited to...

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