Controllable Release of Povidone-Iodine from Networked Pectin@Carboxymethyl Pullulan Hydrogel

Povidone-iodine (PI) is a common antiseptic reagent which is used for skin infections and wound healing. The control release of PI is quite important to heal the deep and intense wounds. Herein, the preparation of biodegradable pectin@carboxymethyl pullulan (Pe@CMP) hydrogel was carried out and applied for controllable release of PI. CMP was synthesized by interaction of monochloroacetic acid with pullulan at different ratios. The Pe@CMP hydrogel was then prepared by crosslinking of pectin with CMP in presence of glutaraldehyde as cross linker. After carboxymethylation, COOH contents were enlarged to be 24.2–51.2 mmol/kg and degree of substitution was 0.44–0.93. The rheological properties of Pe@CMP hydrogel were enlarged by increment of pectin ratio. Swelling ratio in water (16.0–18.0%) was higher than that of artificial sweat (11.7–13.2%). Pe@CMP hydrogel containing 20% pectin, exhibited the lowest release and 57.7% from PI was released within 360 min. The biological activity of the released PI was monitored to be highly efficient. The kinetic of release was fitted well to the first ordered reaction and Higuchi models. The mechanism of release was explained by the swelling of hydrogel. The networked structure of hydrogel was opened by swelling and PI was released from the outer pores followed by inner pores, achieving the controllable release.

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A preliminary clinical trial comparing wet silver dressings versus wet‐to‐dry povidone‐iodine dressings for wound healing in pemphigus vulgaris patients

Dermatologic Therapy ◽

10.1111/dth.14906 ◽

2021 ◽

Author(s):

JiHui Chen ◽

Qin Zou ◽

Michael R Hamblin ◽

Xiang Wen

Keyword(s):

Clinical Trial ◽

Wound Healing ◽

Povidone Iodine ◽

Pemphigus Vulgaris ◽

Preliminary Clinical Trial

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Investigation of the biological activity, mechanical properties and wound healing application of a novel scaffold based on lignin–agarose hydrogel and silk fibroin embedded zinc chromite nanoparticles

RSC Advances ◽

10.1039/d1ra01300a ◽

2021 ◽

Vol 11 (29) ◽

pp. 17914-17923

Author(s):

Reza Eivazzadeh-Keihan ◽

Hooman Aghamirza Moghim Aliabadi ◽

Fateme Radinekiyan ◽

Mohammad Sobhani ◽

Farzane khalili ◽

...

Keyword(s):

Mechanical Properties ◽

Wound Healing ◽

Biological Activity ◽

Silk Fibroin ◽

Agarose Hydrogel ◽

Novel Scaffold ◽

Fibroin Solution ◽

Zinc Chromite

Given the important aspects of wound healing approaches, in this work, an innovative biocompatible nanobiocomposite scaffold was designed and prepared based on cross-linked lignin–agarose hydrogel, extracted silk fibroin solution, and zinc chromite (ZnCr2O4) nanoparticles.

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Comparison of topical honey and povidone iodine-based dressings for wound healing: a systematic review and meta-analysis

Journal of Wound Care ◽

10.12968/jowc.2021.30.sup4.s28 ◽

2021 ◽

Vol 30 (Sup4) ◽

pp. S28-S36

Author(s):

Fujie Zhang ◽

Zongnan Chen ◽

Feng Su ◽

Taijuan Zhang

Keyword(s):

Wound Healing ◽

Hospital Stay ◽

Analogue Scale ◽

Povidone Iodine ◽

Meta Analysis ◽

Length Of Hospital Stay ◽

Beneficial Effects ◽

Vas Score ◽

Wound Recovery ◽

Hospital Stay Duration

Objectives: In this review and meta-analysis, we analyse the evidence to compare the efficacy of honey and povidone iodine-based dressings on the outcome of wound healing. Method: A systematic literature search was performed using PRISMA guidelines in academic databases including MEDLINE, Scopus, Embase and CENTRAL. A meta-analysis was carried out to assess the effect of honey and povidone iodine-based dressings on mean healing duration, mean hospital stay duration and visual analogue scale (VAS) score of pain. Results: From the search, 12 manuscripts with a total of 1236 participants (mean age: 40.7±11.7 years) were included. The honey-based dressings demonstrated a medium-to-large effect in reduction of mean healing duration (Hedge's g: –0.81), length of hospital stay (–3.1) and VAS score (–1.2) as compared with the povidone iodine-based dressings. We present evidence (level 1b) in favour of using honey for improvement of wound recovery as compared with povidone iodine. Conclusion: This review and meta-analysis demonstrate beneficial effects of honey-based dressings over povidone iodine-based dressings for wound recovery.

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Pharmacological Evaluation of Chrozophora tinctoria as Wound Healing Potential in Diabetic Rat’s Model

BioMed Research International ◽

10.1155/2016/7475124 ◽

2016 ◽

Vol 2016 ◽

pp. 1-7 ◽

Cited By ~ 4

Author(s):

Harikesh Maurya ◽

Monika Semwal ◽

Susheel Kumar Dubey

Keyword(s):

Wound Healing ◽

Disease Control ◽

Povidone Iodine ◽

Diabetic Rats ◽

Control Group ◽

Standard Drug ◽

Group Iii ◽

Group I ◽

Elevated Blood Glucose Level ◽

Pharmacological Potential

Objective. The study was designed to evaluate pharmacological potential of hydroalcoholic leaves extract of Chrozophora tinctoria intended for wound healing in diabetic rats’ model. Methods. The method used to evaluate the pharmacological potential of hydroalcoholic leave extract was physical incision rat model. In this model, cutting of the skin and/or other tissues with a sharp blade has been made and the rapid disruption of tissue integrity with minimal collateral damage was observed shortly. Animals used in the study were divided into four groups that consist of six animals in each group. Group I serves as normal control, Group II serves as disease control, Group III was used as standard treatment (Povidone iodine 50 mg/kg b.w.), and Group IV was used for test drug (C. tinctoria 50 mg/kg b.w.). Result. The hydroalcoholic leave extract of Chrozophora tinctoria has been significantly observed to heal the wound (98%) in diabetic rats within 21 days, while standard drug (Povidone iodine) healed the wound about 95% in the same condition. The oral dose (50 mg/kg b.w.) of Chrozophora tinctoria was also found to improve the elevated blood glucose level in comparison to disease control group, which increased after the oral administration of Streptozotocin. Conclusion. The Chrozophora tinctoria has significant wound healing potential in the animal having physically damaged tissue in diabetic condition.

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Peer review report 4 on “Povidone iodine in wound healing: A review of current concepts and practices”

International Journal of Surgery ◽

10.1016/j.ijsu.2017.07.007 ◽

2017 ◽

Vol 37 ◽

pp. 411

Keyword(s):

Wound Healing ◽

Peer Review ◽

Povidone Iodine

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PENGARUH PEMBERIAN GEL KOMBINASI EKSTRAK GETAH PEPAYA (Carica papaya L) DAN EKSTRAK DAGING LIDAH BUAYA (Aloe vera) TERHADAP PROSES PENYEMBUHAN ULKUS TRAUMATIKUS PADA MALE WISTAR RATS YANG MENDERITA DIABETES MELITUS

ODONTO Dental Journal ◽

10.30659/odj.2.2.41-46 ◽

2015 ◽

Vol 2 (1) ◽

pp. 41

Author(s):

Umi Kulsum ◽

Ratnawati Hendari ◽

Siti Chumaeroh

Keyword(s):

Wound Healing ◽

Ulcer Healing ◽

Wistar Rats ◽

Povidone Iodine ◽

Healing Process ◽

Aloe Vera ◽

Control Group ◽

Significant Difference ◽

Male Wistar Rats ◽

Papaya Latex

Introduction: Research on the use of papaya and aloevera sap on wound healing each been done, but effects the combination of the two extracts on wound healing in diabetes mellitus condition has not been done.Purpose: This study aims to determine the effect of a gel combination of papaya latex and aloevera flesh extracts on the traumatics ulcer healing process in diabetic rats.Methods: True experimental laboratory research with the post-test-only control group design that performed on 28 male wistar rats which were divided intofour groups: DM and non-DM rat that treatment with povidone iodine and gel combination of papaya latex and aloevera flesh extract. The treatment was done for 7 days with smearing that was given 2x/day. Traumatics ulcer healing seen from the number of fibroblasts that then were analyzed by One WayAnova and post hoc LSD test.Results: The results showed the number of fibroblasts in DM and non-DM rat with povidone iodine were 44.6 and 42.73; in the DM and non-DM rat with a gel combination of papaya latex and aloe vera flesh extracts were 61.10 and 77.03. One Way Anova test resulted p-value = 0.000, it was mean that there were at least a significant difference on the number of fibroblasts in the two groups. Differences of the number fibroblasts was shown in all groups, except in the group DM and non-DM rats with povidone iodine (p = 0.764).Conclusion: Conclusion of the study was the provision of a gel combination of papaya latex and aloevera flesh extracts effect on the traumatics ulcer healing process in diabetic rats.

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AMAZING ANTIMICROBIAL AND WOUND HEALING POTENTIAL OF ACACIA CATECHU BARK EXTRACTS- A REVIEW

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2021.v14i10.43009 ◽

2021 ◽

pp. 1-7

Author(s):

ARCHANA TIWARI ◽

AVINASH TIWARI

Keyword(s):

Wound Healing ◽

Secondary Metabolites ◽

Review Article ◽

Present Review ◽

Skin Infections ◽

Bioactive Components ◽

Medicinal Properties ◽

Pathogenic Microbes ◽

Acacia Catechu ◽

Physiological Reactions

Plants are not only the source of food, oxygen, and shelter, but the same are also a potential foundation of medicines. Many natural and plant-derived antimicrobial and wound healing compounds have been recognized. In the present review, we have studied the main bioactive components of Acacia catechu with their medicinal roles. Most of these bioactive components are secondary metabolites which are produced by plants as side products of certain physiological reactions and are of no use for the plant itself. These components have been reported for their medicinal properties. In this review, we have mentioned some antibacterial, antifungal, and wound healing properties of A. catechu with its known bioactive components. The aim of this review article is, to enlist the possible potent bioactive components of the plant, against pathogenic microbes that can replace the use of chemicals and synthetic antibiotics for the treatment of skin infections and other diseases.

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Anti-inflammatory properties of a liposomal hydrogel with povidone-iodine (Repithel®) for wound healing in vitro

Burns ◽

10.1016/j.burns.2007.11.014 ◽

2008 ◽

Vol 34 (6) ◽

pp. 845-855 ◽

Cited By ~ 43

Author(s):

C.J. Beukelman ◽

A.J.J. van den Berg ◽

M.J. Hoekstra ◽

R. Uhl ◽

K. Reimer ◽

...

Keyword(s):

Wound Healing ◽

Povidone Iodine ◽

Anti Inflammatory

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ACCELERATED WOUND HEALING ABILITY OF SACRAN HYDROGEL FILM BY KERATINOCYTE GROWTH FACTOR IN ALLOXAN-INDUCED DIABETIC MICE

International Journal of Applied Pharmaceutics ◽

10.22159/ijap.2018v10i2.24217 ◽

2018 ◽

Vol 10 (2) ◽

pp. 57 ◽

Cited By ~ 4

Author(s):

Nasrul Wathoni ◽

Aliya Nur Hasanah ◽

Ahmed Fouad Abdelwahab Mohammed ◽

Elasari Dwi Pratiwi ◽

Ripa’atul Mahmudah

Keyword(s):

Wound Healing ◽

Tensile Strength ◽

Growth Factor ◽

Keratinocyte Growth Factor ◽

Research Work ◽

Physicochemical Characterization ◽

Swelling Ratio ◽

Diabetic Mice ◽

Mice Model ◽

Hydrogel Film

Objective: The main objective of the research work was to fabricate sacran hydrogel film containing keratinocyte growth factor (Sacran/KGF-HGF), and to evaluate their wound healing ability in alloxan-induced diabetic mice model.Methods: The physicochemical characterization of Sacran/KGF-HGF were investigated by thickness, tensile strength, swelling ratio, x-ray diffractometer (XRD), scanning electron microscope (SEM), and biodegradability. The wound healing ability was investigated by creating two full-thickness excisional wounds inalloxan-induced diabetic mice.Results: The thickness, tensile strength, and swelling ratio results showed that KGF in the Sacran/KGF-HGF improved not only the thickness of sacran hydrogel film (Sacran-HGF), but also the tensile strength and swelling ability of Sacran-HGF. The XRD and SEM results confirmed that the Sacran/KGF-HGF were amorphous and similar morphology to Sacran-HGF, respectively. The biodegradability results revealed that the Sacran/KGF-HGF degraded for about 41.29% in trichloroacetic acid (TCA) and 22.92% in TrypLE™ (recombinant enzyme) solutions. In addition, KGF improved the degradability of Sacran/KGF-HGF in both solutions. Interestingly, the Sacran/KGF-HGF, which was applied on wound site, considerably improved the wound healing ability of Sacran-HGF at 6, 9 and 12 d in alloxan-induced diabetic mice model, compared to control (non-treated).Conclusion: These results suggest that KGF has the potential to promote the chronic wound healing ability of Sacran-HGF.

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